Ben Tan.jpg

Benjamin R. Tan, Jr., MD

Associate Professor
Department of Medicine
Oncology Division
Medical Oncology

Clinical Interests

  • Upper and lower GI oncology


  • 314-362-9115 (tel)
  • 314-362-7086 (fax)
  • 11th Floor Mid-Campus Center (office)
  • Division of Oncology
    Campus Box 8056
    Washington University Medical School
    660 South Euclid Avenue
    St. Louis, MO 63110


  • Interferon-based chemoradiation followed by gemcitabine for resected pancreatic adenocarcinoma: long-term follow-up
    Ohman KA, Liu J, Linehan DC, Tan MC, Tan BR, Fields RC, Strasberg SM, Hawkins WG
    HPB (Oxford) 2017 May;19(5):449-457
  • Liver transplantation for advanced hepatocellular carcinoma after downstaging without up-front stage restrictions
    Chapman WC, Garcia-Aroz S, Vachharajani N, Fowler K, Saad N, Lin Y, Wellen J, Tan B, Khan AS, Doyle MB
    J Am Coll Surg 2017 Apr;224(4):610-621
  • A phase 1 dose-escalation and expansion study of binimetinib (MEK162), a potent and selective oral MEK1/2 inhibitor
    Bendell JC, Javle M, Bekaii-Saab TS, Finn RS, Wainberg ZA, Laheru DA, Weekes CD, Tan BR, Khan GN, Zalupski MM, Infante JR, Jones S, Papadopoulos KP, Tolcher AW, Chavira RE, Christy-Bittel JL, Barrett E, Patnaik A
    Br J Cancer 2017 Feb 28;116(5):575-583
  • PET of poly (ADP-ribose) polymerase activity in cancer: preclinical assessment and first in-human studies
    Michel LS, Dyroff S, Brooks FJ, Spayd KJ, Lim S, Engle JT, Phillips S, Tan B, Wang-Gillam A, Bognar C, Chu W, Zhou D, Mach RH, Laforest R, Chen DL
    Radiology 2017 Feb;282(2):453-463
  • Utility of a multidisciplinary tumor board in the management of pancreatic and upper gastrointestinal diseases: an observational study
    Brauer DG, Strand MS, Sanford DE, Kushnir VM, Lim KH, Mullady DK, Tan BR Jr, Wang-Gillam A, Morton AE, Ruzinova MB, Parikh PJ, Narra VR, Fowler KJ, Doyle MB, Chapman WC, Strasberg SS, Hawkins WG, Fields RC
    HPB (Oxford) 2016 Dec 1; [Epub ahead of print]
  • Quality of life outcomes from a phase 2 trial of short-course radiation therapy followed by FOLFOX chemotherapy as preoperative treatment for rectal cancer
    Khwaja SS, Roy A, Markovina S, Dewees TA, Hunt S, Tan B, Myerson RJ, Olsen JR, Parikh PJ
    Int J Radiat Oncol Biol Phys 2016 Aug 1;95(5):1429-38
  • Imaging features of biphenotypic primary liver carcinoma (hepatocholangiocarcinoma) and the potential to mimic hepatocellular carcinoma: LI-RADS analysis of CT and MRI features in 61 cases
    Potretzke TA, Tan BR, Doyle MB, Brunt EM, Heiken JP, Fowler KJ
    AJR Am J Roentgenol 2016 Jul;207(1):25-31
  • Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial
    Nywening TM, Wang-Gillam A, Sanford DE, Belt BA, Panni RZ, Cusworth BM, Toriola AT, Nieman RK, Worley LA, Yano M, Fowler KJ, Lockhart AC, Suresh R, Tan BR, Lim KH, Fields RC, Strasberg SM, Hawkins WG, DeNardo DG, Goedegebuure SP, Linehan DC
    Lancet Oncol 2016 May;17(5):651-662
  • Efficacy and toxicity of rectal cancer reirradiation using IMRT for patients who have received prior pelvic radiation therapy
    Youssef FF, Parikh PJ, DeWees TA, Mutch MG, Tan BR, Grigsby PW, Meyerson RJ, Olsen JR
    Adv Radiat Oncol 2016 Apr-Jun;1(2):94-100
  • Biphenotypic primary liver carcinomas: assessing outcomes of hepatic directed therapy
    Fowler K, Saad NE, Brunt E, Doyle MB, Amin M, Vachharajani N, Tan B, Chapman WC
    Ann Surg Oncol 2015 Dec;22(13):4130-7
  • Complete response to erlotinib and bevacizumab in a patient with biphenotypic (hepatobiliary) primary liver carcinoma
    Zhou A, Amin M, Fowler KJ, Brunt EM, Keller J, Tan B
    J Natl Compr Canc Netw 2015 Dec;13(12):1468-1473
  • A phase II study of adjuvant gemcitabine plus docetaxel followed by concurrent chemoradation in resected pancreaticobiliary carcinoma
    Cho M, Wang-Gillam A, Myerson R, Gao F, Strasberg S, Picus J, Sorscher S, Fournier C, Nagaraj G, Parikh P, Suresh R, Linehan D, Tan BR
    HPB (Oxford) 2015 Jul;17(7):587-93
  • A phase II trial of bevacizumab plus temsirolimus in patients with advanced hepatocellular carcinoma
    Knox JJ, Qin R, Strosberg JR, Tan B, Kaubisch A, El-Khoueiry AB, Bekaii-Saab TS, Rousey SR, Chen HX, Erlichman C
    Invest New Drugs 2015 Feb;33(1):241-6
  • Histological features and severity of oxaliplatin-induced liver injury and clinical associations
    Nalbantoglu I, Tan BR Jr, Linehan DC, Gao F, Brunt EM
    J Dig Dis 2014 Oct;15(10):553-560
  • Thymidylate synthase genotype-directed chemotherapy for patients with gastric and gastroesophageal junction cancers
    Goff LW, Thakkar N, Du L, Chan E, Tan BR, Cardin DB, McLeod HL, Berlin JD, Zehnbauer B, Fournier C, Picus J, Wang-Gillam A, Lee W, Lockhart AC
    PLoS One 2014 Sep 18;9(9):e107424
  • A phase I study of pegylated liposomal doxorubicin and temsirolimus in patients with refractory solid malignancies
    Wang-Gillam A, Thakkar N, Lockhart AC, Williams K, Baggstrom M, Naughton M, Suresh R, Ma C, Tan B, Lee W, Jiang X, Mwandoro T, Trull L, Belanger S, Creekmore AN, Gao F, Fracasso PM, Picus J
    Cancer Chemother Pharmacol 2014 Aug;74(2):419-26
  • Five fractions of radiation therapy followed by 4 cycles of FOLFOX chemotherapy as preoperative treatment for rectal cancer
    Myerson RJ, Tan B, Hunt S, Olsen J, Birnbaum E, Fleshman J, Gao F, Hall L, Kodner I, Lockhart AC, Mutch M, Naughton M, Picus J, Rigden C, Safar B, Sorscher S, Suresh R, Wang-Gillam A, Parikh P
    Int J Radiat Oncol Biol Phys 2014 Mar 15;88(4):829-36
  • Complete response and prolonged disease-free survival in a patient with recurrent duodenal adenocarcinoma treated with bevacizumab plus FOLFOX6
    Nagaraj G, Zarbalian Y, Flora K, Tan BR Jr
    J Gastrointest Oncol 2014 Feb;5(1):E1-6
  • Vitamin D deficiency and prognostics among patients with pancreatic adenocarcinoma
    Cho M, Peddi PF, Ding K, Chen L, Thomas D, Wang J, Lockhart AC, Tan B, Wang-Gillam A
    J Transl Med 2013 Sep 8;11:206
  • A multidisciplinary approach to the diagnosis and treatment of gastrointestinal stromal tumor
    Mullady DK, Tan BR
    J Clin Gastroenterol 2013 Aug;47(7):578-85
  • Geriatric assessment is associated with completion of chemotherapy, toxicity and survival in older adults with cancer
    Wildes TM, Ruwe AP, Fournier C, Gao F, Carson KR, Piccirillo JF, Tan B, Colditz GA
    J Geriatr Oncol 2013 Jul;4(3):227-234
  • A phase I study of IMP321 and gemcitabine as the front-line therapy in patients with advanced pancreatic adenocarcinoma
    Wang-Gillam A, Plambeck-Suess S, Goedegebuure P, Simon PO, Mitchem JB, Hornick JR, Sorscher S, Picus J, Suresh R, Lockhart AC, Tan B, Hawkins WG
    Invest New Drugs 2013 Jun;31(3):707-13
  • Expert insight commentary on article "Extracolonic cancer risk rises with Lynch syndrome"
    Tan BR
    Clinical Oncology News 2012;7(11):23
  • Delayed repeated intraperitoneal chemotherapy after cytoreductive surgery for colorectal and appendiceal carcinomatosis
    Fajardo AD, Tan B, Reddy R, Fleshman J
    Dis Colon Rectum 2012 Oct;55(10):1044-52
  • Expert insight commentary on article "For anti-EGFR therapy, not all KRAS mutations created equal"
    Tan BR
    Clinical Oncology News 2012;7(9):28
  • Multi-institutional experience with FOLFIRINOX in pancreatic adenocarcinoma
    Peddi PF, Lubner S, McWilliams R, Tan BR, Picus J, Sorscher SM, Suresh R, Lockhart AC, Wang J, Menias C, Gao F, Linehan D, Wang-Gillam A
    JOP 2012 Sep 10;13(5):497-501
  • Methylenetetrahydrofolate reductase genetic polymorphisms and toxicity to 5-FU-based chemoradiation in rectal cancer
    Thomas F, Motsinger-Reif AA, Hoskins JM, Dvorak A, Roy S, Alyasiri A, Myerson RJ, Fleshman JW, Tan BR, McLeod HL
    Br J Cancer 2011 Nov 22;105(11):1654-62
  • A Phase 1 study of UCN-01 in combination with irinotecan in patients with resistant solid tumor malignancies
    Fracasso PM, Williams KJ, Chen RC, Picus J, Ma CX, Ellis MJ, Tan BR, Pluard TJ, Adkins DR, Naughton MJ, Rader JS, Arquette MA, Fleshman JW, Creekmore AN, Goodner SA, Wright LP, Guo Z, Ryan CE, Tao Y, Soares EM, Cai SR, Lin L, Dancey J, Rudek MA, McLeod HL, Piwnica-Worms H
    Cancer Chemother Pharmacol 2011 Jun;67(6):1225-37
  • Thymidylate synthase genotype-directed neoadjuvant chemoradiation for patients with rectal adenocarcinoma
    Tan BR, Thomas F, Myerson RJ, Zehnbauer B, Trinkaus K, Malyapa RS, Mutch MG, Abbey EE, Alyasiry A, Fleshman JW, McLeod HL
    J Clin Oncol 2011 Mar 1;29(7):875-83
  • A phase 2 trial of gemcitabine, 5-fluorouracil, and radiation therapy in locally advanced nonmetastatic pancreatic adenocarcinoma: Cancer and Leukemia Group B (CALGB) 80003
    Mamon HJ, Niedzwiecki D, Hollis D, Tan BR, Mayer RJ, Tepper JE, Goldberg RM, Blackstock AW, Fuchs CS
    Cancer 2011 Jun 15;117(12):2620-8
  • Detection of the G>C SNP and rare mutations in the 28-bp repeat of TYMS using gel-based capillary electrophoresis
    Thomas F, Hoskins JM, Dvorak A, Tan BR, McLeod HL
    Pharmacogenomics 2010 Dec;11(12):1751-1756
  • The benefit of adjuvant chemotherapy in elderly patients with stage III colorectal cancer is independent of age and comorbidity
    Wildes TM, Kallogjeri D, Powers B, Vlahiotis A, Mutch M, Spitznagel EL, Tan B, Piccirillo JF
    J Geriatr Oncol 2010 Oct 1;1(2):48-56
  • Gemcitabine with carboplatin for advanced biliary tract cancers: a phase II single institution study
    Williams KJ, Picus J, Trinkhaus K, Fournier CC, Suresh R, James JS, Tan BR
    HPB (Oxford) 2010 Aug;12(6):418-26
  • A phase I study of pegylated liposomal doxorubicin and irinotecan in patients with solid tumors
    Morgensztern D, Baggstrom MQ, Pillot G, Tan B, Fracasso P, Suresh R, Wildi J, Govindan R
    Chemotherapy 2009;55(6):441-5
  • Circulating mesothelin protein and cellular antimesothelin immunity in patients with pancreatic cancer
    Johnston FM, Tan MC, Tan BR Jr, Porembka MR, Brunt EM, Linehan DC, Simon PO Jr, Plambeck-Suess S, Eberlein TJ, Hellstrom KE, Hellstrom I, Hawkins WG, Goedegebuure P
    Clin Cancer Res 2009 Nov 1;15(21):6511-8
  • Colorectal and anal cancers
    Tan BR
    In: Cancer: Principles & Practice of Oncology Review, 2nd edition (Govindan R, ed), Lippincott Williams & Wilkins 2009
  • Small intestine and gastrointestinal stromal tumors
    Tan BR
    In: Cancer: Principles & Practice of Oncology Review, 2nd edition (Govindan R, ed), Lippincott Williams & Wilkins 2009
  • Radiotherapy for epidermoid carcinoma of the anus: thirty years' experience
    Myerson RJ, Outlaw ED, Chang A, Birnbaum EH, Fleshman JW, Grigsby PW, Kodner IJ, Malayapa RS, Mutch MG, Parikh P, Picus J, Tan BR
    Int J Radiat Oncol Biol Phys 2009 Oct 1;75(2):428-35
  • Phase 1 and pharmacokinetic study of weekly docosahexaenoic acid-paclitaxel, Taxoprexin, in resistant solid tumor malignancies
    Fracasso PM, Picus J, Wildi JD, Goodner SA, Creekmore AN, Gao F, Govindan R, Ellis MJ, Tan BR, Linette GP, Fu CJ, Pentikis HS, Zumbrun SC, Egorin MJ, Bellet RE
    Cancer Chemother Pharmacol 2009 Feb;63(3):451-8
  • Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial
    Dematteo RP, Ballman KV, Antonescu CR, Maki RG, Pisters PW, Demetri GD, Blackstein ME, Blanke CD, von Mehren M, Brennan MF, Patel S, McCarter MD, Polikoff JA, Tan BR, Owzar K
    Lancet 2009 Mar 28;373(9669):1097-104
  • Salvage radioembolization of liver-dominant metastases with a resin-based microsphere: initial outcomes
    Stuart JE, Tan B, Myerson RJ, Garcia-Ramirez J, Goddu SM, Pilgram TK, Brown DB
    J Vasc Interv Radiol 2008 Oct;19(10):1427-33
  • Phase I study of biweekly oxaliplatin, gemcitabine and capecitabine in patients with advanced upper gastrointestinal malignancies
    Tan BR, Brenner WS, Picus J, Marsh S, Gao F, Fournier C, Fracasso PM, James J, Yen-Revollo JL, McLeod HL
    Ann Oncol 2008 Oct;19(10):1742-8
  • Adjuvant interferon-based chemoradiation followed by gemcitabine for resected pancreatic adenocarcinoma: a single-institution phase II study
    Linehan DC, Tan MC, Strasberg SM, Drebin JA, Hawkins WG, Picus J, Myerson RJ, Malyapa RS, Hull M, Trinkaus K, Tan BR
    Ann Surg 2008 Aug;248(2):145-51
  • Treatment of locally advanced and metastatic pancreatic cancer
    Tan BR, Carenza J, Picus J
    In: Contemporary Issues in Cancer Imaging (Reznik R, Husband JE, eds), Cambridge University, 2008:166-174
  • HIV-associated malignancies
    Ratner L, Tan B
    In: The Washington Manual of Oncology, Second Edition (Govindan R, Arquette M, eds), Lippincott Williams & Wilkins, 2008: 344-362
  • Gastrointestinal malignancies: colorectal malignancies
    Tan B, Picus J
    In: The Washington Manual of Oncology, Second Edition (Govindan R, Arquette M, eds), Lippincott Williams & Wilkins, 2008: 190-196
  • Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab
    Khambata-Ford S, Garrett CR, Meropol NJ, Basik M, Harbison CT, Wu S, Wong TW, Huang X, Takimoto CH, Godwin AK, Tan BR, Krishnamurthi SS, Burris HA 3rd, Poplin EA, Hidalgo M, Baselga J, Clark EA, Mauro DJ
    J Clin Oncol 2007 Aug 1;25(22):3230-7
  • Long-term outcome after chemoembolization and embolization of hepatic metastatic lesions from neuroendocrine tumors
    Ho AS, Picus J, Darcy MD, Tan B, Gould JE, Pilgram TK, Brown DB
    AJR Am J Roentgenol 2007 May;188(5):1201-7
  • FDG-PET/CT in the evaluation of anal carcinoma
    Cotter SE, Grigsby PW, Siegel BA, Dehdashti F, Malyapa RS, Fleshman JW, Birnbaum EH, Wang X, Abbey E, Tan B, Kodner IJ, Hunt SR, Lowney JK, Mutch MG, Dietz DW, Myerson RJ
    Int J Radiat Oncol Biol Phys 2006 Jul 1;65(3):720-5
  • Expression of epidermal growth factor receptor in squamous cell carcinomas of the anal canal is independent of gene amplification
    Alvarez G, Perry A, Tan BR, Wang HL
    Mod Pathol 2006 Jul;19(7):942-9
  • Phase I study of pegylated liposomal doxorubicin and the multidrug-resistance modulator, valspodar
    Fracasso PM, Blum KA, Ma MK, Tan BR, Wright LP, Goodner SA, Fears CL, Hou W, Arquette MA, Picus J, Denes A, Mortimer JE, Ratner L, Ivy SP, McLeod HL
    Br J Cancer 2005 Jul 11;93(1):46-53
  • A phase II study of alternating cycles of split course radiation therapy and gemcitabine chemotherapy for inoperable pancreatic or biliary tract carcinoma
    Lin LL, Picus J, Drebin JA, Linehan DC, Solis J, Strasberg SM, Tan B, Thorstad WL, Myerson R
    Am J Clin Oncol 2005 Jun;28(3):234-41
  • In: Cancer: Principles & Practice of Oncology Review, 1st edition (Govindan R, ed)
    Tan B, Ratner L
    Lippincott Williams & Wilkins 2005
  • Pharmacogenetic influences on treatment response and toxicity in colorectal cancer
    Tan BR, McLeod HL
    Semin Oncol 2005 Feb;32(1):113-9
  • Analysis of protein expression and gene mutation of c-kit in colorectal neuroendocrine carcinomas
    Akintola-Ogunremi O, Pfeifer JD, Tan BR, Yan Y, Zhu X, Hart J, Goldblum JR, Burgart L, Lauwers GY, Montgomery E, Lewin D, Washington K, Bronner M, Xiao SY, Greenson JK, Lamps L, Lazenby A, Wang HL
    Am J Surg Pathol 2003 Dec;27(12):1551-8
  • AIDS-related lymphomas
    Smukler AJ, Tan BR, Ratner L
    Contemporary Oncol 2003 Aug 15;2(12):1-11
  • Phase I dose and sequencing study of pegylated liposomal doxorubicin and docetaxel in patients with advanced malignancies
    Fracasso PM, Rodriguez LC, Herzog TJ, Fears CL, Goodner SA, Govindan R, Picus J, Rader JS, Tan BR, Arquette MA
    Cancer 2003 Aug 1;98(3):610-7
  • Hematopoietic growth factors
    Blum K, Tan B
    In: The Washington Manual of Oncology (Govindan R, Arquette M, eds), Lippincott Williams & Wilkins, 2002
  • Pancreatic and hepatobiliary cancers
    Tan B, Picus J
    In: The Washington Manual of Oncology (Govindan R, Arquette M, eds), Lippincott Williams & Wilkins, 2002
  • AIDS-associated malignancies
    Tan B, Ratner L
    In: The Washington Manual of Oncology (Govindan R, Arquette M, eds), Lippincott Williams & Wilkins, 2002
  • Phase I study of rubitecan and gemcitabine in patients with advanced malignancies
    Fracasso PM, Rader JS, Govindan R, Herzog TJ, Arquette MA, Denes A, Mutch DG, Picus J, Tan BR, Fears CL, Goodner SA, Sun SL
    Ann Oncol 2002 Nov;13(11):1819-25
  • Phase I study of pegylated liposomal doxorubicin and gemcitabine in patients with advanced malignancies
    Fracasso PM, Blum KA, Tan BR, Fears CL, Bartlett NL, Arquette MA, Clark RS
    Cancer 2002 Nov 15;95(10):2223-9
  • Chemotherapy for metastatic colorectal cancer: part II
    Tan B, Picus J
    Contemporary Oncol 2002 Aug 15;1(12):1-6
  • Chemotherapy for metastatic colorectal cancer: part I
    Tan B, Picus J
    Contemporary Oncol 2002 Aug 1;1(11):1-6
  • Chemotherapy for human immunodeficiency virus-associated non-Hodgkin's lymphoma in combination with highly active antiretroviral therapy
    Ratner L, Lee J, Tang S, Redden D, Hamzeh F, Herndier B, Scadden D, Kaplan L, Ambinder R, Levine A, Harrington W, Grochow L, Flexner C, Tan B, Straus D
    J Clin Oncol 2001 Apr 15;19(8):2171-8
  • Multidrug resistance transporters and modulation
    Tan B, Piwnica-Worms D, Ratner L
    Curr Opin Oncol 2000 Sep;12(5):450-8
  • Treatment advances in non-Hodgkin's lymphoma
    Tan BR, Bartlett NL
    Expert Opin Pharmacother 2000 Mar;1(3):451-66
  • Membranoproliferative glomerulonephritis following gemcitabine and vinorelbine chemotherapy for peritoneal mesothelioma
    Fracasso PM, Tan BR Jr, Grieff M, Stephenson J Jr, Liapis H, Umbeck NL, Von Hoff DD, Rowinsky EK
    J Natl Cancer Inst 1999 Oct 20;91(20):1779-80
  • Distinct human immunodeficiency virus strains in the bone marrow are associated with the development of thrombocytopenia
    Voulgaropoulou F, Tan B, Soares M, Hahn B, Ratner L
    J Virol 1999 Apr;73(4):3497-504
  • The use of new antiretroviral therapy in combination with chemotherapy
    Tan B, Ratner L
    Curr Opin Oncol 1997 Sep;9(5):455-64