Faculty
Greg Longmore.jpg

Gregory D. Longmore, MD

Professor
Department of Medicine
Oncology Division
Molecular Oncology
Department of Cell Biology & Physiology

Research Interests

  • Epithelia morphogenesis
  • Cancer metastasis

Contact

  • 314-362-8834 (tel)
  • Room 7627 BJC Institute of Health (office)
    Room 7311 BJC Institute of Health (lab)
  • Washington University Medical School
    BJCIH 7th floor ICCE Institute
    Campus Box 8069
    660 South Euclid Avenue
    St. Louis, MO 63110
  • Greg Longmore Lab

Research

People rarely die from their primary tumor, rather it is the spread of their tumor to other organs (metastasis) that leads to death, and when that occurs there is a general lack of treatment options. Crosstalk between tumor cells and their associated cellular, physical, and chemical environment is now appreciated to be critical for tumor progression, metastasis, and response to therapy, yet the cellular and molecular basis for these tumor-environment communications is complex and not fully understood. Our lab is interested in understanding how cancers invade and spread throughout the body with the goal to identify and understand molecular pathways important for metastasis and then develop effective and selective ways to prevent the spread of cancer by targeting these pathways. To address this problem we employ aspects of biochemistry, cell biology, developmental biology, biophysics, genetics, and cell and in vivo imaging.

For details of current projects, see the Longmore Lab webpage.