Faculty
Chuck Kaufman.jpg

Charles K. Kaufman, MD, PhD

Assistant Professor
Department of Medicine
Oncology Division
Molecular Oncology
Department of Developmental Biology

Clinical Interests

  • Melanoma

Research Interests

  • Cancer initiation
  • Epigenetics
  • Developmental biology

Contact

  • 314-273-1330 (office)
  • 314-273-1331 (lab)
  • 314-747-2797 (fax)
  • 558 McDonnell Medical Sciences Building (office/lab)
    4565 McKinley Avenue
    St. Louis, MO 63110
  • Division of Oncology
    Campus Box 8069
    Washington University Medical School
    660 South Euclid Avenue
    St. Louis, MO 63110

Peer-reviewed Manuscripts

  • A Chemical Screen in Zebrafish Embryonic Cells Establishes That Akt Activation Is Required for Neural Crest Development
    Ciarlo C, Kaufman CK, Kinikoglu B, Michael J, Yang S, D Amato C, Blokzijl-Franke S, den Hertog J, Schlaeger TM, Zhou Y, Liao E, Zon LI
    Elife 2017 Aug 23;6
  • Efficient Transduction of Zebrafish Melanoma Cell Lines and Embryos Using Lentiviral Vectors
    Fazio M, Avagyan S, van Rooijen E, Mannherz W, Kaufman CK, Lobbardi R, Langenau DM, Zon LI
    Zebrafish 2017 Aug;14(4):379-382
  • Tumor Diversity and Evolution Revealed Through RADseq
    Perry EB, Makohon-Moore A, Zheng C, Kaufman CK, Cai J, Iacobuzio-Donahue CA, White RM
    Oncotarget 2017 Jun 27;8(26):41792-41805
  • Evolution of the Hypoxia-Sensitive Cells Involved in Amniote Respiratory Reflexes
    Hockman D, Burns AJ, Schlosser G, Gates KP, Jevans B, Mongera A, Fisher S, Unlu G, Knapik EW, Kaufman CK, Mosimann C, Zon LI, Lancman JJ, Dong PDS, Lickert H, Tucker AS, Baker CVH
    Elife 2017 Apr 7;6
  • A Zebrafish Melanoma Model Reveals Emergence of Neural Crest Identity During Melanoma Initiation
    Kaufman CK, Mosimann C, Fan ZP, Yang S, Thomas AJ, Ablain J, Tan JL, Fogley RD, van Rooijen E, Hagedorn EJ, Ciarlo C, White RM, Matos DA, Puller AC, Santoriello C, Liao EC, Young RA, Zon LI
    Science 2016 Jan 29;351(6272):aad2197
  • A Quantitative System for Studying Metastasis Using Transparent Zebrafish
    Heilmann S, Ratnakumar K, Langdon EM, Kansler ER, Kim IS, Campbell NR, Perry EB, McMahon AJ, Kaufman CK, van Rooijen E, Lee W, Iacobuzio-Donahue CA, Hynes RO, Zon LI, Xavier JB, White RM
    Cancer Res 2015 Oct 15;75(20):4272-82
  • Neural Crest Development and Craniofacial Morphogenesis Is Coordinated by Nitric Oxide and Histone Acetylation
    Kong Y, Grimaldi M, Curtin E, Dougherty M, Kaufman C, White RM, Zon LI, Liao EC
    Chem Biol 2014 Apr 24;21(4):488-501
  • The Genetic Heterogeneity and Mutational Burden of Engineered Melanomas in Zebrafish Models
    Yen J, White RM, Wedge DC, Van Loo P, de Ridder J, Capper A, Richardson J, Jones D, Raine K, Watson IR, Wu CJ, Cheng J, Martincorena I, Nik-Zainal S, Mudie L, Moreau Y, Marshall J, Ramakrishna M, Tarpey P, Shlien A, Whitmore I, Gamble S, Latimer C, Langdon E, Kaufman C, Dovey M, Taylor A, Menzies A, McLaren S, O'Meara S, Butler A, Teague J, Lister J, Chin L, Campbell P, Adams DJ, Zon LI, Patton EE, Stemple DL, Futreal PA
    Genome Biol 2013;14(10):R113
  • Small Molecule Screening in Zebrafish: Swimming in Potential Drug Therapies
    Tamplin OJ, White RM, Jing L, Kaufman CK, Lacadie SA, Li P, Taylor AM, Zon LI
    Wiley Interdiscip Rev Dev Biol 2012 May-Jun;1(3):459-68
  • DHODH Modulates Transcriptional Elongation in the Neural Crest and Melanoma
    White RM, Cech J, Ratanasirintrawoot S, Lin CY, Rahl PB, Burke CJ, Langdon E, Tomlinson ML, Mosher J, Kaufman C, Chen F, Long HK, Kramer M, Datta S, Neuberg D, Granter S, Young RA, Morrison S, Wheeler GN, Zon LI
    Nature 2011 Mar 24;471(7339):518-22
  • Ubiquitous Transgene Expression and Cre-Based Recombination Driven by the Ubiquitin Promoter in Zebrafish
    Mosimann C, Kaufman CK, Li P, Pugach EK, Tamplin OJ, Zon LI
    Development 2011 Jan;138(1):169-77
  • Chemical Genetic Screening in the Zebrafish Embryo
    Kaufman CK*, White RM*, Zon L (* Authors contributed equally)
    Nat Protoc 2009;4(10):1422-32
  • GATA-3: An Unexpected Regulator of Cell Lineage Determination in Skin
    Kaufman CK, Zhou P, Pasolli HA, Rendl M, Bolotin D, Lim KC, Dai X, Alegre ML, Fuchs E
    Genes Dev 2003 Sep 1;17(17):2108-22
  • Dissection of a Complex Enhancer Element: Maintenance of Keratinocyte Specificity but Loss of Differentiation Specificity
    Kaufman CK*, Sinha S*, Bolotin D, Fan J, Fuchs E (* Authors contributed equally)
    Mol Cell Biol 2002 Jun;22(12):4293-308
  • It's Got You Covered. NF-KappaB in the Epidermis
    Kaufman CK, Fuchs E
    J Cell Biol 2000 May 29;149(5):999-1004
  • Characterization of the Rhodobacter Capsulatus Housekeeping RNA Polymerase. In Vitro Transcription of Photosynthesis and Other Genes
    Cullen PJ*, Kaufman CK*, Bowman WC, Kranz RG (* Authors contributed equally)
    J Biol Chem 1997 Oct 24;272(43):27266-73