John F. DiPersio, M.D., Ph.D.

John DiPersio
  • Professor
    • Department of Medicine
      • Oncology Division
        • Bone Marrow Transplantation & Leukemia Section
        • Stem Cell Biology Section
    • Department of Pediatrics
    • Department of Pathology & Immunology
  • Clinical interests
    • Allogeneic stem cell transplantation
    • Haploidentical stem cell transplantation
  • Research interests
    • Hematopoietic growth factor receptors
    • Murine models of graft-versus-host disease and graft-versus-leukemia

Research

My research focuses on fundamental and translational aspects of leukemia and stem cell biology. These studies include identification of genetic abnormalities in human leukemias, understanding processes involving stem cell and leukemia cell trafficking and clinical and translational programs in both leukemia/MDS and stem cell transplantation. My laboratory utilizes unique mouse models of allogeneic stem cell transplantation to explore novel genetic and epigenetic interventions aimed at mitigating graft vs. host disease (GvHD) while maintaining graft vs. leukemia (GvL). My role in these studies is to oversee all aspects of the Phase I/II clinical trial examining the safety and effectiveness of AzaC treatment as GvHD prophylaxis in patients with AML and MDS undergoing allogeneic stem cell transplant.

Biographical Sketch

Education

1973 B.A. in Biology (Magna Cum Laude), Williams College, Williamstown, MA
1980 M.D./Ph.D. in Microbiology, University of Rochester, Rochester, NY

Post-graduate Training

1980-1981 Intern (Straight Medicine), Parkland Memorial Hospital, UT Southwestern, Dallas, TX
1981-1983 Resident, Parkland Memorial Hospital, UT Southwestern, Dallas, TX
1983-1984 Chief Resident, Parkland Memorial Hospital, UT Southwestern, Dallas, TX
1984-1987 Fellow, Division of Hematology-Oncology, UCLA School of Medicine, Los Angeles, CA

Academic Positions

1987-1988 Instructor of Medicine, Division of Hematology-Oncology, UCLA School of Medicine, Los Angeles, CA
1988-1990 Assistant Professor of Medicine, Division of Hematology-Oncology, UCLA School of Medicine, Los Angeles, CA
1990-1994 Assistant Professor of Oncology, University of Rochester School of Medicine and Dentistry, Rochester, NY
1990-1994 Director, Bone Marrow Transplant Program, Strong Memorial Hospital, Rochester, NY
1990-1994 Assistant Professor of Medicine, Hematology Unit, University of Rochester School of Medicine, Rochester, NY
1994-1997 Associate Professor of Medicine, Pediatrics and Pathology, Washington University School of Medicine, St. Louis, MO
1994-2000 Chief, Division of Bone Marrow Transplantation & Stem Cell Biology, Washington University School of Medicine, St. Louis, MO
1997-present Professor of Medicine, Pediatrics and Pathology/Immunology, Washington University School of Medicine, St. Louis, MO
2000-2003 Acting Director, Division of Medical Oncology, Washington University School of Medicine, St. Louis, MO
2000-2006 Director, Section of Bone Marrow Transplantation & Leukemia, Washington University School of Medicine, St. Louis, MO
2000-present Deputy Director, Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO
2003-present Chief, Division of Oncology, Washington University School of Medicine, St. Louis, MO
2006-2011 Scientific Director, Good Manufacturing Procedure (GMP) Facility, Siteman Cancer Center

Board Certification

1984 American Board of Internal Medicine
1987 American Board of Internal Medicine (Medical Oncology)
1988 American Board of Internal Medicine (Hematology)

Selected Honors & Professional Memberships

1996 Elected, American Society of Clinical Investigation (ASCI)
1997 Recipient, Lewis T. and Rosalind B. Apple Chair in Oncology
2000-2006 Leukemia and Lymphoma Society of America, Career Development Award Study Section Member
2000 Chairman, NHLBI Consensus Conference on Allo Transplantation for Non-Malignant Diseases
2001 ISHAGE Meeting, First Prize, Scientific Merit: “Control of GvHD using genetically modified T cells”
2002 Member, Executive Committee IBMTR/ABMTR
2003-2006 Award Member, ASH Committee on Educational Affairs, Washington DC
2003-2006 Member, Board of Directors, American Society of Biology and Marrow Transplant
2004-2009 NCI (NIH) Permanent CONC Study Section Member
2005 Chairman, Study Section RFA HL-04-017 (NHLBI) Specialized Center for Cell Based Therapy
2006 NIH (ZRG)/CSR, Gene Therapy and Inborn Errors, Special Emphasis Review Panel
2006 Member, ASH Committee on Gene and Cell Therapy
2007-2012 Co-Chair, CIBMTR Acute Leukemia Working Committee
2008 “Great Teacher” Lecture NIH
2008 NCI P01 Special Emphasis Panel ZCA1-RPRB-J, Bethesda MD
2008 ASH Scientific Committees on Cell and Gene Therapy and Hematopoiesis
2008-2011 Member, Scientific and Medical Research Funding, California Institute of Regenerative Medicine (CIRM)
2009 Member, Review Panel, Center Grants, National Medical Research Council, Singapore
2009 Member, ASBMT Committee on Research Priorities
2010 Recipient, Virginia E. and Samuel J. Golman Endowed Professorship in Medicine
2010 ASH/CRTI Faculty/Mentor
2010 Washington University Divisions of Hematology and Oncology “Teacher of the Year”
2010 Member, External Advisory Board, Cancer Therapy and Research Center, UT San Antonio
2010 Chairman, NIH NIAID ZAI1 MFH-01 P01 Special Emphasis Panel
2011 NIH (BST-M)/CSR - Special Emphasis Panel
2011 Study Section, Doris Duke Center Grants for Sickle Cell Disease
2011 Chairman, NIH/NIDDK P01 Special Emphasis Panel, Methylation and Hematopoiesis
2012-2014 Vice Chair (2012-13) and Chair (2013-14) ASH Scientific Committee on Hematopoiesis
2013 NIH Study Section for Loan Repayment Program
2013 Daniel P. Schuster Distinguished Translational Investigator Award, Washington University
2013 Member, Association of American Physicians (AAP)
2013 Member, NCI Provocative Questions B Study Section