Fellows
Francesca Ferraro.jpg

Francesca Ferraro, MD, PhD

First-year Fellow (entered program in 2016)

Clinical Focus

  • Malignant hematology
  • Oncology

Research Focus

  • Malignant hematology

Type of Research

  • Basic and translational

Profile

Education
Undergraduate degree, University of Parma, Italy
MD, University of Parma, Italy
PhD, Center for Regenerative Medicine, MGH, Harvard Stem Cell Institute
Post-graduate Training
Residency, Pennsylvania Hospital, University of Pennsylvania, Philadelphia, PA

Publications

  • JUN is a key transcriptional regulator of the unfolded protein response in acute myeloid leukemia
    Zhou C, Martinez E, Di Marcantonio D, Patel-Solanki N, Aghayev T, Peri S, Ferraro F, Skorski T, Scholl C, Frohling S, Balachandran S, Wiest DL, Sykes SM
    Leukemia 2016 Nov 14; [Epub ahead of print]
  • Distinctive mesenchymal-parenchymal cell pairings govern B cell differentiation in the bone marrow
    Yu VW, Lymperi S, Oki T, Jones A, Swiatek P, Vasic R, Ferraro F, Scadden DT
    Stem Cell Reports 2016 Aug 9;7(2):220-235
  • Transcriptome comparison of distinct osteolineage subsets in the hematopoietic stem cell niche using a triple fluorescent transgenic mouse model
    Yu VW, Lymperi S, Ferraro F, Scadden DT
    Genom Data 2015 Jun 5;5:318-9
  • Cardioprotection by targeting the pool of resident and extracardiac progenitors
    Urbanek K, Frati C, Graiani G, Madeddu D, Falco A, Cavalli S, Lorusso B, Gervasi A, Prezioso L, Savi M, Ferraro F, Galaverna F, Rossetti P, Lagrasta CA, Re F, Quaini E, Rossi F, Angelis AD, Quaini F
    Curr Drug Targets 2015;16(8):884-94
  • Bone marrow macrophages contribute to diabetic stem cell mobilopathy by producing oncostatin M
    Albiero M, Poncina N, Ciciliot S, Cappellari R, Menegazzo L, Ferraro F, Bolego C, Cignarella A, Avogaro A, Fadini GP
    Diabetes 2015 Aug;64(8):2957-68
  • Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow
    Yu VW, Saez B, Cook C, Lotinun S, Pardo-Saganta A, Wang YH, Lymperi S, Ferraro F, Raaijmakers MH, Wu JY, Zhou L, Rajagopal J, Kronenberg HM, Baron R, Scadden DT
    J Exp Med 2015 May 4;212(5):759-74
  • Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning
    Saez B, Ferraro F, Yusuf RZ, Cook CM, Yu VW, Pardo-Saganta A, Sykes SM, Palchaudhuri R, Schajnovitz A, Lotinun S, Lymperi S, Mendez-Ferrer S, Toro RD, Day R, Vasic R, Acharya SS, Baron R, Lin CP, Yamaguchi Y, Wagers AJ, Scadden DT
    Blood 2014 Nov 6;124(19):2937-47
  • Direct measurement of local oxygen concentration in the bone marrow of live animals
    Spencer JA, Ferraro F, Roussakis E, Klein A, Wu J, Runnels JM, Zaher W, Mortensen LJ, Alt C, Turcotte R, Yusuf R, Cote D, Vinogradov SA, Scadden DT, Lin CP
    Nature 2014 Apr 10;508(7495):269-73
  • Proplatelet generation in the mouse requires PKCepsilon-dependent RhoA inhibition
    Gobbi G, Mirandola P, Carubbi C, Masselli E, Sykes SM, Ferraro F, Nouvenne A, Thon JN, Italiano JE Jr, Vitale M
    Blood 2013 Aug 15;122(7):1305-11
  • Differential stem- and progenitor-cell trafficking by prostaglandin E2
    Hoggatt J, Mohammad KS, Singh P, Hoggatt AF, Chitteti BR, Speth JM, Hu P, Poteat BA, Stilger KN, Ferraro F, Silberstein L, Wong FK, Farag SS, Czader M, Milne GL, Breyer RM, Serezani CH, Scadden DT, Guise TA, Srour EF, Pelus LM
    Nature 2013 Mar 21;495(7441):365-9
  • Diabetes impairs hematopoietic stem cell mobilization by altering niche function
    Ferraro F, Lymperi S, Mendez-Ferrer S, Saez B, Spencer JA, Yeap BY, Masselli E, Graiani G, Prezioso L, Rizzini EL, Mangoni M, Rizzoli V, Sykes SM, Lin CP, Frenette PS, Quaini F, Scadden DT
    Sci Transl Med 2011 Oct 12;3(104):104ra101
  • Differential niche and Wnt requirements during acute myeloid leukemia progression
    Lane SW, Wang YJ, Lo Celso C, Ragu C, Bullinger L, Sykes SM, Ferraro F, Shterental S, Lin CP, Gilliland DG, Scadden DT, Armstrong SA, Williams DA
    Blood 2011 Sep 8;118(10):2849-56
  • AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias
    Sykes SM, Lane SW, Bullinger L, Kalaitzidis D, Yusuf R, Saez B, Ferraro F, Mercier F, Singh H, Brumme KM, Acharya SS, Scholl C, Tothova Z, Attar EC, Frohling S, DePinho RA, Armstrong SA, Gilliland DG, Scadden DT
    Cell 2011 Sep 2;146(5):697-708
  • Guanine nucleotide exchange factor Vav1 regulates perivascular homing and bone marrow retention of hematopoietic stem and progenitor cells
    Sanchez-Aguilera A, Lee YJ, Lo Celso C, Ferraro F, Brumme K, Mondal S, Kim C, Dorrance A, Luo HR, Scadden DT, Williams DA
    Proc Natl Acad Sci U S A 2011 Jun 7;108(23):9607-12
  • Inhibition of osteoclast function reduces hematopoietic stem cell numbers in vivo
    Lymperi S, Ersek A, Ferraro F, Dazzi F, Horwood NJ
    Blood 2011 Feb 3;117(5):1540-9
  • Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
    Mendez-Ferrer S, Michurina TV, Ferraro F, Mazloom AR, Macarthur BD, Lira SA, Scadden DT, Ma'ayan A, Enikolopov GN, Frenette PS
    Nature 2010 Aug 12;466(7308):829-34

Peer-reviewed Reviews

  • Concise review: diabetes, the bone marrow niche, and impaired vascular regeneration
    Fadini GP, Ferraro F, Quaini F, Asahara T, Madeddu P
    Stem Cells Transl Med 2014 Aug;3(8):949-57
  • Resident cardiac stem cells
    Frati C, Savi M, Graiani G, Lagrasta C, Cavalli S, Prezioso L, Rossetti P, Mangiaracina C, Ferraro F, Madeddu D, Musso E, Stilli D, Rossini A, Falco A, Angelis AD, Rossi F, Urbanek K, Leri A, Kajstura J, Anversa P, Quaini E, Quaini F
    Curr Pharm Des 2011 Oct;17(30):3252-7
  • The HSC niche concept has turned 31. Has our knowledge matured?
    Lymperi S, Ferraro F, Scadden DT
    Ann N Y Acad Sci 2010 Mar;1192:12-8
  • Cancer treatment-induced cardiotoxicity: a cardiac stem cell disease?
    Prezioso L, Tanzi S, Galaverna F, Frati C, Testa B, Savi M, Graiani G, Lagrasta C, Cavalli S, Galati S, Madeddu D, Lodi Rizzini E, Ferraro F, Musso E, Stilli D, Urbanek K, Piegari E, De Angelis A, Maseri A, Rossi F, Quaini E, Quaini F
    Cardiovasc Hematol Agents Med Chem 2010 Jan;8(1):55-75
  • The regenerative potential of the human heart
    Quaini F, Urbanek K, Graiani G, Lagrasta C, Maestri R, Monica M, Boni A, Ferraro F, Delsignore R, Tasca G, Leri A, Kajstura J, Quaini E, Anversa P
    Int J Cardiol 2004 Jun;95 Suppl 1:S26-8

Peer-reviewed Book Chapters

  • Adult stem cells and their niches
    Ferraro F, Celso CL, Scadden D
    In: The Cell Biology of Stem Cells. Springer; 2010. p. 155-168
  • The skeletal stem cells
    Park D, Hoggatt J, Ferraro F, Scadden DT
    In: Osteoporosis, 4th Edition. Elsevier. Marcus R, Feldman D, Dempster D, Cauley J, Luckey M, eds. Vol. 2, Chapter 7, p. 127-147