Faculty
Dan Link.jpg

Daniel C. Link, MD

Professor
Department of Medicine
Oncology Division
Stem Cell Biology
Department of Pathology & Immunology

Clinical Interests

  • Hematopoietic stem cell transplantation
  • Leukemia
  • Neutropenia

Research Interests

  • Stem cells
  • Stem cell niche
  • Leukemogenesis

Contact

  • 314-362-8771 (office)
  • 314-362-8872 (lab)
  • 314-362-9333 (fax)
  • 613 Southwest Tower (office)
  • 613 Southwest Tower (lab)
  • Division of Oncology
    Section of Stem Cell Biology
    Campus Box 8007
    Washington University Medical School
    660 South Euclid Avenue
    St. Louis, MO 63110

Peer-reviewed Manuscripts

  • miR-125b promotes leukemogenesis via VEGFA
    Wong TN, Link DC
    Blood 2017 Mar 16;129(11):1409-1410
  • CpG island hypermethylation mediated by DNMT3A is a consequence of AML progression
    Spencer DH, Russler-Germain DA, Ketkar S, Helton NM, Lamprecht TL, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Shinawi M, Westervelt P, Payton JE, Wartman LD, Welch JS, Wilson RK, Walter MJ, Link DC, DiPersio JF, Ley TJ
    Cell 2017 Feb 23;168(5):801-816
  • Mutational landscape and response are conserved in peripheral blood of AML and MDS patients during decitabine therapy
    Duncavage EJ, Uy GL, Petti AA, Miller CA, Lee YS, Tandon B, Gao F, Fronick CC, O'Laughlin M, Fulton RS, Wilson RK, Jacoby MA, Cashen AF, Wartman LD, Walter MJ, Westervelt P, Link DC, DiPersio JF, Ley TJ, Welch JS
    Blood 2017 Mar 9;129(10):1397-1401
  • N-cadherin regulation of bone growth and homeostasis is osteolineage stage-specific
    Fontana F, Hickman-Brecks CL, Salazar VS, Revollo L, Abou-Ezzi G, Grimston SK, Jeong SY, Watkins M, Fortunato M, Alippe Y, Link DC, Mbalaviele G, Civitelli R
    J Bone Miner Res 2017 Feb 27; [Epub ahead of print]
  • Concise review: the malignant hematopoietic stem cell niche
    Yao JC, Link DC
    Stem Cells 2017 Jan;35(1):3-8
  • TP53 and decitabine in acute myeloid leukemia and myelodysplastic syndromes
    Welch JS, Petti AA, Miller CA, Fronick CC, O'Laughlin M, Fulton RS, Wilson RK, Baty JD, Duncavage EJ, Tandon B, Lee YS, Wartman LD, Uy GL, Ghobadi A, Tomasson MH, Pusic I, Romee R, Fehniger TA, Stockerl-Goldstein KE, Vij R, Oh ST, Abboud CN, Cashen AF, Schroeder MA, Jacoby MA, Heath SE, Luber K, Janke MR, Hantel A, Khan N, Sukhanova MJ, Knoebel RW, Stock W, Graubert TA, Walter MJ, Westervelt P, Link DC, DiPersio JF, Ley TJ
    N Engl J Med 2016 Nov 24;375(21):2023-2036
  • Targeting of mesenchymal stromal cells by Cre-recombinase transgenes commonly used to target osteoblast lineage cells
    Zhang J, Link DC
    J Bone Miner Res 2016 Nov;31(11):2001-2007
  • Dynamic changes in the clonal structure of MDS and AML in response to epigenetic therapy
    Uy GL, Duncavage EJ, Chang GS, Jacoby MA, Miller CA, Shao J, Heath S, Elliott K, Reinick T, Fulton RS, Fronick CC, O'Laughlin M, Ganel L, Abboud CN, Cashen AF, DiPersio JF, Wilson RK, Link DC, Welch JS, Ley TJ, Graubert TA, Westervelt P, Walter MJ
    Leukemia 2016 Oct 14; [Epub ahead of print]
  • Marrow adipose tissue expansion coincides with insulin resistance in MAGP1-deficient mice
    Walji TA, Turecamo SE, Sanchez AC, Anthony BA, Abou-Ezzi G, Scheller EL, Link DC, Mecham RP, Craft CS
    Front Endocrinol (Lausanne) 2016 Jun 30;7:87
  • Comprehensive genomic analysis reveals FLT3 activation and a therapeutic strategy for a patient with relapsed adult B-lymphoblastic leukemia
    Griffith M, Griffith OL, Krysiak K, Skidmore ZL, Christopher MJ, Klco JM, Ramu A, Lamprecht TL, Wagner AH, Campbell KM, Lesurf R, Hundal J, Zhang J, Spies NC, Ainscough BJ, Larson DE, Heath SE, Fronick C, O'Laughlin S, Fulton RS, Magrini V, McGrath S, Smith SM, Miller CA, Maher CA, Payton JE, Walker JR, Eldred JM, Walter MJ, Link DC, Graubert TA, Westervelt P, Kulkarni S, DiPersio JF, Mardis ER, Wilson RK, Ley TJ
    Exp Hematol 2016 Jul;44(7):603-13
  • Rapid expansion of preexisting nonleukemic hematopoietic clones frequently follows induction therapy for de novo AML
    Wong TN, Miller CA, Klco JM, Petti A, Demeter R, Helton NM, Li T, Fulton RS, Heath SE, Mardis ER, Westervelt P, DiPersio JF, Walter MJ, Welch JS, Graubert TA, Wilson RK, Ley TJ, Link DC
    Blood 2016 Feb 18;127(7):893-7
  • Genomic analysis of germ line and somatic variants in familial myelodysplasia/acute myeloid leukemia
    Churpek JE, Pyrtel K, Kanchi KL, Shao J, Koboldt D, Miller CA, Shen D, Fulton R, O'Laughlin M, Fronick C, Pusic I, Uy GL, Braunstein EM, Levis M, Ross J, Elliott K, Heath S, Jiang A, Westervelt P, DiPersio JF, Link DC, Walter MJ, Welch J, Wilson R, Ley TJ, Godley LA, Graubert TA
    Blood 2015 Nov 26;126(22):2484-90
  • Targeting bone marrow lymphoid niches in acute lymphoblastic leukemia
    Uy GL, Hsu YM, Schmidt AP, Stock W, Fletcher TR, Trinkaus KM, Westervelt P, DiPersio JF, Link DC
    Leuk Res 2015 Dec;39(12):1437-42
  • Association between mutation clearance after induction therapy and outcomes in acute myeloid leukemia
    Klco JM, Miller CA, Griffith M, Petti A, Spencer DH, Ketkar-Kulkarni S, Wartman LD, Christopher M, Lamprecht TL, Helton NM, Duncavage EJ, Payton JE, Baty J, Heath SE, Griffith OL, Shen D, Hundal J, Chang GS, Fulton R, O'Laughlin M, Fronick C, Magrini V, Demeter RT, Larson DE, Kulkarni S, Ozenberger BA, Welch JS, Walter MJ, Graubert TA, Westervelt P, Radich JP, Link DC, Mardis ER, DiPersio JF, Wilson RK, Ley TJ
    JAMA 2015 Aug 25;314(8):811-822
  • Granulocyte colony-stimulating factor reprograms bone marrow stromal cells to actively suppress B lymphopoiesis in mice
    Day RB, Bhattacharya D, Nagasawa T, Link DC
    Blood 2015 May 14;125(20):3114-7
  • Acute ether lipid deficiency affects neutrophil biology in mice
    Lodhi IJ, Link DC, Semenkovich CF
    Cell Metab 2015 May 5;21(5):652-3
  • MicroRNA-223 regulates granulopoiesis but is not required for HSC maintenance in mice
    Trissal MC, DeMoya RA, Schmidt AP, Link DC
    PLoS One 2015 Mar 20;10(3):e0119304
  • PTEN regulates natural killer cell trafficking in vivo
    Leong JW, Schneider SE, Sullivan RP, Parikh BA, Anthony BA, Singh A, Jewell BA, Schappe T, Wagner JA, Link DC, Yokoyama WM, Fehniger TA
    Proc Natl Acad Sci U S A 2015 Feb 17;112(7):E700-9
  • The diversity of mutations and clinical outcomes for ELANE-associated neutropenia
    Makaryan V, Zeidler C, Bolyard AA, Skokowa J, Rodger E, Kelley ML, Boxer LA, Bonilla MA, Newburger PE, Shimamura A, Zhu B, Rosenberg PS, Link DC, Welte K, Dale DC
    Curr Opin Hematol 2015 Jan;22(1):3-11
  • Peroxisomal lipid synthesis regulates inflammation by sustaining neutrophil membrane phospholipid composition and viability
    Lodhi IJ, Wei X, Yin L, Feng C, Adak S, Abou-Ezzi G, Hsu F, Link DC, Semenkovich CF
    Cell Metab 2015 Jan 6;21(1):51-64
  • Quantifying ultra-rare pre-leukemic clones via targeted error-corrected sequencing
    Young AL, Wong TN, Hughes AE, Heath SE, Ley TJ, Link DC, Druley TE
    Leukemia 2015 Jul;29(7):1608-1611
  • Osteoclasts are dispensable for hematopoietic progenitor mobilization by granulocyte colony-stimulating factor in mice
    Rao M, Supakorndej T, Schmidt AP, Link DC
    Exp Hematol 2015 Feb;43(2):110-4e1-2
  • Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia
    Wong TN, Ramsingh G, Young AL, Miller CA, Touma W, Welch JS, Lamprecht TL, Shen D, Hundal J, Fulton RS, Heath S, Baty JD, Klco JM, Ding L, Mardis ER, Westervelt P, DiPersio JF, Walter MJ, Graubert TA, Ley TJ, Druley TE, Link DC, Wilson RK
    Nature 2015 Feb 26;518(7540):552-555
  • Age-related mutations associated with clonal hematopoietic expansion and malignancies
    Xie M, Lu C, Wang J, McLellan MD, Johnson KJ, Wendl MC, McMichael JF, Schmidt HK, Yellapantula V, Miller CA, Ozenberger BA, Welch JS, Link DC, Walter MJ, Mardis ER, DiPersio JF, Chen F, Wilson RK, Ley TJ, Ding L
    Nat Med 2014 Dec;20(12):1472-1478
  • Caspase-9 is required for normal hematopoietic development and protection from alkylator-induced DNA damage in mice
    Lu EP, McLellan M, Ding L, Fulton R, Mardis ER, Wilson RK, Miller CA, Westervelt P, DiPersio JF, Link DC, Walter MJ, Ley TJ, Graubert TA
    Blood 2014 Dec 18;124(26):3887-95
  • Tumor-induced STAT3 activation in monocytic myeloid-derived suppressor cells enhances stemness and mesenchymal properties in human pancreatic cancer
    Panni RZ, Sanford DE, Belt BA, Mitchem JB, Worley LA, Goetz BD, Mukherjee P, Wang-Gillam A, Link DC, Denardo DG, Goedegebuure SP, Linehan DC
    Cancer Immunol Immunother 2014 May;63(5):513-28
  • Clonal architecture of secondary acute myeloid leukemia defined by single-cell sequencing
    Hughes AE, Magrini V, Demeter R, Miller CA, Fulton R, Fulton LL, Eades WC, Elliott K, Heath S, Westervelt P, Ding L, Conrad DF, White BS, Shao J, Link DC, DiPersio JF, Mardis ER, Wilson RK, Ley TJ, Walter MJ, Graubert TA
    PLoS Genet 2014 Jul 10;10(7):e1004462
  • Functional heterogeneity of genetically defined subclones in acute myeloid leukemia
    Klco JM, Spencer DH, Miller CA, Griffith M, Lamprecht TL, O'Laughlin M, Fronick C, Magrini V, Demeter RT, Fulton RS, Eades WC, Link DC, Graubert TA, Walter MJ, Mardis ER, DiPersio JF, Wilson RK, Ley TJ
    Cancer Cell 2014 Mar 17;25(3):379-92
  • G-CSF regulates hematopoietic stem cell activity, in part, through activation of Toll-like receptor signaling
    Schuettpelz LG, Borgerding JN, Christopher MJ, Gopalan PK, Romine MP, Herman AC, Woloszynek JR, Greenbaum AM, Link DC
    Leukemia 2014 Sep;28(9):1851-60
  • Acquired copy number alterations of miRNA genes in acute myeloid leukemia are uncommon
    Ramsingh G, Jacoby MA, Shao J, De Jesus Pizzaro RE, Shen D, Trissal M, Getz AH, Ley TJ, Walter MJ, Link DC
    Blood 2013 Oct 10;122(15):e44-51
  • Clonal diversity of recurrently mutated genes in myelodysplastic syndromes
    Walter MJ, Shen D, Shao J, Ding L, White BS, Kandoth C, Miller CA, Niu B, McLellan MD, Dees ND, Fulton R, Elliot K, Heath S, Grillot M, Westervelt P, Link DC, DiPersio JF, Mardis E, Ley TJ, Wilson RK, Graubert TA
    Leukemia 2013 Jun;27(6):1275-82
  • Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia
    Ley TJ, Miller C, Ding L, Raphael BJ, Mungall AJ, Robertson A, Hoadley K, Triche TJ Jr, Laird PW, Baty JD, Fulton LL, Fulton R, Heath SE, Kalicki-Veizer J, Kandoth C, Klco JM, Koboldt DC, Kanchi KL, Kulkarni S, Lamprecht TL, Larson DE, Lin L, Lu C, McLellan MD, McMichael JF, Payton J, Schmidt H, Spencer DH, Tomasson MH, Wallis JW, Wartman LD, Watson MA, Welch J, Wendl MC, Ally A, Balasundaram M, Birol I, Butterfield Y, Chiu R, Chu A, Chuah E, Chun HJ, Corbett R, Dhalla N, Guin R, He A, Hirst C, Hirst M, Holt RA, Jones S, Karsan A, Lee D, Li HI, Marra MA, Mayo M, Moore RA, Mungall K, Parker J, Pleasance E, Plettner P, Schein J, Stoll D, Swanson L, Tam A, Thiessen N, Varhol R, Wye N, Zhao Y, Gabriel S, Getz G, Sougnez C, Zou L, Leiserson MD, Vandin F, Wu HT, Applebaum F, Baylin SB, Akbani R, Broom BM, Chen K, Motter TC, Nguyen K, Weinstein JN, Zhang N, Ferguson ML, Adams C, Black A, Bowen J, Gastier-Foster J, Grossman T, Lichtenberg T, Wise L, Davidsen T, Demchok JA, Shaw KR, Sheth M, Sofia HJ, Yang L, Downing JR, Eley G, Alonso S, Ayala B, Baboud J, Backus M, Barletta SP, Berton DL, Chu AL, Girshik S, Jensen MA, Kahn A, Kothiyal P, Nicholls MC, Pihl TD, Pot DA, Raman R, Sanbhadti RN, Snyder EE, Srinivasan D, Walton J, Wan Y, Wang Z, Issa JP, Le Beau M, Carroll M, Kantarjian H, Kornblau S, Bootwalla MS, Lai PH, Shen H, Van Den Berg DJ, Weisenberger DJ, Link DC, Walter MJ, Ozenberger BA, Mardis ER, Westervelt P, Graubert TA, DiPersio JF, Wilson RK
    N Engl J Med 2013 May 30;368(22):2059-74
  • CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance
    Greenbaum A, Hsu YM, Day RB, Schuettpelz LG, Christopher MJ, Borgerding JN, Nagasawa T, Link DC
    Nature 2013 Mar 14;495(7440):227-30
  • Kruppel-like factor 7 overexpression suppresses hematopoietic stem and progenitor cell function
    Schuettpelz LG, Gopalan PK, Giuste FO, Romine MP, van Os R, Link DC
    Blood 2012 Oct 11;120(15):2981-9
  • Clonal architecture of secondary acute myeloid leukemia
    Walter MJ, Shen D, Ding L, Shao J, Koboldt DC, Chen K, Larson DE, McLellan MD, Dooling D, Abbott R, Fulton R, Magrini V, Schmidt H, Kalicki-Veizer J, O'Laughlin M, Fan X, Grillot M, Witowski S, Heath S, Frater JL, Eades W, Tomasson M, Westervelt P, DiPersio JF, Link DC, Mardis ER, Ley TJ, Wilson RK, Graubert TA
    N Engl J Med 2012 Mar 22;366(12):1090-8
  • The origin and evolution of mutations in acute myeloid leukemia
    Welch JS, Ley TJ, Link DC, Miller CA, Larson DE, Koboldt DC, Wartman LD, Lamprecht TL, Liu F, Xia J, Kandoth C, Fulton RS, McLellan MD, Dooling DJ, Wallis JW, Chen K, Harris CC, Schmidt HK, Kalicki-Veizer JM, Lu C, Zhang Q, Lin L, O'Laughlin MD, McMichael JF, Delehaunty KD, Fulton LA, Magrini VJ, McGrath SD, Demeter RT, Vickery TL, Hundal J, Cook LL, Swift GW, Reed JP, Alldredge PA, Wylie TN, Walker JR, Watson MA, Heath SE, Shannon WD, Varghese N, Nagarajan R, Payton JE, Baty JD, Kulkarni S, Klco JM, Tomasson MH, Westervelt P, Walter MJ, Graubert TA, Dipersio JF, Ding L, Mardis ER, Wilson RK
    Cell 2012 Jul 20;150(2):264-78
  • N-cadherin in osteolineage cells is not required for maintenance of hematopoietic stem cells
    Greenbaum AM, Revollo LD, Woloszynek JR, Civitelli R, Link DC
    Blood 2012 Jul 12;120(2):295-302
  • Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing
    Ding L, Ley TJ, Larson DE, Miller CA, Koboldt DC, Welch JS, Ritchey JK, Young MA, Lamprecht T, McLellan MD, McMichael JF, Wallis JW, Lu C, Shen D, Harris CC, Dooling DJ, Fulton RS, Fulton LL, Chen K, Schmidt H, Kalicki-Veizer J, Magrini VJ, Cook L, McGrath SD, Vickery TL, Wendl MC, Heath S, Watson MA, Link DC, Tomasson MH, Shannon WD, Payton JE, Kulkarni S, Westervelt P, Walter MJ, Graubert TA, Mardis ER, Wilson RK, DiPersio JF
    Nature 2012 Jan 11;481(7382):506-10
  • Dual functions of cell-autonomous and non-cell-autonomous ADAM10 activity in granulopoiesis
    Yoda M, Kimura T, Tohmonda T, Uchikawa S, Koba T, Takito J, Morioka H, Matsumoto M, Link DC, Chiba K, Okada Y, Toyama Y, Horiuchi K
    Blood 2011 Dec 22;118(26):6939-42
  • Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes
    Graubert TA, Shen D, Ding L, Okeyo-Owuor T, Lunn CL, Shao J, Krysiak K, Harris CC, Koboldt DC, Larson DE, McLellan MD, Dooling DJ, Abbott RM, Fulton RS, Schmidt H, Kalicki-Veizer J, O'Laughlin M, Grillot M, Baty J, Heath S, Frater JL, Nasim T, Link DC, Tomasson MH, Westervelt P, Dipersio JF, Mardis ER, Ley TJ, Wilson RK, Walter MJ
    Nat Genet 2011 Dec 11;44(1):53-7
  • A truncation mutant of Csf3r cooperates with PML-RARalpha to induce acute myeloid leukemia in mice
    Kunter G, Woloszynek JR, Link DC
    Exp Hematol 2011 Dec;39(12):1136-43
  • Use of whole-genome sequencing to diagnose a cryptic fusion oncogene
    Welch JS, Westervelt P, Ding L, Larson DE, Klco JM, Kulkarni S, Wallis J, Chen K, Payton JE, Fulton RS, Veizer J, Schmidt H, Vickery TL, Heath S, Watson MA, Tomasson MH, Link DC, Graubert TA, Dipersio JF, Mardis ER, Ley TJ, Wilson RK
    JAMA 2011 Apr 20;305(15):1577-1584
  • Identification of a novel TP53 cancer susceptibility mutation through whole-genome sequencing of a patient with therapy-related AML
    Link DC, Schuettpelz LG, Shen D, Wang J, Walter MJ, Kulkarni S, Payton JE, Ivanovich J, Goodfellow PJ, Le Beau M, Koboldt DC, Dooling DJ, Fulton RS, Bender RH, Fulton LL, Delehaunty KD, Fronick CC, Appelbaum EL, Schmidt H, Abbott R, O'Laughlin M, Chen K, McLellan MD, Varghese N, Nagarajan R, Heath S, Graubert TA, Ding L, Ley TJ, Zambetti GP, Wilson RK, Mardis ER
    JAMA 2011 Apr 20;305(15):1568-1576
  • Activation of the unfolded protein response is associated with impaired granulopoiesis in transgenic mice expressing mutant Elane
    Nanua S, Murakami M, Xia J, Grenda DS, Woloszynek J, Strand M, Link DC
    Blood 2011 Mar 31;117(13):3539-47
  • Expression of the G-CSF receptor in monocytic cells is sufficient to mediate hematopoietic progenitor mobilization by G-CSF in mice
    Christopher MJ, Rao M, Liu F, Woloszynek JR, Link DC
    J Exp Med 2011 Feb 14;208(2):251-60
  • DNMT3A mutations in acute myeloid leukemia
    Ley TJ, Ding L, Walter MJ, McLellan MD, Lamprecht T, Larson DE, Kandoth C, Payton JE, Baty J, Welch J, Harris CC, Lichti CF, Townsend RR, Fulton RS, Dooling DJ, Koboldt DC, Schmidt H, Zhang Q, Osborne JR, Lin L, O'Laughlin M, McMichael JF, Delehaunty KD, McGrath SD, Fulton LA, Magrini VJ, Vickery TL, Hundal J, Cook LL, Conyers JJ, Swift GW, Reed JP, Alldredge PA, Wylie T, Walker J, Kalicki J, Watson MA, Heath S, Shannon WD, Varghese N, Nagarajan R, Westervelt P, Tomasson MH, Link DC, Graubert TA, DiPersio JF, Mardis ER, Wilson RK
    N Engl J Med 2010 Dec 16;363(25):2424-33
  • Next-generation sequencing identifies the natural killer cell microRNA transcriptome
    Fehniger TA, Wylie T, Germino E, Leong JW, Magrini VJ, Koul S, Keppel CR, Schneider SE, Koboldt DC, Sullivan RP, Heinz ME, Crosby SD, Nagarajan R, Ramsingh G, Link DC, Ley TJ, Mardis ER
    Genome Res 2010 Nov;20(11):1590-604
  • Complete characterization of the microRNAome in a patient with acute myeloid leukemia
    Ramsingh G, Koboldt DC, Trissal M, Chiappinelli KB, Wylie T, Koul S, Chang LW, Nagarajan R, Fehniger TA, Goodfellow P, Magrini V, Wilson RK, Ding L, Ley TJ, Mardis ER, Link DC
    Blood 2010 Dec 9;116(24):5316-5326
  • shRNA-mediated decreases in c-Met levels affect the differentiation potential of human mesenchymal stem cells and reduce their capacity for tissue repair
    Rosova I, Link D, Nolta JA
    Tissue Eng Part A 2010 Aug;16(8):2627-39
  • CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow
    Eash KJ, Greenbaum AM, Gopalan PK, Link DC
    J Clin Invest 2010 Jul 1;120(7):2423-31
  • Systemic levels of G-CSF and interleukin-6 determine the angiogenic potential of bone marrow resident monocytes
    Gregory AD, Capoccia BJ, Woloszynek JR, Link DC
    J Leukoc Biol 2010 Jul;88(1):123-31
  • Stable long-term risk of leukaemia in patients with severe congenital neutropenia maintained on G-CSF therapy
    Rosenberg PS, Zeidler C, Bolyard AA, Alter BP, Bonilla MA, Boxer LA, Dror Y, Kinsey S, Link DC, Newburger PE, Shimamura A, Welte K, Dale DC
    Br J Haematol 2010 Jul 1;150(2):196-9
  • Prevalence of mutations in ELANE, GFI1, HAX1, SBDS, WAS and G6PC3 in patients with severe congenital neutropenia
    Xia J, Bolyard AA, Rodger E, Stein S, Aprikyan AA, Dale DC, Link DC
    Br J Haematol 2009 Nov;147(4):535-42
  • Contribution of granulocyte colony-stimulating factor to the acute mobilization of endothelial precursor cells by vascular disrupting agents
    Shaked Y, Tang T, Woloszynek J, Daenen LG, Man S, Xu P, Cai SR, Arbeit JM, Voest EE, Chaplin DJ, Smythe J, Harris A, Nathan P, Judson I, Rustin G, Bertolini F, Link DC, Kerbel RS
    Cancer Res 2009 Oct 1;69(19):7524-8
  • Recurring mutations found by sequencing an acute myeloid leukemia genome
    Mardis ER, Ding L, Dooling DJ, Larson DE, McLellan MD, Chen K, Koboldt DC, Fulton RS, Delehaunty KD, McGrath SD, Fulton LA, Locke DP, Magrini VJ, Abbott RM, Vickery TL, Reed JS, Robinson JS, Wylie T, Smith SM, Carmichael L, Eldred JM, Harris CC, Walker J, Peck JB, Du F, Dukes AF, Sanderson GE, Brummett AM, Clark E, McMichael JF, Meyer RJ, Schindler JK, Pohl CS, Wallis JW, Shi X, Lin L, Schmidt H, Tang Y, Haipek C, Wiechert ME, Ivy JV, Kalicki J, Elliott G, Ries RE, Payton JE, Westervelt P, Tomasson MH, Watson MA, Baty J, Heath S, Shannon WD, Nagarajan R, Link DC, Walter MJ, Graubert TA, DiPersio JF, Wilson RK, Ley TJ
    N Engl J Med 2009 Sep 10;361(11):1058-66
  • Acquired copy number alterations in adult acute myeloid leukemia genomes
    Walter MJ, Payton JE, Ries RE, Shannon WD, Deshmukh H, Zhao Y, Baty J, Heath S, Westervelt P, Watson MA, Tomasson MH, Nagarajan R, O'Gara BP, Bloomfield CD, Mrozek K, Selzer RR, Richmond TA, Kitzman J, Geoghegan J, Eis PS, Maupin R, Fulton RS, McLellan M, Wilson RK, Mardis ER, Link DC, Graubert TA, DiPersio JF, Ley TJ
    Proc Natl Acad Sci U S A 2009 Aug 4;106(31):12950-5
  • High throughput digital quantification of mRNA abundance in primary human acute myeloid leukemia samples
    Payton JE, Grieselhuber NR, Chang LW, Murakami M, Geiss GK, Link DC, Nagarajan R, Watson MA, Ley TJ
    J Clin Invest 2009 Jun;119(6):1714-26
  • Revascularization of ischemic limbs after transplantation of human bone marrow cells with high aldehyde dehydrogenase activity
    Capoccia BJ, Robson DL, Levac KD, Maxwell DJ, Hohm SA, Neelamkavil MJ, Bell GI, Xenocostas A, Link DC, Piwnica-Worms D, Nolta JA, Hess DA
    Blood 2009 May 21;113(21):5340-51
  • Dicer and outcomes in patients with acute myeloid leukemia (AML)
    Martin MG, Payton JE, Link DC
    Leuk Res 2009 Aug;33(8):e127
  • CXCR4 is a key regulator of neutrophil release from the bone marrow under basal and stress granulopoiesis conditions
    Eash KJ, Means JM, White DW, Link DC
    Blood 2009 May 7;113(19):4711-9
  • Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization
    Christopher MJ, Liu F, Hilton MJ, Long F, Link DC
    Blood 2009 Aug 13;114(7):1331-9
  • Hypoxic preconditioning results in increased motility and improved therapeutic potential of human mesenchymal stem cells
    Rosova I, Dao M, Capoccia B, Link D, Nolta JA
    Stem Cells 2008 Aug;26(8):2173-82
  • DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome
    Ley TJ, Mardis ER, Ding L, Fulton B, McLellan MD, Chen K, Dooling D, Dunford-Shore BH, McGrath S, Hickenbotham M, Cook L, Abbott R, Larson DE, Koboldt DC, Pohl C, Smith S, Hawkins A, Abbott S, Locke D, Hillier LW, Miner T, Fulton L, Magrini V, Wylie T, Glasscock J, Conyers J, Sander N, Shi X, Osborne JR, Minx P, Gordon D, Chinwalla A, Zhao Y, Ries RE, Payton JE, Westervelt P, Tomasson MH, Watson M, Baty J, Ivanovich J, Heath S, Shannon WD, Nagarajan R, Walter MJ, Link DC, Graubert TA, DiPersio JF, Wilson RK
    Nature 2008 Nov 6;456(7218):66-72
  • Recruitment of the inflammatory subset of monocytes to sites of ischemia induces angiogenesis in a monocyte chemoattractant protein-1-dependent fashion
    Capoccia BJ, Gregory AD, Link DC
    J Leukoc Biol 2008 Sep;84(3):760-8
  • Granulocyte colony-stimulating factor induces osteoblast apoptosis and inhibits osteoblast differentiation
    Christopher MJ, Link DC
    J Bone Miner Res 2008 Nov;23(11):1765-74
  • Divergent pathways in COS-7 cells mediate defective internalization and intracellular routing of truncated G-CSFR forms in SCN/AML
    Hunter MG, McLemore M, Link DC, Loveland M, Copelan A, Avalos BR
    PLoS ONE 2008 Jun 18;3(6):e2452
  • Rapid mobilization of functional donor hematopoietic cells without G-CSF using plerixafor, an antagonist of the CXCR4/SDF-1 interaction
    Devine SM, Vij R, Rettig M, Todt L, McGlauchlen K, Fisher N, Devine H, Link DC, Calandra G, Bridger G, Westervelt P, Dipersio JF
    Blood 2008 Aug 15;112(4):990-8
  • Identification of somatic JAK1 mutations in patients with acute myeloid leukemia
    Xiang Z, Zhao Y, Mitaksov V, Fremont DH, Kasai Y, Molitoris A, Ries RE, Miner TL, McLellan MD, Dipersio JF, Link DC, Payton JE, Graubert TA, Watson M, Shannon W, Heath SE, Naggarajan R, Mardis ER, Wilson RK, Ley TJ, Tomasson MH
    Blood 2008 May 1;111(9):4809-12
  • Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia
    Tomasson MH, Xiang Z, Walgren R, Zhao Y, Kasai Y, Miner T, Ries RE, Lubman O, Fremont D, McLellan MD, Payton JE, Westervelt P, Dipersio JF, Link DC, Walter MJ, Graubert TA, Watson M, Baty J, Heath S, Shannon WD, Nagarajan R, Bloomfield CD, Mardis ER, Wilson RK, Ley TJ
    Blood 2008 May 1;111(9):4797-808
  • Csf3r mutations in mice confer a strong clonal HSC advantage via activation of Stat5
    Liu F, Kunter G, Krem MM, Eades WC, Cain JA, Tomasson MH, Hennighausen L, Link DC
    J Clin Invest 2008 Mar;118(3):946-55
  • Neutrophil elastase mutations and risk of leukaemia in severe congenital neutropenia
    Rosenberg PS, Alter BP, Link DC, Stein S, Rodger E, Bolyard AA, Aprikyan AA, Bonilla MA, Dror Y, Kannourakis G, Newburger PE, Boxer LA, Dale DC
    Br J Haematol 2008 Jan;140(2):210-3
  • Mutations of the ELA2 gene found in patients with severe congenital neutropenia induce the unfolded protein response and cellular apoptosis
    Grenda DS, Murakami M, Ghatak J, Xia J, Boxer LA, Dale D, Dinauer MC, Link DC
    Blood 2007 Dec 15;110(13):4179-87
  • Lentiviral-mediated RNAi inhibition of Sbds in murine hematopoietic progenitors impairs their hematopoietic potential
    Rawls AS, Gregory AD, Woloszynek JR, Liu F, Link DC
    Blood 2007 Oct 1;110(7):2414-22
  • Distinct patterns of mutations occurring in de novo AML versus AML arising in the setting of severe congenital neutropenia
    Link DC, Kunter G, Kasai Y, Zhao Y, Miner T, McLellan MD, Ries RE, Kapur D, Nagarajan R, Dale DC, Bolyard AA, Boxer LA, Welte K, Zeidler C, Donadieu J, Bellanne-Chantelot C, Vardiman JW, Caligiuri MA, Bloomfield CD, DiPersio JF, Tomasson MH, Graubert TA, Westervelt P, Watson M, Shannon W, Baty J, Mardis ER, Wilson RK, Ley TJ
    Blood 2007 Sep 1;110(5):1648-55
  • Regulation of lipopolysaccharide-induced increases in neutrophil glucose uptake
    Schuster DP, Brody SL, Zhou Z, Bernstein M, Arch R, Link D, Mueckler M
    Am J Physiol Lung Cell Mol Physiol 2007 Apr;292(4):L845-51
  • Regulation of systemic and local neutrophil responses by G-CSF during pulmonary Pseudomonas aeruginosa infection
    Gregory AD, Hogue LA, Ferkol TW, Link DC
    Blood 2007 Apr 15;109(8):3235-43
  • Commonly dysregulated genes in murine APL cells
    Yuan W, Payton JE, Holt MS, Link DC, Watson MA, DiPersio JF, Ley TJ
    Blood 2007 Feb 1;109(3):961-70
  • STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils
    Panopoulos AD, Zhang L, Snow JW, Jones DM, Smith AM, El Kasmi KC, Liu F, Goldsmith MA, Link DC, Murray PJ, Watowich SS
    Blood 2006 Dec 1;108(12):3682-90
  • Angiogenic cells can be rapidly mobilized and efficiently harvested from the blood following treatment with AMD3100
    Shepherd RM, Capoccia BJ, Devine SM, Dipersio J, Trinkaus KM, Ingram D, Link DC
    Blood 2006 Dec 1;108(12):3662-7
  • G-CSF and AMD3100 mobilize monocytes into the blood that stimulate angiogenesis in vivo through a paracrine mechanism
    Capoccia BJ, Shepherd RM, Link DC
    Blood 2006 Oct 1;108(7):2438-45
  • Src family kinases are important negative regulators of G-CSF-dependent granulopoiesis
    Mermel CH, McLemore ML, Liu F, Pereira S, Woloszynek J, Lowell CA, Link DC
    Blood 2006 Oct 15;108(8):2562-8
  • The number of endothelial progenitor cell colonies in the blood is increased in patients with angiographically significant coronary artery disease
    Guven H, Shepherd RM, Bach RG, Capoccia BJ, Link DC
    J Am Coll Cardiol 2006 Oct 17;48(8):1579-87
  • p120 nucleolar-proliferating antigen is a direct target of G-CSF signaling during myeloid differentiation
    Khanna-Gupta A, Sun H, Zibello T, Lozovatsky L, Ghosh PK, Link DC, McLemore ML, Berliner N
    J Leukoc Biol 2006 May;79(5):1011-21
  • Activation of Tyk2 and Stat3 is required for the apoptotic actions of interferon-beta in primary pro-B cells
    Gamero AM, Potla R, Wegrzyn J, Szelag M, Edling AE, Shimoda K, Link DC, Dulak J, Baker DP, Tanabe Y, Grayson JM, Larner AC
    J Biol Chem 2006 Jun 16;281(24):16238-44
  • G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow
    Semerad CL, Christopher MJ, Liu F, Short B, Simmons PJ, Winkler I, Levesque JP, Chappel J, Ross FP, Link DC
    Blood 2005 Nov 1;106(9):3020-7
  • Mutations of the SBDS gene are present in most patients with Shwachman-Diamond syndrome
    Woloszynek JR, Rothbaum RJ, Rawls AS, Minx PJ, Wilson RK, Mason PJ, Bessler M, Link DC
    Blood 2004 Dec 1;104(12):3588-90
  • G-CSF induced progenitor mobilization in mice with PIGA- blood cells
    Han B, Unsinger J, Liu F, Link DC, Bessler M
    Hematol J 2004;5(4):347-52
  • Characterization of hematopoietic progenitor mobilization in protease-deficient mice
    Levesque JP, Liu F, Simmons PJ, Betsuyaku T, Senior RM, Pham C, Link DC
    Blood 2004 Jul 1;104(1):65-72
  • Ischemia-reperfusion induces G-CSF gene expression by renal medullary thick ascending limb cells in vivo and in vitro
    Zhang Y, Woodward VK, Shelton JM, Richardson JA, Zhou XJ, Link D, Kielar ML, Jeyarajah DR, Lu CY
    Am J Physiol Renal Physiol 2004 Jun;286(6):F1193-201
  • A pilot study of high-throughput, sequence-based mutational profiling of primary human acute myeloid leukemia cell genomes
    Ley TJ, Minx PJ, Walter MJ, Ries RE, Sun H, McLellan M, DiPersio JF, Link DC, Tomasson MH, Graubert TA, McLeod H, Khoury H, Watson M, Shannon W, Trinkaus K, Heath S, Vardiman JW, Caligiuri MA, Bloomfield CD, Milbrandt JD, Mardis ER, Wilson RK
    Proc Natl Acad Sci U S A 2003 Nov 25;100(24):14275-80
  • A mouse-based strategy for cyclophosphamide pharmacogenomic discovery
    Watters JW, Kloss EF, Link DC, Graubert TA, McLeod HL
    J Appl Physiol 2003 Oct;95(4):1352-60
  • Pivotal role of granulocyte colony-stimulating factor in the development of progenitors in the common myeloid pathway
    Richards MK, Liu F, Iwasaki H, Akashi K, Link DC
    Blood 2003 Nov 15;102(10):3562-8
  • G-CSF is an essential regulator of neutrophil trafficking from the bone marrow to the blood
    Semerad CL, Liu F, Gregory AD, Stumpf K, Link DC
    Immunity 2002 Oct;17(4):413-23
  • Mice expressing a neutrophil elastase mutation derived from patients with severe congenital neutropenia have normal granulopoiesis
    Grenda DS, Johnson SE, Mayer JR, McLemore ML, Benson KF, Horwitz M, Link DC
    Blood 2002 Nov 1;100(9):3221-8
  • STAT-3 activation is required for normal G-CSF-dependent proliferation and granulocytic differentiation
    McLemore ML, Grewal S, Liu F, Archambault A, Poursine-Laurent J, Haug J, Link DC
    Immunity 2001 Feb;14(2):193-204
  • Expression of the G-CSF receptor on hematopoietic progenitor cells is not required for their mobilization by G-CSF
    Liu F, Poursine-Laurent J, Link DC
    Blood 2000 May 15;95(10):3025-31
  • A role for G-CSF receptor signaling in the regulation of hematopoietic cell function but not lineage commitment or differentiation
    Semerad CL, Poursine-Laurent J, Liu F, Link DC
    Immunity 1999 Aug;11(2):153-61
  • A functional granulocyte colony-stimulating factor receptor is required for normal chemoattractant-induced neutrophil activation
    Betsuyaku T, Liu F, Senior RM, Haug JS, Brown EJ, Jones SL, Matsushima K, Link DC
    J Clin Invest 1999 Mar;103(6):825-32
  • Upregulation of interleukin 6 and granulocyte colony-stimulating factor receptors by transcription factor CCAAT enhancer binding protein alpha (C/EBP alpha) is critical for granulopoiesis
    Zhang P, Iwama A, Datta MW, Darlington GJ, Link DC, Tenen DG
    J Exp Med 1998 Sep 21;188(6):1173-84
  • Increased granulocyte colony-stimulating factor responsiveness but normal resting granulopoiesis in mice carrying a targeted granulocyte colony-stimulating factor receptor mutation derived from a patient with severe congenital neutropenia
    McLemore ML, Poursine-Laurent J, Link DC
    J Clin Invest 1998 Aug 1;102(3):483-92
  • Specific signals generated by the cytoplasmic domain of the granulocyte colony-stimulating factor (G-CSF) receptor are not required for G-CSF- dependent granulocytic differentiation
    Jacob J, Haug JS, Raptis S, Link DC
    Blood 1998 Jul 15;92(2):353-61
  • Interleukin-6 and the granulocyte colony-stimulating factor receptor are major independent regulators of granulopoiesis in vivo but are not required for lineage commitment or terminal differentiation
    Liu F, Poursine-Laurent J, Wu HY, Link DC
    Blood 1997 Oct 1;90(7):2583-90
  • The granulocyte colony-stimulating factor receptor is required for the mobilization of murine hematopoietic progenitors into peripheral blood by cyclophosphamide or interleukin-8 but not flt-3 ligand
    Liu F, Poursine-Laurent J, Link DC
    Blood 1997 Oct 1;90(7):2522-8
  • Impaired production and increased apoptosis of neutrophils in granulocyte colony-stimulating factor receptor-deficient mice
    Liu F, Wu HY, Wesselschmidt R, Kornaga T, Link DC
    Immunity 1996 Nov;5(5):491-501
  • Suppression of apoptosis during cytokine deprivation of 32D cells is not sufficient to induce complete granulocytic differentiation
    Rodel JE, Link DC
    Blood 1996 Feb 1;87(3):858-64
  • Distinct tyrosine kinase activation and Triton X-100 insolubility upon Fc gamma RII or Fc gamma RIIIB ligation in human polymorphonuclear leukocytes. Implications for immune complex activation of the respiratory burst
    Zhou MJ, Lublin DM, Link DC, Brown EJ
    J Biol Chem 1995 Jun 2;270(22):13553-60
  • The proto-oncogene c-fgr is expressed in normal mantle zone B lymphocytes and is developmentally regulated during myelomonocytic differentiation in vivo
    Link DC, Zutter M
    Blood 1995 Jan 15;85(2):472-9
  • Cysteine3 of Src family protein tyrosine kinase determines palmitoylation and localization in caveolae
    Shenoy-Scaria AM, Dietzen DJ, Kwong J, Link DC, Lublin DM
    J Cell Biol 1994 Jul;126(2):353-63
  • Characterization of the 5' untranslated region of the human c-fgr gene and identification of the major myelomonocytic c-fgr promoter
    Link DC, Gutkind SJ, Robbins KC, Ley TJ
    Oncogene 1992 May;7(5):877-84
  • 1,25-Dihydroxyvitamin D3 induces monocytic differentiation of the PLB- 985 leukemic line and promotes c-fgr mRNA expression
    Perkins SL, Link DC, Kling S, Ley TJ, Teitelbaum SL
    J Leukoc Biol 1991 Nov;50(5):427-33
  • A novel c-fgr exon utilized in Epstein-Barr virus-infected B lymphocytes but not in normal monocytes
    Gutkind JS, Link DC, Katamine S, Lacal P, Miki T, Ley TJ, Robbins KC
    Mol Cell Biol 1991 Mar;11(3):1500-7
  • Secondary alpha-deuterium isotope effects on reactions of the grignard reagent from 1-bromopentane-1, 1-d2
    Link DC, Hill EA
    Organometallics 1982;1:1510-150
  • Gem-dimethyl effect in a grignard reagent cyclization-cleavage rearrangement
    Link DC, Donndelinger P, Hill EA
    J Org Chem 1981;46:1177-1182