Faculty
Vivek Arora.jpg

Vivek K. Arora, MD, PhD

Assistant Professor
Department of Medicine
Oncology Division
Molecular Oncology

Contact

  • 314-454-8681 (tel)
  • 314-747-2797 (fax)
  • 8th Floor, McDonnell Sciences Building
  • Washington University School of Medicine
    Division of Oncology
    Campus Box 8069
    660 South Euclid Avenue
    St. Louis, MO 63110

Publications

  • Regulation of the Glucocorticoid Receptor Via a BET-Dependent Enhancer Drives Antiandrogen Resistance in Prostate Cancer
    Shah N, Wang P, Wongvipat J, Karthaus WR, Abida W, Armenia J, Rockowitz S, Drier Y, Bernstein BE, Long HW, Freedman ML, Arora VK, Zheng D, Sawyers CL
    Elife 2017 Sep 11;6
  • Organoid Cultures Derived From Patients With Advanced Prostate Cancer
    Gao D, Vela I, Sboner A, Iaquinta PJ, Karthaus WR, Gopalan A, Dowling C, Wanjala JN, Undvall EA, Arora VK, Wongvipat J, Kossai M, Ramazanoglu S, Barboza LP, Di W, Cao Z, Zhang QF, Sirota I, Ran L, MacDonald TY, Beltran H, Mosquera JM, Touijer KA, Scardino PT, Laudone VP, Curtis KR, Rathkopf DE, Morris MJ, Danila DC, Slovin SF, Solomon SB, Eastham JA, Chi P, Carver B, Rubin MA, Scher HI, Clevers H, Sawyers CL, Chen Y
    Cell 2014 Sep 25;159(1):176-87
  • Aggressive Variants of Castration-Resistant Prostate Cancer
    Beltran H, Tomlins S, Aparicio A, Arora V, Rickman D, Ayala G, Huang J, True L, Gleave ME, Soule H, Logothetis C, Rubin MA
    Clin Cancer Res 2014 Jun 1;20(11):2846-50
  • Glucocorticoid Receptor Confers Resistance to Antiandrogens by Bypassing Androgen Receptor Blockade
    Arora VK, Schenkein E, Murali R, Subudhi SK, Wongvipat J, Balbas MD, Shah N, Cai L, Efstathiou E, Logothetis C, Zheng D, Sawyers CL
    Cell 2013 Dec 5;155(6):1309-22
  • Androgen Receptor Signaling Regulates DNA Repair in Prostate Cancers
    Polkinghorn WR, Parker JS, Lee MX, Kass EM, Spratt DE, Iaquinta PJ, Arora VK, Yen WF, Cai L, Zheng D, Carver BS, Chen Y, Watson PA, Shah NP, Fujisawa S, Goglia AG, Gopalan A, Hieronymus H, Wongvipat J, Scardino PT, Zelefsky MJ, Jasin M, Chaudhuri J, Powell SN, Sawyers CL
    Cancer Discov 2013 Nov;3(11):1245-53
  • Overcoming Mutation-Based Resistance to Antiandrogens With Rational Drug Design
    Balbas MD, Evans MJ, Hosfield DJ, Wongvipat J, Arora VK, Watson PA, Chen Y, Greene GL, Shen Y, Sawyers CL
    Elife 2013 Apr 9;2:e00499
  • ARN-509: A Novel Antiandrogen for Prostate Cancer Treatment
    Clegg NJ, Wongvipat J, Joseph JD, Tran C, Ouk S, Dilhas A, Chen Y, Grillot K, Bischoff ED, Cai L, Aparicio A, Dorow S, Arora V, Shao G, Qian J, Zhao H, Yang G, Cao C, Sensintaffar J, Wasielewska T, Herbert MR, Bonnefous C, Darimont B, Scher HI, Smith-Jones P, Klang M, Smith ND, De Stanchina E, Wu N, Ouerfelli O, Rix PJ, Heyman RA, Jung ME, Sawyers CL, Hager JH
    Cancer Res 2012 Mar 15;72(6):1494-503
  • Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-Deficient Prostate Cancer
    Carver BS, Chapinski C, Wongvipat J, Hieronymus H, Chen Y, Chandarlapaty S, Arora VK, Le C, Koutcher J, Scher H, Scardino PT, Rosen N, Sawyers CL
    Cancer Cell 2011 May 17;19(5):575-86
  • Integrative Genomic Profiling of Human Prostate Cancer
    Taylor BS, Schultz N, Hieronymus H, Gopalan A, Xiao Y, Carver BS, Arora VK, Kaushik P, Cerami E, Reva B, Antipin Y, Mitsiades N, Landers T, Dolgalev I, Major JE, Wilson M, Socci ND, Lash AE, Heguy A, Eastham JA, Scher HI, Reuter VE, Scardino PT, Sander C, Sawyers CL, Gerald WL
    Cancer Cell 2010 Jul 13;18(1):11-22
  • Development of a Second-Generation Antiandrogen for Treatment of Advanced Prostate Cancer
    Tran C, Ouk S, Clegg NJ, Chen Y, Watson PA, Arora V, Wongvipat J, Smith-Jones PM, Yoo D, Kwon A, Wasielewska T, Welsbie D, Chen CD, Higano CS, Beer TM, Hung DT, Scher HI, Jung ME, Sawyers CL
    Science 2009 May 8;324(5928):787-90
  • Activation of P21-Activated Kinase 2 by Human Immunodeficiency Virus Type 1 Nef Induces Merlin Phosphorylation
    Wei BL, Arora VK, Raney A, Kuo LS, Xiao GH, O'Neill E, Testa JR, Foster JL, Garcia JV
    J Virol 2005 Dec;79(23):14976-80
  • Genetic and Functional Diversity of Human Immunodeficiency Virus Type 1 Subtype B Nef Primary Isolates
    Foster JL, Molina RP, Luo T, Arora VK, Huang Y, Ho DD, Garcia JV
    J Virol 2001 Feb;75(4):1672-80
  • Lentivirus Nef Specifically Activates Pak2
    Arora VK, Molina RP, Foster JL, Blakemore JL, Chernoff J, Fredericksen BL, Garcia JV
    J Virol 2000 Dec;74(23):11081-7
  • The Third Intracellular Loop of the Rat Gonadotropin-Releasing Hormone Receptor Couples the Receptor to Gs- And G(Q/11)-Mediated Signal Transduction Pathways: Evidence From Loop Fragment Transfection in GGH3 Cells
    Ulloa-Aguirre A, Stanislaus D, Arora V, Vaananen J, Brothers S, Janovick JA, Conn PM
    Endocrinology 1998 May;139(5):2472-8
  • The Cloning of a Caenorhabditis Elegans Guanylyl Cyclase and the Construction of a Ligand-Sensitive Mammalian/Nematode Chimeric Receptor
    Baude EJ, Arora VK, Yu S, Garbers DL, Wedel BJ
    J Biol Chem 1997 Jun 20;272(25):16035-9
  • Biphasic Action of Cyclic Adenosine 3',5'- Monophosphate in Gonadotropin-Releasing Hormone (GnRH) Analog-Stimulated Hormone Release From GH3 Cells Stably Transfected With GnRH Receptor Complementary Deoxyribonucleic Acid
    Stanislaus D, Arora V, Awara WM, Conn PM
    Endocrinology 1996 Mar;137(3):1025-31