Faculty
John DiPersio.jpg

John F. DiPersio, MD, PhD

Professor
Department of Medicine
Oncology Division
Bone Marrow Transplantation & Leukemia
Stem Cell Biology
Department of Pediatrics
Department of Pathology & Immunology

Clinical Interests

  • Allogeneic stem cell transplantation
  • Haploidentical stem cell transplantation

Research Interests

  • Hematopoietic growth factor receptors
  • Murine models of graft-versus-host disease and graft-versus-leukemia
  • Leukemia genomics

Contact

  • 314-454-8306 (tel)
  • 314-454-7551 (fax)
  • 11th Floor Mid-Campus Center (office)
  • 626 Southwest Tower (lab)
  • Division of Oncology
    Campus Box 8007
    Washington University Medical School
    660 South Euclid Avenue
    St. Louis, MO 63110

Book Chapters

  • CXCR4/CXCL12 as a therapeutic target
    Uy G, DiPersio J
    In: Targeted Therapy of Acute Myeloid Leukemia. Chapter 31: 607-615, 2015
  • Relevance and clinical implications of tumor cell mobilization in autologous transplantation of myeloma and non hodgkin's lymphoma
    Fruehauf S, Ho AD, DiPersio J
    In: Novel Developments in Stem Cell Mobilization: Focus on CXCR4. Chapter 10: 201-220, 2012
  • Application of CXCR4-inhibitors in leukemia
    Ansstas G, Mir F, Rettig M, Schroeder M, DiPersio J
    In: Novel Developments in Stem Cell Mobilization: Focus on CXCR4. Chapter 17: 335-350, 2012
  • Allogeneic stransplantation for myelodysplastic syndromes
    Uy GL, DiPersio JF
    In: Allogeneic Stem Cell Transplantation, Contemporary Hematology Second Edition. Chapter 14, pp 203-17
  • Chapter 2 CXCR4 and mobilization of hematopoietic precursors
    Rettig MP, Ramirez P, Nervi B, DiPersio JF
    Methods Enzymol 2009;460:57-90
  • Role of hematopoietic stem cell transplantation in acute myelogenous leukemia and myelodysplastic syndrome
    Tallman MS, Mathews V, DiPersio JF
    Cancer Treat Res 2009;144:415-39
  • Improving stem cell mobilization strategies: future directions
    Bensinger W, DiPersio JF, McCarty JM
    Bone Marrow Transplant 2009 Feb;43(3):181-95
  • Hematopoietic stem cell transplants for solid tumors
    Kuperman DI, DiPersio JF
    In: Principles and Practice of Surgical Oncology, 2e, Chapter 5: 90-98, 2009
  • The Education Book
    DiPersio JF
    Associate Editor, ASBMT Meeting Scientific Program Committee 2008
  • Mobilization of autologous peripheral blood hematopoietic cells for hematopoietic cell therapy
    Shea T, DiPersio JF
    In: Thomas Hematopoietic Cell Transplantation (K Blume, S Forman, F Appelbaum, eds), 2008
  • Therapy options in imatinib failures
    Ramirez P, DiPersio JF
    Oncologist 2008 Apr;13(4):424-34
  • Principles of hematopoietic stem cell transplantation
    Uy G, Nervi B, DiPersio JF
    In: Washington University Manual of Oncology, Chapter 5: 47-60, 2007
  • Inside the minds
    DiPersio JF
    Aspatore Books 2007
  • Principles and practice of surgical oncology: multidisciplinary approach to difficult problems
    DiPersio JF
    2007
  • Acute leukemias, Chapter 27
    Nervi B, DiPersio JF
    In: Cancer: Principles and Practice of Oncology Review: First Edition. Ed. R. Govindan, Lippincott Williams on Wilkins, 2005
  • Analysis of dendritic cell content within allografts mobilized following G-CSF or GM-CSF does not reveal significant differences in DC1 or DC2 subsets
    Devine SM, Ritchey J, DiPersio JF
    The Journal of Supportive Oncology, Vol. 2, Supplement 2, March/April 2004
  • Allogeneic stem cell transplantation for myelodysplastic syndrome and aplastic anaemia, Chapter 46
    Mathews V, DiPersio JF
    In: Clinical Neoplastic Hematology. Ed. M. Serekes, B. Bolwell and M. Kalaycco. McGraw Hill 2004
  • Transfusion considerations
    Goodnough LT, DiPersio JF
    In: Management of Infection In Oncology Patients. Wingard JR, Bowden RA, eds., Martin Dunitz, New York, NY, 431-441, 2003
  • Issues in the management of cancer-related thrombocytopenia
    Goodnough LT, DiPersio JF
    Oncology (Williston Park) 2002 Nov;16(11):1558-67; discussion 1570, 1572-4
  • Use of filgrastim (r-metHuG-CSF) in neutrophil transfusions
    Adkins DA, Brown RA, Goodnough LT, DiPersio JF
    In: Filgrastim (r-metHuG-CSF) in Clinical Practice 2nd Edition, eds. Morstyn G, Dexter M; Marcel Dekker, Inc., New York, NY, 149-164, 1998
  • Hematopoietic growth factors
    Kouides PA and DiPersio JF
    In: Haskell, C. (ed.), Cancer Treatment, Chapter 87, W.B. Saunders Co., 1996
  • High-dose chemotherapy followed by autologous stem cell rescue for refractory Hodgkin's disease and non-Hodgkin's lymphoma
    Rapoport AP, Rowe JM, DiPersio JF
    In: Autologous Bone Marrow Transplantation for Hodgkin's Disease, non-Hodgkin's Lymphoma and Multiple Myeloma, Zander AR and Barlogie B (Eds.), Springer-Verlag, New York, Berlin, pg. 87-94, 1993
  • Activation of neutrophils by granulocyte-macrophage colony-stimulating factor
    DiPersio JF, Abboud CN
    In: Granulocyte Responses to Cytokines: Basic and Clinical Research. Coffey, R.G., Ed. Marcel Dekker Inc., New York, NY, 1991
  • Colony-stimulating factors: enhancement of effector cell function
    DiPersio JF
    Cancer Surv 1990;9(1):81-113
  • Hematopoietic growth factors
    DiPersio JF, Golde DW
    In: Cancer Treatment, 3rd ed., Haskell CM (ed). W.B. Saunders, Philadelphia, 1990
  • The expression and target cell specificity of human granulocyte- macrophage colony-stimulating factor
    Nimer SD, Gasson JC, DiPersio JF
    Year Immunol 1988;3:144-51
  • Granulocytic growth factors elaborated by human cell lines
    DiPersio JF, Brennan JK, Lichtman MA
    In: Hematopoietic Cell Differentiation (ICN-UCLA) Symposia on Molecular and Cellular Biology, Vol. X, Golde DW, Cline MJ, Metcalf D, Fox CF (eds). Academic Press, New York, p.433, 1978

Invited Reviews

  • Can every patient be mobilized?
    DiPersio JF
    Best Pract Res Clin Haematol 2010 Dec;23(4):519-23
  • Therapy options in imatinib failures
    DiPersio JF
    Community Oncology 2007
  • Issues in stem cell mobilization: a 2007 perspective
    DiPersio JF
    ASBMT/CIBMTR 2007
  • Mobilization of stem cells using AMD-3100: early experience in the allogeneic transplantation setting
    DiPersio JF
    Blood and Marrow Transplantation Reviews 2007
  • New perspectives in allogeneic transplantation of hematopoietic cells
    DiPersio JF
    EBMT Proceedings Book 2006
  • Biology of stem cell egress and mobilization
    Cashen A, Nervi B, Devine S, Link D, DiPersio J
    Biology of Blood and Bone Marrow Transplantion 2005
  • Cytokines and stem cell mobilization for autologous and allogeneic transplantation
    Cashen AF, Link D, Devine S, DiPersio J
    Curr Hematol Rep 2004 Nov;3(6):406-12
  • Novel strategies for hematopoietic stem cell mobilization
    Devine SM, Link D, DiPersio JF
    Curr Opin Organ Transplant 2004;9:54-63
  • Stem cell transplantation in acute myelogenous leukemia in first remission: what are the options?
    Mathews V, DiPersio JF
    Curr Hematol Rep 2004 Jul;3(4):235-41
  • Use of the anti-idiotype breast cancer vaccine 11D10 in conjunction with autologous stem cell transplantation in patients with metastatic breast cancer
    Reece DE, Foon KA, Chatterjee MB, Adkins D, Broun ER, Connaghan DG, DiPersio JF, Holland HK, Howard DA, Hale GA, Klingemann HG, Munn RK, Raptis A, Phillips GL
    Clin Breast Cancer 2003 Feb;3 Suppl 4:S152-7
  • Recent advances in allogeneic hematopoietic stem-cell transplantation
    Devine SM, Adkins DR, Khoury H, Brown RA, Vij R, Blum W, DiPersio JF
    J Lab Clin Med 2003 Jan;141(1):7-32
  • Arsenic trioxide (trisenox) therapy for acute promyelocytic leukemia in the setting of hematopoietic stem cell transplantation
    Douer D, Hu W, Giralt S, Lill M, DiPersio J
    Oncologist 2003;8(2):132-40
  • Innovations in allogeneic stem-cell transplantation
    DiPersio JF, Khoury H, Haug J, Vij R, Adkins DR, Goodnough LT, Brown RA
    Semin Hematol 2000 Jan;37(1 Suppl 2):33-41
  • Purine analog regimens for allogeneic transplant?
    Adkins D, Brown R, Goodnough L, Khoury H, DiPersio J
    J Clin Oncol 1999 Jun;17(6):1958-60
  • Activation of neutrophils by granulocyte-macrophage colony-stimulating factor
    DiPersio JF, Abboud CN
    Immunol Ser 1992;57:457-84
  • Granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF): receptor biology, signal transduction, and neutrophil activation
    Rapoport AP, Abboud CN, DiPersio JF
    Blood Rev 1992 Mar;6(1):43-57
  • Granulocyte-macrophage colony-stimulating factor (GM-CSF) and neutrophil functions
    Rapoport AP, DiPersio JF
    Focus on Growth Factors 1991;2(4):4-8
  • GM-CSF: receptor structure and transmembrane signaling
    DiPersio JF, Golde DW, Gasson JD
    Int J Cell Cloning 1990 Jan;8 Suppl 1:63-74; discussion 74-5
  • In vitro probes of hematopoiesis
    DiPersio JF
    PhD Thesis, Department of Microbiology, University of Rochester, 1980