Faculty
Mike Naughton.jpg

Michael J. Naughton, MD

Assistant Professor
Department of Medicine
Oncology Division
Medical Oncology

Contact

  • 314-996-8270 (tel)
  • 314-362-7086 (fax)
  • Washington University School of Medicine
    Siteman Cancer Center
    10 Barnes West Drive, Suite 203
    St. Louis, MO 63141

Publications

  • A Phase II Trial of Neoadjuvant MK2206, an AKT Inhibitor, With Anastrozole in Clinical Stage 2 or 3 PIK3CA Mutant ER Positive and HER2 Negative Breast Cancer
    Ma CX, Suman V, Goetz MP, Northfelt DW, Burkard ME, Ademuyiwa F, Naughton MJ, Margenthaler J, Aft R, Gray RJ, Tevaarwerk AJ, Wilke LG, Haddad TC, Moynihan T, Loprenzi C, Hieken T, Barnell EK, Skidmore ZL, Feng YY, Krysiak K, Hoog J, Guo Z, Nehring L, Wisinski KB, Mardis ER, Hagemann IS, Vij K, Sanati S, Al-Kateb H, Griffith OL, Griffith M, Doyle A, Erlichman C, Ellis MJ
    Clin Cancer Res 2017 Sep 5; [Epub ahead of print]
  • NeoPalAna: Neoadjuvant Palbociclib, a Cyclin-Dependent Kinase 4/6 Inhibitor, and Anastrozole for Clinical Stage 2 or 3 Estrogen Receptor-Positive Breast Cancer
    Ma CX, Gao F, Luo J, Northfelt DW, Goetz M, Forero A, Hoog J, Naughton M, Ademuyiwa F, Suresh R, Anderson KS, Margenthaler J, Aft R, Hobday T, Moynihan T, Gillanders W, Cyr A, Eberlein TJ, Hieken T, Krontiras H, Guo Z, Lee MV, Spies NC, Skidmore ZL, Griffith OL, Griffith M, Thomas S, Bumb C, Vij K, Bartlett CH, Koehler M, Al-Kateb H, Sanati S, Ellis MJ
    Clin Cancer Res 2017 Aug 1;23(15):4055-4065
  • Randomized Phase II Trial of Fulvestrant Alone or in Combination With Bortezomib in Hormone Receptor-Positive Metastatic Breast Cancer Resistant to Aromatase Inhibitors: A New York Cancer Consortium Trial
    Adelson K, Ramaswamy B, Sparano JA, Christos PJ, Wright JJ, Raptis G, Han G, Villalona-Calero M, Ma CX, Hershman D, Baar J, Klein P, Cigler T, Budd GT, Novik Y, Tan AR, Tannenbaum S, Goel A, Levine E, Shapiro CL, Andreopoulou E, Naughton M, Kalinsky K, Waxman S, Germain D
    NPJ Breast Cancer 2016 Dec 14;2:16037
  • Neratinib Efficacy and Circulating Tumor DNA Detection of HER2 Mutations in HER2 Non-Amplified Metastatic Breast Cancer
    Ma CX, Bose R, Gao F, Freedman RA, Telli ML, Kimmick G, Winer EP, Naughton MJ, Goetz MP, Russell C, Tripathy D, Cobleigh M, Forero A, Pluard TJ, Anders CK, Niravath P, Thomas S, Anderson J, Bumb C, Banks KC, Lanman RB, Bryce R, Lalani AS, Pfeifer JD, Hayes DF, Pegram MD, Blackwell K, Bedard PL, Al-Kateb H, Ellis MJ
    Clin Cancer Res 2017 Jul 5; [Epub ahead of print]
  • Impact of a Behavioral Weight Loss Intervention on Comorbidities in Overweight and Obese Breast Cancer Survivors
    Sedjo RL, Flatt SW, Byers T, Colditz GA, Demark-Wahnefried W, Ganz PA, Wolin KY, Elias A, Krontiras H, Liu J, Naughton M, Pakiz B, Parker BA, Wyatt H, Rock CL
    Support Care Cancer 2016 Aug;24(8):3285-93
  • Impact of Neoadjuvant and Adjuvant Chemotherapy on Immediate Tissue Expander Breast Reconstruction
    Dolen UC, Schmidt AC, Um GT, Sharma K, Naughton M, Zoberi I, Margenthaler JM, Myckatyn TM
    Ann Surg Oncol 2016 Jul;23(7):2357-66
  • A Phase I Study of the AKT Inhibitor MK-2206 in Combination With Hormonal Therapy in Postmenopausal Women With Estrogen Receptor-Positive Metastatic Breast Cancer
    Ma CX, Sanchez C, Gao F, Crowder R, Naughton M, Pluard T, Creekmore A, Guo Z, Hoog J, Lockhart AC, Doyle A, Erlichman C, Ellis MJ
    Clin Cancer Res 2016 Jun 1;22(11):2650-8
  • A Phase I Trial of BKM120 (Buparlisib) in Combination With Fulvestrant in Postmenopausal Women With Estrogen Receptor-Positive Metastatic Breast Cancer
    Ma CX, Luo J, Naughton M, Ademuyiwa F, Suresh R, Griffith M, Griffith OL, Skidmore ZL, Spies NC, Ramu A, Trani L, Pluard T, Nagaraj G, Thomas S, Guo Z, Hoog J, Han J, Mardis E, Lockhart AC, Ellis MJ
    Clin Cancer Res 2016 Apr 1;22(7):1583-91
  • Lymphovascular Space Invasion and Lack of Downstaging After Neoadjuvant Chemotherapy Are Strong Predictors of Adverse Outcome in Young Women With Locally Advanced Breast Cancer
    Khwaja SS, Ivanovich J, DeWees TA, Ochoa L, Mullen DF, Thomas M, Margenthaler JA, Cyr A, Naughton M, Sanati S, Eberlein TJ, Gillanders WE, Aft RL, Zoberi JE, Zoberi I
    Cancer Med 2016 Feb;5(2):230-8
  • Quality of Life Outcomes From the Exercise and Nutrition Enhance Recovery and Good Health for You (ENERGY)-Randomized Weight Loss Trial Among Breast Cancer Survivors
    Demark-Wahnefried W, Colditz GA, Rock CL, Sedjo RL, Liu J, Wolin KY, Krontiras H, Byers T, Pakiz B, Parker BA, Naughton M, Elias A, Ganz PA
    ENERGY Trial Group

    Breast Cancer Res Treat 2015 Nov;154(2):329-337
  • Results of the Exercise and Nutrition to Enhance Recovery and Good Health for You (ENERGY) Trial: A Behavioral Weight Loss Intervention in Overweight or Obese Breast Cancer Survivors
    Rock CL, Flatt SW, Byers TE, Colditz GA, Demark-Wahnefried W, Ganz PA, Wolin KY, Elias A, Krontiras H, Liu J, Naughton M, Pakiz B, Parker BA, Sedjo RL, Wyatt H
    J Clin Oncol 2015 Oct 1;33(28):3169-76
  • Effect of Weight Loss on Bone Health in Overweight/Obese Postmenopausal Breast Cancer Survivors
    Toriola AT, Liu J, Ganz PA, Colditz GA, Yang L, Izadi S, Naughton MJ, Schwartz AL, Wolin KY
    Breast Cancer Res Treat 2015 Aug;152(3):637-43
  • Randomized Phase III Trial of Paclitaxel Once per Week Compared With Nanoparticle Albumin-Bound Nab-Paclitaxel Once per Week or Ixabepilone With Bevacizumab as First-Line Chemotherapy for Locally Recurrent or Metastatic Breast Cancer: CALGB 40502/NCCTG N063H (Alliance)
    Rugo HS, Barry WT, Moreno-Aspitia A, Lyss AP, Cirrincione C, Leung E, Mayer EL, Naughton M, Toppmeyer D, Carey LA, Perez EA, Hudis C, Winer EP
    J Clin Oncol 2015 Jul 20;33(21):2361-2369
  • Randomized Trial of Oral Cyclophosphamide and Veliparib in High-Grade Serous Ovarian, Primary Peritoneal, or Fallopian Tube Cancers, or BRCA-Mutant Ovarian Cancer
    Kummar S, Oza AM, Fleming GF, Sullivan DM, Gandara DR, Naughton MJ, Villalona-Calero MA, Morgan RJ Jr, Szabo PM, Youn A, Chen AP, Ji J, Allen DE, Lih CJ, Mehaffey MG, Walsh WD, McGregor PM 3rd, Steinberg SM, Williams PM, Kinders RJ, Conley BA, Simon RM, Doroshow JH
    Clin Cancer Res 2015 Apr 1;21(7):1574-1582
  • Adjuvant Ovarian Suppression in Premenopausal Breast Cancer
    Francis PA, Regan MM, Fleming GF, Lang I, Ciruelos E, Bellet M, Bonnefoi HR, Climent MA, Da Prada GA, Burstein HJ, Martino S, Davidson NE, Geyer CE Jr, Walley BA, Coleman R, Kerbrat P, Buchholz S, Ingle JN, Winer EP, Rabaglio-Poretti M, Maibach R, Ruepp B, Giobbie-Hurder A, Price KN, Colleoni M, Viale G, Coates AS, Goldhirsch A, Gelber RD
    International Breast Cancer Study Group (Contributors include: Naughton MJ)

    N Engl J Med 2015 Jan 29;372(5):436-46
  • Safety and Preliminary Evidence of Biologic Efficacy of a Mammaglobin-A DNA Vaccine in Patients With Stable Metastatic Breast Cancer
    Tiriveedhi V, Tucker N, Herndon J, Li L, Sturmoski M, Ellis M, Ma C, Naughton M, Lockhart AC, Gao F, Fleming T, Goedegebuure P, Mohanakumar T, Gillanders WE
    Clin Cancer Res 2014 Dec 1;20(23):5964-75
  • A Phase I Study of Pegylated Liposomal Doxorubicin and Temsirolimus in Patients With Refractory Solid Malignancies
    Wang-Gillam A, Thakkar N, Lockhart AC, Williams K, Baggstrom M, Naughton M, Suresh R, Ma C, Tan B, Lee W, Jiang X, Mwandoro T, Trull L, Belanger S, Creekmore AN, Gao F, Fracasso PM, Picus J
    Cancer Chemother Pharmacol 2014 Aug;74(2):419-26
  • Adjuvant Exemestane With Ovarian Suppression in Premenopausal Breast Cancer
    Pagani O, Regan MM, Walley BA, Fleming GF, Colleoni M, Lang I, Gomez HL, Tondini C, Burstein HJ, Perez EA, Ciruelos E, Stearns V, Bonnefoi HR, Martino S, Geyer CE Jr, Pinotti G, Puglisi F, Crivellari D, Ruhstaller T, Winer EP, Rabaglio-Poretti M, Maibach R, Ruepp B, Giobbie-Hurder A, Price KN, Bernhard J, Luo W, Ribi K, Viale G, Coates AS, Gelber RD, Goldhirsch A, Francis PA
    (Contributors include: Naughton MJ)

    N Engl J Med 2014 Jul 10;371(2):107-18
  • Five Fractions of Radiation Therapy Followed by 4 Cycles of FOLFOX Chemotherapy as Preoperative Treatment for Rectal Cancer
    Myerson RJ, Tan B, Hunt S, Olsen J, Birnbaum E, Fleshman J, Gao F, Hall L, Kodner I, Lockhart AC, Mutch M, Naughton M, Picus J, Rigden C, Safar B, Sorscher S, Suresh R, Wang-Gillam A, Parikh P
    Int J Radiat Oncol Biol Phys 2014 Mar 15;88(4):829-36
  • A Prospective Longitudinal Clinical Trial Evaluating Quality of Life After Breast-Conserving Surgery and High-Dose-Rate Interstitial Brachytherapy for Early-Stage Breast Cancer
    Garsa AA, Ferraro DJ, DeWees TA, Deshields TL, Margenthaler JA, Cyr AE, Naughton M, Aft R, Gillanders WE, Eberlein T, Matesa MA, Ochoa LL, Zoberi I
    Int J Radiat Oncol Biol Phys 2013 Dec 1;87(5):1043-50
  • A Randomized Phase II Trial Investigating the Effect of Platelet Function Inhibition on Circulating Tumor Cells in Patients With Metastatic Breast Cancer
    Roop RP, Naughton MJ, Van Poznak C, Schneider JG, Lammers PE, Pluard TJ, Johnson F, Eby CS, Weilbaecher KN
    Clin Breast Cancer 2013 Dec;13(6):409-15
  • Endocrine-Therapy-Resistant ESR1 Variants Revealed by Genomic Characterization of Breast-Cancer-Derived Xenografts
    Li S, Shen D, Shao J, Crowder R, Liu W, Prat A, He X, Liu S, Hoog J, Lu C, Ding L, Griffith OL, Miller C, Larson D, Fulton RS, Harrison M, Mooney T, McMichael JF, Luo J, Tao Y, Goncalves R, Schlosberg C, Hiken JF, Saied L, Sanchez C, Giuntoli T, Bumb C, Cooper C, Kitchens RT, Lin A, Phommaly C, Davies SR, Zhang J, Kavuri MS, McEachern D, Dong YY, Ma C, Pluard T, Naughton M, Bose R, Suresh R, McDowell R, Michel L, Aft R, Gillanders W, DeSchryver K, Wilson RK, Wang S, Mills GB, Gonzalez-Angulo A, Edwards JR, Maher C, Perou CM, Mardis ER, Ellis MJ
    Cell Rep 2013 Sep 26;4(6):1116-30
  • Analysis of Fat Necrosis After Adjuvant High-Dose-Rate Interstitial Brachytherapy for Early Stage Breast Cancer
    Garsa AA, Ferraro DJ, Dewees T, Margenthaler JA, Naughton M, Aft R, Gillanders WE, Eberlein T, Matesa MA, Zoberi I
    Brachytherapy 2013 Mar-Apr;12(2):99-106
  • Cosmetic Analysis Following Breast-Conserving Surgery and Adjuvant High-Dose-Rate Interstitial Brachytherapy for Early-Stage Breast Cancer: A Prospective Clinical Study
    Garsa AA, Ferraro DJ, Dewees T, Margenthaler JA, Naughton M, Aft R, Gillanders WE, Eberlein T, Matesa MA, Zoberi I
    Int J Radiat Oncol Biol Phys 2013 Mar 15;85(4):965-70
  • Reducing Breast Cancer Recurrence With Weight Loss, a Vanguard Trial: The Exercise and Nutrition to Enhance Recovery and Good Health for You (ENERGY) Trial
    Rock CL, Byers TE, Colditz GA, Demark-Wahnefried W, Ganz PA, Wolin KY, Elias A, Krontiras H, Liu J, Naughton M, Pakiz B, Parker BA, Sedjo RL, Wyatt H
    Contemp Clin Trials 2013 Mar;34(2):282-95
  • Mammaglobin-A cDNA Vaccination of Breast Cancer Patients Induces Antigen-Specific Cytotoxic CD4+ICOS(Hi) T Cells
    Tiriveedhi V, Fleming TP, Goedegebuure PS, Naughton M, Ma C, Lockhart C, Gao F, Gillanders WE, Mohanakumar T
    Breast Cancer Res Treat 2013 Feb;138(1):109-18
  • A Phase II Study of UCN-01 in Combination With Irinotecan in Patients With Metastatic Triple Negative Breast Cancer
    Ma CX, Ellis MJ, Petroni GR, Guo Z, Cai SR, Ryan CE, Lockhart AC, Naughton MJ, Pluard TJ, Brenin CM, Picus J, Creekmore AN, Mwandoro T, Yarde ER, Reed J, Ebbert M, Bernard PS, Watson M, Doyle LA, Dancey J, Piwnica-Worms H, Fracasso PM
    Breast Cancer Res Treat 2013 Jan;137(2):483-92
  • Phase II Trial of Temsirolimus in Patients With Metastatic Breast Cancer
    Fleming GF, Ma CX, Huo D, Sattar H, Tretiakova M, Lin L, Hahn OM, Olopade FO, Nanda R, Hoffman PC, Naughton MJ, Pluard T, Conzen SD, Ellis MJ
    Breast Cancer Res Treat 2012 Nov;136(2):355-63
  • Effect of (Neo)adjuvant Zoledronic Acid on Disease-Free and Overall Survival in Clinical Stage II/III Breast Cancer
    Aft RL, Naughton M, Trinkaus K, Weilbaecher K
    Br J Cancer 2012 Jun 26;107(1):7-11
  • Comparison of Accelerated Partial Breast Irradiation Via Multicatheter Interstitial Brachytherapy Versus Whole Breast Radiation
    Ferraro DJ, Garsa AA, Dewees TA, Margenthaler JA, Naughton M, Aft R, Gillanders WE, Eberlein T, Matesa MA, Zoberi I
    Radiat Oncol 2012 Mar 29;7(1):53
  • A Phase 1 Study of UCN-01 in Combination With Irinotecan in Patients With Resistant Solid Tumor Malignancies
    Fracasso PM, Williams KJ, Chen RC, Picus J, Ma CX, Ellis MJ, Tan BR, Pluard TJ, Adkins DR, Naughton MJ, Rader JS, Arquette MA, Fleshman JW, Creekmore AN, Goodner SA, Wright LP, Guo Z, Ryan CE, Tao Y, Soares EM, Cai SR, Lin L, Dancey J, Rudek MA, McLeod HL, Piwnica-Worms H
    Cancer Chemother Pharmacol 2011 Jun;67(6):1225-37
  • Phase I Study of Everolimus Plus Weekly Paclitaxel and Trastuzumab in Patients With Metastatic Breast Cancer Pretreated With Trastuzumab
    Andre F, Campone M, O'Regan R, Manlius C, Massacesi C, Tarek S, Mukhopadhyay P, Soria JC, Naughton M, Hurvitz SA
    J Clin Oncol 2010 Dec 1;28(34):5110-5
  • A Gene Expression Signature That Predicts the Therapeutic Response of the Basal-Like Breast Cancer to Neoadjuvant Chemotherapy
    Lin Y, Lin S, Watson M, Trinkaus KM, Kuo S, Naughton MJ, Weilbaecher K, Fleming TP, Aft RL
    Breast Cancer Res Treat 2010 Oct;123(3):691-699
  • Breast Cancer Adjuvant Chemotherapy Decisions in Older Women: The Role of Patient Preference and Interactions With Physicians
    Mandelblatt JS, Sheppard VB, Hurria A, Kimmick G, Isaacs C, Taylor KL, Kornblith AB, Noone AM, Luta G, Tallarico M, Barry WT, Hunegs L, Zon R, Naughton M, Winer E, Hudis C, Edge SB, Cohen HJ, Muss H
    J Clin Oncol 2010 Jul 1;28(19):3146-53
  • The Cancer Pain Inventory: Preliminary Development and Validation
    Deshields TL, Tait RC, Manwaring J, Trinkaus KM, Naughton M, Hawkins J, Jeffe DB
    Psychooncology 2010 Jul;19(7):684-92
  • Effect of Zoledronic Acid on Disseminated Tumour Cells in Women With Locally Advanced Breast Cancer: An Open Label, Randomised, Phase 2 Trial
    Aft R, Naughton M, Trinkaus K, Watson M, Ylagan L, Chavez-MacGregor M, Zhai J, Kuo S, Shannon W, Diemer K, Herrmann V, Dietz J, Ali A, Ellis M, Weiss P, Eberlein T, Ma C, Fracasso PM, Zoberi I, Taylor M, Gillanders W, Pluard T, Mortimer J, Weilbaecher K
    Lancet Oncol 2010 May;11(5):421-8
  • Evolution of Capecitabine Dosing in Breast Cancer
    Naughton M
    Clin Breast Cancer 2010 Apr;10(2):130-5
  • A Phase I Study With Neratinib (HKI-272), an Irreversible Pan ErbB Receptor Tyrosine Kinase Inhibitor, in Patients With Solid Tumors
    Wong KK, Fracasso PM, Bukowski RM, Lynch TJ, Munster PN, Shapiro GI, Janne PA, Eder JP, Naughton MJ, Ellis MJ, Jones SF, Mekhail T, Zacharchuk C, Vermette J, Abbas R, Quinn S, Powell C, Burris HA
    Clin Cancer Res 2009 Apr 1;15(7):2552-8
  • PET-Based Estradiol Challenge as a Predictive Biomarker of Response to Endocrine Therapy in Women With Estrogen-Receptor-Positive Breast Cancer
    Dehdashti F, Mortimer JE, Trinkaus K, Naughton MJ, Ellis M, Katzenellenbogen JA, Welch MJ, Siegel BA
    Breast Cancer Res Treat 2009 Feb;113(3):509-17
  • Isolation and Molecular Profiling of Bone Marrow Micrometastases Identifies TWIST1 as a Marker of Early Tumor Relapse in Breast Cancer Patients
    Watson MA, Ylagan LR, Trinkaus KM, Gillanders WE, Naughton MJ, Weilbaecher KN, Fleming TP, Aft RL
    Clin Cancer Res 2007 Sep 1;13(17):5001-9
  • "I'm Pregnant and I Have Breast Cancer"
    Naughton MJ, Ellis M
    BMC Cancer 2007 May 30;7:93
  • Symptom Evaluation in Palliative Medicine: Patient Report Vs Systematic Assessment
    Homsi J, Walsh D, Rivera N, Rybicki LA, Nelson KA, Legrand SB, Davis M, Naughton M, Gvozdjan D, Pham H
    Support Care Cancer 2006 May;14(5):444-53
  • Discussing Do-Not-Resuscitate Status: Furthering the Discourse (Letter)
    Naughton M, Davis M
    J Clin Oncol 2003 May 1;21(9 Suppl):26s; discussion 26s
  • Symptom Assessment in Cancer Patients
    Naughton M, Homsi J
    Curr Oncol Rep 2002 May;4(3):256-63
  • Symptom Control in Cancer Patients: The Clinical Pharmacology and Therapeutic Role of Suppositories and Rectal Suspensions
    Davis MP, Walsh D, LeGrand SB, Naughton M
    Support Care Cancer 2002 Mar;10(2):117-38
  • Morphine in Cancer Pain Management: A Practical Guide
    Donnelly S, Davis MP, Walsh D, Naughton M
    Support Care Cancer 2002 Jan;10(1):13-35
  • Pharmacological Therapy of Advanced Prostate Cancer: A State of the Art Guide
    Naughton M, Picus J
    Am J Cancer 2002;1:13-22
  • Scatter Factor-Hepatocyte Growth Factor Elevation in the Serum of Patients With Prostate Cancer
    Naughton M, Picus J, Zhu X, Catalona WJ, Vollmer RT, Humphrey PA
    J Urol 2001 Apr;165(4):1325-8
  • Tularemia--An Unusual Cause of a Solitary Pulmonary Nodule in the Post-Transplant Setting
    Naughton M, Brown R, Adkins D, DiPersio J
    Bone Marrow Transplant 1999 Jul;24(2):197-9
  • Bone Marrow Staging in Patients With Non-Hodgkin's Lymphoma: Is Flow Cytometry a Useful Test? - Reply
    Naughton MJ, Hess JL, Zutter MM, Bartlett NL
    Cancer 1999 Jan 1;85(1):241-2
  • Bone Marrow Staging in Patients With Non-Hodgkin's Lymphoma: Is Flow Cytometry a Useful Test?
    Naughton MJ, Hess JL, Zutter MM, Bartlett NL
    Cancer 1998 Mar 15;82(6):1154-9