As a medical oncologist interested in thoracic malignancies, I have led a number of institutional and multi-center phase II and III studies in lung cancer over the past decade. Advances in genomics and drug development have now made it possible to develop rational targeted therapies in molecularly defined subset of patients. Working with The Cancer Genome Institute at Washington University School of Medicine and with The Cancer Genome Atlas (TCGA) project sponsored by the NCI, I am actively involved in sequencing the whole genomes and exomes of several hundred patients with lung cancer. I am the co-chair of the lung cancer disease-working group for TCGA project. In addition, I am leading the efforts to move personalized therapies in early stage and locally advanced lung cancer. I have developed prognostic markers reflecting global genomic alterations in lung cancer. I am the Principal Investigator for the Washington University School of Medicine Clinical Oncology Paul Calabresi K12 training grant.