Faculty
John Welch.jpg

John S. Welch, MD, PhD

Assistant Professor
Department of Medicine
Oncology Division
Stem Cell Biology

Research Interests

  • Acute myeloid leukemia
  • Myelodysplastic syndrome
  • Genomics

Contact

  • 314-362-2626 (tel)
  • 314-362-9333 (fax)
  • Southwest Tower, Room 626 (office)
  • Southwest Tower, Room 626 (lab)
  • Division of Oncology
    Section of Stem Cell Biology
    Campus Box 8007
    Washington University Medical School
    660 South Euclid Avenue
    St. Louis, MO 63110

Peer-reviewed Scientific Publications

  • Dynamic changes in the clonal structure of MDS and AML in response to epigenetic therapy
    Uy GL, Duncavage EJ, Chang GS, Jacoby MA, Miller CA, Shao J, Heath S, Elliott K, Reineck T, Fulton RS, Fronick CC, O'Laughlin M, Ganel L, Abboud CN, Cashen AF, DiPersio JF, Wilson RK, Link DC, Welch JS, Ley TJ, Graubert TA, Westervelt P, Walter MJ
    Leukemia 2017 Apr;31(4):872-881
  • CpG island hypermethylation mediated by DNMT3A is a consequence of AML progression
    Spencer DH, Russler-Germain DA, Ketkar S, Helton NM, Lamprecht TL, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Shinawi M, Westervelt P, Payton JE, Wartman LD, Welch JS, Wilson RK, Walter MJ, Link DC, DiPersio JF, Ley TJ
    Cell 2017 Feb 23;168(5):801-816
  • Mutational landscape and response are conserved in peripheral blood of AML and MDS patients during decitabine therapy
    Duncavage EJ, Uy GL, Petti AA, Miller CA, Lee YS, Tandon B, Gao F, Fronick CC, O'Laughlin M, Fulton RS, Wilson RK, Jacoby MA, Cashen AF, Wartman LD, Walter MJ, Westervelt P, Link DC, DiPersio JF, Ley TJ, Welch JS
    Blood 2017 Mar 9;129(10):1397-1401
  • TP53 and decitabine in acute myeloid leukemia and myelodysplastic syndromes
    Welch JS, Petti AA, Miller CA, Fronick CC, O'Laughlin M, Fulton RS, Wilson RK, Baty JD, Duncavage EJ, Tandon B, Lee YS, Wartman LD, Uy GL, Ghobadi A, Tomasson MH, Pusic I, Romee R, Fehniger TA, Stockerl-Goldstein KE, Vij R, Oh ST, Abboud CN, Cashen AF, Schroeder MA, Jacoby MA, Heath SE, Luber K, Janke MR, Hantel A, Khan N, Sukhanova MJ, Knoebel RW, Stock W, Graubert TA, Walter MJ, Westervelt P, Link DC, DiPersio JF, Ley TJ
    N Engl J Med 2016 Nov 24;375(21):2023-2036
  • Pathways of retinoid synthesis in mouse macrophages and bone marrow cells
    Niu H, Hadwiger G, Fujiwara H, Welch JS
    J Leukoc Biol 2016 Jun;99(6):797-810
  • Rapid expansion of preexisting nonleukemic hematopoietic clones frequently follows induction therapy for de novo AML
    Wong TN, Miller CA, Klco JM, Petti A, Demeter R, Helton NM, Li T, Fulton RS, Heath SE, Mardis ER, Westervelt P, DiPersio JF, Walter MJ, Welch JS, Graubert TA, Wilson RK, Ley TJ, Link DC
    Blood 2016 Feb 18;127(7):893-7
  • Hand-foot syndrome following decitabine
    Ali AM, Jacoby M, Welch JS
    Ann Hematol 2016 Feb;95(3):535-6
  • Patterns and functional implications of rare germline variants across 12 cancer types
    Lu C, Xie M, Wendl MC, Wang J, McLellan MD, Leiserson MD, Huang KL, Wyczalkowski MA, Jayasinghe R, Banerjee T, Ning J, Tripathi P, Zhang Q, Niu B, Ye K, Schmidt HK, Fulton RS, McMichael JF, Batra P, Kandoth C, Bharadwaj M, Koboldt DC, Miller CA, Kanchi KL, Eldred JM, Larson DE, Welch JS, You M, Ozenberger BA, Govindan R, Walter MJ, Ellis MJ, Mardis ER, Graubert TA, DiPersio JF, Ley TJ, Wilson RK, Goodfellow PJ, Raphael BJ, Chen F, Johnson KJ, Parvin JD, Ding L
    Nat Commun 2015 Dec 22;6:10086
  • Genomic analysis of germ line and somatic variants in familial myelodysplasia/acute myeloid leukemia
    Churpek JE, Pyrtel K, Kanchi KL, Shao J, Koboldt D, Miller CA, Shen D, Fulton R, O'Laughlin M, Fronick C, Pusic I, Uy GL, Braunstein EM, Levis M, Ross J, Elliott K, Heath S, Jiang A, Westervelt P, DiPersio JF, Link DC, Walter MJ, Welch J, Wilson R, Ley TJ, Godley LA, Graubert TA
    Blood 2015 Nov 26;126(22):2484-90
  • Association between mutation clearance after induction therapy and outcomes in acute myeloid leukemia
    Klco JM, Miller CA, Griffith M, Petti A, Spencer DH, Ketkar-Kulkarni S, Wartman LD, Christopher M, Lamprecht TL, Helton NM, Duncavage EJ, Payton JE, Baty J, Heath SE, Griffith OL, Shen D, Hundal J, Chang GS, Fulton R, O'Laughlin M, Fronick C, Magrini V, Demeter RT, Larson DE, Kulkarni S, Ozenberger BA, Welch JS, Walter MJ, Graubert TA, Westervelt P, Radich JP, Link DC, Mardis ER, DiPersio JF, Wilson RK, Ley TJ
    JAMA 2015 Aug 25;314(8):811-822
  • Absence of natural intracellular retinoids in mouse bone marrow cells and implications for PML-RARA transformation
    Niu H, Chacko J, Hadwiger G, Welch JS
    Blood Cancer J 2015 Feb 27;5:e284
  • Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia
    Wong TN, Ramsingh G, Young AL, Miller CA, Touma W, Welch JS, Lamprecht TL, Shen D, Hundal J, Fulton RS, Heath S, Baty JD, Klco JM, Ding L, Mardis ER, Westervelt P, DiPersio JF, Walter MJ, Graubert TA, Ley TJ, Druley TE, Link DC, Wilson RK
    Nature 2015 Feb 26;518(7540):552-555
  • SciClone: inferring clonal architecture and tracking the spatial and temporal patterns of tumor evolution
    Miller CA, White BS, Dees ND, Griffith M, Welch JS, Griffith OL, Vij R, Tomasson MH, Graubert TA, Walter MJ, Ellis MJ, Schierding W, DiPersio JF, Ley TJ, Mardis ER, Wilson RK, Ding L
    PLoS Comput Biol 2014 Aug 7;10(8):e1003665
  • A phase I dose escalation study of oral bexarotene in combination with intravenous decitabine in patients with AML
    Welch JS, Niu H, Uy GL, Westervelt P, Abboud CN, Vij R, Stockerl-Goldstein KE, Jacoby M, Pusic I, Schroeder MA, DiPersio JF, Cashen AF
    Am J Hematol 2014 Aug;89(8):E103-8
  • Age-related mutations associated with clonal hematopoietic expansion and malignancies
    Xie M, Lu C, Wang J, McLellan MD, Johnson KJ, Wendl MC, McMichael JF, Schmidt HK, Yellapantula V, Miller CA, Ozenberger BA, Welch JS, Link DC, Walter MJ, Mardis ER, DiPersio JF, Chen F, Wilson RK, Ley TJ, Ding L
    Nat Med 2014 Dec;20(12):1472-1478
  • Mutation position within evolutionary subclonal architecture in AML
    Welch JS
    Semin Hematol 2014 Oct;51(4):273-81
  • Mutational landscape and significance across 12 major cancer types
    Kandoth C, McLellan MD, Vandin F, Ye K, Niu B, Lu C, Xie M, Zhang Q, McMichael JF, Wyczalkowski MA, Leiserson MD, Miller CA, Welch JS, Walter MJ, Wendl MC, Ley TJ, Wilson RK, Raphael BJ, Ding L
    Nature 2013 Oct 17;502(7471):333-9
  • Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia
    Ley TJ, Miller C, Ding L, Raphael BJ, Mungall AJ, Robertson A, Hoadley K, Triche TJ Jr, Laird PW, Baty JD, Fulton LL, Fulton R, Heath SE, Kalicki-Veizer J, Kandoth C, Klco JM, Koboldt DC, Kanchi KL, Kulkarni S, Lamprecht TL, Larson DE, Lin L, Lu C, McLellan MD, McMichael JF, Payton J, Schmidt H, Spencer DH, Tomasson MH, Wallis JW, Wartman LD, Watson MA, Welch J, Wendl MC, Ally A, Balasundaram M, Birol I, Butterfield Y, Chiu R, Chu A, Chuah E, Chun HJ, Corbett R, Dhalla N, Guin R, He A, Hirst C, Hirst M, Holt RA, Jones S, Karsan A, Lee D, Li HI, Marra MA, Mayo M, Moore RA, Mungall K, Parker J, Pleasance E, Plettner P, Schein J, Stoll D, Swanson L, Tam A, Thiessen N, Varhol R, Wye N, Zhao Y, Gabriel S, Getz G, Sougnez C, Zou L, Leiserson MD, Vandin F, Wu HT, Applebaum F, Baylin SB, Akbani R, Broom BM, Chen K, Motter TC, Nguyen K, Weinstein JN, Zhang N, Ferguson ML, Adams C, Black A, Bowen J, Gastier-Foster J, Grossman T, Lichtenberg T, Wise L, Davidsen T, Demchok JA, Shaw KR, Sheth M, Sofia HJ, Yang L, Downing JR, Eley G, Alonso S, Ayala B, Baboud J, Backus M, Barletta SP, Berton DL, Chu AL, Girshik S, Jensen MA, Kahn A, Kothiyal P, Nicholls MC, Pihl TD, Pot DA, Raman R, Sanbhadti RN, Snyder EE, Srinivasan D, Walton J, Wan Y, Wang Z, Issa JP, Le Beau M, Carroll M, Kantarjian H, Kornblau S, Bootwalla MS, Lai PH, Shen H, Van Den Berg DJ, Weisenberger DJ, Link DC, Walter MJ, Ozenberger BA, Mardis ER, Westervelt P, Graubert TA, DiPersio JF, Wilson RK
    N Engl J Med 2013 May 30;368(22):2059-74
  • Expression and function of PML-RARA in the hematopoietic progenitor cells of Ctsg-PML-RARA mice
    Wartman LD, Welch JS, Uy GL, Klco JM, Lamprecht T, Varghese N, Nagarajan R, Ley TJ
    PLoS One 2012;7(10):e46529
  • Solid, low-attenuation splenic lesions on computed tomography in patients with indolent lymphoma often signal transformation: a series of ten patients
    Welch JS, Foyil KV, Powers ML, Middleton WD, Bartlett NL
    Clin Lymphoma Myeloma Leuk 2012 Dec;12(6):452-4
  • The origin and evolution of mutations in acute myeloid leukemia
    Welch JS, Ley TJ, Link DC, Miller CA, Larson DE, Koboldt DC, Wartman LD, Lamprecht TL, Liu F, Xia J, Kandoth C, Fulton RS, McLellan MD, Dooling DJ, Wallis JW, Chen K, Harris CC, Schmidt HK, Kalicki-Veizer JM, Lu C, Zhang Q, Lin L, O'Laughlin MD, McMichael JF, Delehaunty KD, Fulton LA, Magrini VJ, McGrath SD, Demeter RT, Vickery TL, Hundal J, Cook LL, Swift GW, Reed JP, Alldredge PA, Wylie TN, Walker JR, Watson MA, Heath SE, Shannon WD, Varghese N, Nagarajan R, Payton JE, Baty JD, Kulkarni S, Klco JM, Tomasson MH, Westervelt P, Walter MJ, Graubert TA, Dipersio JF, Ding L, Mardis ER, Wilson RK
    Cell 2012 Jul 20;150(2):264-78
  • Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing
    Ding L, Ley TJ, Larson DE, Miller CA, Koboldt DC, Welch JS, Ritchey JK, Young MA, Lamprecht T, McLellan MD, McMichael JF, Wallis JW, Lu C, Shen D, Harris CC, Dooling DJ, Fulton RS, Fulton LL, Chen K, Schmidt H, Kalicki-Veizer J, Magrini VJ, Cook L, McGrath SD, Vickery TL, Wendl MC, Heath S, Watson MA, Link DC, Tomasson MH, Shannon WD, Payton JE, Kulkarni S, Westervelt P, Walter MJ, Graubert TA, Mardis ER, Wilson RK, DiPersio JF
    Nature 2012 Jan 11;481(7382):506-10
  • Combination decitabine, arsenic trioxide, and ascorbic acid for the treatment of myelodysplastic syndrome and acute myeloid leukemia: a phase I study
    Welch JS, Klco JM, Gao F, Procknow E, Uy GL, Stockerl-Goldstein KE, Abboud CN, Westervelt P, Dipersio JF, Hassan A, Cashen AF, Vij R
    Am J Hematol 2011 Sep;86(9):796-800
  • Use of whole-genome sequencing to diagnose a cryptic fusion oncogene
    Welch JS, Westervelt P, Ding L, Larson DE, Klco JM, Kulkarni S, Wallis J, Chen K, Payton JE, Fulton RS, Veizer J, Schmidt H, Vickery TL, Heath S, Watson MA, Tomasson MH, Link DC, Graubert TA, Dipersio JF, Mardis ER, Ley TJ, Wilson RK
    JAMA 2011 Apr 20;305(15):1577-1584
  • Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression
    Wartman LD, Larson DE, Xiang Z, Ding L, Chen K, Lin L, Cahan P, Klco JM, Welch JS, Li C, Payton JE, Uy GL, Varghese N, Ries RE, Hoock M, Koboldt DC, McLellan MD, Schmidt H, Fulton RS, Abbott RM, Cook L, McGrath SD, Fan X, Dukes AF, Vickery T, Kalicki J, Lamprecht TL, Graubert TA, Tomasson MH, Mardis ER, Wilson RK, Ley TJ
    J Clin Invest 2011 Apr 1;121(4):1445-1455
  • PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice
    Welch JS, Yuan W, Ley TJ
    J Clin Invest 2011 Apr 1;121(4):1636-45
  • Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice
    Welch JS, Klco JM, Varghese N, Nagarajan R, Ley TJ
    Blood 2011 Feb 24;117(8):2460-8
  • DNMT3A mutations in acute myeloid leukemia
    Ley TJ, Ding L, Walter MJ, McLellan MD, Lamprecht T, Larson DE, Kandoth C, Payton JE, Baty J, Welch J, Harris CC, Lichti CF, Townsend RR, Fulton RS, Dooling DJ, Koboldt DC, Schmidt H, Zhang Q, Osborne JR, Lin L, O'Laughlin M, McMichael JF, Delehaunty KD, McGrath SD, Fulton LA, Magrini VJ, Vickery TL, Hundal J, Cook LL, Conyers JJ, Swift GW, Reed JP, Alldredge PA, Wylie T, Walker J, Kalicki J, Watson MA, Heath S, Shannon WD, Varghese N, Nagarajan R, Westervelt P, Tomasson MH, Link DC, Graubert TA, DiPersio JF, Mardis ER, Wilson RK
    N Engl J Med 2010 Dec 16;363(25):2424-33
  • A protease-resistant PML-RAR{alpha} has increased leukemogenic potential in a murine model of acute promyelocytic leukemia
    Uy GL, Lane AA, Welch JS, Grieselhuber NR, Payton JE, Ley TJ
    Blood 2010 Nov 4;116(18):3604-10
  • Limited engraftment of low-risk myelodysplastic syndrome cells in NOD/SCID gamma-C chain knockout mice
    Martin MG, Welch JS, Uy GL, Fehniger TA, Kulkarni S, Duncavage EJ, Walter MJ
    Leukemia 2010 Sep;24(9):1662-4
  • Salvage therapy for acute myeloid leukemia with fludarabine, cytarabine, and idarubicin with or without gemtuzumab ozogamicin and with concurrent or sequential G-CSF
    Martin MG, Augustin KM, Uy GL, Welch JS, Hladnik L, Goyal S, Tiwari D, Monahan RS, Reichley RM, Cashen AF, Stockerl-Goldstein K, Westervelt P, Abboud CN, DiPersio JF, Vij R
    Am J Hematol 2009 Nov;84(11):733-7
  • Therapy related acute myeloid leukemia in breast cancer survivors, a population-based study
    Martin MG, Welch JS, Luo J, Ellis MJ, Graubert TA, Walter MJ
    Breast Cancer Res Treat 2009 Dec;118(3):593-8
  • Cladribine in the treatment of acute myeloid leukemia: a single-institution experience
    Martin MG, Welch JS, Augustin K, Hladnik L, DiPersio JF, Abboud CN
    Clin Lymphoma Myeloma 2009 Aug;9(4):298-301
  • Interleukin-4 induction of the CC chemokine TARC (CCL17) in murine macrophages is mediated by multiple STAT6 sites in the TARC gene promoter
    Liddiard K, Welch JS, Lozach J, Heinz S, Glass CK, Greaves DR
    BMC Mol Biol 2006 Nov 29;7:45
  • Ritual in Western medicine and its role in placebo healing
    Welch JS
    The Journal of Religion and Health 2003;42:21-34
  • Why bad things happen at all: a search for clarity among the problems of evil
    Welch JS
    BYU Studies 2003;42:75-90
  • Genomics and inductive reasoning: revolution, renaissance, or rhetoric?
    Welch JS, Rogler G
    Genet Med 2003 Nov-Dec;5(6):476-8
  • PPARgamma and PPARdelta negatively regulate specific subsets of lipopolysaccharide and IFN-gamma target genes in macrophages
    Welch JS, Ricote M, Akiyama TE, Gonzalez FJ, Glass CK
    Proc Natl Acad Sci U S A 2003 May 27;100(11):6712-7
  • TH2 cytokines and allergic challenge induce Ym1 expression in macrophages by a STAT6-dependent mechanism
    Welch JS, Escoubet-Lozach L, Sykes DB, Liddiard K, Greaves DR, Glass CK
    J Biol Chem 2002 Nov 8;277(45):42821-9
  • Maternal hypercholesterolemia during pregnancy promotes early atherogenesis in LDL receptor-deficient mice and alters aortic gene expression determined by microarray
    Napoli C, de Nigris F, Welch JS, Calara FB, Stuart RO, Glass CK, Palinski W
    Circulation 2002 Mar 19;105(11):1360-7
  • 15-deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway
    Straus DS, Pascual G, Li M, Welch JS, Ricote M, Hsiang CH, Sengchanthalangsy LL, Ghosh G, Glass CK
    Proc Natl Acad Sci U S A 2000 Apr 25;97(9):4844-9
  • Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase
    Huang JT, Welch JS, Ricote M, Binder CJ, Willson TM, Kelly C, Witztum JL, Funk CD, Conrad D, Glass CK
    Nature 1999 Jul 22;400(6742):378-82
  • Differential utilization of Ras signaling pathways by macrophage colony-stimulating factor (CSF) and granulocyte-macrophage CSF receptors during macrophage differentiation
    Guidez F, Li AC, Horvai A, Welch JS, Glass CK
    Mol Cell Biol 1998 Jul;18(7):3851-61
  • Expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein
    Ricote M, Huang J, Fajas L, Li A, Welch J, Najib J, Witztum JL, Auwerx J, Palinski W, Glass CK
    Proc Natl Acad Sci U S A 1998 Jun 23;95(13):7614-9