Faculty
Stuart Kornfeld.jpg

Stuart Kornfeld, MD

Professor
Department of Medicine
Hematology Division
Department of Biochemistry & Molecular Biophysics

Clinical Interests

  • General hematology

Research Interests

  • Intracellular protein trafficking
  • Lysosomes
  • Glycoproteins

Contact

  • 314-362-8803 (office)
  • 314-362-8828 (lab)
  • 314-362-8826 (fax)
  • Room 8826 Clinical Sciences Research Building (office)
  • Room 8828 Clinical Sciences Research Building (lab)
  • Hematology Division
    Campus Box 8125
    Washington University Medical School
    660 South Euclid Avenue
    St. Louis, MO 63110

Publications

  • Engineering of GlcNAc-1-phosphotransferase for production of highly phosphorylated lysosomal enzymes for enzyme replacement therapy
    Liu L, Lee WS, Doray B, Kornfeld S
    Mol Ther Methods Clin Dev 2017 Mar 29;5:59-65
  • Role of spacer-1 in the maturation and function of GlcNAc-1-phosphotransferase
    Liu L, Lee WS, Doray B, Kornfeld S
    FEBS Lett 2017 Jan;591(1):47-55
  • Phil Majerus: Champion of low-dose aspirin therapy
    Kornfeld SA
    Proc Natl Acad Sci U S A 2016 Aug 30;113(35):9668-9
  • Mucolipidosis III GNPTG missense mutations cause misfolding of the gamma subunit of GlcNAc-1-phosphotransferase
    van Meel E, Kornfeld S
    Hum Mutat 2016 Jul;37(7):623-626
  • Multiple domains of GlcNAc-1-phosphotransferase mediate recognition of lysosomal enzymes
    van Meel E, Lee WS, Liu L, Qian Y, Doray B, Kornfeld S
    J Biol Chem 2016 Apr 8;291(15):8295-307
  • Training the next generation of biomedical investigators in glycosciences
    Agre P, Bertozzi C, Bissell M, Campbell KP, Cummings RD, Desai UR, Estes M, Flotte T, Fogleman G, Gage F, Ginsburg D, Gordon JI, Hart G, Hascall V, Kiessling L, Kornfeld S, Lowe J, Magnani J, Mahal LK, Medzhitov R, Roberts RJ, Sackstein R, Sarkar R, Schnaar R, Schwartz N, Varki A, Walt D, Weissman I
    J Clin Invest 2016 Feb 1;126(2):405-408
  • The lysosomal enzyme receptor protein (LERP) is not essential, but is implicated in lysosomal function in Drosophila melanogaster
    Hasanagic M, van Meel E, Luan S, Aurora R, Kornfeld S, Eissenberg JC
    Biol Open 2015 Sep 24;4(10):1316-25
  • Tuberous sclerosis, polycystic kidney disease and mucolipidosis III gamma caused by a microdeletion unmasking a recessive mutation
    Barea JJ, van Meel E, Kornfeld S, Bird LM
    Am J Med Genet A 2015 Nov;167(11):2844-2846
  • Analysis of mucolipidosis II/III GNPTAB missense mutations identifies domains of UDP-GlcNAc:lysosomal enzyme GlcNAc-1-phosphotransferase involved in catalytic function and lysosomal enzyme recognition
    Qian Y, van Meel E, Flanagan-Steet H, Yox A, Steet R, Kornfeld S
    J Biol Chem 2015 Jan 30;290(5):3045-56
  • Exome sequencing for mucolipidosis III: Detection of a novel GNPTAB gene mutation in a patient with a very mild phenotype
    Sperb-Ludwig F, Alegra T, Velho RV, Ludwig N, Kim CA, Kok F, Kitajima JP, van Meel E, Kornfeld S, Burin MG, Schwartz IVD
    Mol Genet Metab Rep 2014 Dec 5;2:34-37
  • Neurologic abnormalities in mouse models of the lysosomal storage disorders mucolipidosis II and mucolipidosis III gamma
    Idol RA, Wozniak DF, Fujiwara H, Yuede CM, Ory DS, Kornfeld S, Vogel P
    PLoS One 2014 Oct 14;9(10):e109768
  • Impact of genetic background on neonatal lethality of GGA2 gene-trap mice
    Doray B, Govero J, Kornfeld S
    G3 (Bethesda) 2014 Mar 17;4(5):885-90
  • Mislocalization of phosphotransferase as a cause of mucolipidosis III alphabeta
    van Meel E, Qian Y, Kornfeld SA
    Proc Natl Acad Sci U S A 2014 Mar 4;111(9):3532-7
  • Rare recessive loss-of-function methionyl-tRNA synthetase mutations presenting as a multi-organ phenotype
    van Meel E, Wegner DJ, Cliften P, Willing MC, White FV, Kornfeld S, Cole FS
    BMC Med Genet 2013 Oct 8;14:106
  • N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (NAGPA)
    Kornfeld S
    In: Taniguchi N, Honke K, Fukuda M, Narimatsu H, Yamaguchi Y, Angata T (Eds) Handbook of Glycosyltransferases and Related Genes: Springer-Verlag Berlin Heidelberg, 2013
  • The DMAP interaction domain of UDP-GlcNAc:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase is a substrate recognition module
    Qian Y, Flanagan-Steet H, van Meel E, Steet R, Kornfeld SA
    Proc Natl Acad Sci U S A 2013 Jun 18;110(25):10246-51
  • Structure and function of the DUF2233 domain in bacteria and in the human mannose 6-phosphate uncovering enzyme
    Das D, Lee WS, Grant JC, Chiu HJ, Farr CL, Vance J, Klock HE, Knuth MW, Miller MD, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Kornfeld S, Wilson IA
    J Biol Chem 2013 Jun 7;288(23):16789-99
  • I-cell disease and pseudo-Hurler polydystrophy: Disorders of lysosomal enzyme phosphorylation and localization
    Braulke T, Raas-Rothschild A, Kornfeld S
    In: D Valle, A Beaudet, B Vogelstein, K Kinzler, S Antonarakis, A Ballabio, C Scriver, W Sly, B Childs, F Bunz, KM Gibson, G Mitchell (Eds), The Online Metabolic and Molecular Bases of Inherited Disease (http://www.ommbid.com) (in press, 2012)
  • Do GGA adaptors bind Internal DXXLL motifs?
    Doray B, Misra S, Qian Y, Brett TJ, Kornfeld S
    Traffic 2012 Oct;13(10):1315-25
  • Analysis of Gga null mice demonstrates a non-redundant role for mammalian GGA2 during development
    Govero J, Doray B, Bai H, Kornfeld S
    PLoS One 2012;7(1):e30184
  • Analysis of mannose 6-phosphate uncovering enzyme mutations associated with persistent stuttering
    Lee WS, Kang C, Drayna D, Kornfeld S
    J Biol Chem 2011 Nov 18;286(46):39786-93
  • Disruption of the man-6-p targeting pathway in mice impairs osteoclast secretory lysosome biogenesis
    van Meel E, Boonen M, Zhao H, Oorschot V, Ross FP, Kornfeld S, Klumperman J
    Traffic 2011 Jul;12(7):912-24
  • Vacuolization of mucolipidosis type II mouse exocrine gland cells represents accumulation of autolysosomes
    Boonen M, van Meel E, Oorschot V, Klumperman J, Kornfeld S
    Mol Biol Cell 2011 Apr;22(8):1135-47
  • A fascination with sugars
    Kornfeld S
    Mol Biol Cell 2010 Nov;21(22):3773-5
  • UDP-GlcNAc:Glycoprotein N-acetylglucosamine-1-phosphotransferase mediates the initial step in the formation of the methylphosphomannosyl residues on the high mannose oligosaccharides of Dictyostelium discoideum glycoproteins
    Qian Y, West CM, Kornfeld S
    Biochem Biophys Res Commun 2010 Mar 19;393(4):678-681
  • Functions of the alpha, beta, and gamma subunits of UDP-GlcNAc:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase
    Qian Y, Lee I, Lee WS, Qian M, Kudo M, Canfield WM, Lobel P, Kornfeld S
    J Biol Chem 2010 Jan 29;285(5):3360-70
  • Acceptance of the 2010 George M. Kober Medal
    Kornfeld S
    J Clin Invest 2010 Jul 1;120(7):2639-40
  • Glycan microarray analysis of P-type lectins reveals distinct phosphomannose glycan recognition
    Song X, Lasanajak Y, Olson LJ, Boonen M, Dahms NM, Kornfeld S, Cummings RD, Smith DF
    J Biol Chem 2009 Dec 11;284(50):35201-14
  • The physician scientist training program in internal medicine at Washington University School of Medicine
    Muslin AJ, Kornfeld S, Polonsky KS
    Acad Med 2009 Apr;84(4):468-71
  • Mice lacking mannose 6-phosphate uncovering enzyme activity have a milder phenotype than mice deficient for N-acetylglucosamine-1-phosphotransferase activity
    Boonen M, Vogel P, Platt KA, Dahms N, Kornfeld S
    Mol Biol Cell 2009 Oct;20(20):4381-9
  • P-type Lectins
    Varki A, Kornfeld S
    In: Varki A, Cummings RD, Esko JD, Freeze HH, Stanley P, Bertozzi CR, Hart GW, Etzler ME (Eds), Essentials of Glycobiology (2nd ed), 425-437. Cold Spring Harbor: Cold Spring Harbor Laboratory Press, 2009
  • Comparative pathology of murine mucolipidosis types II and IIIC
    Vogel P, Payne BJ, Read R, Lee WS, Gelfman CM, Kornfeld S
    Vet Pathol 2009 Mar;46(2):313-24
  • Cargo-sorting signals promote polymerization of adaptor protein-1 in an Arf-1.GTP-independent manner
    Lee I, Drake MT, Traub LM, Kornfeld S
    Arch Biochem Biophys 2008 Nov 1;479(1):63-8
  • Identification of acidic dileucine signals in LRP9 that interact with both GGAs and AP-1/AP-2
    Doray B, Knisely JM, Wartman L, Bu G, Kornfeld S
    Traffic 2008 Sep;9(9):1551-62
  • Binding of cargo sorting signals to AP-1 enhances its association with ADP ribosylation factor 1-GTP
    Lee I, Doray B, Govero J, Kornfeld S
    J Cell Biol 2008 Feb 11;180(3):467-72
  • Mice lacking alpha/beta subunits of GlcNAc-1-phosphotransferase exhibit growth retardation, retinal degeneration, and secretory cell lesions
    Gelfman CM, Vogel P, Issa TM, Turner CA, Lee WS, Kornfeld S, Rice DS
    Invest Ophthalmol Vis Sci 2007 Nov;48(11):5221-8
  • Murine UDP-GlcNAc:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase lacking the gamma-subunit retains substantial activity toward acid hydrolases
    Lee WS, Payne BJ, Gelfman CM, Vogel P, Kornfeld S
    J Biol Chem 2007 Sep 14;282(37):27198-203
  • The gamma/sigma1 and alpha/sigma2 hemicomplexes of clathrin adaptors AP-1 and AP-2 harbor the dileucine recognition site
    Doray B, Lee I, Knisely J, Bu G, Kornfeld S
    Mol Biol Cell 2007 May;18(5):1887-96
  • Selective action of the iminosugar isofagomine, a pharmacological chaperone for mutant forms of acid-beta-glucosidase
    Steet R, Chung S, Lee WS, Pine CW, Do H, Kornfeld S
    Biochem Pharmacol 2007 May 1;73(9):1376-83
  • The iminosugar isofagomine increases the activity of N370S mutant acid beta-glucosidase in Gaucher fibroblasts by several mechanisms
    Steet RA, Chung S, Wustman B, Powe A, Do H, Kornfeld SA
    Proc Natl Acad Sci U S A 2006 Sep 12;103(37):13813-8
  • COG-7-deficient human fibroblasts exhibit altered recycling of Golgi proteins
    Steet R, Kornfeld S
    Mol Biol Cell 2006 May;17(5):2312-21
  • Identification of the minimal lysosomal enzyme recognition domain in cathepsin D
    Steet R, Lee WS, Kornfeld S
    J Biol Chem 2005 Sep 30;280(39):33318-23
  • A splicing mutation in the alpha/beta GlcNAc-1-phosphotransferase gene results in an adult onset form of mucolipidosis III associated with sensory neuropathy and cardiomyopathy
    Steet RA, Hullin R, Kudo M, Martinelli M, Bosshard NU, Schaffner T, Kornfeld S, Steinmann B
    Am J Med Genet A 2005 Feb 1;132(4):369-75
  • The Washington University Medical Scientist Training Program
    Sullivan B, Kornfeld SA, Frieden C, Goldberg DE
    Mo Med 2004 Sep-Oct;101(5):491-5
  • Blasts from the past
    Insel PA, Kornfeld S, Majerus PW, Marks AR, Marks PA, Relman AS, Scharschmidt BF, Stossel TP, Varki AP, Weiss SJ, Wilson JD
    J Clin Invest 2004 Oct;114(8):1017-33
  • The GGA proteins: key players in protein sorting at the trans-Golgi network
    Ghosh P, Kornfeld S
    Eur J Cell Biol 2004 Jul;83(6):257-62
  • The cytoplasmic tail of the cation-independent mannose 6-phosphate receptor contains four binding sites for AP-1
    Ghosh P, Kornfeld S
    Arch Biochem Biophys 2004 Jun 15;426(2):225-30
  • Mutation of the COG complex subunit gene COG7 causes a lethal congenital disorder
    Wu X, Steet RA, Bohorov O, Bakker J, Newell J, Krieger M, Spaapen L, Kornfeld S, Freeze HH
    Nat Med 2004 May;10(5):518-23
  • GGA1 interacts with the adaptor protein AP-1 through a WNSF sequence in its hinge region
    Bai H, Doray B, Kornfeld S
    J Biol Chem 2004 Apr 23;279(17):17411-7
  • Mammalian GGAs act together to sort mannose 6-phosphate receptors
    Ghosh P, Griffith J, Geuze HJ, Kornfeld S
    J Cell Biol 2003 Nov 24;163(4):755-66
  • Endoplasmic reticulum-associated degradation of mammalian glycoproteins involves sugar chain trimming to Man6-5GlcNAc2
    Frenkel Z, Gregory W, Kornfeld S, Lederkremer GZ
    J Biol Chem 2003 Sep 5;278(36):34119-24
  • Phosphorylation-induced conformational changes regulate GGAs 1 and 3 function at the trans-Golgi network
    Ghosh P, Kornfeld S
    J Biol Chem 2003 Apr 18;278(16):14543-9
  • AP-1 binding to sorting signals and release from clathrin-coated vesicles is regulated by phosphorylation
    Ghosh P, Kornfeld S
    J Cell Biol 2003 Mar 3;160(5):699-708
  • Mannose 6-phosphate receptors: new twists in the tale
    Ghosh P, Dahms NM, Kornfeld S
    Nat Rev Mol Cell Biol 2003 Mar;4(3):202-12
  • Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network
    Doray B, Ghosh P, Griffith J, Geuze HJ, Kornfeld S
    Science 2002 Sep 6;297(5587):1700-3
  • Human mannose 6-phosphate uncovering enzyme is synthesized as a pro-enzyme that is activated by the endoprotease furin
    Do H, Lee WS, Ghosh P, Hollowell T, Canfield W, Kornfeld S
    J Biol Chem 2002 Aug 16;277(33):29737-44
  • Autoinhibition of the ligand-binding site of GGA1/3 VHS domains by an internal acidic cluster-dileucine motif
    Doray B, Bruns K, Ghosh P, Kornfeld S
    Proc Natl Acad Sci U S A 2002 Jun 11;99(12):8072-7
  • Interaction of the cation-dependent mannose 6-phosphate receptor with GGA proteins
    Doray B, Bruns K, Ghosh P, Kornfeld S
    J Biol Chem 2002 May 24;277(21):18477-82
  • Multiple signals regulate trafficking of the mannose 6-phosphate-uncovering enzyme
    Lee WS, Rohrer J, Kornfeld R, Kornfeld S
    J Biol Chem 2002 Feb 1;277(5):3544-51
  • Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor
    Zhu Y, Doray B, Poussu A, Lehto VP, Kornfeld S
    Science 2001 Jun 1;292(5522):1716-8
  • gamma Subunit of the ap-1 adaptor complex binds clathrIn: implications for cooperative binding in coated vesicle assembly
    Doray B, Kornfeld S
    Mol Biol Cell 2001 Jul;12(7):1925-35
  • I-cell disease and pseudo-Hurler polydystrophy: Disorders of lysosomal enzyme phosphorylation and localization
    Kornfeld S, Sly WS
    In C.R. Scriver, A.L. Beaudet, W.S. Sly, and D. Valle (Eds), The Metabolic Basis of Inherited Disease (8th ed), Vol. III, 3469-3482. New York: McGraw Hill, 2001
  • Adaptor protein 1-dependent clathrin coat assembly on synthetic liposomes and Golgi membranes
    Zhu Y, Drake MT, Kornfeld S
    Methods Enzymol 2001;329:379-87
  • The assembly of AP-3 adaptor complex-containing clathrin-coated vesicles on synthetic liposomes
    Drake MT, Zhu Y, Kornfeld S
    Mol Biol Cell 2000 Nov;11(11):3723-36
  • Asparagine-linked oligosaccharides protect Lamp-1 and Lamp-2 from intracellular proteolysis
    Kundra R, Kornfeld S
    J Biol Chem 1999 Oct 22;274(43):31039-46
  • Identification of amino acids that modulate mannose phosphorylation of mouse DNase I, a secretory glycoprotein [In Process Citation]
    Nishikawa A, Nanda A, Gregory W, Frenz J, Kornfeld S
    J Biol Chem 1999 Jul 2;274(27):19309-15
  • ADP-ribosylation factor 1 dependent clathrin-coat assembly on synthetic liposomes
    Zhu Y, Drake MT, Kornfeld S
    Proc Natl Acad Sci U S A 1999 Apr 27;96(9):5013-8
  • High-affinity binding of the AP-1 adaptor complex to trans-golgi network membranes devoid of mannose 6-phosphate receptors
    Zhu Y, Traub LM, Kornfeld S
    Mol Biol Cell 1999 Mar;10(3):537-49
  • The rate of internalization of the mannose 6-phosphate/insulin-like growth factor II receptor is enhanced by multivalent ligand binding
    York SJ, Arneson LS, Gregory WT, Dahms NM, Kornfeld S
    J Biol Chem 1999 Jan 8;274(2):1164-71
  • Presidential address: meeting the challenge of change
    Kornfeld S
    Proc Assoc Am Physicians 1998 Sep-Oct;110(5):439-42
  • ADP-ribosylation factor 1 transiently activates high-affinity adaptor protein complex AP-1 binding sites on Golgi membranes
    Zhu Y, Traub LM, Kornfeld S
    Mol Biol Cell 1998 Jun;9(6):1323-37
  • Mannose 6-phosphate/insulin-like growth factor-II receptor targets the urokinase receptor to lysosomes via a novel binding interaction
    Nykjaer A, Christensen EI, Vorum H, Hager H, Petersen CM, Roigaard H, Min HY, Vilhardt F, Moller LB, Kornfeld S, Gliemann J
    J Cell Biol 1998 May 4;141(3):815-28
  • Diseases of abnormal protein glycosylation: An emerging area
    Kornfeld S
    J Clin Invest 1998;101:1293-1295
  • Wortmannin retards the movement of the mannose 6-phosphate/insulin-like growth factor II receptor and its ligand out of endosomes
    Kundra R, Kornfeld S
    J Biol Chem 1998 Feb 13;273(7):3848-53
  • Proper sorting of the cation-dependent mannose 6-phosphate receptor in endosomes depends on a pair of aromatic amino acids in its cytoplasmic tail
    Schweizer A, Kornfeld S, Rohrer J
    Proc Natl Acad Sci U S A 1997 Dec 23;94(26):14471-6
  • Different domains of mammalian ADP-ribosylation factor 1 mediate interaction with selected target proteins
    Liang JO, Sung TC, Morris AJ, Frohman MA, Kornfeld S
    J Biol Chem 1997 Dec 26;272(52):33001-8
  • The trans-Golgi network: a late secretory sorting station
    Traub LM, Kornfeld S
    Curr Opin Cell Biol 1997 Aug;9(4):527-33
  • The phosphorylation of bovine DNase I Asn-linked oligosaccharides is dependent on specific lysine and arginine residues
    Nishikawa A, Gregory W, Frenz J, Cacia J, Kornfeld S
    J Biol Chem 1997 Aug 1;272(31):19408-12
  • Comparative activity of ADP-ribosylation factor family members in the early steps of coated vesicle formation on rat liver Golgi membranes [published erratum appears in J Biol Chem 1998 Jan 23;273(4):2488]
    Liang JO, Kornfeld S
    J Biol Chem 1997 Feb 14;272(7):4141-8
  • AP-2-containing clathrin coats assemble on mature lysosomes
    Traub LM, Bannykh SI, Rodel JE, Aridor M, Balch WE, Kornfeld S
    J Cell Biol 1996 Dec;135(6 Pt 2):1801-14
  • The biogenesis of the MHC class II compartment in human I-cell disease B lymphoblasts
    Glickman JN, Morton PA, Slot JW, Kornfeld S, Geuze HJ
    J Cell Biol 1996 Mar;132(5):769-85
  • Cysteine34 of the cytoplasmic tail of the cation-dependent mannose 6- phosphate receptor is reversibly palmitoylated and required for normal trafficking and lysosomal enzyme sorting
    Schweizer A, Kornfeld S, Rohrer J
    J Cell Biol 1996 Feb;132(4):577-84
  • The targeting of Lamp1 to lysosomes is dependent on the spacing of its cytoplasmic tail tyrosine sorting motif relative to the membrane
    Rohrer J, Schweizer A, Russell D, Kornfeld S
    J Cell Biol 1996 Feb;132(4):565-76
  • A mannose 6-phosphate-containing N-linked glycopeptide derived from lysosomal acid lipase is bound to MHC class II in B lymphoblastoid cell lines
    Dustin ML, McCourt DW, Kornfeld S
    J Immunol 1996 Mar 1;156(5):1841-7
  • Reassessment of the subcellular localization of p63
    Schweizer A, Rohrer J, Slot JW, Geuze HJ, Kornfeld S
    J Cell Sci 1995 Jun;108 ( Pt 6):2477-85
  • A determinant in the cytoplasmic tail of the cation-dependent mannose 6- phosphate receptor prevents trafficking to lysosomes
    Rohrer J, Schweizer A, Johnson KF, Kornfeld S
    J Cell Biol 1995 Sep;130(6):1297-306
  • I-cell disease and pseudo-Hurler polydystrophy: Disorders of lysosomal enzyme phosphorylation and localization
    Kornfeld S, Sly WS
    In CR Scriver, AL Beaudet, WS Sly, and D Valle (Eds.), The Metabolic Basis of Inherited Disease (7th ed), pp. 2495-2508. 1995.  New York: McGraw Hill
  • Determination of the structural requirements for palmitoylation of p63
    Schweizer A, Rohrer J, Kornfeld S
    J Biol Chem 1995 Apr 21;270(16):9638-44
  • Different domains of the AP-1 adaptor complex are required for Golgi membrane binding and clathrin recruitment
    Traub LM, Kornfeld S, Ungewickell E
    J Biol Chem 1995 Mar 3;270(9):4933-42
  • A novel mutagenesis strategy identifies distantly spaced amino acid sequences that are required for the phosphorylation of both the oligosaccharides of procathepsin D by N-acetylglucosamine 1- phosphotransferase
    Dustin ML, Baranski TJ, Sampath D, Kornfeld S
    J Biol Chem 1995 Jan 6;270(1):170-9
  • Subcellular localization and targeting of cathepsin E
    Finley EM, Kornfeld S
    J Biol Chem 1994 Dec 9;269(49):31259-66
  • Herpes simplex virus glycoprotein D acquires mannose 6-phosphate residues and binds to mannose 6-phosphate receptors
    Brunetti CR, Burke RL, Kornfeld S, Gregory W, Masiarz FR, Dingwell KS, Johnson DC
    J Biol Chem 1994 Jun 24;269(25):17067-74
  • Retention of p63 in an ER-Golgi intermediate compartment depends on the presence of all three of its domains and on its ability to form oligomers
    Schweizer A, Rohrer J, Hauri HP, Kornfeld S
    J Cell Biol 1994 Jul;126(1):25-39
  • Biochemical dissection of AP-1 recruitment onto Golgi membranes
    Traub LM, Ostrom JA, Kornfeld S
    J Cell Biol 1993 Nov;123(3):561-73
  • Mannose 6-phosphate-independent targeting of lysosomal enzymes in I- cell disease B lymphoblasts
    Glickman JN, Kornfeld S
    J Cell Biol 1993 Oct;123(1):99-108
  • Phosphorylation of Asn-linked oligosaccharides located at novel sites on the lysosomal enzyme cathepsin D
    Cantor AB, Kornfeld S
    J Biol Chem 1992 Nov 15;267(32):23357-63
  • Lysosomal enzyme phosphorylation. II. Protein recognition determinants in either lobe of procathepsin D are sufficient for phosphorylation of both the amino and carboxyl lobe oligosaccharides
    Cantor AB, Baranski TJ, Kornfeld S
    J Biol Chem 1992 Nov 15;267(32):23349-56
  • Lysosomal enzyme phosphorylation. I. Protein recognition determinants in both lobes of procathepsin D mediate its interaction with UDP- GlcNAc:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase
    Baranski TJ, Cantor AB, Kornfeld S
    J Biol Chem 1992 Nov 15;267(32):23342-8
  • The cytoplasmic tail of the mannose 6-phosphate/insulin-like growth factor-II receptor has two signals for lysosomal enzyme sorting in the Golgi
    Johnson KF, Kornfeld S
    J Cell Biol 1992 Oct;119(2):249-57
  • A His-Leu-Leu sequence near the carboxyl terminus of the cytoplasmic domain of the cation-dependent mannose 6-phosphate receptor is necessary for the lysosomal enzyme sorting function
    Johnson KF, Kornfeld S
    J Biol Chem 1992 Aug 25;267(24):17110-5
  • A method for [3H]mannose labeling of Asn-linked oligosaccharides on recombinant glycoproteins synthesized in Xenopus oocytes
    Cantor AB, Kornfeld S
    Anal Biochem 1992 Sep;205(2):220-6
  • Characterization of UDP-N-acetylglucosamine:glycoprotein N- acetylglucosamine-1-phosphotransferase from Acanthamoeba castellanii
    Ketcham CM, Kornfeld S
    J Biol Chem 1992 Jun 5;267(16):11654-9
  • Purification of UDP-N-acetylglucosamine:glycoprotein N- acetylglucosamine-1-phosphotransferase from Acanthamoeba castellanii and identification of a subunit of the enzyme
    Ketcham CM, Kornfeld S
    J Biol Chem 1992 Jun 5;267(16):11645-53
  • Characterization of the signal for rapid internalization of the bovine mannose 6-phosphate/insulin-like growth factor-II receptor
    Jadot M, Canfield WM, Gregory W, Kornfeld S
    J Biol Chem 1992 Jun 5;267(16):11069-77
  • Structure and function of the mannose 6-phosphate/insulinlike growth factor II receptors
    Kornfeld S
    Annu Rev Biochem 1992;61:307-30
  • Mapping and molecular modeling of a recognition domain for lysosomal enzyme targeting
    Baranski TJ, Koelsch G, Hartsuck JA, Kornfeld S
    J Biol Chem 1991 Dec 5;266(34):23365-72
  • The bovine mannose 6-phosphate/insulin-like growth factor II receptor. Localization of mannose 6-phosphate binding sites to domains 1-3 and 7- 11 of the extracytoplasmic region
    Westlund B, Dahms NM, Kornfeld S
    J Biol Chem 1991 Dec 5;266(34):23233-9
  • Localization of the signal for rapid internalization of the bovine cation-independent mannose 6-phosphate/insulin-like growth factor-II receptor to amino acids 24-29 of the cytoplasmic tail
    Canfield WM, Johnson KF, Ye RD, Gregory W, Kornfeld S
    J Biol Chem 1991 Mar 25;266(9):5682-8
  • Cation-dependent mannose 6-phosphate receptor contains two internalization signals in its cytoplasmic domain [published erratum appears in Proc Natl Acad Sci U S A 1991 Feb 15;88(4):1591]
    Johnson KF, Chan W, Kornfeld S
    Proc Natl Acad Sci U S A 1990 Dec;87(24):10010-4
  • Generation of a lysosomal enzyme targeting signal in the secretory protein pepsinogen
    Baranski TJ, Faust PL, Kornfeld S
    Cell 1990 Oct 19;63(2):281-91
  • Role of mannose 6-phosphate receptors in lysosomal enzyme targeting
    Kornfeld S
    In:  Proceedings of the Robert A. Welch Foundation Conference on Chemical Research. XXXIII.  Membrane Proteins: Targeting and Transduction, 143-155, 1990
  • Lysosomal enzyme targeting
    Kornfeld S
    Biochem Soc Trans 1990 Jun;18(3):367-74
  • The biogenesis of lysosomes
    Kornfeld S, Mellman I
    Annu Rev Cell Biol 1989;5:483-525
  • Mannose 6-phosphate receptors and lysosomal enzyme targeting
    Dahms NM, Lobel P, Kornfeld S
    J Biol Chem 1989 Jul 25;264(21):12115-8
  • Isolation and characterization of membranes from bovine liver which are highly enriched in mannose 6-phosphate receptors
    Messner DJ, Griffiths G, Kornfeld S
    J Cell Biol 1989 Jun;108(6):2149-62
  • Mutations in the cytoplasmic domain of the 275 kd mannose 6-phosphate receptor differentially alter lysosomal enzyme sorting and endocytosis
    Lobel P, Fujimoto K, Ye RD, Griffiths G, Kornfeld S
    Cell 1989 Jun 2;57(5):787-96
  • The cation-dependent mannose 6-phosphate receptor. Structural requirements for mannose 6-phosphate binding and oligomerization
    Dahms NM, Kornfeld S
    J Biol Chem 1989 Jul 5;264(19):11458-67
  • The chicken liver cation-independent mannose 6-phosphate receptor lacks the high affinity binding site for insulin-like growth factor II
    Canfield WM, Kornfeld S
    J Biol Chem 1989 May 5;264(13):7100-3
  • Ligand interactions of the cation-dependent mannose 6-phosphate receptor. Comparison with the cation-independent mannose 6-phosphate receptor
    Tong PY, Kornfeld S
    J Biol Chem 1989 May 15;264(14):7970-5
  • Ligand interactions of the cation-independent mannose 6-phosphate receptor. The stoichiometry of mannose 6-phosphate binding
    Tong PY, Gregory W, Kornfeld S
    J Biol Chem 1989 May 15;264(14):7962-9
  • Expression of the yeast aspartyl protease, proteinase A. Phosphorylation and binding to the mannose 6-phosphate receptor are altered by addition of cathepsin D sequences
    Faust PL, Kornfeld S
    J Biol Chem 1989 Jan 5;264(1):479-88
  • The mannose 6-phosphate receptor and the biogenesis of lysosomes
    Griffiths G, Hoflack B, Simons K, Mellman I, Kornfeld S
    Cell 1988 Feb 12;52(3):329-41
  • The cation-independent mannose 6-phosphate receptor binds insulin-like growth factor II
    Tong PY, Tollefsen SE, Kornfeld S
    J Biol Chem 1988 Feb 25;263(6):2585-8
  • Cloning and sequence analysis of the cation-independent mannose 6- phosphate receptor
    Lobel P, Dahms NM, Kornfeld S
    J Biol Chem 1988 Feb 15;263(5):2563-70
  • Intracellular movement of two mannose 6-phosphate receptors: return to the Golgi apparatus
    Duncan JR, Kornfeld S
    J Cell Biol 1988 Mar;106(3):617-28
  • Trafficking of lysosomal enzymes
    Kornfeld S
    FASEB J 1987 Dec;1(6):462-8
  • Renin, a secretory glycoprotein, acquires phosphomannosyl residues
    Faust PL, Chirgwin JM, Kornfeld S
    J Cell Biol 1987 Nov;105(5):1947-55
  • Expression of human cathepsin D in Xenopus oocytes: phosphorylation and intracellular targeting
    Faust PL, Wall DA, Perara E, Lingappa VR, Kornfeld S
    J Cell Biol 1987 Nov;105(5):1937-45
  • 46 kd mannose 6-phosphate receptor: cloning, expression, and homology to the 215 kd mannose 6-phosphate receptor
    Dahms NM, Lobel P, Breitmeyer J, Chirgwin JM, Kornfeld S
    Cell 1987 Jul 17;50(2):181-92
  • Studies of the biosynthesis of the cation-dependent mannose 6-phosphate receptor in murine cell lines
    Gasa S, Kornfeld S
    Arch Biochem Biophys 1987 Aug 15;257(1):170-6
  • Cloning of the bovine 215-kDa cation-independent mannose 6-phosphate receptor [published erratum appears in Proc Natl Acad Sci U S A 1987 Nov;84(21):7523]
    Lobel P, Dahms NM, Breitmeyer J, Chirgwin JM, Kornfeld S
    Proc Natl Acad Sci U S A 1987 Apr;84(8):2233-7
  • The high mannose oligosaccharides of Dictyostelium discoideum glycoproteins contain a novel intersecting N-acetylglucosamine residue
    Couso R, van Halbeek H, Reinhold V, Kornfeld S
    J Biol Chem 1987 Apr 5;262(10):4521-7
  • The interaction of phosphorylated oligosaccharides and lysosomal enzymes with bovine liver cation-dependent mannose 6-phosphate receptor
    Hoflack B, Fujimoto K, Kornfeld S
    J Biol Chem 1987 Jan 5;262(1):123-9
  • Phosphorylation of the oligosaccharide of uteroferrin by UDP- GlcNAc:glycoprotein N-acetylglucosamine-1-phosphotransferases from rat liver, Acanthamoeba castellani, and Dictyostelium discoideum requires alpha 1,2-linked mannose residues
    Couso R, Lang L, Roberts RM, Kornfeld S
    J Biol Chem 1986 May 15;261(14):6326-31
  • Glycoprotein phosphorylation in simple eucaryotic organisms. Identification of UDP-GlcNAc:glycoprotein N-acetylglucosamine-1- phosphotransferase activity and analysis of substrate specificity
    Lang L, Couso R, Kornfeld S
    J Biol Chem 1986 May 15;261(14):6320-5
  • Purification and characterization of UDP-N-acetylgalactosamine: polypeptide N-acetylgalactosaminyltransferase from bovine colostrum and murine lymphoma BW5147 cells
    Elhammer A, Kornfeld S
    J Biol Chem 1986 Apr 25;261(12):5249-55
  • Deletion of clustered O-linked carbohydrates does not impair function of low density lipoprotein receptor in transfected fibroblasts
    Davis CG, Elhammer A, Russell DW, Schneider WJ, Kornfeld S, Brown MS, Goldstein JL
    J Biol Chem 1986 Feb 25;261(6):2828-38
  • Trafficking of lysosomal enzymes in normal and disease states
    Kornfeld S
    J Clin Invest 1986 Jan;77(1):1-6
  • Lysosomal storage defects
    Kornfeld S, Sly WS
    Hosp Pract (Off Ed) 1985 Aug 15;20(8):71-5, 78-82
  • Lysosomal enzyme phosphorylation in human fibroblasts. Kinetic parameters offer a biochemical rationale for two distinct defects in the uridine diphospho-N-acetylglucosamine:lysosomal enzyme precursor N-acetylglucosamine-1-phosphotransferase
    Lang L, Takahashi T, Tang J, Kornfeld S
    J Clin Invest 1985 Dec;76(6):2191-5
  • Purification and characterization of a cation-dependent mannose 6-phosphate receptor from murine P388D1 macrophages and bovine liver
    Hoflack B, Kornfeld S
    J Biol Chem 1985 Oct 5;260(22):12008-14
  • Cloning and sequence analysis of cDNA for human cathepsin D
    Faust PL, Kornfeld S, Chirgwin JM
    Proc Natl Acad Sci U S A 1985 Aug;82(15):4910-4
  • Lysosomal enzyme binding to mouse P388D1 macrophage membranes lacking the 215-kDa mannose 6-phosphate receptor: evidence for the existence of a second mannose 6-phosphate receptor
    Hoflack B, Kornfeld S
    Proc Natl Acad Sci U S A 1985 Jul;82(13):4428-32
  • Assembly of asparagine-linked oligosaccharides
    Kornfeld R, Kornfeld S
    Annu Rev Biochem 1985;54:631-64
  • Lysosomal enzyme phosphorylation. Recognition of a protein-dependent determinant allows specific phosphorylation of oligosaccharides present on lysosomal enzymes
    Lang L, Reitman M, Tang J, Roberts RM, Kornfeld S
    J Biol Chem 1984 Dec 10;259(23):14663-71
  • Identification of methylphosphomannosyl residues as components of the high mannose oligosaccharides of Dictyostelium discoideum glycoproteins
    Gabel CA, Costello CE, Reinhold VN, Kurz L, Kornfeld S
    J Biol Chem 1984 Nov 25;259(22):13762-9
  • A murine cytotoxic T lymphocyte cell line resistant to Vicia villosa lectin is deficient in UDP-GalNAc:beta-galactose beta 1,4-N- acetylgalactosaminyltransferase
    Conzelmann A, Kornfeld S
    J Biol Chem 1984 Oct 25;259(20):12536-42
  • Beta-linked N-acetylgalactosamine residues present at the nonreducing termini of O-linked oligosaccharides of a cloned murine cytotoxic T lymphocyte line are absent in a Vicia villosa lectin-resistant mutant cell line
    Conzelmann A, Kornfeld S
    J Biol Chem 1984 Oct 25;259(20):12528-35
  • UDP-N-acetylglucosamine: lysosomal enzyme N-acetylglucosamine-1- phosphotransferase
    Reitman ML, Lang L, Kornfeld S
    Methods Enzymol 1984;107:163-72
  • The distribution of repeating [Gal beta 1,4GlcNAc beta 1,3] sequences in asparagine-linked oligosaccharides of the mouse lymphoma cell lines BW5147 and PHAR 2.1
    Cummings RD, Kornfeld S
    J Biol Chem 1984 May 25;259(10):6253-60
  • Two enzymes involved in the synthesis of O-linked oligosaccharides are localized on membranes of different densities in mouse lymphoma BW5147 cells
    Elhammer A, Kornfeld S
    J Cell Biol 1984 Jul;99(1 Pt 1):327-31
  • Targeting of beta-glucuronidase to lysosomes in mannose 6-phosphate receptor-deficient MOPC 315 cells
    Gabel CA, Kornfeld S
    J Cell Biol 1984 Jul;99(1 Pt 1):296-305
  • A simplified procedure for synthesizing large quantities of highly purified uridine [beta-32P]diphospho-N-acetylglucosamine
    Lang L, Kornfeld S
    Anal Biochem 1984 Jul;140(1):264-9
  • Processing of lysosomal enzyme oligosaccharide units
    Goldberg DE, Gabel CA, Kornfeld S
    In: Lysosomes in Biology and Pathology, 7, JT Dingle, RT Dean and W Sly (eds.)., Elsevier Science Publishers, 45-62, 1984
  • Studies of the biosynthesis of the mannose 6-phosphate receptor in receptor-positive and -deficient cell lines
    Goldberg DE, Gabel CA, Kornfeld S
    J Cell Biol 1983 Dec;97(6):1700-6
  • Biosynthesis of N- and O-linked oligosaccharides of the low density lipoprotein receptor
    Cummings RD, Kornfeld S, Schneider WJ, Hobgood KK, Tolleshaug H, Brown MS, Goldstein JL
    J Biol Chem 1983 Dec 25;258(24):15261-73
  • The mod A mutant of Dictyostelium discoideum is missing the alpha 1,3- glucosidase involved in asparagine-linked oligosaccharide processing
    Freeze HH, Yeh R, Miller AL, Kornfeld S
    J Biol Chem 1983 Dec 25;258(24):14880-4
  • Structural analysis of the asparagine-linked oligosaccharides from three lysosomal enzymes of Dictyostelium discoideum. Evidence for an unusual acid-stable phosphodiester
    Freeze HH, Yeh R, Miller AL, Kornfeld S
    J Biol Chem 1983 Dec 25;258(24):14874-9
  • Demonstration of the enzymatic mechanisms of alpha-N-acetyl-D-glucosamine-1-phosphodiester N-acetylglucosaminidase (formerly called alpha-N-acetylglucosaminylphosphodiesterase) and lysosomal alpha-N- acetylglucosaminidase
    Varki A, Sherman W, Kornfeld S
    Arch Biochem Biophys 1983 Apr 1;222(1):145-9
  • Evidence for extensive subcellular organization of asparagine-linked oligosaccharide processing and lysosomal enzyme phosphorylation
    Goldberg DE, Kornfeld S
    J Biol Chem 1983 Mar 10;258(5):3159-65
  • The spectrum of anionic oligosaccharides released by endo-beta-N-acetylglucosaminidase H from glycoproteins. Structural studies and interactions with the phosphomannosyl receptor
    Varki A, Kornfeld S
    J Biol Chem 1983 Mar 10;258(5):2808-18
  • Identification and characterization of cells deficient in the mannose 6-phosphate receptor: evidence for an alternate pathway for lysosomal enzyme targeting
    Gabel CA, Goldberg DE, Kornfeld S
    Proc Natl Acad Sci U S A 1983 Feb;80(3):775-9
  • Structural studies of oligosaccharides of rat IgE and reexamination of the high-mannose oligosaccharide of human IgE
    Rearick JI, Kulczycki A Jr, Kornfeld S
    Arch Biochem Biophys 1983 Jan;220(1):95-105
  • A mouse lymphoma cell line resistant to the leukoagglutinating lectin from Phaseolus vulgaris is deficient in UDP-GlcNAc: alpha-D-mannoside beta 1,6 N-acetylglucosaminyltransferase
    Cummings RD, Trowbridge IS, Kornfeld S
    J Biol Chem 1982 Nov 25;257(22):13421-7
  • Lysosomal enzyme oligosaccharide phosphorylation in mouse lymphoma cells: specificity and kinetics of binding to the mannose 6-phosphate receptor in vivo
    Gabel CA, Goldberg DE, Kornfeld S
    J Cell Biol 1982 Nov;95(2 Pt 1):536-42
  • Fractionation of asparagine-linked oligosaccharides by serial lectin- Agarose affinity chromatography. A rapid, sensitive, and specific technique
    Cummings RD, Kornfeld S
    J Biol Chem 1982 Oct 10;257(19):11235-40
  • Characterization of the structural determinants required for the high affinity interaction of asparagine-linked oligosaccharides with immobilized Phaseolus vulgaris leukoagglutinating and erythroagglutinating lectins
    Cummings RD, Kornfeld S
    J Biol Chem 1982 Oct 10;257(19):11230-4
  • Lysosomal enzyme phosphorylation in mouse lymphoma cell lines with altered asparagine-linked oligosaccharides
    Gabel CA, Kornfeld S
    J Biol Chem 1982 Sep 25;257(18):10605-12
  • A lectin-resistant mouse lymphoma cell line is deficient in glucosidase II, a glycoprotein-processing enzyme
    Reitman ML, Trowbridge IS, Kornfeld S
    J Biol Chem 1982 Sep 10;257(17):10357-63
  • Steps in the phosphorylation of the high mannose oligosaccharides of lysosomal enzymes
    Kornfeld S, Reitman ML, Varki A, Goldberg D, Gabel CA
    Ciba Found Symp 1982;(92):138-56
  • Demonstration of the heterozygous state for I-cell disease and pseudo- Hurler polydystrophy by assay of N-acetylglucosaminylphosphotransferase in white blood cells and fibroblasts
    Varki A, Reitman ML, Vannier A, Kornfeld S, Grubb JH, Sly WS
    Am J Hum Genet 1982 Sep;34(5):717-29
  • Oligosaccharide processing during glycoprotein biosynthesis
    Kornfeld S
    In: The Glycoconjugates, Vol. III, M Horowitz (ed.) Academic Press, 3-23, 1982
  • N-asparagine-linked oligosaccharides: processing
    Tabas I, Kornfeld S
    Methods Enzymol 1982;83:416-29
  • Identification of a variant of mucolipidosis III (pseudo-Hurler polydystrophy): a catalytically active N- acetylglucosaminylphosphotransferase that fails to phosphorylate lysosomal enzymes
    Varki AP, Reitman ML, Kornfeld S
    Proc Natl Acad Sci U S A 1981 Dec;78(12):7773-7
  • The phosphorylation of beta-glucuronidase oligosaccharides in mouse P388D1 cells
    Goldberg DE, Kornfeld S
    J Biol Chem 1981 Dec 25;256(24):13060-7
  • Lysosomal enzyme targeting. N-Acetylglucosaminylphosphotransferase selectively phosphorylates native lysosomal enzymes
    Reitman ML, Kornfeld S
    J Biol Chem 1981 Dec 10;256(23):11977-80
  • Purification and characterization of rat liver alpha-N-acetylglucosaminyl phosphodiesterase
    Varki A, Kornfeld S
    J Biol Chem 1981 Oct 10;256(19):9937-43
  • Glucose starvation alters lipid-linked oligosaccharide biosynthesis in Chinese hamster ovary cells
    Rearick JI, Chapman A, Kornfeld S
    J Biol Chem 1981 Jun 25;256(12):6255-61
  • Fibroblasts from patients with I-cell disease and pseudo-Hurler polydystrophy are deficient in uridine 5'-diphosphate-N- acetylglucosamine: glycoprotein N-acetylglucosaminylphosphotransferase activity
    Reitman ML, Varki A, Kornfeld S
    J Clin Invest 1981 May;67(5):1574-9
  • UDP-N-acetylglucosamine:glycoprotein N-acetylglucosamine-1-phosphotransferase. Proposed enzyme for the phosphorylation of the high mannose oligosaccharide units of lysosomal enzymes
    Reitman ML, Kornfeld S
    J Biol Chem 1981 May 10;256(9):4275-81
  • Identification of the mannosyl donors involved in the synthesis of lipid-linked oligosaccharides
    Rearick JI, Fujimoto K, Kornfeld S
    J Biol Chem 1981 Apr 25;256(8):3762-9
  • The effect of oligosaccharide chains of different sizes on the maturation and physical properties of the G protein of vesicular stomatitis virus
    Gibson R, Kornfeld S, Schlesinger S
    J Biol Chem 1981 Jan 10;256(1):456-62
  • A Role of oligosaccharides in glycoprotein biosynthesis
    Gibson R, Kornfeld S, Schlesinger S
    TIBS 1980;5:290-293
  • Structural studies of phosphorylated high mannose-type oligosaccharides
    Varki A, Kornfeld S
    J Biol Chem 1980 Nov 25;255(22):10847-58
  • Mouse lymphoma cell lines resistant to pea lectin are defective in fucose metabolism
    Reitman ML, Trowbridge IS, Kornfeld S
    J Biol Chem 1980 Oct 25;255(20):9900-6
  • An autosomal dominant gene regulates the extent of 9-O-acetylation of murine erythrocyte sialic acids. A probable explanation for the variation in capacity to activate the human alternate complement pathway
    Varki A, Kornfeld S
    J Exp Med 1980 Sep 1;152(3):532-44
  • Identification of a rat liver alpha-N-acetylglucosaminyl phosphodiesterase capable of removing "blocking" alpha-N- acetylglucosamine residues from phosphorylated high mannose oligosaccharides of lysosomal enzymes
    Varki A, Kornfeld S
    J Biol Chem 1980 Sep 25;255(18):8398-401
  • Role of glycosylation in the proteolytic processing and secretion of the 4th component of complement (Ss protein) of the mouse
    Roos MH, Shreffler DC, Kornfeld S
    J Immunol 1980 Oct;125(4):1869-71
  • Biosynthetic intermediates of beta-glucuronidase contain high mannose oligosaccharides with blocked phosphate residues
    Tabas I, Kornfeld S
    J Biol Chem 1980 Jul 25;255(14):6633-9
  • Characterization of the oligosaccharide units of the fourth component of complement (Ss protein) synthesized by murine macrophages
    Roos MH, Kornfeld S, Shreffler DC
    J Immunol 1980 Jun;124(6):2860-3
  • The primary glycosylation defect in class E Thy-1-negative mutant mouse lymphoma cells is an inability to synthesize dolichol-P-mannose
    Chapman A, Fujimoto K, Kornfeld S
    J Biol Chem 1980 May 25;255(10):4441-6
  • Structure of glycoproteins and their oligosaccharide units
    Kornfeld R, Kornfeld S
    In: The Biochemistry of Glycoproteins and Proteoglycans, WJ Lennarz (ed.) Plenum Press, 1-34, 1980
  • Structure of an unusual complex-type oligosaccharide isolated from Chinese hamster ovary cells
    Li E, Gibson R, Kornfeld S
    Arch Biochem Biophys 1980 Feb;199(2):393-9
  • Partial purification and characterization of the glucosidases involved in the processing of asparagine-linked oligosaccharides
    Michael JM, Kornfeld S
    Arch Biochem Biophys 1980 Jan;199(1):249-58
  • Use of lectins in the study of mammalian glycoproteins
    Kornfeld S, Kornfeld R
    In: The Glycoconjugates, 2, M.I. Horowitz and W. Pigman (eds.) Academic Press, 437-447, 1979
  • Purification and characterization of a rat liver Golgi alpha- mannosidase capable of processing asparagine-linked oligosaccharides
    Tabas I, Kornfeld S
    J Biol Chem 1979 Nov 25;254(22):11655-63
  • Class E Thy-1 negative mouse lymphoma cells utilize an alternate pathway of oligosaccharide processing to synthesize complex-type oligosaccharides
    Kornfeld S, Gregory W, Chapman A
    J Biol Chem 1979 Nov 25;254(22):11649-54
  • Structural studies of the major high mannose oligosaccharide units from Chinese hamster ovary cell glycoproteins
    Li E, Kornfeld S
    J Biol Chem 1979 Mar 10;254(5):1600-5
  • The biosynthesis of the major lipid-linked oligosaccharide of Chinese hamster ovary cells occurs by the ordered addition of mannose residues
    Chapman A, Li E, Kornfeld S
    J Biol Chem 1979 Oct 25;254(20):10243-9
  • The nonglycosylated glycoprotein of vesicular stomatitis virus is temperature-sensitive and undergoes intracellular aggregation at elevated temperatures
    Gibson R, Schlesinger S, Kornfeld S
    J Biol Chem 1979 May 10;254(9):3600-7
  • Structure of the lipid-linked oligosaccharides that accumulate in class E Thy-1-negative mutant lymphomas
    Chapman A, Trowbridge IS, Hyman R, Kornfeld S
    Cell 1979 Jul;17(3):509-15
  • Biosynthesis of lipid-linked oligosaccharides. Isolation and structure of a second lipid-linked oligosaccharide in Chinese hamster ovary cells
    Li E, Kornfeld S
    J Biol Chem 1979 Apr 25;254(8):2754-8
  • Vertebrate lectins, Comparison of properties of beta-galactoside-binding lectins from tissues of calf and chicken
    Briles EB, Gregory W, Fletcher P, Kornfeld S
    J Cell Biol 1979 Jun;81(3):528-37
  • Restricted replication of two alphaviruses in ricin-resistant mouse L cells with altered glycosyltransferase activities
    Gottlieb C, Kornfeld S, Schlesinger S
    J Virol 1979 Jan;29(1):344-51
  • The synthesis of complex-type oligosaccharides. III. Identification of an alpha-D-mannosidase activity involved in a late stage of processing of complex-type oligosaccharides
    Tabas I, Kornfeld S
    J Biol Chem 1978 Nov 10;253(21):7779-86
  • The synthesis of complex-type oligosaccharides. II. Characterization of the processing intermediates in the synthesis of the complex oligosaccharide units of the vesicular stomatitis virus G protein
    Kornfeld S, Li E, Tabas I
    J Biol Chem 1978 Nov 10;253(21):7771-8
  • The synthesis of complex-type oligosaccharides. I. Structure of the lipid-linked oligosaccharide precursor of the complex-type oligosaccharides of the vesicular stomatitis virus G protein
    Li E, Tabas I, Kornfeld S
    J Biol Chem 1978 Nov 10;253(21):7762-70
  • Lectin-resistant cell surface variants of eukaryotic cells
    Briles EB, Kornfeld S
    TIBS 1978;3:223-228
  • Effect of tunicamycin on IgM, IgA, and IgG secretion by mouse plasmacytoma cells
    Hickman S, Kornfeld S
    J Immunol 1978 Sep;121(3):990-6
  • Structure of the altered oligosaccharide present in glycoproteins from a clone of Chinese hamster ovary cells deficient in N- acetylglucosaminyltransferase activity
    Li E, Kornfeld S
    J Biol Chem 1978 Sep 25;253(18):6426-31
  • Synthesis and infectivity of vesicular stomatitis virus containing nonglycosylated G protein
    Gibson R, Leavitt R, Kornfeld S, Schlesinger S
    Cell 1978 Apr;13(4):671-9
  • Isolation and metastatic properties of detachment variants of B16 melanoma cells
    Briles EB, Kornfeld S
    J Natl Cancer Inst 1978 Jun;60(6):1217-22
  • Processing of high mannose oligosaccharides to form complex type oligosaccharides on the newly synthesized polypeptides of the vesicular stomatitis virus G protein and the IgG heavy chain
    Tabas I, Schlesinger S, Kornfeld S
    J Biol Chem 1978 Feb 10;253(3):716-22
  • Impaired intracellular migration and altered solubility of nonglycosylated glycoproteins of vesicular stomatitis virus and Sindbis virus
    Leavitt R, Schlesinger S, Kornfeld S
    J Biol Chem 1977 Dec 25;252(24):9018-23
  • Humoral immunostimulation. VII. Sialic acid masks antigenic sites on an antibody-selected bariant cell line
    Shearer WT, Gottlieb C, Kornfeld S
    J Immunol 1977 Aug;119(2):614-7
  • Effect of wheat germ agglutinin on membrane transport
    Li E, Kornfeld S
    Biochim Biophys Acta 1997;469:202-210
  • Studies of the mechanism of tunicamycin in hibition of IgA and IgE secretion by plasma cells
    Hickman S, Kulczycki A Jr, Lynch RG, Kornfeld S
    J Biol Chem 1977 Jun 25;252(12):4402-8
  • Tunicamycin inhibits glycosylation and multiplication of Sindbis and vesicular stomatitis viruses
    Leavitt R, Schlesinger S, Kornfeld S
    J Virol 1977 Jan;21(1):375-85
  • Isolation of wheat germ agglutinin-resistant clones of Chinese hamster ovary cells deficient in membrane sialic acid and galactose
    Briles EB, Li E, Kornfeld S
    J Biol Chem 1977 Feb 10;252(3):1107-16
  • Isolation and characterization of two mouse L cell lines resistant to the toxic lectin ricin
    Gottlieb C, Kornfeld S
    J Biol Chem 1976 Dec 25;251(24):7761-8
  • Isolation and properties of beta-galactoside binding lectins of calf heart and lung
    de Waard A, Hickman S, Kornfeld S
    J Biol Chem 1976 Dec 10;251(23):7581-7
  • Detection of mutagenic activity in human urine using mutant strains of Salmonella typhimurium
    Minnich V, Smith ME, Thompson D, Kornfeld S
    Cancer 1976 Sep;38(3):1253-8
  • Comparative aspects of glycoprotein structure
    Kornfeld R, Kornfeld S
    Annu Rev Biochem 1976;45:217-37
  • Characterization of the oligosaccharide units of the bovine erythrocyte membrane glycoprotein
    Emerson WA, Kornfeld S
    Biochemistry 1976 Apr 20;15(8):1697-703
  • Growth of enveloped RNA viruses in a line of chinese hamster ovary cells with deficient N-acetylglucosaminyltransferase activity
    Schlesinger S, Gottlieb C, Feil P, Gelb N, Kornfeld S
    J Virol 1975 Jan;17(1):239-46
  • Effect of lectins on hormone release from isolated rat islets of langerhans
    Ewart RB, Kornfeld S, Kipnis DM
    Diabetes 1975 Aug;24(8):705-14
  • Deficient uridine diphosphate-N-acetylglucosamine:glycoprotein N-acetylglucosaminyltransferase activity in a clone of Chinese hamster ovary cells with altered surface glycoproteins
    Gottlieb C, Baenziger J, Kornfeld S
    J Biol Chem 1975 May 10;250(9):3303-9
  • Localization of the binding sites for the Ricinus communis, Agaricus bisporus and wheat germ lectins on human erythrocyte membranes
    Triche TJ, Tillack TW, Kornfeld S
    Biochim Biophys Acta 1975 Jul 18;394(4):540-9
  • Structure of membrane receptors for plant lectins
    Kornfeld R, Kornfeld S
    Ann N Y Acad Sci 1974;234(0):276-82
  • Structure of the carbohydrate units of IgA1 immunoglobulin. II. Structure of the O-glycosidically linked oligosaccharide units
    Baenziger J, Kornfeld S
    J Biol Chem 1974 Nov 25;249(22):7270-81
  • Structure of the carbohydrate units of IgA1 immunoglobulin. I. Composition, glycopeptide isolation, and structure of the asparagine- linked oligosaccharide units
    Baenziger J, Kornfeld S
    J Biol Chem 1974 Nov 25;249(22):7260-9
  • Membrane glycoproteins as plant lectin receptors
    Kornfeld S, Adair W, Gottlieb C, Kornfeld R
    In: Biology and Chemistry of Eucaryotic Cell Surfaces, Miami Winter Symposium. EYC Lee and E. Smith (eds.), Academic Press, 291-311, 1974
  • Isolation of a clone of Chinese hamster ovary cells deficient in plant lectin-binding sites
    Gottlieb C, Skinner AM, Kornfeld S
    Proc Natl Acad Sci U S A 1974 Apr;71(4):1078-82
  • Isolation of the receptors for wheat germ agglutinin and the Ricinus communis lectins from human erythrocytes using affinity chromatography
    Adair W, Kornfeld S
    J Biol Chem 1974;249:4696-4704
  • Inhibition of protein and DNA synthesis in human lymphocytes by the Ricinus communis agglutinins
    Kornfeld S, Eider W, Gregory W
    In: Lymphocyte Recognition and Effector Mechanisms, Lindahl-Kiessling and D. Osoba (eds.), Academic Press, 515-519, 1974
  • Structure of the carbohydrate units of IgE immunoglobulin. II. Sequence of the sialic acid-containing glycopeptides
    Baenziger J, Kornfeld S, Kochwa S
    J Biol Chem 1974 Mar 25;249(6):1897-903
  • Structure of the carbohydrate units of IgE immunoglobulin. I. Over-all composition, glycopeptide isolation, and structure of the high mannose oligosaccharide unit
    Baenziger J, Kornfeld S, Kochwa S
    J Biol Chem 1974 Mar 25;249(6):1889-96
  • Inhibition of protein and DNA synthesis in mammalian cells by the Ricinus communis agglutins
    Kornfeld S, Eider W, Gregory W
    In:  Control of Proliferation in Animal Cells, B Clarkson and R Baserga (eds.) Cold Spring Harbor Laboratory Publisher, 435-445, 1974
  • Red kidney bean phytohemagglutinin
    Kornfeld R, Gregory W, Kornfeld S
    Methods Enzymol 1972;28:344-349
  • The nature of the erythrocyte receptor site for Robinia pseudoaccacia phytohemagglutinin
    Leseney AM, Bourrillon R, Kornfeld S
    Arch Biochem Biophys 1972 Dec;153(2):831-6
  • Studies of two subpopulations of human lymphocytes differing in responsiveness to concanavalin A
    Boldt S, Skinner AM, Kornfeld S
    J Clin Invest 1972 Dec;51(12):3225-34
  • Characterization of the cell surface receptor for the Agaricus bisporus hemagglutinin
    Presant CA, Kornfeld S
    J Biol Chem 1972 Nov 10;247(21):6937-45
  • Excretion of deoxyribonucleic acid by lymphocytes stimulated with phytohemagglutinin or antigen
    Rogers JC, Boldt D, Kornfeld S, Skinner A, Valeri CR
    Proc Natl Acad Sci U S A 1972 Jul;69(7):1685-9
  • The structure of the glycopeptides of a human M-immunoglobulin
    Hickman S, Kornfeld R, Osterland CK, Kornfeld S
    J Biol Chem 1972 Apr 10;247(7):2156-63
  • The structure of phytohemagglutinin receptor sites
    Kornfeld S, Kornfeld R
    In:  Glycoproteins of Blood Cells and Plasma, GA Jamieson and TJ Greenwalt (eds.) J.B. Lippincott, Philadelphia, p. 50, 1971
  • Hepatic uptake of proteins coupled to fetuin glycopeptide
    Rogers JC, Kornfeld S
    Biochem Biophys Res Commun 1971 Nov 5;45(3):622-9
  • The nature of the cell surface receptor site for Lens culinaris phytohemagglutinin
    Kornfeld S, Rogers J, Gregory W
    J Biol Chem 1971 Nov;246(21):6581-6
  • The structure of the glycopeptide of human gamma G myeloma proteins
    Kornfeld R, Keller J, Baenziger J, Kornfeld S
    J Biol Chem 1971 May 25;246(10):3259-68
  • Cell surface receptors--structure and function
    Kornfeld S, Kornfeld R
    Prog Hematol 1971;7:161-83
  • The rapid induction by phytohemagglutinin of increased alpha-aminoisobutyric acid uptake by lymphocytes
    Mendelsohn J, Skinner A, Kornfeld S
    J Clin Invest 1971 Apr;50(4):818-26
  • The structure of a phytohemagglutinin receptor site from human erythrocytes
    Kornfeld R, Kornfeld S
    J Biol Chem 1970 May 25;245(10):2536-45
  • Solubilization and partial characterization of a phytohemagglutinin receptor site from human erythrocytes
    Kornfeld S, Kornfeld R
    Proc Natl Acad Sci U S A 1969 Aug;63(4):1439-46
  • Decreased phytohemagglutinin receptor sites in chronic lymphocytic leukemia
    Kornfeld S
    Biochim Biophys Acta 1969 Dec 30;192(3):542-5
  • The effect of metal attachment to human apotransferrin on its binding to reticulocytes
    Kornfeld S
    Biochim Biophys Acta 1969 Nov 11;194(1):25-33
  • The identification and partial characterization of lysosomes in human reticulocytes
    Kornfeld S, Gregory W
    Biochim Biophys Acta 1969 May 6;177(3):615-24
  • Intracellular catabolism of hemoglobin and iron dextran by the rat liver
    Kornfeld S, Chipman B, Brown EB
    J Lab Clin Med 1969 Feb;73(2):181-93
  • The conversion of glucosamine to glucose by white blood cell cultures
    Kornfeld S, Greogry W
    Biochim Biophys Acta 1968 Jun 24;158(3):468-70
  • The effects of structural modifications on the biologic activity of human transferrin
    Kornfeld S
    Biochemistry 1968 Mar;7(3):945-54
  • The formation of thymidine diphosphate L-rhamnose
    Kornfeld S, Glaser L
    Methods Enzymol 1966;8:302-306
  • The metabolism of glucosamine by tissue culture cells
    Kornfeld S, Ginsburg V
    Exp Cell Res 1966 Mar;41(3):592-600
  • The intracellular site of synthesis of soluble blood group substance
    Kornfeld S, Kornfeld R, Ginsburg V
    Arch Biochem Biophys 1965 Apr;110:1-7
  • Thymidine diphosphate N-acetylglucosamine pyrophosphorylase activity of hog gastric mucosa
    Kornfeld R, Kornfeld S, Ginsburg V
    Biochem Biophys Res Commun 1964;17:578-581
  • The feedback control of sugar nucleotide biosynthesis in liver
    Kornfeld S, Kornfeld R, Neufeld E, O'Brien PJ
    Proc Natl Acad Sci U S A 1964 Aug;52:371-9
  • The enzymatic synthesis of thymidine-linked sugars. V. Thymidine diphosphate amino sugars
    Kornfeld S, Glaser L
    J Biol Chem 1962 Oct;237:3052-9
  • The enzymatic synthesis of thymidine-linked sugars. IV. Thymidine diphosphate amino sugars
    Kornfeld S, Glaser L
    Biochim Biophys Acta 1962 Jan 1;56:184-5
  • The enzymatic synthesis of thymidine-linked sugars. II. Thymidine diphosphate L-rhamnose
    Glaser L, Kornfeld S
    J Biol Chem 1961 Jun;236:1795-9
  • The enzymatic synthesis of thymidine-linked sugars. I. Thymidine diphosphate glucose
    Kornfeld S, Glaser
    J Biol Chem 1961 Jun;236:1791-4
  • The enzymatic synthesis of thymidine diphosphate glucose and thymidine diphosphate rhamnose
    Kornfeld S, Glaser L
    Biochim Biophys Acta 1960 Aug 26;42:548-50
  • Preparation and properties of phosphomannomutase from baker's yeast
    Glaser L, Kornfeld S, Brown DH
    Biochim Biophys Acta 1959 Jun;33(2):522-6