Research Seminars | Division of Hematology | Washington University in St. Louis

In this series, research seminars given by Division faculty or guest speakers alternate with work-in-progress talks given by graduate students and post-doctoral fellows.

Schedule

Thursday, Noon-1:00 PM
Room 8841 Clinical Sciences Research Building (in person)
RCR Training: Responsible Conduct of Research (registered participants only)

Archive by Academic year

2023-2024

Date	Speaker	Title
Sep 14, 2023	Andrew Young Grant Challen lab	WORK-IN-PROGRESS SEMINAR Spatial Organization of Hematopoietic Clones in the Bone Marrow of a Polycythemia Vera Patient
Sep 21, 2023	Suneet Agarwal, MD, PHD _{Boston Children’s/Harvard Medical School}	HEMATOLOGY SPECIAL SEMINAR
Sep 28, 2023	Fan He Steve Oh lab	WORK-IN-PROGRESS SEMINAR Galectin-1 Fuels Monocyte-Driven Hyperinflammation and Represents a Novel Therapeutic Target in Myeloproliferative Neoplasms
~~Oct 5, 2023~~	~~Monique Chavez~~ ~~Matt Walter lab~~	~~WORK-IN-PROGRESS SEMINAR~~
Oct 12, 2023	Orsola di Martino _{Steve Sykes lab}	WORK-IN-PROGRESS SEMINAR DDIT4 modulates multiple aspects of mitochondrial and lysosomal network dynamics that influence AML progression and chemotherapy-response mechanisms
Oct 19, 2023	Rong Lu, PHD _{University of Southern California (USC)}	HEMATOLOGY SPECIAL SEMINAR Heterogeneity and coordination of hematopoietic stem cells
Oct 26, 2023	Stefan Tarnawsky _{Matt Walter}	WORK-IN-PROGRESS SEMINAR The Fitness of U2AF1-Mutant Hematopoietic Clones
Nov 2, 2023	Jingu Lee _{Gus Cho lab}	WORK-IN-PROGRESS SEMINAR Role of neutrophil CRACR2A in calcium signaling and neutrophil recruitment during vascular inflammation
Nov 30, 2023	Jiye Yi _{Yoona Kang lab}	WORK-IN-PROGRESS SEMINAR Unfolded protein response signaling as a regulator of myeloid versus erythroid lineage decision
Jan 18, 2024	Hochang Jeong _{Luis Batista lab}	WORK-IN-PROGRESS SEMINAR Targeted differentiation of human ESCs to unravel the pathogenesis of bone marrow failure
Jan 25, 2024	Lei Ding, PHD _{Columbia University}	HEMATOLOGY SPECIAL SEMINAR The regulation of hematopoietic stem cells and their niche in health and disease
Feb 1, 2024	Jae-Sung Kim _{Gus Cho lab}	WORK-IN-PROGRESS SEMINAR The role of RIPK1 in platelet activation during arterial thrombosis and ischemic stroke
Feb 8, 2024	John Hwa, MD, PHD, FRACP _{Yale University}	HEMATOLOGY SPECIAL SEMINAR A new platelet novel; rewriting stories without a clot
~~Feb 15, 2024~~	Tyler Parsons _{Grant Challen lab} Molly Brakhane _{Steve Oh lab}	~~WORK-IN-PROGRESS SEMINAR~~
Feb 22, 2024	Sanjay Patel, MD, MPH _Cornell	HEMATOLOGY SPECIAL SEMINAR Spatial Mapping of Human Hematopoiesis at Single Cell Resolution in Aging and Myelodysplasia
Feb 29, 2024	Paul Boucher _{David Curi}_{el lab} Molly Brakhane _{Steve Oh lab}	WORK-IN-PROGRESS SEMINAR Engineered Adenovirus-antibody molecular complexes for precision in vivo targeting of hematopoietic cells Aberrant Activity of the Calcium Sensor STIM1 Underlies Congenital Platelet Disorders and Myeloproliferative Neoplasms
Mar 7, 2024	Michael Bern _{Timothy Ley lab} Wilbur Song _{Todd Fehniger}_lab	WORK-IN-PROGRESS SEMINAR Mechanisms of Chemotherapy Resistance in Primary-Refractory Acute Myeloid Leukemia Engineering chemotaxis toward secreted solid tumor antigens
Mar 14, 2024	Vishwanath Jha _{Gus Cho lab}	WORK-IN-PROGRESS SEMINAR Novel mechanisms regulating platelet function under Hypoxia
Mar 21, 2024	Judith Sokei _{Steve Sykes lab}	WORK-IN-PROGRESS SEMINAR The role of key regulatory enzymes of 1C Metabolism in Normal and Malignant Hematopoiesis
Mar 28, 2024	Raj Doray _{Stuart Kornfeld lab}	WORK-IN-PROGRESS SEMINAR Molecular Insights into the Regulation of GlcNAc-1-phosphotransferase by TMEM251
Apr 4, 2024	Ami Patel _{University of Utah Huntsman Cancer Institute}	HEMATOLOGY SPECIAL SEMINAR CMML as an MPN: therapeutic opportunities and future directions
Apr 11, 2024	Mousumi Chakraborty _{Laura Schuettpelz lab}	WORK-IN-PROGRESS SEMINAR Role of transmembrane adaptor protein SCIMP in the regulation of hematopoietic stem cells
Apr 18, 2024	Mia Warmka _{Laura Schuettpelz lab}	WORK-IN-PROGRESS SEMINAR The tetraspanin CD53 promotes the clonal advantage of Dnmt3a-deficient hematopoietic stem cells
Apr 25, 2024	Jesse Zaretsky _{Sid Puram lab}	WORK-IN-PROGRESS SEMINAR
May 2, 2024	Seongmoon Jo _{Luis Batista lab}	WORK-IN-PROGRESS SEMINAR
May 9, 2024	Infencia Xavier Raj _{Grant Challen lab} Aishwarya Krishnan _{Grant Challen lab}	WORK-IN-PROGRESS SEMINAR
May 16, 2024	Jinzhi Wang _{Gus Cho lab}	WORK-IN-PROGRESS SEMINAR
May 23, 2024	Aniruddha Samajdar _{Luis Batista lab}	WORK-IN-PROGRESS SEMINAR

2022-2023

Date	Speaker	Title
Sep 8, 2022	Luis Batista	RCR TRAINING Misconduct
Sep 22, 2022	Lijun Xia, MD, PhD Oklahoma Medical Research Foundation	HEMATOLOGY SPECIAL SEMINAR Platelet CLEC-2 in Vascular Integrity and Thrombosis
Sep 29, 2022	Benjamin Jennings Stuart Kornfeld lab Ho-Chang Jeong Luis Batista lab	WORK-IN-PROGRESS SEMINAR A Weak ER Retrieval Motif in SARS CoV-2 Spike Protein Mediates Both New Virus Infectivity and Cell-Cell Spreading USB1 Is a miRNA Deadenylase That Regulates Hematopoietic Development
Oct 6, 2022	Luis Batista	RCR TRAINING Data Management
Oct 6, 2022	Peter Agre, MD Johns Hopkins University	STANLEY J. KORSMEYER MEMORIAL LECTURE Aquaporin Water Channels: From Atomic Structure to Malaria
Oct 13, 2022	Gregg L. Semenza, MD, PhD Johns Hopkins University	48TH ANNUAL CARL MOORE LECTURE Regulation of Erythropoiesis by Hypoxia-Inducible Factors
Oct 27, 2022	Tripti Kumari Gus Cho lab	WORK-IN-PROGRESS SEMINAR Role of SGLT1/2 on Intravascular Cell-Cell Aggregation and Vaso-Occlusion Mediated Conditions in Mouse Model of Sickle Cell Disease
Nov 3, 2022	Luis Batista	RCR TRAINING Peer Review and Authorship
Nov 10, 2022	Monique Chavez Matt Walter lab Ethan Cordes Luis Batista lab	WORK-IN-PROGRESS SEMINAR The Contribution of Subclonal Gene Mutations in Myelodysplastic Syndrome Progression TGS1 Depletion Increases Telomerase RNA Stability in Dyskeratosis Congenita
Nov 17, 2022	Shannon Elf, PhD University of Chicago	HEMATOLOGY SPECIAL SEMINAR Type 1 and Type 2 Calreticulin Mutations Activate Discrete Unfolded Protein Response Pathways to Drive Myeloproliferative Neoplasms
Dec 1, 2022	Luis Batista	RCR TRAINING Resource Sharing
Jan 5, 2023	Yoona Kang	RCR TRAINING Human and Animal Research
Jan 13, 2023	Joan S. Brugge, PhD Harvard Medical School	12TH ROSALIND KORNFELD LECTURE Mechanisms of Cancer Therapy Resistance
Jan 19, 2023	Angelo Laranjeira Steve Oh lab	WORK-IN-PROGRESS SEMINAR Dysregulated Signaling Pathways in Myeloproliferative Neoplasms
Jan 26, 2023	Michael Kramer Tim Ley lab	WORK-IN-PROGRESS SEMINAR Proteomics of Pre-Leukemic and Leukemic Hematopoietic Cells With AML-Associated DNMT3A and/or NPM1 Mutations
Feb 2, 2023	Grant Challen	RCR TRAINING Mentor/Mentee
Feb 9, 2023	Fernando Camargo, PhD Boston Children’s Hospital	HEMATOLOGY SPECIAL SEMINAR Ancestry and Function in the Hematopoietic System
Feb 14, 2023	Xin Gao, PhD University of Wisconsin	HEMATOLOGY SPECIAL SEMINAR Regulation of Hematopoietic Stem Cell Mobilization by the Bone Marrow Niche
Feb 16, 2023	Stefan Tarnawsky Matt Walter lab	WORK-IN-PROGRESS SEMINAR Fitness of U2AF1-Mutant Clones
Feb 23, 2023	Jesse Zaretsky Sidharth Puram lab	WORK-IN-PROGRESS SEMINAR Single-Cell Analysis of Neoadjuvant Immunotherapy in Head and Neck Cancer
Feb 28, 2023	Jonas S. Jutzi, MD, PhD Harvard Medical School	HEMATOLOGY SPECIAL SEMINAR Biology and Therapeutic Targeting of Myeloproliferative Neoplasms
Mar 2, 2023	Fan He Steve Oh lab	WORK-IN-PROGRESS SEMINAR Single-Cell Analysis Reveals Galectin-1 as a Novel Monocyte Marker and Therapeutic Target in MPN
Mar 9, 2023	Paul Boucher David Curiel lab	WORK-IN-PROGRESS SEMINAR Adenovirus Vectors for B Cell Gene Therapy
Mar 16, 2023	Andrew Dunbar, MD Memorial Sloan-Kettering Cancer Center	HEMATOLOGY SPECIAL SEMINAR Molecular Pathogenesis and Therapy of Myeloproliferative Neoplasms
Mar 23, 2023	Kim Johansson Dan Link lab	WORK-IN-PROGRESS SEMINAR Is Ribosomal Stress a Therapeutic Vulnerability in T-ALL?
Mar 28, 2023	Shannon Elf, PhD University of Chicago	HEMATOLOGY SPECIAL SEMINAR The Pathobiology of Type 1 Versus Type 2 Calreticulin-Mutated Myeloproliferative Neoplasms
Mar 30, 2023	Andrew Young Grant Challen lab Jeremy Baeten Dan Link lab	WORK-IN-PROGRESS SEMINAR Pre-Leukemic KMT2A Rearrangements After Topoisomerase Inhibitor Therapy Synergistic Lethality of Decitabine and ATR Inhibition in TP53-Mutant AML
Apr 6, 2023	John Crispino, PhD St. Jude Children’s Research Hospital	HEMATOLOGY SPECIAL SEMINAR Mechanisms of Leukemogenesis in Down Syndrome
Apr 10, 2023	Lev Silberstein, MD, PhD Fred Hutchinson Cancer Research Center	HEMATOLOGY SPECIAL SEMINAR Keeping Stem Cells Dormnant
Apr 13, 2023	Jae-Sung Kim Gus Cho lab	WORK-IN-PROGRESS SEMINAR The Role of RIPK1 in Platelet Activation and Arterial Thrombosis
Apr 20, 2023	Darby Agovino Luis Batista lab	WORK-IN-PROGRESS SEMINAR Establishing the Molecular Mechanism of Disease Induced by Mutant ENY2
Apr 27, 2023	David Russler-Germain Todd Fehniger lab Michel Iglesia Li Ding lab	WORK-IN-PROGRESS SEMINAR Clinicogenomics of Follicular Lymphoma Metastasis in Colorectal Cancer: Tumor Microenvironment and Treatment Effects
May 4, 2023	Molly Brakhane Steve Oh lab Luana Chiquetto Laura Schuettpelz lab	WORK-IN-PROGRESS SEMINAR Calcium Dysregulation in MPN Platelets The Role of Stathmin-1 in Regulation of HSCs
May 11, 2023	Barbara Soares Luis Batista lab	WORK-IN-PROGRESS SEMINAR Impact of DNMT3A on Telomere Regulation in Human Cells
May 18, 2023	Robert Signer, PhD University of California San Diego	HEMATOLOGY SPECIAL SEMINAR Stem Cell Fitness and Longevity: The Role of Proteostasis
May 25, 2023	Jeeseung Kim Yoona Kang lab Jingu Lee Gus Cho lab	WORK-IN-PROGRESS SEMINAR MPP3 Subset Is Novel Source of Plasma Cell Role of Neutrophil CRACR2A in Neutrophil Recruitment During Inflammation

2021-2022

Date	Speaker	Title
Sep 2, 2021	Xiaoping Du, MD, PhD University of Illinois at Chicago	Novel Mechanisms of Integrin Outside-In Signaling and the Concept of Treating Thrombosis and Inflammation Without Causing Bleeding
Sep 16, 2021	Hochang Jeong Luis Batista Lab	WORK-IN-PROGRESS SEMINAR USB1 Is a miRNA Deacetylase That Regulates Hematopoietic Development
Sep 23, 2021	Daniel Fisher Steve Oh Lab	WORK-IN-PROGRESS SEMINAR JAK2 and NF Kappa B Hyperactivation in Mouse Hematopoiesis and Myeloproliferative Neoplasms
Sep 30, 2021	Won Kyun Koh Grant Challen Lab	WORK-IN-PROGRESS SEMINAR Non Canonical Role of DNMT3A in HSC Function
Oct 7, 2021	Juo-Chin Robin Yao Dan Link Lab	WORK-IN-PROGRESS SEMINAR TGF-β Signaling in Stromal Cells Contributes to Myelofibrosis, but Not Niche Disruption, in MPNs Throught JNK Activation
Oct 21, 2021	Tripti Kumari Gus Cho Lab	WORK-IN-PROGRESS SEMINAR Identification of an Inhibitor of PDI-GPIbα Signaling as a Novel Anti-Thromboinflammatory Agent
Oct 28, 2021	Monique Chavez Matt Walter Lab	WORK-IN-PROGRESS SEMINAR A Mouse Model of Subclonal Gene Mutations in Myelodysplastic Syndrome
Nov 4, 2021	Balraj Doray Stuart Kornfeld Lab	WORK-IN-PROGRESS SEMINAR Insight Into Regulation of GlcNAc-1-Phosphotransferase Function as Revealed Through Cryo-EM Analysis
Nov 11, 2021	Angelo Laranjeira Steve Oh Lab	WORK-IN-PROGRESS SEMINAR Pevonedistat Targets Malignant Cells in Myeloproliferative Neoplasms in Vitro and in Vivo Via NFκB Pathway Inhibition
Nov 18, 2021	Michael Kramer Tim Ley Lab	WORK-IN-PROGRESS SEMINAR Analysis of the Proteome of De Novo Acute Myeloid Leukemia
Jan 6, 2022	Michel Iglesia Li Ding Lab	WORK-IN-PROGRESS SEMINAR Precursor Populations and Transitional States in Breast Cancer
Jan 13, 2022	Yoon-A Kang	Decoding Lineage Specification Mechanisms in Hematopoietic Stem and Multipotent Progenitor Populations
Jan 20, 2022	Tim Kong Steve Oh Lab	WORK-IN-PROGRESS SEMINAR Comprehensive Profiling of Clinical JAK Inhibitors in Myeloproliferative Neoplasms
Feb 3, 2022	Andrew Young Grant Challen Lab	WORK-IN-PROGRESS SEMINAR Spacial Characterization of Clonal Mutations in the Bone Marrow
Feb 10, 2022	Fan He Steve Oh Lab	WORK-IN-PROGRESS SEMINAR The Metabolic Dysregulation of Platelets in MPN Disease
Feb 17, 2022	Luana Chiquetto Laura Schuettpelz Lab	WORK-IN-PROGRESS SEMINAR The Role of Stathmin-1 in the Regulation of HSCs
Feb 24, 2022	David Russler-Germain Todd Fehniger Lab	WORK-IN-PROGRESS SEMINAR Updating Our Clinico-Genomic Understanding of Follicular Lymphoma
Mar 3, 2022	Jeremy Baeten Dan Link Lab	WORK-IN-PROGRESS SEMINAR Synergistic Lethality of Decitabine and ATR Inhibition in TP53-Mutant AML
Mar 9, 2022	Matthew Rondina, MD University of Utah	DIVISION OF HEMATOLOGY SPECIAL SEMINAR MHC-I Antigen Presentation by Platelets Suppresses CD8+ T Cells During Sepsis
Mar 10, 2022	Paul Rice-Boucher David Curiel Lab	WORK-IN-PROGRESS SEMINAR Adenoviral Vector Mediated Gene Editing of the B Cell Receptor as an HIV Vaccine
Mar 17, 2022	Brendan Mathias Jeff Bednarski Lab	WORK-IN-PROGRESS SEMINAR MYSM1 in DNA Damage Signaling During B Cell Development
Apr 1, 2022	Nigel Mackman, PhD UNC – Chapel Hill	J. EVAN SADLER SPECIAL LECTURE Mechanisms of Cancer-Associated Thrombosis .mp4
Apr 7, 2022	Stephanie Crowley Jeff Bednarski Lab	WORK-IN-PROGRESS SEMINAR Bclaf1 Promotes Hematopoietic Stem Cell Repopulating Capacity
Apr 21, 2022	Zev Greenberg Laura Schuettpelz Lab	WORK-IN-PROGRESS SEMINAR The Tetraspanin CD53 Protects Hematopoietic Stem Cells Following Cellular Stress Through Induction of DREAM Complex-Mediated Quiescence
Apr 28, 2022	David O’Leary Abby Green lab	WORK-IN-PROGRESS SEMINAR Loss of SMC5/6 Sensitizes Leukemia Cells to APOBEC3A Cytosine Deaminase Activity
May 5, 2022	Molly Brakhane Steve Oh Lab	WORK-IN-PROGRESS SEMINAR Role of Calcium Signaling in Hematopoiesis in MPNs
May 12, 2022	Kim Johansson Dan Link Lab	WORK-IN-PROGRESS SEMINAR Idasanutlin and Navitoclax Induce Synergistic Cell Death in T-ALL Patient-Derived Xenografts
May 19, 2022	Vishwanath Jha Gus Cho Lab	WORK-IN-PROGRESS SEMINAR Role of Platelet ERO1α in Platelet Activation and Arterial Thrombosis
May 26, 2022	Barbara Soares Luis Batista Lab	WORK-IN-PROGRESS SEMINAR DNMT3A as a Novel Regulator of Telomerase in Human Stem Cells

2020-2021

Date	Speaker	Title
Sep 10, 2020	Michael Munroe Luis Batista lab	WORK-IN-PROGRESS SEMINAR Telomere Dysfunction Inpairs Hepatocyte Development and Function Via Repression of HNF4A
Sep 17, 2020	Daniel Fisher Stephen Oh lab	WORK-IN-PROGRESS SEMINAR NF kappa B Hyperactivation in Myeloproliferative Neoplasms
Sep 24, 2020	Won Kyun Koh Grant Challen lab	WORK-IN-PROGRESS SEMINAR Non-Canonical Role of DNMT3A in HSC Function
Oct 1, 2020	Ben Jennings Stuart Kornfeld lab	WORK-IN-PROGRESS SEMINAR Molecular Mechanisms Regulating the Localization of SARS-CoV2 Spike Protein and Golgi Glycosyltransferases
Oct 8, 2020	Pamela Wong Todd Fehniger lab	WORK-IN-PROGRESS SEMINAR The Role of T-box Transcription Factors Eomes and Tbet in Mature Human Natural Killer Cells
Oct 15, 2020	Andrea Bredemeyer Kory Lavine lab	WORK-IN-PROGRESS SEMINAR Generation of Yolk-Sac-Like and Definitive Macrophages From Human PSCs
Oct 22, 2020	Alex Vessoni Luis Batista lab	WORK-IN-PROGRESS SEMINAR Investigating the Consequences of Telomere Dysfunction in Human Stem Cells
Oct 29, 2020	Monique Chavez Lukas Wartman lab	WORK-IN-PROGRESS SEMINAR Investigating Lenalidomide Treatment-Based Secondary B-Cell Acute Lymphoblastic Leukemia
Nov 5, 2020	Jared Fowles Stephen Oh lab	WORK-IN-PROGRESS SEMINAR Dysregulated Inflammation in Myeloproliferative Neoplasms and Disease Progression
Nov 6, 2020	Jennifer Lippincott-Schwartz, PhD HHMI Janelia Research Campus	11TH ROSALIND KORNFELD LECTURE Imaging Interacting Organelles to Understand Metabolic Homeostasis
Nov 12, 2020	Sharon A. Savage, MD National Cancer Institute	MEDICINE GRAND ROUNDS The Growing Clinical and Genetic Spectrum of Telomere Biology Disorders
Jan 7, 2021	David Ginsburg, MD University of Michigan Medical School, Ann Arbor, MI	JOINT SEMINAR WITH DEPARTMENT OF GENETICS FV/FVIII and Cargo Receptors in the ER: From Bedside to Bench
Jan 14, 2021	Farid Kadyrov Kory Lavine lab	WORK-IN-PROGRESS SEMINAR The Effects of Hypoxia on Monocyte/Macrophage Specification and Function During Ischemic Heart Injury
Jan 21, 2021	Angelo Brunelli Stephen Oh lab	WORK-IN-PROGRESS SEMINAR Pevonedistat Targets Malignant Cells in Myeloproliferative Neoplasms in Vitro and in Vivo Via NFkB Pathway Inhibition
Jan 28, 2021	Hochang Jeong Luis Batista lab	WORK-IN-PROGRESS SEMINAR Human ESC Modeling of Poikiloderma With Neutropenia Unveils Defective Hematopoietic Development Caused by Mutation in USB1
Feb 4, 2021	Ryan Day Tim Ley lab	WORK-IN-PROGRESS SEMINAR Distinct Profiles of CBF Leukemias
Feb 11, 2021	Fan He Stephen Oh lab	WORK-IN-PROGRESS SEMINAR The Characteristics of Platelets in Essential Thrombocythemia
Feb 18, 2021	Andrew Koenig Kory Lavine lab	WORK-IN-PROGRESS SEMINAR Cellular Atlas of the Failing Human Heart
Feb 23, 2021	Satish Nandakumar, PhD Boston Children’s Hospital	HEMATOLOGY FACULTY CANDIDATE How Can We Learn About Healthy and Diseased Hematopoiesis From Human Genetic Studies?
Feb 25, 2021	David Russler-Germain Todd Fehniger lab	WORK-IN-PROGRESS SEMINAR Novel Mutations Contributing to Follicular Lymphoma
Mar 2, 2021	Bo Shen, PhD UT Southwestern Medical Center	HEMATOLOGY FACULTY CANDIDATE Novel Regulators of Bone Marrow Stem Cells: Growth and Mechanical Force
Mar 4, 2021	Jeremy Baeten Dan Link lab	WORK-IN-PROGRESS SEMINAR TP53 in Clonal Hematopoiesis
Mar 11, 2021	Paul Boucher David Curiel lab	WORK-IN-PROGRESS SEMINAR Adenoviral Vector Mediated Gene Editing of the B Cell Receptor as an HIV Vaccine
Mar 16, 2021	Lingbo Zhang, PhD Cold Spring Harbor Laboratory	HEMATOLOGY FACULTY CANDIDATE Understanding and Targeting Hematopoietic Stem and Progenitor Cells
Mar 18, 2021	Rachel DeWeerd Abby Green lab	WORK-IN-PROGRESS SEMINAR The Experimentally-Defined APOBEC3A Signature Is Prevalent in Human Cancers
Mar 30, 2021	Yoon A. Kang, PhD Columbia University	HEMATOLOGY FACULTY CANDIDATE Who Does the Work? Lineage-Biased MPPs Tailor Blood Production
Apr 1, 2021	Kim Johansson Dan Link lab	WORK-IN-PROGRESS SEMINAR Is Nucleolar Stress a Therapeutic Vulnerability for T-Cell Acute Lymphoblastic Leukemia?
Apr 8, 2021	Ramon Jin Jason Mills lab	WORK-IN-PROGRESS SEMINAR The Role of SOX2 in Barrett’s Esophagus and Esophageal Adenocarcinoma
Apr 13, 2021	José A. López, MD University of Washington, Seattle, WA	HEMATOLOGY SPECIAL SEMINAR The Significance of Endothelium-Bound von Willebrand Factor
Apr 15, 2021	Brett Herzog David DeNardo lab	WORK-IN-PROGRESS SEMINAR Restoring Immune-Mediated Tumor Control in the Fibrotic NSCLC Microenvironment
Apr 20, 2021	Stephanie Grainger, PhD San Diego State University	HEMATOLOGY FACULTY CANDIDATE From Fish to Dish and Back Again: Deciphering Wnt/Fzd Cues in Hematopoietic Stem Cell Development
Apr 22, 2021	Michael Iglesia Li Ding lab	WORK-IN-PROGRESS SEMINAR Breast Cancer Subtype Heterogeneity at the Single-Cell Level
Apr 27, 2021	Alan E. Mast, MD, PhD Versiti Blood Center of Wisconsin, Milwaukee, WI	HEMATOLOGY SPECIAL SEMINAR The TFPI Anticoagulant Activity Modulates Cerebrovascular Development
May 6, 2021	Babak Razani, MD, PhD Cardiovascular Division	RESEARCH SEMINAR Dietary Protein and Amino Acid-Mediated mTOR Signaling in Atherosclerosis
May 13, 2021	Stephanie Crowley Jeffrey Bednarski lab	WORK-IN-PROGRESS SEMINAR BCLAF1 Regulation of Hematopoietic Stem Cell Repopulating Capacity
May 20, 2021	Vishwanath Jha Gus Cho lab	WORK-IN-PROGRESS SEMINAR Role of Platelet ERO1α in Platelet Activation and Arterial Thrombosis
Jun 30, 2021	Sydney Lu, MD, PhD Memorial Sloan-Kettering Cancer Center	HEMATOLOGY FACULTY CANDIDATE Targeting RNA Binding Proteins in Cancer

2019-2020

Date	Speaker	Title
Sep 19, 2019	Alex Vessoni Luis Batista lab Taylor Collins Stephen Oh lab	WORK-IN-PROGRESS SEMINAR DNA Damage Response in Human Embryonic Stem Cells With Short Telomeres Interrogating the Role of ASXL1 and JAK2 Mutations in MPNs Utilizing Human Pluripotent Stem Cells
Oct 3, 2019	Carissa Dege Chris Sturgeon lab	WORK-IN-PROGRESS SEMINAR Potently Cytotoxic Natural Killer Cell Potential Initially Emerges From Erythro-Myeloid Progenitors During Mammalian Development
Oct 17, 2019	Patrycja M. Dubielecka, PhD Warren Alpert Medical School of Brown University, Providence, RI	Signaling at the Crossroads: From Inflammaging to Cancer
Oct 24, 2019	Brett Herzog David DeNardo lab Stephanie Luff Chris Sturgeon lab	WORK-IN-PROGRESS SEMINAR Reactive Fibrosis in Lung Cancer: Impact on Immunity and Progression Top Notch Blood: The Involvement of NOTCH Signaling in Extra-Embryonic Hematopoiesis
Oct 31, 2019	Laurie H. Glimcher, MD Dana-Farber Cancer Institute, Boston, MA	STANLEY J. KORSMEYER MEMORIAL LECTURE ER Stress: Reprogramming the Tumor Microenvironment
Nov 12, 2019	Helen Hobbs, MD UT Southwestern Medical Center, Dallas, TX	47TH ANNUAL CARL MOORE LECTURE Mechanisms of Lipid Accumulation: Implications for Fatty Liver Disease
Nov 21, 2019	Jared Fowles Stephen Oh lab Casey Katerndahl Tim Ley lab	WORK-IN-PROGRESS SEMINAR Mass Cytometry Analysis of Bone Marrow and Peripheral Blood Hematopoietic Cell Populations in Polycythemia Vera The Mechanisms Underlying PML-RARA-Induced Self-Renewal and Transformation
Dec 12, 2019	Ben Jennings Stuart Kornfeld lab Ramon Jin Jason Mills lab	WORK-IN-PROGRESS SEMINAR Identifying Molecular Mechanisms Regulating the Localization of Golgi Glycosyltransferases Patient-Derived Organoids to Study Barrett’s Esophagus and Esophageal Carcinogenesis
Jan 9, 2020	Hochang Jeong Luis Batista lab Patrick Grierson Kian Lim lab	WORK-IN-PROGRESS SEMINAR USB1 Mutation Causes Defective Hematopoiesis The MK2/Hsp27 Axis Determines Sensitivity to Chemotherapy in Pancreatic Ductal Adenocarcinoma
Jan 27, 2020	Daniel C. Link, MD Washington University, St. Louis, MO	Pathogenesis of Congenital Neutropenia and Mechanisms of Leukemic Transformation
Jan 30, 2020	Daniel Fisher Stephen Oh lab Zev Greenberg Laura Schuettpelz lab	WORK-IN-PROGRESS SEMINAR NFκB Hyperactivation in Myeloproliferative Neoplasms: Insights From Human Patients and Mouse Models Loss of CD53 Impairs B Cell Migration
Jan 31, 2020	Matthew Rondina, MD University of Utah, Salt Lake City, UT	HEMATOLOGY GRAND ROUNDS Platelet Transcriptomics as Discovery Tools in Human Health and Disease
Feb 3, 2020	Steven Lentz, MD, PhD University of Iowa, Iowa City, IA	Vascular Stress Management: Oxidative Mechanisms in Thrombosis and Stroke
Feb 10, 2020	Mary Armanios, MD Johns Hopkins University, Baltimore, MD	The Telomere Syndromes: A Paradigm for Molecular Medicine
Feb 13, 2020	Dirk Hockemeyer, PhD University of California, Berkeley, CA	Elucidating the Mechanisms of Cancer Cell Immortality
Feb 14, 2020	Jaehyung (Gus) Cho, PhD University of Illinois, Chicago, IL	HEMATOLOGY GRAND ROUNDS Mechanisms Regulating Intravascular Cell-Cell Interactions in Thrombosis and Inflammation
Feb 17, 2020	Karin Hoffmeister, MD Medical College of Wisconsin, Milwaukee, WI	Glycans in Translational and Clinical Research
Feb 27, 2020	Wang-Sik Lee Stuart Kornfeld lab	WORK-IN-PROGRESS SEMINAR Analysis of Lysosomal Storage Disease-Causing Missense Mutations Within the Transmembrane Domain of GlcNAc-1-Phosphotransferase
Feb 28, 2020	Kenneth Ataga, MD University of Tennessee, Memphis, TN	HEMATOLOGY GRAND ROUNDS Meeting Unmet Needs in Sickle Cell Disease
Mar 9, 2020	Robert Flaumenhaft, MD, PhD Harvard Medical School, Boston, MA	Test Tube to Trial: Protein Disulfide Isomerase as an Antithrombotic Target

2018-2019

Date	Speaker	Title
Aug 30, 2018	Andrew Elefanty, PhD Murdoch Children’s Research Institute, Melbourne, Australia	Dissection of Human Haematopoiesis From Pluripotent Stem Cells
Sep 20, 2018	Lingheng Li, PhD Stowers Institute, Kansas City, MO	Expansion of Hematopoietic Stem Cells and Targeting Leukemia Stem Cells
Sep 27, 2018	Carissa Dege Chris Sturgeon lab Kirsten Brenner Luis Batista lab	WORK-IN-PROGRESS SEMINAR Ontogeny Is a Critical Determinant of Human Pluripotent Stem Cell Derived Natural Killer Cell Function A Telomere-Independent Role for the Telomerase RNA Component in Human Embryonic Stem Cells
Oct 11, 2018	Joshua Muia Evan Sadler lab	WORK-IN-PROGRESS SEMINAR Insights Into the Structure and Regulation of a Metalloprotease Involved in Cardiovascular Disease
Oct 25, 2018	Wilson Fok Luis Batista lab Darlene Monlish Laura Schuettpelz lab	WORK-IN-PROGRESS SEMINAR Inhibition of Polyadenylation Activity by Silencing of PAPD5 Restores Telomerase and Rescues Hematopoietic Failure in Dyskeratosis Congenita Differential Effects of TLR1/2 and TLR2/6 Signaling on Normal and Premalignant Hematopoietic Stem and Progenitor Cells
Nov 2, 2018	Carolyn R. Bertozzi, PhD Stanford University, Palo Alto, CA	10TH ROSALIND KORNFELD LECTURE Targeting the Cancer Glycocalyx
Nov 8, 2018	Karen Hirschi, PhD Yale Cardiovascular Research Center, New Haven, CT	Regulation of Hemogenic Endothelial Cell Specification
Dec 13, 2018	Taylor Collins Stephen Oh lab Megan Zimmerman Dan Link lab	WORK-IN-PROGRESS SEMINAR Interrogation of ASXL1 Mutations in Combination With the JAK2 V617F Mutation in MPNs MDM2 Inhibition in T-Cell Acute Lymphoblastic Leukemia
Jan 7, 2019	Jorge A. DiPaola, MD University of Colorado, Denver, CO	Studying Megakaryocytes, From Inherited Disorders to Old Age Platelets
Jan 17, 2019	Deepti Sood Gupta Jeff Bednarski lab	WORK-IN-PROGRESS SEMINAR A Novel SPIC/BCLAF1 Complex Reprograms PU.1 Activity in Pre-B Cells With Rag-Mediated DNA Breaks
Jan 24, 2019	Daniel Fisher Stephen Oh lab	WORK-IN-PROGRESS SEMINAR Interacting Roles of Hyperactive Signaling and Cytokine Overproduction in Myeloproliferative Neoplasms
Jan 31, 2019	Mary Armanios, MD Johns Hopkins University, Baltimore, MD	MEDICINE GRAND ROUNDS The Telomere Syndromes: Implications for Patient Care
Jan 31, 2019	Benjamin L. Ebert, MD, PhD Harvard Medical School, Boston, MA	46TH CARL MOORE LECTURE The Genetics of Hematologic Neoplasia: From Clonal Hematopoiesis to Acute Leukemia
Feb 14, 2019	Philip Creamer Chris Sturgeon lab Julia Wagner Todd Fehniger lab	WORK-IN-PROGRESS SEMINAR Defining the Role of CDX4 During Human Definitive Hematopoietic Specification A Novel NK Cell-Specific Inducible Cre Model Reveals a Critical Role for Eomes in the Survival, Homeostasis, and Function of Mature NK Cells
Feb 21, 2019	Jared Fowles Stephen Oh lab	WORK-IN-PROGRESS SEMINAR Investigating the Genomic and Inflammatory Profiles of Young and Old Polycythemia Patients
Feb 28, 2019	Stephanie Luff Chris Sturgeon lab Zev Greenberg Laura Schuettpelz lab	WORK-IN-PROGRESS SEMINAR Recapitulating Intraembryonic Hematopoiesis in the Dish Regulation of Early B Cell Development by the Tetraspanin CD53
Mar 21, 2019	Dhanam Anbukumar Evan Sadler lab	WORK-IN-PROGRESS SEMINAR The Function of Copper Ions in vWF Multimer Assembly
Mar 28, 2019	Alex Vessoni Luis Batista lab Christina Mikulka Mark Sands lab	WORK-IN-PROGRESS SEMINAR Telomere Dysfunction and Oncogene Stress Induces Differential Responses in Human Embryonic Stem Cells Cell-Autonomous Expression of the Lysosomal Hydrolase GALC: A New Model of Krabbe Disease
Apr 4, 2019	Brett Herzog David DeNardo lab Ramon Jin Jason Mills lab	WORK-IN-PROGRESS SEMINAR Desmoplasia in Lung Cancer Immunity and Progression Barrett’s Esophagus and Esophageal Adenocarcinoma
Apr 18, 2019	Kyle Cottrell Jason Weber lab Melissa Berrien-Elliott Todd Fehniger lab	WORK-IN-PROGRESS SEMINAR Upregulation of 5’TOP mRNAs Following Loss of the Tumor Suppressor ARF miR-142 Is Required for NK Cell Homeostasis and Function
Apr 25, 2019	Minori Tamai Todd Druley lab Hochang Jeong Luis Batista lab	WORK-IN-PROGRESS SEMINAR Modeling Infant Leukemia With Human Pluripotent Stem Cells Determining Therapeutic Targets to Restore Hematopoietic Output in Dyskeratosis Congenita
May 2, 2019	Tom Girard	WORK-IN-PROGRESS SEMINAR The TFPIαβ (γKO) Mouse Is a Better Model for Studying Human TF-Related Diseases
May 9, 2019	Patrick Grierson Kian Lim lab Casey Katerndahl Tim Ley lab	WORK-IN-PROGRESS SEMINAR Overcoming the MK2/ Hsp27 Axis to Potentiate the Effect of Chemotherapy in Pancreatic Ductal Adenocarcinoma (PDAC) The Mechanisms Underlying PML-RARA-Induced Self-Renewal and Transformation
Jun 3, 2019	John P. Sheehan, Jr., MD University of Wisconsin, Madison, WI	Plasma Factor IXa in Systemic Hypercoagulability

2017-2018

Date	Speaker	Title
Aug 3, 2017	Huichun Zhan, MD, MS Stony Brook University	The Hematopoietic Niche in Myeloproliferative Neoplasms
Sep 22, 2017	Bonnie L. Bassler, PhD Princeton University	9TH ROSALIND KORNFELD LECTURE Bacterial Quorum Sensing and Its Control
Sep 28, 2017	Angela Fleischman, MD, PhD University of California, Irvine	Inflammation as a Driver of Clonal Expansion in Myeloproliferative Neoplasm
Oct 5, 2017	Wilson Fok Luis Batista lab Taylor Collins Stephen Oh lab	WORK-IN-PROGRESS SEMINAR Understanding How Telomere Dysfunction and RNA Processing Defects Lead to Human Disease Interrogation of ASXL1 Mutations in Combination With the JAK2 V617F Mutation in MPNs
Oct 10, 2017	Riccardo Dalla-Favera, MD Institute for Cancer Genetics, Columbia University	STANLEY J. KORSMEYER MEMORIAL LECTURE Molecular Genetics of B Cell Lymphoma
Oct 12, 2017	Carissa Dege Chris Sturgeon lab Kirsten Brenner Luis Batista lab	WORK-IN-PROGRESS SEMINAR Natural Born Killers? Determining Function and Ontological Origins of Two Distinct Natural Killer Cell Populations Derived From Human Pluripotent Stem Cells A Telomere-Independent Role for the Telomerase RNA Component in Human Embryonic Stem Cells
Oct 27, 2017	Vivian G. Cheung, MD University of Michigan	45TH CARL MOORE LECTURE It’s in the RNA: Implications for Human Disease
Nov 2, 2017	Dhanam Anbukumar Evan Sadler lab	WORK-IN-PROGRESS SEMINAR The Involvement of Copper Transport in Von Willebrand Factor Biosynthesis
Nov 16, 2017	Steve Snyder Stephen Oh lab Julia Wagner Todd Fehniger lab	WORK-IN-PROGRESS SEMINAR Exploring the Role of NFκB in PMN Mouse Models Impact of Inducible Eomes Deletion on the Murine NK Cell Compartment
Nov 30, 2017	Joshua Muia Evan Sadler lab	WORK-IN-PROGRESS SEMINAR Two Metalloproteases Involved in Cardiovascular Disease
Dec 14, 2017	Tanner Johanns Gavin Dunn lab	WORK-IN-PROGRESS SEMINAR Neoantigens as Therapeutic Targets in Glioblastoma
Jan 11, 2018	Jian Zhu Evan Sadler lab	WORK-IN-PROGRESS SEMINAR Structural and Functional Studies of ADAMTS13: AUC, HDX, and EM
Jan 18, 2018	Terrence Wong	Clonal Evolution of Hematopoietic Stem Cells During Chemotherapy and Transplantation
Jan 25, 2018	Daniel Fisher Stephen Oh lab	WORK-IN-PROGRESS SEMINAR Utilizing Mass Cytometry and Mouse Models to Understand Myeloproliferative Neoplasms
Feb 1, 2018	Philip Creamer Chris Sturgeon lab Jared Fowles Stephen Oh lab	WORK-IN-PROGRESS SEMINAR Investigating Gene Expression During Human Definitive Hematopoietic Specification Genomic Dissection of Age-Related Differences in Polycythemia Vera
Feb 15, 2018	Tom Girard	A Balance Between Pro- and Anti-Coagulant Factors to Abate Bleeding and Avoid Thrombosis
Feb 22, 2018	Agnel Sfeir, PhD New York University	Protecting Our Genomes: Whenever, Wherever
Mar 7, 2018	Stephen S. Chung, MD Memorial Sloan Kettering Cancer Center	Less Can Be More: Novel Insights Into Hematologic Malignancies Revealed in Rare Stem Cell Populations
Mar 15, 2018	Alex Vessoni Luis Batista lab Stephanie Luff Chris Sturgeon lab	WORK-IN-PROGRESS SEMINAR Investigating Cell Death and DNA Damage Response in hESCs With Short Telomeres Twice Spliced: Exploring HOXA9 Variants in Embryonic Hematopoiesis
Mar 22, 2018	Garima Gupta Tyagi Evan Sadler lab	WORK-IN-PROGRESS SEMINAR Single Molecule Analysis of VWF Extension and Cleavage Using Magnetic Tweezers
Mar 29, 2018	Chang Liu Rob Mitra lab	WORK-IN-PROGRESS SEMINAR Rapid High-Resolution HLA Typing by Nanopore Sequencing
Apr 4, 2018	Chris Richardson, PhD University of California, Berkeley	The Fanconi Anemia Pathway Plays a Key Role in DNA Repair at CRISPR-Cas9 Cut Sites
Apr 5, 2018	Paul J. Gadue, PhD Children’s Hospital of Philadelphia	Megakaryocyte Development From Stem Cell Sources
Apr 12, 2018	Lin Liu Stuart Kornfeld lab	WORK-IN-PROGRESS SEMINAR Golgi Retention of Glycosyltransferases Requires Binding of Its N-Terminal Cytoplasmic Tail to Coatomer
Apr 26, 2018	Casey Katerndahl Tim Ley lab Christina Mikulka Mark Sands lab	WORK-IN-PROGRESS SEMINAR The Mechanisms Underlying PML-RARA-Induced Transformation and Self-Renewal Cell-Autonomous Expression of the Lysosomal Enzyme GALC in the Twitcher Mouse

2016-2017

Date	Speaker	Title
Sep 15, 2016	Patrick M. Viatour, PharmD, PhD University of Pennsylvania	E2f Factors Integrate Cell Cycle and Non Cell Cycle Functions to Dictate Stem Cell Fate
Sep 22, 2016	Wilson Fok Luis Batista lab Dhanam Anbukumar Evan Sadler lab	WORK-IN-PROGRESS p53 Stabilization Following Progressive Telomere Shortening Differentially Regulates Human Hematopoietic Specification Copper Transport in Von Willebrand Factor Biosynthesis
Sep 29, 2016	Jeffrey J. Bednarski, MD, PhD Department of Pediatrics	Physiologic and Genotoxic DNA Damage Activate Distinct Cellular Responses in Developing B Lymphocytes
Oct 14, 2016	John Stamatoyannopoulos, MD University of Washington	44TH CARL MOORE LECTURE Decoding the Human Regulatory Genome
Oct 20, 2016	Kirsten Brenner Luis Batista lab Joshua Muia Evan Sadler lab	WORK-IN-PROGRESS Telomere-independent Functions of the Telomerase RNA Component in Human Stem Cells Evolution and Allosteric Regulation of ADAMTS13
Oct 27, 2016	Steve Snyder Stephen Oh lab Carissa Dege Chris Sturgeon lab	WORK-IN-PROGRESS The Role of NFκB in MPN Mouse Models Generation and Characterization of Human Pluripotent Stem Cell-derived Natural Killer Cells
Nov 3, 2016	Hani S. Zaher, PhD Department of Biology	Insights Into the Role of the Ribosome During mRNA and Nascent-Protein Quality Control
Nov 17, 2016	Fernando D. Camargo, PhD Boston Children’s Hospital	Clonal Analysis of Native Hematopoiesis
Jan 12, 2017	Tom Girard George Broze lab	WORK-IN-PROGRESS The Roles of Tissue Factor Pathway Inhibitor in Health and Disease
Jan 19, 2017	Garima Gupta Tyagi Evan Sadler lab Alexandre Vessoni Luis Batista lab	WORK-IN-PROGRESS Single Molecule Analysis of VWF Extension and Cleavage Using Magnetic Tweezers Impact of Telomere Shortening on Mitochondria of Human Embryonic Stem Cells
Jan 26, 2017	Michael R. Bruchas, PhD Departments of Anesthesiology & Neurobiology	Dissecting Neuromodulatory Circuits in Affective Behavior
Feb 2, 2017	Tanner Johanns Gavin Dunn lab Jian Zhu Evan Sadler lab	WORK-IN-PROGRESS Effect of Prior Radiation on Gliomagenesis and Tumor Immunity The Hunt for the “Minimal” Structure of a Functional ADAMTS13 by Small-Angle X-Ray Scattering
Feb 6, 2017	David B. Sykes, MD, PhD Massachusetts General Hospital	“Curing by Maturing” – Developing Differentiation Therapy for the Treatment of Patients with Acute Myeloid Leukemia
Feb 9, 2017	Milan G. Chheda, MD Oncology Division	Developing a Synthetic Lethal Genetic Screen to Identify Vulnerabilities in IDH1 Mutant Gliomas
Feb 16, 2017	Taylor Brost Collins Stephen Oh lab Julia Wagner Todd Fehniger lab	WORK-IN-PROGRESS Utilizing iPSCs as a Model System to Interrogate Genetically Distinct Clones in Myeloproliferative Neoplasms CD56bright NK Cells Exhibit Potent Anti-Tumor Responses Following IL-15 Priming
Feb 23, 2017	Blair B. Madison, PhD Gastroenterology Division	PLAGL2, a Zinc Finger Transcription Factor That Drives Stem Cell Identity and Colorectal Cancer Tumorigenesis
Mar 2, 2017	Yedda Li Mark Sands lab Evandro Niero Luis Batista lab	WORK-IN-PROGRESS Combination Therapy Improves Lifespan and Clinicobehavioral Performance in Murine Globoid Cell Leukodystrophy Teleomere Shortening Impairs Hepatocyte Differentiation by DNA Damage Signaling Activation
Mar 9, 2017	Alessandro Vindigni, PhD Saint Louis University	Mechanisms of Replication Stress Response to Chemotherapeutics
Mar 23, 2017	Charles K. Kaufman, MD, PhD Oncology Division	Key Events During Cancer Initiation: From Melanocyte to Melanoma
Mar 30, 2017	Melanie Fields K12 Heme Scholars Program	WORK-IN-PROGRESS Cerebral Oxygen Metabolism and Vasoreactivity in Sickle Cell Disease
Apr 6, 2017	Babak Razani, MD, PhD Cardiology Division	Macrophages Epitomize Firefighter Arsonists in Metabolic Diseases. Can We Promote Better Behavior?
Apr 13, 2017	Lin Liu Stuart Kornfeld lab Daniel Fisher Stephen Oh lab	WORK-IN-PROGRESS Producing Highly Phosphorylated Lysosomal Enzymes for Enzyme Replacement Therapy Cytokines and Intracellular Signaling Abnormalities in Myeloproliterative Neoplasms
Apr 20, 2017	Indira U. Mysorekar, PhD Department of Obstetrics & Gynecology	Understanding Pathogenesis of Maternal Fetal Transmission of the Emerging Zika Virus
Apr 27, 2017	Jared Fowles Stephen Oh lab Chang Liu Rob Mitra lab	WORK-IN-PROGRESS Genomic Dissection of Age-Related Differences in Polycythemia Vera Single-Molecule HLA Typing by Oxford Nonopore Technology

2015-2016

Date	Speaker	Title
Sep 10, 2015	Daniel Fisher Stephen Oh lab Balraj Doray Stuart Kornfeld lab	WORK-IN-PROGRESS NFkB Hyperactivation in Myeloproliferative Neoplasms Understanding How GlcNAc-1-Phosphotransferase Recognizes Lysosomal Enzymes: Part I
Sep 24, 2015	Patrick Y. Jay, MD, PhD Pediatrics – Cardiology	Solving Congenital Heart Disease
Oct 1, 2015	Terrence Wong Dan Link, mentor	WORK-IN-PROGRESS Non-Malignant Oligoclonal Hematopoiesis Commonly Follows Induction Chemotherapy for Adult De Novo AML
Oct 8, 2015	Jason Mills, MD, PhD Medicine – Gastroenterology	Stem Cells, Reprogramming, and the Origins of Cancer
Oct 15, 2015	Wilson Fok Luis Batista lab Joshua Muia Evan Sadler lab	WORK-IN-PROGRESS Telomere Dysfunction in Stem Cell Proliferation and Differentiation In Search of the Minimalist ADAMTS13 Using Evolutionary Variations in its Allosteric Properties
Oct 29, 2015	Jeffrey R Millman, PhD Medicine – Endocrinology	Generation of Functional Human Pancreatic β Cells from Pluripotent Stem Cells In Vitro
Nov 5, 2015	Minji Byun, PhD Medicine – Rheumatology	Searching for the Genetic Etiology of Infectious Diseases
Nov 13, 2015	Jennifer A. Doudna, PhD UC Berkeley	8TH ROSALIND KORNFELD LECTURE The CRISPR-Cas9 Genome Engineering Revolution
Nov 19, 2015	Alan E. Mast, MD, PhD Blood Center of Wisconsin	Tissue Factor Pathway Inhibitor Biochemistry and Relation to Bleeding and Clotting Disorders
Dec 10, 2015	Tom Girard George Broze lab Dhanam Anbukumar Evan Sadler lab	WORK-IN-PROGRESS Evaluating Blockade of the Protein Z-Dependent Protease Inhibitor Pathway as a Potential Treatment for Hemophilia The ATP7A Copper Transporter Is Required for VWF Multimerization
Dec 17, 2015	Vivek K. Arora, MD, PhD Medicine – Oncology	Defining Novel Oncogenic Drug Targets in Bladder Cancer
Jan 7, 2016	Cates Mullaney Grant Challen lab	WORK-IN-PROGRESS The Role of Kdm6b in Hematopoiesis
Jan 11, 2016	Ammon M. Fager, MD, PhD Duke University	Human Platelets Express Endothelial Protein C Receptor Which Contributes to the Binding and Activity of rFVIIa
Jan 14, 2016	Alfred Kim, MD, PhD Medicine – Rheumatology	Glomerular Podocyte Cytokine Signaling Drives Proteinuria: Implications in Nephrotic Syndromes
Jan 15, 2016	James G. Taylor, MD Hematology Branch, NHLBI	Epidemiologic and Mechanistic Insights into Risk Factors for Death in Adults with Sickle Cell Anemia
Jan 21, 2016	Brian Kim, MD Dermatology	Immune Regulation of Atopic and Chronic Itch
Jan 28, 2016	Ren-Huai Huang Evan Sadler lab Wang-Sik Lee Stuart Kornfeld lab	WORK-IN-PROGRESS pH-Dependent Association Within N-terminal D Domains of Von Willebrand Factor Role of the Subunits of GlcNAc-Phosphotransferase in Lysosomal Enzyme Recognition
Feb 4, 2016	Nima Mosammaparast, MD, PhD Pathology & Immunology	Ubiquitin Dependent Regulatory Mechanisms in the Alkylation Damage Response
Feb 11, 2016	Garima Gupta Tyagi Evan Sadler lab Matt Christopher Tim Ley lab	WORK-IN-PROGRESS Single Molecule Analysis of Von Willebrand Factor Extension and Cleavage Using Magnetic Tweezers WT1 in Normal and Malignant Hematopoiesis
Feb 16, 2016	Yvette Y. Yien, PhD Harvard Medical School	Mitochondrial Transporters in Erythroid Heme Metabolism
Feb 18, 2016	Kory Lavine, MD, PhD Medicine – Cardiology	Making Sense of Cardiac Macrophage Ontogeny and Function
Feb 25, 2016	Jeff Ward Robert Schreiber lab	WORK-IN-PROGRESS Identification and Therapeutic Targeting of Tumor Specific Mutant Antigens
Mar 2, 2016	Hans Clevers, MD, PhD University of Utrecht, The Netherlands	43RD CARL MOORE LECTURE Lgr5 Stem Cell-Grown Organoids and Their Applications
Mar 8, 2016	Isabel Beerman, PhD Boston Children’s Hospital	Hematopoietic Stem Cell Aging
Mar 10, 2016	Steve Snyder Stephen Oh lab Jian Zhu Evan Sadler lab	WORK-IN-PROGRESS Mechanisms of Dysregulated Signaling in Mouse Models of Myeloproliferative Neoplasms Study of Allosteric Regulation of ADAMTS13 by Small-Angle X-Ray Scattering
Mar 17, 2016	Gregory Wu, MD, PhD Neurology	The Role of B Cell Antigen Presentation in a Murine Autoimmune Model of Multiple Sclerosis
Mar 24, 2016	Yedda Li Mark Sands lab Kirsten Brenner Luis Batista lab	WORK-IN-PROGRESS Combination Therapy Increases Lifespan and Improves Clinicobehavioral Performance in the Murine Model of Globoid Cell Leukodystrophy Telomere-Independent Functions of the Telomerase RNA Component in Human Stem Cells
Mar 31, 2016	Katherine C. Fuh, MD, PhD Obstetrics & Gynecology	Functional Genomics of Ovarian Cancer Metastasis
Mar 31, 2016	Paul F. Bray, MD Jefferson Medical College	Plateletomics: Exploring Platelet Biology Via Multi-omic Data Integration
Apr 7, 2016	Lin Liu Stuart Kornfeld lab	WORK-IN-PROGRESS Uncovering Novel Regulatory Roles of the “Spacer 1” Region of the GlcNAc-1-Phosphotransferase
Apr 14, 2016	Michael Kharas, PhD Sloan Kettering Institute	RNA Binding Proteins and the Control of the Leukemic Stem Cell Program
Apr 21, 2016	Kristen Sanfilippo Ken Carson, mentor Melanie Fields Jin-Moo Lee labas, PhD Sloan Kettering Institute	WORK-IN-PROGRESS Statin Therapy Increases Survival in Myeloma Functional Connectivity in Sickle Cell Disease
May 5, 2016	Carissa Dege Chris Sturgeon lab Tanner Johanns Gavin Dunn lab	WORK-IN-PROGRESS Characterization of Human Pluripotent Stem Cell Derived Natural Killer Cells An Immunogenomic Approach to Identify Glioblastoma-Specific CD8 T Cells
May 12, 2016	Frank McCormick, PhD UC San Francisco	STANLEY J. KORSMEYER MEMORIAL LECTURE New Ways of Targeting Ras
May 19, 2016	Taylor Brost Stephen Oh lab	WORK-IN-PROGRESS Interrogation of Genetically Distinct Clones Using MPN Patient-Specific IPSCs
Jul 20, 2016	Rami Khoriaty, MD University of Michigan	Congenital Dyserythropoietic Anemia Type II and Transport of Proteins from the ER to Golgi

2014-2015

Date	Speaker	Title
Sep 5, 2014	Ren-Huai Huang Evan Sadler lab Tom Girard George Broze lab	WORK-IN-PROGRESS The Role of D Domains in VWF Tubule Assembling Impact of Coagulation Regulators in Mouse Models of Various Diseases
Sep 19, 2014	J. Evan Sadler, MD, PhD Chair, Division of Hematology P. Roy Vagelos, MD Chairman of the Board, University of Pennsylvania Chairman, Regeneron and Theravance Pharmaceuticals Sandra Hofmann, MD, PhD Professor of Internal Medicine and Molecular Genetics University of Texas Southwestern Medical Center Stephen Prescott, MD President Oklahoma Medical Research Foundation John York, PhD Chair, Department of Biochemistry Vanderbilt University Medical Center	PHILIP W. MAJERUS SYMPOSIUM Introduction Phil, Science, and Medicine Molecular Basis of Infantile Batten Disease Lipid Messengers: I Met Them in St. Louis Insights into Inositol Phosphate Cellular Signaling Pathways
Sep 26, 2014	Daniel Fisher Stephen Oh lab	WORK-IN-PROGRESS Mass Cytometry Study Identifies NFκB Signaling as a Potential Disease Driver in Myeloproliferative Neoplasms
Oct 3, 2014	David B. Wilson, MD, PhD Department of Pediatrics	RESPONSIBLE CONDUCT OF RESEARCH Human Experimentation
Oct 10, 2014	Paul F. Bray, MD Thomas Jefferson University	Platelet PAR4 Functional Genomics: Racial Disparities in Anti-Platelet Therapy
Oct 17, 2014	Dhanam Anbukumar Evan Sadler lab Helena van Meel Stuart Kornfeld lab	WORK-IN-PROGRESS A Calcium Conundrum: The Role of Calcium in VWF Multimerization Analysis of Mucolipidosis II/III GNPTAB Missense Mutations Identifies Domains of GlcNAc-1-Phosphotransferase Involved in Catalytic Function and Lysosomal Enzyme Recognition
Oct 24, 2014	Sandra Schmid, PhD University of Texas Southwestern Medical Center	7TH ROSALIND KORNFELD LECTURE Dynamin: The Master Regulator of Clathrin-Mediated Endocytosis
Oct 31, 2014	Eric Duncavage Matt Walter lab Terrence Wong Dan Link lab	WORK-IN-PROGRESS Sequencing Based Detection of Low Frequency Variants in MDS The Role of Early TP53 Mutations in the Origin and Evolution of Therapy-Related AML
Nov 7, 2014	Monita P. Wilson, PhD Hematology Division	The Many Roles of ITPK1, an Inositol Kinase
Nov 14, 2014	Balraj Doray Stuart Kornfeld lab Wilson Fok Luis Batista lab	WORK-IN-PROGRESS Assembly of UDP-GlcNAc-1-Phosphotransferase, a Multi-Subunit Protein Telomere Dysfunction in Stem Cell Proliferation and Differentiation
Nov 21, 2014	David Sabatini, MD, PhD Whitehead Institute	42ND CARL MOORE LECTURE Regulation of Growth by the mTOR Pathway
Dec 12, 2014	Monita P. Wilson, PhD Hematology Division	RESPONSIBLE CONDUCT OF RESEARCH Collection, Recording, and Analysis of Data
Dec 19, 2014	Douglas M. Tollefsen, MD, PhD Hematology Division	RESPONSIBLE CONDUCT OF RESEARCH Accusation of Fraud
Jan 9, 2015	J. Evan Sadler, MD, PhD Hematology Division	Von Willebrand Factor, ADAMTS13 and Thrombotic Microangiopathy
Jan 16, 2015	Luis Batista, PhD Hematology Division	RESPONSIBLE CONDUCT OF RESEARCH Student-Mentor Relationships
Jan 23, 2015	Tomas Ganz, MD, PhD University of California – Los Angeles	Systemic Iron Homeostasis and Its Disorders
Jan 30, 2015	Joshua Muia Evan Sadler lab Cates Mallaney Grant Challen lab	WORK-IN-PROGRESS Insights Into ADAMTS13 Diversity Across Multiple Animal Species Interactions Between Dnmt3a and Repressive Chromatin Regulate Hematopoietic Stem Cell Function and Transformation
Feb 6, 2015	Stuart Kornfeld, MD Hematology Division	Role of the γ Subunit of UDP-GlcNAc:Lysosomal Enzyme GlcNAc-1-Phosphotransferase in Lysosomal Enzyme Phosphorylation
Feb 13, 2015	Wang-Sik Lee Stuart Kornfeld lab Kirsten Brenner Luis Batista lab	WORK-IN-PROGRESS The Mannose 6-Phosphate Lysosomal Targeting Pathway and Persistent Stuttering Regulation of the Telomerase RNA Component TERC in Human Development and Disease
Feb 20, 2015	Christopher M. Sturgeon, PhD Hematology Division	Modeling Developmental Hematopoiesis Using Pluripotent Stem Cells
Feb 27, 2015	Elizabeth Engle Stephen Oh lab	WORK-IN-PROGRESS Intersection of Dysregulated Cytokines and Signaling in Myeloproliferative Neoplasms
Mar 6, 2015	Kenneth Murphy, MD, PhD Department of Pathology & Immunology	Dendritic Cell Diversification
Mar 9, 2015	Sang Min, MD, PhD University of Pennsylvania	Role of Phosphoinositides in Platelet-Mediated Inflammation and Thrombosis
Mar 13, 2015	Angela Hirbe David Gutmann lab Mathew Cherian Lee Ratner lab	WORK-IN-PROGRESS Whole Exome Sequencing Reveals the Temporal Sequence of Genetic Changes During Malignant Transformation and Metastasis in a Single Patient With NF1-Associated Plexiform Neurofibroma Role of the PI3K-Akt-mTOR Pathway in HTLV Induced Leukemogenesis
Mar 20, 2015	Marielle Boonen, PhD Université de Namur, Belgium	Cathepsin D and Neuronal Differentiation: Lessons From the Identification of a New Binding Partner
Mar 27, 2015	Grant A. Challen, PhD Oncology Division	RESPONSIBLE CONDUCT OF RESEARCH Authorship, Peer Review, and Confidentiality
Apr 3, 2015	Anthony R. French, MD, PhD Department of Pediatrics	Regulation of NK Cell Proliferation
Apr 10, 2015	Jeff Ward Robert Schreiber lab Matt Christopher Tim Ley lab	WORK-IN-PROGRESS High-Throughput Identification of Tumor Neoantigen-Specific Cytotoxic T-Cells Cold Shock Domain Proteins in Normal and Malignant Hematopoiesis
Apr 17, 2015	Dana Abendschein, PhD Department of Medicine, Cardiovascular Division	Can We Inhibit Thrombosis Without Increasing Bleeding?
Apr 24, 2015	David Russler-Germain Tim Ley lab	WORK-IN-PROGRESS Molecular Consequences of DNMT3A Mutations in AML
May 1, 2015	Kian-Huat Lim, MD, PhD Oncology Division	Toll-like Receptor Signaling in Human Cancer
May 8, 2015	Jian Zhu Evan Sadler lab Melanie Fields Jin-Moo Lee lab	WORK-IN-PROGRESS A Folded ADAMTS13 Conformation Identified by SAXS Can Account for Allosteric Regulation by Distal TSP and CUB Domains MR Measurements of Cerebral Blood Flow and Oxygen Extraction Fraction in Pediatric Sickle Cell Disease
May 15, 2015	Beth Wang Chris Sturgeon lab	WORK-IN-PROGRESS Transcriptional Regulation of Human Primitive and Definitive Hematopoietic Progenitor Specification
May 22, 2015	Katherine P. Ponder, MD Hematology Division	Central Nervous System-Directed Gene Therapy for Mucopolysaccharidosis VII
May 29, 2015	Luis F. Z. Batista, PhD Hematology Division	Generation of an Isogenic Model to Study the Consequences of Telomerase Mutations in Human Stem Cells

2013-2014

Date	Speaker	Title
Sep 6, 2013	David G. DeNardo, PhD Oncology Division, Molecular Oncology Section	Reprogramming Macrophages to Improve Responses to Chemo- and Immunotherapy
Sep 13, 2013	Stephen T. Oh, MD, PhD Hematology Division	RESPONSIBLE CONDUCT OF RESEARCH (FOR TRAINEES) Human Experimentation
Sep 20, 2013	Jing Huang Evan Sadler laboratory Ryan Sullivan Todd Fehniger laboratory	WORK-IN-PROGRESS The Distinct Role of Two pH Sensing Histidines in the Multimer Assembly and Tubular Storage of von Willebrand Factor MiR-15/16 Antagonizes Myb to Control Natural Killer Cell Differentiation and Maturation
Sep 27, 2013	Monita P. Wilson, PhD Hematology Division	RESPONSIBLE CONDUCT OF RESEARCH (FOR TRAINEES) Collection, Recording, and Analysis of Data
Oct 4, 2013	Matthew J. C. Ellis, MB, BChir, PhD Oncology Division, Breast Oncology Section	The Genomics and Proteomics of Breast Cancer
Oct 11, 2013	Beth Levine, MD Department of Medicine, UT Southwestern Medical Center	6TH ROSALIND KORNFELD LECTURE Novel Links Between Autophagy Proteins, Cell Biology, and Metabolism
Oct 18, 2013	Jacqueline E. Payton, MD, PhD Department of Pathology & Immunology	Targeting the Malignant Epigenome in B cell Lymphoma
Oct 25, 2013	Eline van Meel Stuart Kornfeld laboratory Tom Girard George Broze laboratory	WORK-IN-PROGRESS Mislocalization of Phosphotransferase as a Cause of Mucolipidosis III alpha/beta Tissue Factor Pathway Inhibitor Structures, Functions and Physiology
Nov 1, 2013	Todd A. Fehniger, MD, PhD Oncology Division, Stem Cell Biology Section	Molecular Regulation of NK Cell Development and Function
Nov 8, 2013	Ren-Huai Huang Evan Sadler laboratory Monica Qian Stuart Kornfeld laboratory	WORK-IN-PROGRESS VWF Tubular Assembly in Vitro by D Domains Analysis of Mutations in MLII and MLIII α/β Patients – a New Way to Study Lysosomal Enzyme Sorting
Nov 15, 2013	Dan R. Littman, MD, PhD Department of Pathology, NYU Langone Medical Center	41ST CARL MOORE LECTURE Shaping of the Immune Response by the Commensal Microbiota
Dec 13, 2013	Grant A. Challen, PhD Oncology Division, Molecular Oncology Section	The Epigenetics of Hematopoietic Stem Cell Self-Renewal and Transformation
Dec 20, 2013	Dhanam Anbukumar Evan Sadler laboratory Balraj Doray Stuart Kornfeld laboratory	WORK-IN-PROGRESS Cation Dependence of vWF Multimerization Influence of Genetic Background on Lethality of GGA2 Knockout Mice
Jan 10, 2014	Deborah Novack, MD, PhD Department of Medicine, Division of Bone & Mineral Diseases	NIK’ing the Bone: Mechanisms for Control of the Osteoclast
Jan 17, 2014	Maria Trissal Dan Link laboratory Angela Verdoni Tim Ley laboratory	WORK-IN-PROGRESS Dysregulation and Recurrent Mutation of miRNA-142 in Acute Myeloid Leukemia Understanding the Role of the DNMT3A R882H Mutation in AML Pathogenesis
Jan 24, 2014	Andrew Yoo, PhD Department of Developmental Biology	Control of Neuronal Subtype Specificity During MicroRNA-Mediated Neuronal Reprogramming
Jan 31, 2014	Matthew J. Walter, MD Oncology Division, Stem Cell Biology Section	RESPONSIBLE CONDUCT OF RESEARCH (FOR TRAINEES) Student-Mentor Relationships
Feb 7, 2014	Deepta Bhattacharya, PhD Department of Pathology & Immunology	Convergent Differentiation During Hematopoiesis
Feb 14, 2014	Daniel Fisher Stephen Oh laboratory Kristen Sanfilippo Ken Carson, mentor	WORK-IN-PROGRESS Signaling in Myeloproliferative Neoplasms Studied by Single Cell Mass Cytometry Zoledronic Acid Versus Pamidronate in Patients with Multiple Myeloma: a Comparative Effectiveness Research Project
Feb 28, 2014	Terrence Wong Dan Link laboratory Eric Duncavage Matt Walter laboratory	WORK-IN-PROGRESS The Role of TP53 Mutations in the Origin and Evolution of Therapy-Related AML Detection of Subclonal Population in MDS
Mar 7, 2014	Gregory A. Storch, MD Department of Pediatrics	Virologic, Genomic, and Transcriptomic Analysis of Fever Without a Source in Young Children
Mar 14, 2014	Garima Gupta Tyagi Evan Sadler laboratory	WORK-IN-PROGRESS Interactions Between VWF and ADAMTS13 (Catalytic and Non-catalytic)
Mar 21, 2014	J. Evan Sadler, MD, PhD Hematology Division	RESPONSIBLE CONDUCT OF RESEARCH (FOR TRAINEES) Authorship, Peer Review, and Confidentiality
Mar 28, 2014	Joshua Muia Evan Sadler laboratory Christopher Cole Tim Ley laboratory	WORK-IN-PROGRESS ADAMTS13 is Conformationally Autoinhibited by its Distal Domains and is Allosterically Activated by Von Willebrand Factor The Role of Dnmt3a in Acute Promyelocytic Leukemia
Apr 4, 2014	Joshua Field, MD, MS Medical College of Wisconsin	The Potential Role of Invariant NKT Cells in Sickle Cell Disease
Apr 11, 2014	Wang-Sik Lee Stuart Kornfeld laboratory Meagan Jacoby Matt Walter laboratory	WORK-IN-PROGRESS Analysis of Missense Mutations in the α,β-Subunit of GlcNAc-Phosphotransferase Associated with Stuttering Investigating DNA Double-Strand Break Repair in MDS and AML
Apr 18, 2014	Jacques U. Baenziger, MD, PhD Department of Pathology & Immunology	Molecular Multi-tasking: New Insights into Hepatic Glycan Receptor Function
Apr 25, 2014	Cates Mallaney Grant Challen laboratory Mathew Cherian Lee Ratner laboratory	WORK-IN-PROGRESS Interactions Between Dnmt3a and Repressive Chromatin Regulate Hematopoietic Stem Cell Function and Transformation Role of the PI3K-Akt mTOR Pathway in Human T Cell Leukemia Induced Transformation
May 9, 2014	Jian Zhu Evan Sadler laboratory Angela Hirbe David Gutmann laboratory	WORK-IN-PROGRESS Structural Studies of ADAMTS13 Using Small-angle X-ray Scattering Defining the Molecular Events Underlying Malignant Transformation in NF1-related MPNSTs Through Whole Genome Sequencing
May 15, 2014	Robert D. Schreiber, PhD Department of Pathology & Immunology	STANLEY J. KORSMEYER MEMORIAL LECTURE Cancer Immunoediting: Applying Mechanistic Insights to Cancer Immunotherapy
May 23, 2014	Elizabeth Engle Stephen Oh laboratory David Germain Tim Ley laboratory	WORK-IN-PROGRESS Genetic Complexity and Disease Evolution in Myeloproliferative Neoplasms DNMT3A Mutations in AML
May 30, 2014	Ron Bose, MD, PhD Oncology Division, Breast Oncology Section	RESPONSIBLE CONDUCT OF RESEARCH (FOR TRAINEES) Allegations of Misconduct

2012-2013

Date	Speaker	Title
Sep 14, 2012	Eline van Meel Stuart Kornfeld laboratory Cara Lunn Matt Walter laboratory	WORK-IN-PROGRESS Mannose 6-Phosphate Independent Lysosomal Targeting of Acid alpha-Glucosidase U2AF1 Splicing Factor Mutations in Myelodysplastic Syndromes
Sep 21, 2012	Monita P. Wilson, PhD Hematology Division	ITPK1: an Inositol Kinase Linked to Neural Tube Defects
Sep 28, 2012	Ryan Sullivan Todd Fehniger laboratory Jing Huang Evan Sadler laboratory	WORK-IN-PROGRESS The Role of miR-155 in Natural Killer Cell Function Distinct Functions of pH-Sensing Histidine Residues in the Multimer Assembly and Storage of von Willebrand Factor in Weibel-Palade Bodies
Oct 5, 2012	John S. Welch, MD, PhD Oncology Division, Stem Cell Biology Section	The Origin and Evolution of AML Mutations
Oct 12, 2012	Angela Verdoni Tim Ley laboratory Ren-Huai Huang Evan Sadler laboratory	WORK-IN-PROGRESS Understanding the Role of DNMT3A Mutations in AML Pathogenesis How Von Willebrand Factor is Condensed into Weibel-Palade Bodies
Oct 18, 2012	Roger J. S. Preston, PhD Department of Haematology, Trinity College Dublin, Ireland	Regulating the Regulator: Modulating Activated Protein C Functions for Therapeutic Gain
Oct 19, 2012	Daniel C. Link, MD Oncology Division, Stem Cell Biology Section	Characterizing the Stem Cell Niche
Oct 26, 2012	Monica Qian Stuart Kornfeld laboratory Daniel Fisher Stephen Oh laboratory	WORK-IN-PROGRESS Missense Mutations in Mucolipidosis II and Mucolipidosis III Genomic Study of Myeloproliferative Neoplasia
Nov 2, 2012	Susan R. Wente, PhD Vanderbilt University	5TH ROSALIND KORNFELD LECTURE (ERLANGER AUDITORIUM) Beyond the Pore: From Nuclear mRNA Export to Translation
Nov 9, 2012	Gerald R. Crabtree, MD HHMI/Stanford University	40TH CARL MOORE LECTURE (MOORE AUDITORIUM) Chromatin Regulation: New Methods and Concepts
Nov 16, 2012	Tom Girard George Broze laboratory Dhanam Anbukumar Evan Sadler laboratory	WORK-IN-PROGRESS Protein Z, Protein Z-Dependent Protease Inhibitor (SerpinA10) and the Acute Phase Response Characterizing VWF Propeptide Ca2+ Binding Sites
Dec 14, 2012	Daniel E. Goldberg, MD, PhD Infectious Diseases Division	Trial by Fire and Famine: How the Malaria Parasite Survives in its Host Erythrocyte
Jan 3, 2013	Rong Lu, PhD Institute for Stem Cell Biology and Regenerative Medicine, Stanford University	Systems Analysis of Mouse Hematopoietic Stem Cells in Vivo at the Single Cell Level
Jan 11, 2013	Balraj Doray Stuart Kornfeld laboratory Joshua Muia Evan Sadler laboratory	WORK-IN-PROGRESS Gga2 Knockout Mice Revisited pH Dependent Activity of ADAMTS13 and Self-regulatory Mechanisms
Jan 15, 2013	Jongseong Kim, PhD Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School	Single-molecule Mechanobiology of Von Willebrand Factor (VWF) to Arbitrate Between Bleeding, Hemostasis, and Thrombosis
Jan 18, 2013	J. Evan Sadler, MD, PhD Hematology Division	Assembly and Destruction of von Willebrand Factor
Jan 25, 2013	Sarah Amend Kathy Weilbaecher laboratory Terrence Wong Dan Link laboratory	WORK-IN-PROGRESS Of Mice and Men: Genetic Contributions of Susceptibility to MGUS, the Requisite Precursor of Multiple Myeloma The Genetics of Therapy-related AML
Feb 1, 2013	Stuart Kornfeld, MD Hematology Division	New Insights into the Man-6-P Lysosomal Targeting Pathway Through Analysis of Mutations in I-cell Disease and Pseudo-Hurler Polydystrophy
Feb 7, 2013	Eirini Trompouki, PhD Division of Hematology Oncology, Children’s Hospital Boston	From Zebrafish to Man: BMP and Wnt Signaling Pathways in Normal and Stress Hematopoiesis
Feb 8, 2013	Adam Searleman Ron Bose laboratory Kristen Sanfilippo Ken Carson laboratory	WORK-IN-PROGRESS Mechanisms of Transformation in HER2-Overexpressing Mammary Epithelium Thrombosis in Myeloma
Feb 14, 2013	Dhvanit I. Shah, PhD Division of Hematology, Brigham and Women’s Hospital, Boston	Genetic Screen to Identify Genes Regulating Hematopoiesis
Feb 15, 2013	George J. Broze Jr., MD Hematology Division	Translational Studies of Tissue Factor Inhibitors
Feb 22, 2013	Leili Dolatshahi Evan Sadler laboratory Meagan Jacoby Matt Walter laboratory	WORK-IN-PROGRESS Adjuvant Low Dose Rituximab for Patients with TTP Dysfunctional Double Strand Break Repair in Therapy-related AML
Mar 1, 2013	Garima Gupta Evan Sadler laboratory Mathew Cherian Lee Ratner laboratory	WORK-IN-PROGRESS Non-catalytic Interaction Between VWF and ADAMTS-13 Role of PI3K-Akt-mTOR in HTLV-Tax Induced Transformation
Mar 8, 2013	Katherine N. Weilbaecher, MD Oncology Division, Molecular Oncology Section	Targeting Beta3 Integrin Pathway Genes to Treat Cancer
Mar 15, 2013	David B. Wilson, MD, PhD Division of Hematology/Oncology, Department of Pediatrics	Adrenocortical Development and Tumorigenesis: the Saga of Rosie
Mar 21, 2013	Luis F. Z. Batista, PhD Department of Medicine/Hematology, Stanford University	Human iPS Cells as a Model to Study Telomere Dysfunction-induced Disease
Mar 22, 2013	Christopher Cole Tim Ley laboratory Jian Zhu Evan Sadler laboratory	WORK-IN-PROGRESS Role of DNMT3A in Acute Promyelocytic Leukemia Regulation of ADAMTS13 Activity
Mar 29, 2013	Stephen T. Oh, MD, PhD Hematology Division	Towards an Understanding of Genetic and Phenotypic Complexity in Myeloproliferative Neoplasms
Apr 5, 2013	Maria Trissal Dan Link laboratory Wang-Sik Lee Stuart Kornfeld laboratory	WORK-IN-PROGRESS Dysregulation of the Imprinted DLK1-DIO3 Locus in Promyelocytic Leukemia Structure and Function of the DUF2233 Domain in Bacteria and in Human UCE
Apr 11, 2013	Christopher M. Sturgeon, PhD McEwen Centre for Regenerative Medicine, Toronto	Modeling Developmental Hematopoiesis Using Pluripotent Stem Cells
Apr 12, 2013	Katherine P. Ponder, MD Hematology Division	The Effect of Gene Therapy for Mucopolysaccharidosis After a Decade
Apr 19, 2013	Rachel Idol Stuart Kornfeld laboratory	WORK-IN-PROGRESS CNS Defects in Mice Lacking Mannose-6-Phosphate
Apr 26, 2013	Anna M. Randi, PhD National Heart & Lung Institute, Imperial College London	Von Willebrand Factor Regulates Angiogenesis and Endothelial Progenitors’ Function
May 3, 2013	Betsy Engle Stephen Oh laboratory Timothy Collier Ron Bose laboratory	WORK-IN-PROGRESS Genetic Complexity and Clonal Evolution in Myeloproliferative Neoplasms Probing the Structure and Dimerization of EGFR Family Tyrosine Kinases
May 10, 2013	Michael H. Tomasson, MD Oncology Division, Molecular Oncology Section	The Role of Orphan snoRNA ACA11 in the Pathogenesis of t(4;14)-positive Multiple Myeloma
Sep 6, 2013	David G. DeNardo, PhD Oncology Division, Molecular Oncology Section	Reprogramming Macrophages to Improve Responses to Chemo- and Immunotherapy

2011-2012

Date	Speaker	Title
Sep 7, 2011	Jeff Lichtman, MD Harvard University	INTERDISCIPLINARY SEMINAR SERIES [SPONSORED BY BIOCHEMISTRY & MOLECULAR BIOPHYSICS, BIOMEDICAL ENGINEERING, CELL BIOLOGY & PHYSIOLOGY, DEVELOPMENTAL BIOLOGY, INTERNAL MEDICINE (HEMATOLOGY), AND PEDIATRICS] Imaging the Connectome
Sep 14, 2011	John D. York, PhD Howard Hughes Medical Institute, Duke University	INTERDISCIPLINARY SEMINAR SERIES Inositol Phosphate Communication: Insights into the Cell’s ‘iPhone’
Sep 16, 2011	Jing (Christie) Huang Evan Sadler laboratory Wang-Sik Lee Stuart Kornfeld laboratory	WORK-IN-PROGRESS Cells as a Model System to Study Weibel-Palade Body Targeting and Regulated Secretion of Ultra-large von Willebrand Factor Update on Studies of Mutations Found in the Gene Encoding Uncovering Enzyme in Individuals with Persistent Stuttering
Sep 21, 2011	Matthew Vander Heiden, MD, PhD Massachusetts Institute of Technology	INTERDISCIPLINARY SEMINAR SERIES Metabolic Alterations that Support Cell Proliferation
Sep 28, 2011	Alejandro Sánchez Alvarado, PhD Stowers Institute	INTERDISCIPLINARY SEMINAR SERIES Regeneration: New Parts from Old
Sep 30, 2011	Margaret Young Tim Ley laboratory Ryan Sullivan Todd Fehniger laboratory	WORK-IN-PROGRESS Canonical and Non-canonical HOX Expression Patterns in Acute Myelogenous Leukemia MicroRNA Deficient Natural Killer Cells Exhibit Decreased Survival but Enhanced Cytokine Production and Degranulation Capacity
Oct 5, 2011	Timothy J. Ley, MD Washington University School of Medicine	INTERDISCIPLINARY SEMINAR SERIES The AML Genome
Oct 14, 2011	Eline van Meel Stuart Kornfeld laboratory Matthew Ndonwi George Broze laboratory	WORK-IN-PROGRESS Discovery of the First Disease Causing Mutations in Methionyl-tRNA Synthetase (MARS) Studies on Lipoprotein-free and Lipoprotein-associated Plasma Tissue Factor Pathway Inhibitor
Oct 19, 2011	Carl-Philipp Heisenberg, PhD Institute of Science and Technology Austria	INTERDISCIPLINARY SEMINAR SERIES Cell and Tissue Mechanics in Zebrafish Gastrulation
Oct 26, 2011	Mimi Koehl, PhD University of California, Berkeley	INTERDISCIPLINARY SEMINAR SERIES Fluid Mechanics of Larvae
Nov 4, 2011	Robert P. Mecham, PhD Department of Cell Biology & Physiology	Regulation of Growth Factor Activity by Extracellular Matrix
Nov 11, 2011	Cara Lunn Matt Walter laboratory Jasna Marjanovic Phil Majerus laboratory	WORK-IN-PROGRESS U2AF1 Mutations in Myelodysplastic Syndromes
Nov 18, 2011	Ajit Varki, MD University of California, San Diego	39TH CARL MOORE LECTURE Adventures in Anthropogeny: From Sialic Acids to Human Uniqueness
Dec 2, 2011	Angela Verdoni Tim Ley laboratory Ren-Huai Huang Evan Sadler laboratory	WORK-IN-PROGRESS Understanding the Role of DNA Methyltransferase 3A Mutations in Acute Myeloid Leukemia Pathogenesis Von Willbrand Factor Assembly by D-domains Before Furin Cleavage
Dec 16, 2011	Monica Qian Stuart Kornfeld laboratory Radhika Jagannathan Greg Longmore laboratory	WORK-IN-PROGRESS Functions of the α, β and γ Subunits of UDP-G1cNAc:Lysosomal Enzyme N-acetylglucosamine-1-phosphotransferase Negative Regulation of the Hippo Pathway by the Ajuba LIM Family of Proteins
Jan 6, 2012	Cynthia Kenyon, PhD University of California, San Francisco	4TH ROSALIND KORNFELD LECTURE Genes and Cells that Affect the Rate of C. elegans’ Aging
Jan 13, 2012	J. Evan Sadler, MD, PhD Division of Hematology	Von Willebrand Factor, ADAMTS13, and Thrombotic Microangiopathy
Jan 20, 2012	Daniel Fisher Steve Oh laboratory Jaebok Choi John DiPersio laboratory	WORK-IN-PROGRESS Mass Cytometry Study of Human Myeloproliferative Neoplasia Interferon Gamma Receptor Signaling and T Cell Trafficking in Graft vs. Host Disease
Jan 25, 2012	Katherine A. High, MD The Children’s Hospital of Philadelphia	BIOLOGIC THERAPEUTICS / HEMATOLOGY JOINT SEMINAR In Vivo Gene Transfer for Genetic Disease: Progress and Challenges
Feb 3, 2012	Tom Girard George Broze laboratory Dhanam Anbukumar Evan Sadler laboratory	WORK-IN-PROGRESS Tissue Factor Pathway Inhibitor – βefore and αfter Calcium Binding Studies of von Willebrand Factor Propeptide
Feb 9, 2012	Ann Mullally, MD Harvard Medical School	Characterizing and Therapeutically Targeting MPN Stem Cells in Vivo
Feb 10, 2012	Shin-Ichiro Imai, MD, PhD Department of Developmental Biology	Towards Productive Aging: The Importance of SIRT1 and NAMPT-mediated NAD Biosynthesis in the NAD World
Feb 17, 2012	Balraj Doray Stuart Kornfeld laboratory Joshua Muia Evan Sadler laboratory	WORK-IN-PROGRESS GGA Null Mice: The Final Chapter? Or Not? An Optimized Fluorogenic Assay for ADAMTS13 and Inhibitors in Thrombotic Thrombocytopenic Purpura Patients
Feb 24, 2012	Clay F. Semenkovich, MD Division of Endocrinology, Metabolism & Lipid Research	Lipogenesis: Much More Than Making Fat
Mar 2, 2012	Mark Schroeder John DiPersio laboratory Sarah Amend Kathy Weilbaecher laboratory	WORK-IN-PROGRESS Mobilization of Allogeniec Sibling Peripheral Blood Stem Cell Donors with GM-CSF and Plerixafor – an Interim Analysis Identification of the Genetic Basis of MGUS and Multiple Myeloma Susceptibility in KaLwRij Mice
Mar 9, 2012	Mary C. Dinauer, MD, PhD Department of Pediatrics	Getting a License to Kill: Regulation of the Leukocyte NADPH Oxidase
Mar 16, 2012	Adam Searleman Ron Bose laboratory	WORK-IN-PROGRESS Characterization of a Mouse Model of Ductal Carcinoma In Situ of the Breast
Mar 23, 2012	James H. Morrissey, PhD University of Illinois at Urbana-Champaign	Platelet Polyphosphate at the Nexus of Blood Clotting and Inflammation
Mar 30, 2012	Jian Zhu Evan Sadler laboratory Megan Jacoby Matt Walter laboratory	WORK-IN-PROGRESS Small-angle X-ray Scattering Studies of ADAMTS13 Demonstrate a Conformational Response to Substrate Binding in Solution Dysfunctional Double Strand Break Repair is Present in a Subset of Therapy-related MDS/AML Myeloblasts
Apr 6, 2012	John P. Atkinson, MD Division of Rheumatology	Atypical Hemolytic Uremic Syndrome
Apr 13, 2012	Chunfen Zhang Phil Majerus laboratory Maria Trissal Dan Link laboratory	WORK-IN-PROGRESS The role of Myotubularin-related Phosphatases MTMR8 and MTMR9 in the Control of Autophagy Small Non Coding RNAs in Normal and Malignant Hematopoiesis
Apr 20, 2012	Kyunghee Choi, PhD Department of Pathology & Immunology	Regulation of Hematopoietic and Vascular Development
May 4, 2012	Weikai Li, PhD Department of Biochemistry & Molecular Biophysics	Structure and Function of Vitamin K Epoxide Reductase: Connecting Oxidative Protein Folding with Blood Coagulation
May 11, 2012	Rachel Idol Stuart Kornfeld laboratory	WORK-IN-PROGRESS Uncovering New Phenotypes in Uncovering Enzyme-Deficient Mice
May 18, 2012	Stephen Oh K12 Training Grant Awardee	WORK-IN-PROGRESS JAK2 and Beyond: Genomics and Signaling in Myeloproliferative Neoplasms

2010-2011

Date	Speaker	Title
Sep 10, 2010	Erin O’Shea, PhD Department of Molecular and Cellular Biology, Harvard University	3RD ROSALIND KORNFELD LECTURE Translating DNA Sequence into Gene Expression Output
Sep 17, 2010	Jing Huang Evan Sadler laboratory	WORK-IN-PROGRESS The B Subunits of Shiga-like Toxins Induce Regulated VWF Secretion in a Phospholipase D1 Dependent Manner
Sep 24, 2010	Monita P. Wilson, PhD Division of Hematology	A Mouse Model Linking Aberrant Inositol Metabolism to Defects in Neural Development
Oct 1, 2010	Wang-Sik Lee Stuart Kornfeld laboratory Lucas Wartman Tim Ley laboratory	WORK-IN-PROGRESS Update of the Uncovering Enzyme Research with Stutterers’ mutations Conserved Progression Mutations in Mouse and Human Leukemia Genomes
Oct 8, 2010	Daniel C. Link, MD Division of Oncology	Regulation of Stem Cell and Neutrophil Trafficking from the Bone Marrow
Oct 15, 2010	Marina Kisseleva Phil Majerus laboratory Matthew Ndonwi George Broze laboratory	WORK-IN-PROGRESS O, Brother, Where Art Thou? MTMR8 and MTMR9 Journey Inside the Cell Interaction of TFPI with Factor V
Oct 22, 2010	Douglas M. Tollefsen, MD, PhD Division of Hematology	Activation of Heparin Cofactor II by Arterial Dermatan Sulfate
Nov 5, 2010	Philip W. Majerus, MD Division of Hematology	Inositol Signaling in Human Disease
Nov 12, 2010	Terry Riehl Bill Stenson and Doug Tollefsen laboratories Cara Lunn Matt Walter laboratory	WORK-IN-PROGRESS COX-1+/-COX-2-/- Genotype in Mice is Associated with Shortened Time to Carotid Artery Occlusion Through Increased PAI-1 Discovery of Mutations in Myelodysplastic Syndrome Genomes
Nov 19, 2010	Hal Dietz, MD Institute of Genetic Medicine, Johns Hopkins University	38TH CARL MOORE LECTURE TGFβ in the Pathogenesis and Prevention of Aneurysm: Embracing Paradox
Dec 10, 2010	George J. Broze, Jr., MD Division of Hematology	Tissue Factor Pathway Inhibitor
Dec 17, 2010	Monica Qian Stuart Kornfeld laboratory Paul Bigg Kathy Ponder laboratory	WORK-IN-PROGRESS UDP-GlcNAc:Lysosomal Enzyme N-Acetylglucosamine-1-Phosphotransferase The Pathogenesis of Mitral Valve Disease in Mucopolysaccharidosis VII Dogs
Jan 7, 2011	Brian Van Tine Matthew Ellis and Jim Hsieh laboratories Tom Girard George Broze laboratory	WORK-IN-PROGRESS Taspase1 and HER2+ Breast Cancer The Ups and Downs of Protein Z and the Z-dependent Protease Inhibitor
Jan 14, 2011	Stuart Kornfeld, MD and Terra D. Barnes, PhD Division of Hematology and Department of Anatomy & Neurobiology	The Mannose 6-Phosphate Lysosomal Targeting Pathway and Persistent Stuttering
Jan 21, 2011	Meagan Jacoby Matt Walter laboratory	WORK-IN-PROGRESS DNA Repair Dysfunction in Primary Therapy-related AML/MDS Myeloblasts
Jan 28, 2011	Gregory D. Longmore, MD Division of Hematology	Epithelial Morphogenesis in Development and Disease
Feb 4, 2011	Mark Schroeder John DiPersio laboratory Jennifer Govero Stuart Kornfeld laboratory	WORK-IN-PROGRESS Exploring Cytokines to Treat Graft-vs-Host Disease Strain Dependent Lethality of GGA2 Null Mice: Embryonic vs Neonatal
Feb 11, 2011	Helen M. Piwnica-Worms, PhD Department of Cell Biology & Physiology	Translation of Fundamental Cell Cycle Principles to Targeted Cancer Therapies
Feb 18, 2011	Margaret Young Tim Ley laboratory Ren-Huai Huang Evan Sadler laboratory	WORK-IN-PROGRESS Whole Genome Sequencing of Murine Induced Pluripotent Stem Cells Calcium and pH-Dependent Interactions Within VWF Tubule
Mar 4, 2011	Balraj Doray Stuart Kornfeld laboratory Radhika Jagannathan Greg Longmore laboratory	WORK-IN-PROGRESS GGA Autoinhibition Re-revisited: Do Internal Dileucines Bind GGA VHS Domains Negative Regulation of the Salvador-Warts-Hippo Pathway by the Ajuba LIM Family of Proteins
Mar 11, 2011	Ron Bose, MD, PhD Division of Oncology	Kinase Activation and Signaling: How Does the Her2 Tyrosine Kinase Give Rise to Breast Cancer?
Mar 18, 2011	Ghada Kunter Dan Link laboratory Jian Zhu Evan Sadler laboratory	WORK-IN-PROGRESS Molecular Pathogenesis of Leukemia in Severe Congenital Neutropenia Structural and Functional Study of ADAMTS13
Apr 1, 2011	Adam Searleman Ron Bose laboratory David Tran Greg Longmore laboratory	WORK-IN-PROGRESS Determination of In Vivo Signaling Networks Governing Ductal Carcinoma In Situ Progression The Snail1-Twist1 Cooperation in EMT Maintenance and Cancer Dormancy
Apr 8, 2011	Elaine M. Majerus, MD, PhD Division of Hematology	Studies with an Enhancer of VWF Cleavage–A Novel Potential Anti-thrombotic?
Apr 22, 2011	Katherine P. Ponder, MD Division of Hematology	The Pathogenesis of Mucopolysaccharidosis May Involve Complement Activation
Apr 29, 2011	Chunfen Zhang Phil Majerus laboratory	WORK-IN-PROGRESS Lysine Acetylation of Inositol 1,3,4-Trisphosphate 5/6 Kinase
May 6, 2011	Lawrence F. “Skip” Brass, MD, PhD Division of Hematology/Oncology, University of Pennsylvania	Dynamic Regulation of Platelet Accumulation Following Vascular Injury
May 13, 2011	Maria Trissal Dan Link laboratory Guilherme Baldo Kathy Ponder laboratory	WORK-IN-PROGRESS Role of Small Non-coding RNAs in Normal and Malignant Hematopoiesis Pathogenesis of the Aortic Valve Disease in MPS VII
May 20, 2011	Stephen T. Oh, MD, PhD Division of Hematology	The Missing LNK: Mechanisms of Dysregulated Signaling in Myeloproliferative Neoplasms
May 27, 2011	Rachel Idol Stuart Kornfeld laboratory	WORK-IN-PROGRESS Phenotypic Analysis of Phosphotransferase Deficient Mice
Jun 1, 2011	Thomas F. Deuel, MD Harvard Medical School and The Scripps Research Institute	Shaping the Tumor Phenotype and Microenvironment: New Pathways, New Therapeutic Targets

2009-2010

Date	Speaker	Title
Sep 11, 2009	Gregory D. Longmore, MD Division of Hematology	Epithelial Morphogenesis in Development and Cancer
Sep 18, 2009	Baiwei Gu Monica Bessler and Phil Mason laboratory Ren-Huai Huang Evan Sadler laboratory	WORK-IN-PROGRESS DNA Damage Accumulation, Accelerated Hematopoietic Stem Cell Aging, and Partial Reversal by Antioxidant Treatment in a Mouse Model of Dyskeratosis Congenita A Structural Explanation for the Antithrombotic Activity of ARC1172, a DNA Aptamer that Binds Von Willebrand Factor Domain A1
Sep 25, 2009	George J. Broze, Jr., MD Division of Hematology	Regulation of Coagulation
Oct 2, 2009	Marielle Boonen Stuart Kornfeld laboratory Jing (Christie) Huang Evan Sadler laboratory	WORK-IN-PROGRESS Mucolipidosis Type II Mice Accumulate Autophagolysosomes in Fibroblasts and Serous/mucous Type Secretory Cells The B Subunits of Type 1 and Type 2 Shiga-like Toxins Induce Regulated VWF Secretion in a Phospholipase D Dependent Manner
Oct 16, 2009	Matthew Ndonwi George Broze laboratory	WORK-IN-PROGRESS Effect of Malarial Histidine-rich Protein II (HRPII) on Blood Coagulation
Oct 23, 2009	Audrey R. Odom, MD, PhD Department of Pediatrics	Malaria
Oct 30, 2009	Joan A. Steitz, PhD Department of Molecular Biophysics & Biochemistry, Yale University	2ND ROSALIND KORNFELD LECTURE Regulating the Activity of MicroRNAs in Vertebrate Cells
Nov 6, 2009	Gerald I. Shulman, MD, PhD Department of Internal Medicine, Yale University	37TH CARL MOORE LECTURE Cellular Mechanisms of Insulin Resistance: Implications for Obesity, Lipodystrophy, Metabolic Syndrome and Type 2 Diabetes
Nov 20, 2009	Daniel S. Ory, MD Division of Cardiology	The Niemann-Pick C Pathway: a Key Regulator of Cholesterol Homeostasis
Dec 11, 2009	Balraj Doray Stuart Kornfeld laboratory Trish Anderson Evan Sadler laboratory	WORK-IN-PROGRESS Characterization of Mouse GGA2 Antibodies More on ADAMTS13 Spacer Domain and VWF Substrate Recognition
Jan 8, 2010	Marina Kisseleva Phil Majerus laboratory Kazuhiko Ikeda Monica Bessler and Phil Mason laboratory	WORK-IN-PROGRESS Regulation of Nuclear PI(5)P in Stress Signaling Myeloproliferative Neoplasm-like Hematopoiesis in Mice with Truncated Hmga2 cDNA
Jan 15, 2010	Linda J. Pike, PhD Department of Biochemistry & Molecular Biophysics	Bi-Directional Signaling in the EGF Receptor
Jan 22, 2010	Monica Qian Stuart Kornfeld laboratory Anguo Li Doug Tollefsen laboratory	WORK-IN-PROGRESS Functions of the α, β and γ Subunits of UDP-GlcNAc:Lysosomal Enzyme N-Acetylglucosamine-1-Phosphotransferase Activation of Heparin Cofactor II by Fibroblast Proteoglycans
Jan 29, 2010	Kerry Kornfeld, MD, PhD Department of Developmental Biology	The Role of Zinc in Animal Development and Physiology
Feb 5, 2010	Jingping Ge Monica Bessler and Phil Mason laboratory	WORK-IN-PROGRESS The Consequences of Dyskerin Ablation in Mouse Liver
Feb 26, 2010	Katherine N. Weilbaecher, MD Division of Oncology, Molecular Oncology Section	Hedgehog Signaling in Osteoclasts and Bone Metastasis
Mar 5, 2010	Yukio Fujiki Department of Biology, Kyushu University, Fukuoka, Japan	Peroxisome Biogenesis and Its Dysfunctions in Humans
Mar 12, 2010	Mark S. Sands, PhD Division of Oncology, Stem Cell Biology Section	Lysosomal Dysfunction Results in Altered Energy Balance
Mar 19, 2010	Luke Dang Evan Sadler laboratory Jennifer Govero Stuart Kornfeld laboratory	WORK-IN-PROGRESS Two Histidine Residues Required for the pH Dependent Multimerization of Von Willebrand Factor All GGAs Are Not Created Equal
Mar 26, 2010	David Gailani, MD Departments of Pathology and Medicine, Vanderbilt University	Factor XI and the Intrinsic Pathway in Normal and Pathologic Coagulation
Apr 2, 2010	Rachel Idol Monica Bessler and Phil Mason laboratory	WORK-IN-PROGRESS Mouse Models of Diamond Blackfan Anemia
Apr 23, 2010	Jun Zou Phil Majerus laboratory Chunfen Zhang Phil Majerus laboratory	WORK-IN-PROGRESS Characterization of Myotubularin Related Protein 8 Lysine Acetylation of Inositol 1,3,4-Trisphosphate 5/6-kinase
Apr 30, 2010	Lucio Cocco, MD, PhD Department of Anatomical Sciences, Bologna, Italy	Nuclear Phospholipase C β1 Signalling, MDS and AML: From Bench to Clinics
May 7, 2010	Sandy Chang, MD, PhD Departments of Genetics and Hematopathology, M.D. Anderson Cancer Center	How Telomeres Repress the DNA Damage Response
May 14, 2010	Julie Karue Doug Tollefsen laboratory Ruth Howe Kathy Ponder laboratory	WORK-IN-PROGRESS Function of the N-terminal Domain of Heparin Cofactor II The Role of Cathepsin S and MMP-12 in MPS VII Aortic Disease
May 21, 2010	Weiqiang Gao Evan Sadler laboratory	WORK-IN-PROGRESS Functional Differences of the Non-Catalytic Domains in Human ADAMTS13 and ADAMTS5 in Substrate Cleavage
May 28, 2010	Fang Liu Evan Sadler laboratory	WORK-IN-PROGRESS The Mechanism of VWF Basolateral Secretion in HUVECs

2008-2009

Date	Speaker	Title
Sep 5, 2008	Intaek Lee Stuart Kornfeld laboratory Coy Heldermon Mark Sands laboratory	WORK-IN-PROGRESS The Role of the Gamma-subunit of UDP-GlcNAc:lysosomal Enzyme N-acetylglucosamine-1-phosphotransferase The Effect of Bone Marrow Transplant and Intracranial Gene Therapy in Mucopolysaccharidosis IIIB Mice
Sep 19, 2008	Ren-Huai Huang Evan Sadler laboratory Baiwei Gu Monica Bessler and Phil Mason laboratory	WORK-IN-PROGRESS Structural Basis of VWF for Aptamer Binding and Tubular Storage Is Dyskerin Crucial for Telomere Maintenance, DNA Damage Response and Ageing?
Sep 26, 2008	Monita P. Wilson, PhD Division of Hematology	Neural Tube Defects in Mice with Aberrant Inositol Metabolism
Oct 3, 2008	Marielle Boonen Stuart Kornfeld laboratory John Welch Tim Ley laboratory	Characterization of UCE (Uncovering Enzyme) Knock-out Mouse PML-RARα: Clonal Dominance Precedes Leukemia
Oct 10, 2008	Anmaar Abdul-Nabi Nabeel Yaseen laboratory (Pathology) Priya Gopalan Dan Link laboratory	WORK-IN-PROGRESS Molecular and Biological Effects of AML-associated Fusion Proteins on Primary Human CD34+ Cells Regulation of Hematopoietic Stem Cells by the Bone Marrow Niche
Oct 24, 2008	Jing (Christie) Huang Evan Sadler laboratory Jeff Hiken Phil Mason and Monica Bessler laboratory	WORK-IN-PROGRESS The B-subunits of Shiga-like Toxins 1 and 2 Promote VWF Secretion Via a Cholesterol Sensitive, Clathrin-independent Mechanism in Human Endothelial Cells Quantitative Differences Between Expression Profiles of RBC Proteomes
Oct 31, 2008	Elizabeth Neufeld, PhD Department of Biological Chemistry, David Geffen School of Medicine at UCLA	1ST ROSALIND KORNFELD LECTURE Four Decades of Research on MPS
Nov 7, 2008	Philip J. Mason, PhD Division of Hematology	Telomeres, Ribosomes and Bone Marrow Failure
Nov 14, 2008	Tony Vomund Elaine Majerus laboratory Jennifer Govero Stuart Kornfeld laboratory	WORK-IN-PROGRESS Characterizing the Interaction Between ADAMTS13 and Endothelial Cells Characterization of the GGA Null Mice
Nov 21, 2008	Donald E. Ganem, MD Howard Hughes Medical Institute, University of California, San Francisco	36TH CARL MOORE LECTURE Small Noncoding RNAs and the Biology of Kaposi’s Sarcoma-associated Herpesvirus
Dec 12, 2008	Trish Anderson Evan Sadler laboratory Kazu Ikeda Monica Bessler and Phil Mason laboratory	WORK-IN-PROGRESS Substrate Recognition by the ADAMTS13 Spacer Domain Overexpression of HMGA2 in Normal and PNH Hematopoiesis
Jan 9, 2009	Philip W. Majerus, MD Division of Hematology	Inositols Do It All
Jan 16, 2009	Matthew Ndonwi George Broze laboratory Jun Zou Phil Majerus laboratory	WORK-IN-PROGRESS Malarial Histidine Rich Protein II (HRPII) and Blood Coagulation MTMR9 Increases MTMR6 Enzyme Activity, Stability, and Has a Role in Apoptosis
Jan 23, 2009	Katherine P. Ponder, MD Division of Hematology	The Pathogenesis of Disease in Mucopolysaccharidosis
Jan 30, 2009	Jingping Ge Monica Bessler and Phil Mason laboratory	WORK-IN-PROGRESS Microarray Analysis of snoRNA Expression in Dyskerin Knockout Mice
Feb 6, 2009	J. Evan Sadler, MD, PhD Division of Hematology	Assembly and Destruction of Von Willebrand Factor
Feb 13, 2009	Angie Purvis Evan Sadler laboratory Balraj Doray Stuart Kornfeld laboratory	WORK-IN-PROGRESS pH Dependence of VWF Multimerization and Storage Understanding the GGA Null Phenotype
Feb 20, 2009	Stuart Kornfeld, MD Division of Hematology	New Insights into the Man-6-P Lysosomal Enzyme Targeting System from Mouse Models
Feb 27, 2009	Nayan Sarma Nabeel Yaseen laboratory (Pathology) Rachel Idol Monica Bessler and Phil Mason laboratory	WORK-IN-PROGRESS Molecular Interactions of the Oncogene Nup98-HoxA9 A Mouse Model of Diamond Blackfan Anemia
Mar 13, 2009	Meagan Jacoby Matt Walter laboratory Fang Liu Evan Sadler laboratory	WORK-IN-PROGRESS DNA Repair Genes in Treatment-related AML and MDS Cell Signaling in Stx B Subunit-induced VWF Secretion
Mar 20, 2009	Douglas M. Tollefsen, MD, PhD Division of Hematology	TAP-Annexin V: a Novel Antithrombotic Agent
Mar 27, 2009	Chunfen Zhang Phil Majerus laboratory Rachel Orlowski Elaine Majerus laboratory	WORK-IN-PROGRESS Identification of Lysine Acetylation Sites on Inositol 1,3,4-Trisphosphate 5/6-Kinase Studies with Protein O-fucosyltransferase 2
Apr 3, 2009	Monica Bessler, MD, PhD Division of Hematology	Towards a New Understanding of Bone Marrow Failure
Apr 10, 2009	Mark Schroeder John DiPersio laboratory Weiqiang Gao Evan Sadler laboratory	WORK-IN-PROGRESS Graft Versus Host Disease: a Novel Mouse Model and Therapy Fluorescent VWF Substrates for ADAMTS13
Apr 17, 2009	Elaine M. Majerus, MD, PhD Division of Hematology	Studies on ADAMTS13 and Protein O-fucosyltransferase 2
May 8, 2009	Wang-Sik Lee Stuart Kornfeld laboratory Sharon McDonald Monica Bessler and Phil Mason laboratory	WORK-IN-PROGRESS The Role of the γ-Subunit of GlcNAc-Phosphotransferase Investigating the Interaction of Dyskerin and Pot1b
May 15, 2009	Giri Ramsingh Dan Link laboratory Jason Metcalf Kathy Ponder laboratory	WORK-IN-PROGRESS Characterizing MicroRNAs in Acute Myeloid Leukemia A New and Safer Gene Therapy Vector for Mucopolysaccharidosis I

2007-2008

Date	Speaker	Title
Sep 14, 2007	Ren-Huai Huang Evan Sadler laboratory Shannon Alford Greg Longmore laboratory	WORK-IN-PROGRESS Assembly and Structure of Von Willebrand Factor Tubules in Weibel-Palade Bodies Sphingosine 1-phosphate-mediated Endothelial Cell Migration in Human Platelet Poor Plasma
Sep 21, 2007	Michael H. Tomasson, MD Bone Marrow Transplantation & Leukemia Section, Department of Medicine	Mechanisms of Apoptosis and Transformation in Myc-induced Acute Myeloid Leukemia
Sep 28, 2007	Intaek Lee Stuart Kornfeld laboratory Rachel Idol Monica Bessler and Phil Mason laboratory	WORK-IN-PROGRESS Binding of Cargo Sorting Signals to AP-1 Enhances its Association with ARF1-GTP Human Ribosomal Biogenesis
Oct 5, 2007	Jacques U. Baenziger, MD, PhD Department of Pathology and Immunology
Oct 12, 2007	BaiWei Gu Monica Bessler and Phil Mason laboratory Kyuhwan Shim Evan Sadler laboratory	WORK-IN-PROGRESS Dyskerin, Telomerase and DNA Damage Platelet-von Willebrand Factor Complexes Are Preferred Substrates of ADAMTS13 Under Fluid Shear Stress
Oct 19, 2007	Katherine N. Weilbaecher, MD Molecular Oncology Section, Department of Medicine	CXCR4 Regulation of Osteoclast Development and Tumor Osteolysis
Oct 26, 2007	Balraj Doray Stuart Kornfeld laboratory Weiqiang Gao Evan Sadler laboratory	WORK-IN-PROGRESS Identification of Acidic-dileucine Signals That Bind to GGAs and AP-1/AP-2 Contacts Between Several ADAMTS13 Structural Domains and Von Willebrand Factor Domain A2 Contribute to Substrate Cleavage
Nov 9, 2007	Jun Zou Phil Majerus laboratory Jing (Christie) Huang Evan Sadler laboratory	WORK-IN-PROGRESS Type I Phosphatidylinositol-4,5-bisphosphate 4-phosphatase Regulates Stress-induced Apoptosis The B Subunits of Shiga Toxins Induce Von Willebrand Factor Secretion and Cytoskeletal Remodeling in Human Endothelial Cells
Nov 16, 2007	Arthur Horwich, MD Department of Genetics, Yale University School of Medicine	35TH CARL MOORE LECTURE Protein Folding and Misfolding in the Cell
Nov 30, 2007	Daniel C. Link, MD Stem Cell Biology Section, Department of Medicine	Regulation of the Hematopoietic Stem Cell Niche by G-CSF
Dec 5, 2007	Vytas A. Bankaitis, PhD Department of Cell & Developmental Biology, University of North Carolina, Chapel Hill	A High Resolution Look at a Superfamily of Nanoreactors that Control Phosphoinositide Signaling in Eukaryotic Cells
Dec 14, 2007	Emily H.-Y. Cheng, MD, PhD Molecular Oncology Section, Department of Medicine	Regulation of Cell Death by BCL-2 Family and Beyond
Jan 4, 2008	Fang Liu Evan Sadler laboratory	WORK-IN-PROGRESS The Characteristic of Signaling Pathways Involved in Stx B-induced von Willebrand Factor Secretion
Jan 11, 2008	Lee Ratner, MD, PhD Molecular Oncology Section, Department of Medicine	T-Cell Activation and Lymphoma
Jan 18, 2008	Tony Vomund Elaine Majerus laboratory HongYan Du Monica Bessler and Phil Mason laboratory	WORK-IN-PROGRESS The Interaction of ADAMTS13 and Endothelial Cells The Significance of Telomere Length Measurement in the Diagnosis of Dyskeratosis Congenita
Jan 25, 2008	James J.-D. Hsieh, MD, PhD Molecular Oncology Section, Department of Medicine	Taspase1 Links MLL Proteolysis to Cell Cycle Progression and Beyond
Feb 1, 2008	Zheyong (Jeff) Yu Evan Sadler laboratory Steve Warner Greg Longmore laboratory	WORK-IN-PROGRESS Modulation of ADAMTS13 Activity by Free Amino Acids A Glance at the In Vivo Function of Rho GTPases Through the Fly Eye
Feb 8, 2008	Tom Ellenberger, DVM, PhD Department of Biochemistry and Molecular Biophysics	Chemical Biology of DNA Repair
Feb 15, 2008	Jasna Marjanovic Phil Majerus laboratory Jeff Hiken Monica Bessler and Phil Mason laboratory	WORK-IN-PROGRESS Characterization of Myotubularin Related Protein 8 Label-free Quantitative Proteomic Analysis of Normal and PNH RBC Membranes
Feb 22, 2008	Jason D. Weber, PhD Molecular Oncology Section, Department of Medicine	Regulating mRNA Translation Programs in Cancer
Feb 29, 2008	Trish Anderson Evan Sadler laboratory Yunfeng Feng Greg Longmore laboratory	WORK-IN-PROGRESS ADAMTS13 Spacer Domain and Substrate Recognition Regulation of Cell Migration by α-actinin
Mar 7, 2008	Loren S. Michel, MD Medical Oncology Section, Department of Medicine	Oncogenic Role and Therapeutic Targeting of the Transmembrane Protein Trop-2 in Epithelial Tumors
Mar 14, 2008	Anguo Li Doug Tollefsen laboratory Sara Robledo Monica Bessler and Phil Mason laboratory	WORK-IN-PROGRESS Differential Gene Expression of Injured Arteries in HCII Knockout Mice The Role of Human Ribosomal Proteins in the Maturation of rRNA and Ribosome Production
Mar 28, 2008	Bo Jin Evan Sadler laboratory Matthew Ndonwi George Broze laboratory	WORK-IN-PROGRESS Structural Basis of VWF Cleavage by ADAMTS13 Effect of Protein S on Tissue Factor Pathway Inhibitor (TFPI) Activity
Apr 4, 2008	Daniel E. Goldberg, MD, PhD Division of Infectious Diseases, Department of Medicine	Targeting Intraerythrocytic Malaria Parasites for Chemical Destruction
Apr 11, 2008	Angie Purvis Evan Sadler laboratory Jingping Ge Monica Bessler and Phil Mason laboratory	WORK-IN-PROGRESS Von Willebrand Factor: the Free Thiol Saga Continues Is Dyskerin Essential for Cell Survival and Proliferation?
Apr 18, 2008	Jennifer Govero Stuart Kornfeld laboratory Kazuhiko Ikeda Monica Bessler and Phil Mason laboratory	WORK-IN-PROGRESS Characterization of the GGA Null Mice Overexpression of HMGA2 in Normal and PNH Hematopoietic Cells
Apr 25, 2008	Wang-Sik Lee Stuart Kornfeld laboratory	WORK-IN-PROGRESS IFG, a Potential Therapeutic Agent for Gaucher Disease, Reduces Cholesterol Accumulation in Neimann-Pick C1 Fibroblasts
May 2, 2008	Jonathan D. Gitlin, MD Department of Pediatrics	Copper Homeostasis in Early Development
May 9, 2008	Xiucua Ma Kathy Ponder laboratory Jason Metcalf Kathy Ponder laboratory	WORK-IN-PROGRESS A Self-inactivating Retroviral Vector with Improved Safety for Gene Therapy in Mucopolysaccharidosis I Mice Pathogenesis of Short Bones in Mucopolysaccharidosis VII
May 16, 2008	Meghna Das Thakur Greg Longmore laboratory Hendrik Feys Evan Sadler laboratory	WORK-IN-PROGRESS Role of the Ajuba LIM Protein in Size Control in Drosophila Epithelia Understanding ADAMTS13 When Under (Shear) Stress
May 23, 2008	Timothy A. Graubert, MD Stem Cell Biology Section, Department of Medicine	Genetic Basis of Susceptibility to Therapy-related Leukemia

2006-2007

Date	Speaker	Title
Sep 8, 2006	Monita P. Wilson, PhD Division of Hematology	What the Structure of an Inositol Kinase Tells Us About Its Function
Sep 15, 2006	Jason Metcalf Kathy Ponder laboratory Weiqiang Gao Evan Sadler laboratory	WORK-IN-PROGRESS The Role of Fibroblast Growth Factor Signaling in Mucopolysaccharidosis Bone Defects A C-terminal Exosite of von Willebrand Factor Domain A2 Interacts with ADAMTS13 Spacer Domain to Accelerate Substrate Cleavage
Sep 22, 2006	Paul E. Bock, PhD Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN	Blood Coagulation Out of Control: Molecular Sexuality Mechanism of Prothrombin Activation by Staphylocoagulase
Sep 29, 2006	Phillip I. Tarr, MD Division of Gastroenterology and Nutrition, Department of Pediatrics	Escherichia Coli O157:H7 and the Hemolytic Uremic Syndrome: Host and Microbial Aspects
Oct 6, 2006	John D. York, PhD Department of Pharmacology and Cancer Biology, Duke University, Durham, NC	Signaling Specificity: Inositol Polyphosphate Messengers Regulate Drosophila Development
Oct 13, 2006	Yungfeng Feng Greg Longmore laboratory Intaek Lee Stuart Kornfeld laboratory	WORK-IN-PROGRESS RNAi Oriented Loss of Function Research on α-Actinin Crosstalk Between Two Cargo Binding Sites of Adaptor Protein Complex AP-1
Oct 17, 2006	Barry L. Stoddard, PhD Fred Hutchinson Cancer Research Center, Seattle, WA	The Structure of Human Factor VIII and Its Inhibition Via Mutations, Antibodies, and Small Molecules
Oct 20, 2006	Craig B. Thompson, MD Division of Hematology-Oncology, University of Pennsylvania, Philadelphia, PA	34TH CARL MOORE LECTURE Programmed Cell Death: Apoptosis, Autophagy, and Necrosis
Oct 27, 2006	Baiwei Gu Phil Mason and Monica Bessler laboratory Marina Kisseleva Greg Longmore laboratory	WORK-IN-PROGRESS Molecular Mechanism of Mouse Dyskerin Mutation in Telomere Maintenance and Ribosomal RNA Processing Macrophages Plagued by LIM Protein Deficiency
Nov 3, 2006	Stuart Kornfeld, MD Division of Hematology	Toward a Chaperone-based Therapy for Gaucher Disease
Nov 10, 2006	Kyuhwan Shim Evan Sadler laboratory Hilary Luderer Greg Longmore laboratory	WORK-IN-PROGRESS Platelet-VWF Complexes are Preferred Substrates of ADAMTS13 Under Fluid Shear Stress LIMD1: a New Key to Understanding Skeletal Dynamics
Nov 17, 2006	Katherine P. Ponder, MD Division of Hematology	Gene Therapy for Mucopolysaccharidosis
Jan 5, 2007	Douglas M. Tollefsen, MD, PhD Division of Hematology	Heparin Cofactor II Modulates the Response to Arterial Injury
Jan 12, 2007	Rachel Idol Monica Bessler and Phil Mason laboratory Lindsay Ricketts Elaine Majerus laboratory	WORK-IN-PROGRESS Investigations of Ribosomal Biogenesis in Diamond Blackfan Anemia O-fucosylation of ADAMTS13
Jan 19, 2007	Jun Zho Phil Majerus laboratory Holly Epple Greg Longmore laboratory	WORK-IN-PROGRESS The Role of Type I PIP2 4-phosphatase in Stress Signaling From the Skeleton to the Cytoskeleton: Mechanisms of Osteoclast Function
Jan 26, 2007	Gregory D. Longmore, MD Division of Hematology	LIM Proteins and Epithelial Development and Cancer
Feb 2, 2007	Balraj Doray Stuart Kornfeld laboratory Ren-Huai Huang Evan Sadler laboratory	WORK-IN-PROGRESS The α/σ2 Hemicomplex of Clathrin Adaptor AP-2 Harbors the Dileucine Recognition Site How VWF Propeptide and D’D3 Domain Assemble the Storage Rings in Weibel-Palade Bodies
Feb 9, 2007	Hong-Yan Du Phil Mason and Monica Bessler laboratory	WORK-IN-PROGRESS TERT Haploinsufficiency and Telomere Length in Individuals with 5p- Syndrome
Feb 16, 2007	J. Evan Sadler, MD, PhD Division of Hematology	Von Willebrand Factor, ADAMTS13, and the Regulation of Platelet Adhesion
Feb 23, 2007	Matthew J. Walter, MD Stem Cell Biology Section, Division of Oncology	Myelodysplastic Syndrome and Deletions of Chromosome 5q31.2
Mar 2, 2007	Xiucui Ma Kathy Ponder laboratory Jing Huang Evan Sadler laboratory	WORK-IN-PROGRESS Mechanism of Up-regulation of MMP-12 and Cathepsin S in the Aorta of Mucopolysaccharidosis I Mice αvβ3 Integrin is Involved in the Stabilization of Shear-induced Ultra-long VWF Strings on Endothelial Surface
Mar 9, 2007	George J. Broze Jr., MD Division of Hematology	Protein Z-dependent Protease Inhibitor
Mar 16, 2007	Meghna Das Thakur Greg Longmore laboratory Jeff Hiken Monica Bessler and Phil Mason laboratory	WORK-IN-PROGRESS The Role of LIM Proteins in Cell-Cell Adhesion and Epithelial Polarity Proteomic Analysis of PNH RBCs
Mar 23, 2007	Philip W. Majerus, MD Division of Hematology	Phosphatidylinositol Signaling and Human Disease
Mar 30, 2007	Trish Anderson Evan Sadler laboratory Wang-Sik Lee Stuart Kornfeld laboratory	WORK-IN-PROGRESS ADAMTS13 Structure and Function Studies of a Mouse Model with I-cell Disease and Pseudo-Hurler Polydystrophy
Apr 6, 2007	Monica Bessler, MD, PhD Division of Hematology	Housekeeping Ain’t No Joke! The Importance of Ribosome Biogenesis in Human Blood Disorders
Apr 13, 2007	Sara Robledo Monica Bessler and Phil Mason laboratory Jasna Marjanovic Phil Majerus laboratory	WORK-IN-PROGRESS The Role of Ribosomal Proteins in the Pathogenesis of Diamond Blackfan Anemia Phosphatidylinositol-5-phosphate is a Novel Phospholipase C (PLC) Substrate
Apr 20, 2007	Philip J. Mason, PhD Division of Hematology	Telomeres, Ribosomes and Bone Marrow Failure
Apr 27, 2007	Bo Jin Evan Sadler laboratory Ellen Langer Greg Longmore laboratory	WORK-IN-PROGRESS Studies on the von Willebrand Factor Cysteine Knot Domain Ajuba LIM Proteins are Snail Corepressors that Contribute to Xenopus Neural Crest Development
May 4, 2007	Angie Purvis Evan Sadler laboratory Jingpin Ge Monica Bessler and Phil Mason laboratory	WORK-IN-PROGRESS Identification of Cysteine Residues Essential for von Willebrand Factor (VWF) Multimerization: an Elephant is Born Study of the Function of Dyskerin in a Liver Specific Knock-out Mouse Model
May 11, 2007	Jeff Yu Evan Sadler laboratory Mindy Tittiger Kathy Ponder laboratory	WORK-IN-PROGRESS Investigation of the Biological Function of the C-terminal Domains in ADAMTS13 Parallels in Mucopolysaccharidosis (MPS) I and MPS 7 Aortic Disease
May 18, 2007	Elaine M. Majerus, MD, PhD Division of Hematology	Studies on ADAMTS13

2005-2006

Date	Speaker	Title
Sep 2, 2005	William F. Stenson, MD Division of Gastroenterology, Department of Medicine	Prostaglandins and the Epithelial Response to Radiation Injury
Sep 23, 2005	Lijuan Zhang, PhD Division of Laboratory Medicine, Department of Pathology & Immunology	Heparan and Chondroitin Sulfate Glycosaminoglycans: a Journey from Structure to Function
Sep 30, 2005	Anna Margret Halldorsdottir Doug Tollefsen laboratory	WORK-IN-PROGRESS
Oct 7, 2005	Scott Saunders, MD, PhD Developmental Biology & Genetics, Department of Pediatrics	Heparan Sulfate Proteoglycans: Essential Modulators of Cellular Functions at the Plasma Membrane
Oct 14, 2005	John P. Atkinson, MD Division of Rheumatology, Department of Medicine	HUS: Not Enough Regulation of Innate Immunity
Oct 21, 2005	Weiqiang Gao Evan Sadler laboratory	WORK-IN-PROGRESS
Oct 28, 2005	Hongyan Du Monica Bessler and Phil Mason laboratory	WORK-IN-PROGRESS
Nov 4, 2005	Jason D. Weber, PhD Molecular Oncology Section, Department of Medicine	Interpretation of Oncogenic Signals by the Nucleolus
Nov 11, 2005	Eric Green, MD, PhD National Human Genome Research Institute, NIH, Bethesda, MD	33RD CARL MOORE LECTURE Comparative Genomics: Using Evolution to Decode the Human Genome
Nov 18, 2005	Alex Ungewickell Phil Majerus laboratory	WORK-IN-PROGRESS
Dec 2, 2005	Louis J. Muglia, MD, PhD Division of Endocrinology & Diabetes, Department of Pediatrics	Glucocorticoid Receptor Action During Inflammation
Dec 16, 2005	Christine Pham, MD Division of Rheumatology, Department of Medicine	Neutrophil Serine Proteases: Specific Regulatory Effectors of Immunity
Jan 6, 2006	Rich Steet Stuart Kornfeld laboratory	WORK-IN-PROGRESS
Jan 13, 2006	Alison Goate, PhD Department of Psychiatry	A Novel Risk Factor for Alzheimer’s Disease on Chromosome 10
Jan 20, 2006	Matthew Ndonwi George Broze laboratory	WORK-IN-PROGRESS
Jan 27, 2006	William S. Sly, MD Department of Biochemistry & Molecular Biology, St. Louis University	Functional Genomics of Carbonic Anhydrases: From Osteopetrosis to Protein Folding Diseases
Feb 3, 2006	Hilary Luderer Greg Longmore laboratory	WORK-IN-PROGRESS
Feb 10, 2006	Andrey S. Shaw, MD Department of Pathology & Immunology	Macropinocytosis and Nephrotic Syndrome
Feb 17, 2006	Elaine Majerus Hematology Division	WORK-IN-PROGRESS
Feb 24, 2006	Ren-Huai Huang Evan Sadler laboratory	WORK-IN-PROGRESS
Mar 3, 2006	Raj Doray Stuart Kornfeld laboratory	WORK-IN-PROGRESS
Mar 10, 2006	Tusar Giri Doug Tollefsen laboratory	WORK-IN-PROGRESS
Mar 24, 2006	Sheila A. Stewart, Ph D. Department of Cell Biology & Physiology	The Yin and Yang of Cellular Senescence
Apr 7, 2006	Anton McCaffrey, PhD Division of Infectious Diseases, Department of Medicine, University of Iowa, Iowa City, IA	Keep It Down: There’s More Than One Way to Silence a Gene
Apr 14, 2006	Angie Purvis Evan Sadler laboratory	WORK-IN-PROGRESS
Apr 21, 2006	Richard A. Anderson, PhD Department of Pharmacology, University of Wisconsin, Madison, WI	Phosphoinositide Signaling: From Biochemistry to Human Disease
May 5, 2006	Holly Epple Greg Longmore laboratory	WORK-IN-PROGRESS
May 12, 2006	Rachel Idol Monica Bessler and Phil Mason laboratory	WORK-IN-PROGRESS
May 19, 2006	Jun He Monica Bessler and Phil Mason laboratory	WORK-IN-PROGRESS

2004-2005

Date	Speaker	Title
Sep 10, 2004	Shao-Chun Chang, MD, PhD Division of Hematology	The Pathway to Inositol Hexakisphosphate Synthesis
Sep 24, 2004	Emily H.-Y. Cheng, MD, PhD Division of Oncology, Molecular Oncology Section	Apoptotic Checkpoints at the Mitochondrion
Oct 8, 2004	Enrico Di Cera, MD Department of Biochemistry & Molecular Biophysics	Rational Design of a Thrombin Mutant with Potent and Safe Anticoagulant/antithrombotic Activity in Vivo
Oct 22, 2004	Elaine M. Majerus, MD, PhD Division of Hematology	Regulation of VWF Cleaving Protease (ADAMTS13) Activity
Nov 5, 2004	James J.-D. Hsieh, MD, PhD Division of Oncology, Molecular Oncology Section	Taspase1 Cleaves Mixed-lineage Leukemia Proto-oncogene
Nov 12, 2004	Charles J. Sherr, MD, PhD St. Jude Children’s Research Hospital, Memphis, TN	32ND CARL MOORE LECTURE INK4a-ARF: a Marriage of Tumor Suppressors
Nov 19, 2004	Richard A. Steet, PhD Division of Hematology	COG7 Deficiency: a Novel Congenital Disorder of Glycosylation
Dec 10, 2004	Philip W. Majerus, MD Division of Hematology	Inositol Phosphate Signaling
Dec 17, 2004	Gregory D. Longmore, MD Division of Hematology	Role of LIM Proteins in Cell Adhesion and Migration
Jan 7, 2005	Raj Doray Stuart Kornfeld laboratory Angie Purvis Evan Sadler laboratory	WORK-IN-PROGRESS
Jan 14, 2005	Monica Bessler, MD, PhD Division of Hematology	Paroxysmal Nocturnal Hemoglobinuria – From Bench to Bedside
Jan 21, 2005	Trish Anderson Evan Sadler laboratory Steve Pratt Greg Longmore laboratory	WORK-IN-PROGRESS
Jan 28, 2005	Katherine P. Ponder, MD Division of Hematology	Reducing Immune Responses after Gene Therapy for Genetic Diseases
Feb 4, 2005	Marina Kisseleva Greg Longmore laboratory Wang-Sik Lee Stuart Kornfeld laboratory	WORK-IN-PROGRESS
Feb 11, 2005	J. Evan Sadler, MD, PhD Division of Hematology	Von Willebrand Factor, Bleeding, and Thrombosis
Feb 18, 2005	Alex Ungewickell Phil Majerus laboratory Jun He Phil Mason laboratory	WORK-IN-PROGRESS
Feb 25, 2005	Douglas M. Tollefsen, MD, PhD Division of Hematology	Activation of Heparin Cofactor II by Vascular Glycosaminoglycans
Mar 4, 2005	Cristina Vicente Doug Tollefsen laboratory Michael Ward Greg Longmore laboratory	WORK-IN-PROGRESS
Mar 11, 2005	Stuart Kornfeld, MD Division of Hematology	The GGA Family of Coat Proteins – Key Players in Protein Sorting at the Trans-Golgi Network
Mar 18, 2005	Marek Jasinski Monica Bessler laboratory Lingfei Xu Kathy Ponder laboratory	WORK-IN-PROGRESS
Mar 25, 2005	Philip J. Mason, PhD Division of Hematology	Bone Marrow Failure Caused by Inherited Defects in Telomerase
Apr 1, 2005	Ellen Langer Greg Longmore laboratory Kyuhwan Shim Evan Sadler laboratory	WORK-IN-PROGRESS
Apr 15, 2005	Matthew Ndonwi George Broze laboratory Chris Hugge Phil Majerus laboratory	WORK-IN-PROGRESS
Apr 22, 2005	George J. Broze, Jr., MD Division of Hematology	TFPI Alpha and Beta
Apr 29, 2005	Lukas Wartman Stuart Kornfeld laboratory Li He Doug Tollefsen laboratory	WORK-IN-PROGRESS
May 6, 2005	Ajit Varki, MD University of California – San Diego	Selectins and Cancer: Mechanistic Connections with Therapeutic Implications
May 13, 2005	Rich Steet Stuart Kornfeld laboratory Yunfeng Feng Greg Longmore laboratory	WORK-IN-PROGRESS

2003-2004

Date	Speaker	Title
Sep 12, 2003	Robert P. Mecham, PhD Department of Cell Biology & Physiology	Developmental Adaptation of the Mouse Cardiovascular System to Elastin Haploinsufficiency
Sep 26, 2003	Helen M. Piwnica-Worms, PhD Department of Cell Biology & Physiology	Cell Cycle- and Checkpoint-Control: the CHK1/CDC25A Regulatory Pathway
Oct 10, 2003	Janet D. Rowley, MD Department of Medicine, University of Chicago	31ST CARL MOORE LECTURE New Paradigms from Leukemias
Oct 24, 2003	Anthony J. Muslin, MD Department of Medicine, Division of Cardiovascular Diseases	Signaling Protein Function in Cardiovascular Disease
Nov 7, 2003	Thomas J. Baranski, MD, PhD Department of Medicine, Division of Endocrinology, Diabetes & Metabolism	Understanding the Receptor Switch: How Do Hormones Activate G Proteins?
Nov 21, 2003	Jeffrey D. Milbrandt, MD, PhD Department of Pathology & Immunology	Ret Signaling in Development and Disease
Jan 16, 2004	William C. Parks, PhD Department of Pediatrics, Division of Allergy & Pulmonary Medicine	Extracellular Proteolysis in Epithelial Repair and Defense
Jan 30, 2004	Jan A. Nolta, PhD Department of Medicine, Division of Oncology	Immune Deficient Mouse Models for Studying Human Hematopoietic Stem Cell Biology
Feb 13, 2004	Raphael Kopan, PhD Department of Molecular Biology & Pharmacology	Multiple Roles of Notch in Mouse Development and Tissue Renewal
Feb 27, 2004	Jeffrey E. Saffitz, MD, PhD Department of Pathology & Immunology	Mechanisms of Sudden Death in Cardiomyopathies Caused by Mutations in Cell-Cell Junction Proteins
Mar 12, 2004	Scott J. Hultgren, PhD Department of Molecular Microbiology	Intracellular Bacterial Communities in Bacterial Infections
Mar 26, 2004	Daniel P. Kelly, MD Department of Medicine, Division of Cardiovascular Diseases	PPAR Gamma Coactivator-1 (PGC-1): an Inducible Regulator of Cardiac Mitochondrial Biogenesis and Function
Apr 9, 2004	Guojun Bu, PhD Department of Pediatrics	The LDL Receptor Family: What These Receptors Don’t Do
Apr 23, 2004	Herbert W. “Skip” Virgin, MD, PhD Department of Pathology & Immunology	Learning from Growth of an Ungrowable Virus
May 7, 2004	Kendall J. Blumer, PhD Department of Cell Biology & Physiology	RGS Proteins: New Regulators of Blood Pressure Homeostasis and G Protein-mediated Vasoconstrictor Signaling

2002-2003

Date	Speaker	Title
Sep 13, 2002	Philip W. Majerus, MD Hematology Division	Inositol Signaling
Sep 27, 2002	J. Evan Sadler, MD, PhD Hematology Division	VWF, ADAMTS13, and TTP
Oct 11, 2002	Stuart Kornfeld, MD Hematology Division	GGAs – Key Players in Packaging Man-6-P Receptors into Transport Vesicles
Oct 25, 2002	Ajit P. Varki, MD Department of Medicine, University of California, San Diego	Multiple Differences in Sialic Acid Biology Between Humans and Great Apes
Nov 1, 2002	Monica Bessler, MD, PhD Hematology Division	Bone Marrow Failure and Telomerase
Nov 8, 2002	Richard P. Lifton, MD, PhD Department of Genetics, Yale University	30TH CARL MOORE LECTURE New Insights into Cardiovascular, Renal, and Bone Disease from Human Genetic Studies
Nov 22, 2002	Francois Moreau-Gaudry, MD, PhD Laboratory of Molecular Pathology and Gene Therapy, University of Bordeaux	Gene Therapy of a Mouse Model of Protoporphyria with an Erythroid-specific Lentiviral Vector
Dec 13, 2002	George J. Broze, Jr., MD Hematology Division	Regulation of Coagulation by Protein Z
Jan 10, 2003	Daniel E. Goldberg, MD, PhD Departments of Medicine and Molecular Microbiology	Falciparum Malaria: A Hematological Infectious Disease
Jan 24, 2003	Gregory D. Longmore, MD Hematology Division	The Role of Lim Proteins in Cell Adhesion and Motility
Feb 14, 2003	Mary M. Zutter, MD Department of Pathology and Immunology	The α2β1-integrin Deficient Mouse: Defective Platelet and Mast Cell Function
Feb 21, 2003	David Ginsburg, MD Howard Hughes Medical Institute, University of Michigan, Ann Arbor	Disorders of Hemostasis Due to Genes Outside of the Coagulation System
Mar 6, 2003	Philip J. Mason, PhD Department of Haematology, Imperial College, London	Bone Marrow Failure Caused by Inherited Telomerase Deficiency
Mar 7, 2003	Daniel C. Link, MD Division of Stem Cell Biology	Regulation of Hematopoiesis by G-CSF
Mar 14, 2003	Timothy A. Graubert, MD Division of Stem Cell Biology	Modeling t(8;21) Associated Acute Myelogenous Leukemia in Mice
Apr 4, 2003	Mark S. Sands, PhD Division of Stem Cell Biology	Hematopoietic-directed Therapies for Lysosomal Storage Diseases
Apr 18, 2003	Douglas M. Tollefsen, MD, PhD Hematology Division	Heparin Cofactor II and Thrombosis
May 2, 2003	Linda J. Pike, PhD Department of Biochemistry & Molecular Biophysics	EGF Receptors and Lipid Rafts: Bringing Order to Chaos
May 9, 2003	Katherine P. Ponder, MD Hematology Division	Liver-directed Gene Therapy Corrects Hemophilia B and Mucopolysaccharidosis VII in Dogs
May 30, 2003	Nicholas O. Davidson, MBBS Division of Gastroenterology	RNA Editing: Molecular Mechanisms and Biological Consequences

2001-2002

Date	Speaker	Title
Sep 14, 2001	Steven L. Teitelbaum, MD Department of Pathology	RANK Ligand and Bone Cells
Sep 28, 2001	Rainer K. Brachmann, MD Division of Oncology	Stories Of and Around p53
Oct 12, 2001	Michael H. Tomasson, MD Division of Oncology	The Role of Fusion Oncogenes in the Multi-step Pathogenesis of Acute Leukemia
Oct 24, 2001	Steven R. Lentz, MD, PhD Department of Medicine, University of Iowa	Hyperhomocysteinemia
Oct 26, 2001	Douglas C. Dean, PhD Division of Oncology	The Role for Rb in Tumor Suppression
Nov 16, 2001	Robert J. Lefkowitz, MD Department of Medicine, Duke University	29TH CARL MOORE LECTURE G Protein-coupled Receptors and Their Regulation
Nov 30, 2001	Katherine N. Weilbaecher, MD Division of Oncology	The Role of Beta 3 Integrin in Metastasis
Dec 13, 2001	Timothy J. Ley, MD Division of Oncology	Modeling Acute Promyelocytic Leukemia in the Mouse
Jan 11, 2002	Jay W. Heinecke, MD Division of Lipid Research	Regulation of Matrix Metalloproteinase Activation and Plaque Rupture by Myeloperoxidase
Jan 22, 2002	Beni B. Wolf, MD, PhD University of California, San Diego	Evasion of Mitochondria-dependent Apoptosis by Cancer Cells
Jan 25, 2002	Gerald P. Linette, MD, PhD Division of Oncology	Melanoma Cell Death
Feb 22, 2002	David A. Harris, MD, PhD Department of Cell Biology & Physiology	Molecular Mechanisms Underlying Familial Prion Diseases
Mar 8, 2002	Howard L. McLeod, PharmD Division of Oncology	Cancer Pharmacogenomics
Mar 22, 2002	William A. Frazier, PhD Department of Biochemistry & Molecular Biophysics	Integrin Associated Protein (CD47): a Receptor with Multiple Roles in Vascular Disease
Apr 3, 2002	Philip J. Hogg, PhD Department of Pathology, University of New South Wales, Sydney, Australia	Control of von Willebrand Factor Multimer Size by Thrombospondin-1
Apr 19, 2002	David M. Ornitz, MD, PhD Department of Molecular Biology & Pharmacology	FGF and FGF Receptor Signaling in Skeletal Development and Genetic Disease
May 3, 2002	Jean E. Schaffer, MD Division of Cardiology	Models and Mechanisms of Lipotoxicity
May 17, 2002	Clay F. Semenkovich, MD Division of Endocrinology, Diabetes & Metabolism	Fatty Acid Metabolism as a Mediator of Vascular Disease and Beta Cell Failure in Diabetes

2000-2001

Date	Speaker	Title
Sep 8, 2000	David B. Wilson, MD, PhD Department of Pediatrics	Blood and Guts: Erythroid Transcription Factors and Endoderm Development
Sep 22, 2000	Rosalind H. Kornfeld, PhD Division of Hematology	The Mannose 6-Phosphate ‘Uncovering Enzyme’ Resides in the Trans-Golgi Network
Oct 6, 2000	Jonathan D. Gitlin, MD Department of Pediatrics	The Copper Chaperones
Oct 20, 2000	George J. Broze, Jr., MD Division of Hematology	Protein Z and Thrombosis
Nov 3, 2000	Monica Bessler, MD, PhD Division of Hematology	PNH: the Human Disease and Animal Models
Nov 10, 2000	Philip J. Mason, PhD Hammersmith Hospital, Imperial College, London	The Molecular Genetics of Dyskeratosis Congenita
Nov 17, 2000	Stuart Kornfeld, MD Division of Hematology	The Assembly of Clathrin-Coated Vesicles on Golgi Membranes
Dec 8, 2000	Ronald A. DePinho, MD Harvard Medical School	28TH CARL MOORE LECTURE Telomerase, Tumor Suppressors and Tumorigenesis
Jan 12, 2001	J. Evan Sadler, MD, PhD Division of Hematology	Structure and Function of von Willebrand Factor
Jan 26, 2001	John D. York, PhD Duke University Medical Center	Insights into the Biology of Inositol Signaling
Feb 2, 2001	Katherine P. Ponder, MD Division of Hematology	Degradation of Hepatocyte Nuclear Factor 4 Contributes to Liver Failure
Feb 9, 2001	Susan E. Lyons, MD, PhD National Human Genome Research Institute, NIH	Hematopoietic Studies in the Zebra Fish Model
Feb 9, 2001	Douglas M. Tollefsen, MD, PhD Division of Hematology	Function of Heparin Cofactor II in Vitro and in Vivo
Feb 23, 2001	Susan R. Wente, PhD Department of Cell Biology & Physiology	Nuclear Entry and Exit: the Rules and the Players
Mar 9, 2001	Morgan L. McLemore, MD Division of Oncology	The Effect of Granulocyte Colony-Stimulating Factor Receptor (G-CSFR) Mutations on Granulopoiesis
Mar 23, 2001	Gerard Ailhaud, PhD University of Nice	Early Events and Redundancy in Adipogenesis
Apr 6, 2001	Philip W. Majerus, MD Division of Hematology	Intracellular Signaling by Inositol Phosphates
Apr 20, 2001	Gregory D. Longmore, MD Division of Hematology	Red Blood Cell Development and Leukemogenesis
Apr 24, 2001	Colin S. Duckett, PhD Metabolism Branch, National Cancer Institute, NIH	Role of IAP Proteins in the Control of Cell Survival
May 4, 2001	Monita P. Wilson, PhD Division of Hematology	A Promiscuous Inositol Kinase
May 18, 2001	John P. Atkinson, MD Division of Rheumatology	Immune Adherence Revisited

1999-2000

Date	Speaker	Title
Sep 17, 1999	John F. Hancock, MD, PhD University of Queensland Medical School, Brisbane, Australia	Caveolae, Cholesterol and Trafficking: New Insights into Biological Differences Between the Ras Proteins
Oct 1, 1999	Lyuba Varticovski, MD Department of Medicine, Tufts University	Angiopoietins: Signal Transduction and Regulation of Endothelial Cell Biology
Oct 15, 1999	Samuel L. Stanley, Jr., MD Division of Infectious Diseases	Pathways for Amebic Induction of Inflammation and Programmed Cell Death
Nov 5, 1999	Mark S. Sands, PhD Division of Bone Marrow Transplantation & Stem Cell Biology	Gene Therapy for Lysosomal Storage Diseases
Nov 19, 1999	Mark T. Keating, MD University of Utah	27TH CARL MOORE LECTURE Molecular and Cellular Mechanisms of Cardiac Arrhythmias
Dec 10, 1999	Thomas G. Diacovo, MD Department of Pediatrics	Platelets and the Molecular and Cellular Interactions Governing Their Adhesion: From Arterial Injury to Venular Inflammation
Jan 14, 2000	Timothy J. Ley, MD Division of Bone Marrow Transplantation & Stem Cell Biology	How Do Cytotoxic Lymphocytes Kill Their Target?
Jan 28, 2000	Lee Ratner, MD, PhD Division of Medical & Molecular Oncology	Human T-cell Leukemia Virus Tax, Transactivation, and Transformation
Feb 11, 2000	Samuel A. Santoro, MD, PhD Division of Laboratory Medicine, Departments of Medicine and Pathology	Collagen Receptors: From Ligand Binding to Control of Cell Phenotype
Feb 18, 2000	Othon Iliopoulos, MD Dana-Farber Cancer Institute, Harvard Medical School	Functional Analysis of the von Hippel-Lindau Tumor Suppressor Protein
Feb 25, 2000	Thomas J. Baranski, MD, PhD Division of Endocrinology, Diabetes & Metabolism, Departments of Medicine and Molecular Biology & Pharmacology	Genetic Analysis of G Protein Signalling
Mar 3, 2000	Brian J. Druker, MD Department of Medicine, Oregon Health Sciences University	HEMATOLOGY-ONCOLOGY GRAND ROUNDS CML and STI 571: Validating the Promise of Molecularly Targeted Therapy
Mar 7, 2000	Diana M. Gilligan, MD, PhD Yale University School of Medicine, New Haven, CT	Knockout of β-Adducin Causes Spherocytosis in Mice
Mar 10, 2000	Raphael Kopan, PhD Department of Molecular Biology & Pharmacology	Signaling Through Notch: a Proteolytic Cascade Regulating Cell Fate
Mar 24, 2000	Leif W. Ellisen, MD, PhD Harvard Medical School	Acute Leukemia, Telomeres and DNA Damage Responses
Apr 7, 2000	Joanne E. Levy, MD Harvard Medical School	Iron Metabolism: Insights from Mutant Mice
Apr 21, 2000	William C. Hahn, MD, PhD Whitehead Institute, MIT	Telomerase Immortality in Cancer
May 5, 2000	David R. Piwnica-Worms, MD, PhD Departments of Radiology and Molecular Biology & Pharmacology	Molecular Imaging: Functional Identification of MDR1 Pgp Transport Activity in Tumors and Tissues in Vivo

1998-1999

Date	Speaker	Title
Oct 9, 1998	Rainer Brachmann Division of Molecular Oncology	Yeast as a Genetic Tool to Study the Tumor Suppressor Protein p53
Oct 23, 1998	Nancy Andrews Department of Pediatrics, Harvard University	Iron Deficiency and Iron Overload: Insights from Anemic Animals
Nov 20, 1998	Kerry Kornfeld Department of Molecular Biology & Pharmacology	A Modular System of Docking Sites Mediates MAP Kinase Recognition of Substrate Proteins
Dec 11, 1998	Owen Witte UCLA School of Medicine	26TH CARL MOORE LECTURE Hematolymphoid Signal Transduction by Cytoplasmic Tyrosine Kinases
Dec 18, 1998	George Broze Division of Hematology	What About Protein Z?
Jan 8, 1999	Linton Traub Division of Hematology	Lysosomes, Liposomes and Synaptosomes: What Do They Teach Us About Clathrin-coat Assembly?
Jan 22, 1999	Evan Sadler Division of Hematology	Enteropeptidase, Initiator of a Digestive Protease Cascade
Jan 29, 1999	Rosalind Kornfeld Division of Hematology	Cloning and Expression of N-Acetylglucosamine-1-Phosphodiester α-N-Acetylglucosaminidase, a Key Enzyme in Formation of the Mannose-6-Phosphate Targeting Signal
Feb 12, 1999	Doug Tollefsen Division of Hematology	Allosteric Regulation of Thrombin by a Monoclonal Antibody that Binds to Exosite II
Feb 26, 1999	Greg Longmore Division of Hematology	Role of LIM Proteins in Cell Growth
Mar 12, 1999	Kathy Ponder Division of Hematology	Hepatic Gene Therapy for Plasma Protein Deficiencies and Lysosomal Storage Diseases
Mar 26, 1999	Monica Bessler Division of Hematology	Clonal Evolution in Paroxysmal Nocturnal Hemoglobinuria
Apr 7, 1999	Gerardo Lederkremer Department of Cell Research & Immunology, Tel Aviv University, Israel	Location and Regulation of ER/Proteasomal Protein Quality Control
Apr 9, 1999	Stuart Kornfeld Division of Hematology	Clathrin-Coated Vesicle Formation on Liposomes and Golgi Membranes
Apr 23, 1999	Dan Kelly Division of Cardiology	The Role of PPARa as a ‘Lipostat’ Transcription Factor
May 7, 1999	Jacques Baenziger Department of Pathology	The Sulfated Oligosaccharides on LH Reveal the Roles Played by Glycosylation During the Reproductive Cycle
May 21, 1999	Phil Majerus Division of Hematology	Phosphatidyl Inositols in Cell Signaling
Jun 4, 1999	Mike Dustin Department of Pathology	Visualizing Molecular Events in the Immune Response: Building an Immunological Synapse

1997-1998

Date	Speaker	Title
Oct 17, 1997	Monica Bessler Hematology Division	A Mouse Model for Paroxysmal Nocturnal Hemoglobinuria: Use of the Cre/loxP System to Circumvent Embryonic Lethality
Oct 24, 1997	Jeffrey M. Friedman Rockefeller University	25TH CARL MOORE LECTURE Leptin, Leptin Receptors and the Control of Body Weight
Oct 31, 1997	Anthony J. Muslin Cardiovascular Division	The Role of 14-3-3 Protein in Ras-mediated Signal Transduction
Nov 14, 1997	Daniel C. Link Division of BMT & Stem Cell Biology	Role of G-CSF in Hematopoiesis: Lessons from the G-CSF Receptor Knockout Mice
Dec 12, 1997	Herbert W. “Skip” Virgin Departments of Pathology and Molecular Microbiology	Interplay Between Herpesviruses and the Immune System
Dec 19, 1997	John F. DiPersio Division of BMT & Stem Cell Biology	Cytokine Signaling Pathways
Jan 23, 1998	Matthew L. Thomas Department of Pathology	The Regulation of Adhesion and Signal Transduction by Protein Tyrosine Phosphatases
Jan 30, 1998	Craig A. MacArthur Department of Pediatrics	FGF-8 in Development and Tumorigenesis
Feb 13, 1998	Enrico Di Cera Department of Biochemistry and Molecular Biophysics	Thrombin Allostery
Feb 27, 1998	Nancy M. Dahms Department of Biochemistry, Medical College of Wisconsin	Insight into Lysosomal Enzyme Recognition by the Mannose 6-Phosphate Receptors
Mar 13, 1998	Dwight A. Towler Division of Endocrinology, Diabetes, and Metabolism	Structure-Function Analysis of Msx2-Mediated Transcriptional Suppression: Promoter Repression via RAP74 and the FGF Response Element DNA Binding Protein
Apr 10, 1998	Frank A. “Andy” Norris Hematology Division	The Regulation of PI 3-Kinase Signaling by Inositol Polyphosphate 4-Phosphatases
Apr 24, 1998	Daniel E. Goldberg Division of Infectious Diseases	The Pathway of Hemoglobin Degradation in the Malaria Parasite P. falciparum
May 8, 1998	Gregory D. Longmore Hematology Division	Cytokine Regulation of Lineage Commitment During Hematopoiesis
Jun 5, 1998	William S. Sly Department of Biochemistry, St. Louis University Medical School	Mutations in HFE Protein Cause Hemochromatosis
Jun 12, 1998	Minxiang Gu Hematology Division	Characterization of a Novel Protein Tyrosine Phosphatase – PTPMEG

1996-1997

Date	Speaker	Title
Sep 20, 1996	Phil Majerus Hematology Division	Role of Inositol Phosphates in Intracellular Signalling
Oct 4, 1996	George Broze Hematology Division	Effects of Tissue Factor and Tissue Factor Pathway Inhibitor Gene Deletion
Oct 18, 1996	Stuart Kornfeld Hematology Division	Regulation of Mannose Phosphorylation on Lysosomal and Secretory Glycoproteins
Nov 1, 1996	Greg Longmore Hematology Division	Erythropoietin Receptor Signalling and Red Cell Development
Nov 8, 1996	Monica Bessler Department of Human Genetics, Memorial Sloan-Kettering Cancer Institute	Molecular Basis of Paroxysmal Nocturnal Hemoglobinuria
Nov 15, 1996	Richard Klausner National Cancer Institute, NIH	24TH CARL MOORE LECTURE Cancer Genetics: Dissecting a Tumor Suppressor Gene Pathway
Dec 13, 1996	Kathy Ponder Hematology Division	Gene Therapy for Plasma Protein Deficiencies
Jan 24, 1997	Doug Tollefsen Hematology Division	The Two Faces of Thrombin: Interactions of Exosites I and II with Inhibitors
Feb 7, 1997	Rosalind Kornfeld Hematology Division	Enzymes of Glycoprotein Oligosaccharide Processing
Feb 21, 1997	Evan Sadler Hematology Division	Thrombin Structure and Biological Function
Feb 28, 1997	Alan Permutt Endocrinology, Diabetes & Metabolism Division	Genetic Analysis of Monogenic and Polygenic Disorders of Glucose Metabolism
Mar 28, 1997	Dave Wilson Department of Pediatrics	GATA-binding Proteins and Cardiovascular Development
Apr 11, 1997	Rogier M. Bertina University Hospital, Leiden, The Netherlands	Factor V Leiden and Resistance to Activated Protein C
May 2, 1997	Helen Piwnica-Worms Department of Cell Biology & Physiology	Reversible Phosphorylation and Cell Cycle Control
May 9, 1997	Jonathan Gitlin Department of Pediatrics	Aceruloplasminemia
May 16, 1997	Wayne Yokoyama Rheumatology Division	The Emerging Spectrum of NK Cell Receptors
May 23, 1997	David Harris Department of Cell Biology & Physiology	Prion Diseases: a Cell Biological Perspective

1995-1996

Date	Speaker	Title
Sep 15, 1995	Ramesh A. Shivdasani Dana-Farber Cancer Institute, Boston	Transcriptional Control of Cell Fate Determination and Differentiation in Hematopoiesis: Lessons from Knockout Mice
Sep 29, 1995	Anne Bennett Jefferson Hematology Division	Cell Signalling and the Inositol Polyphosphate 5-Phosphatase Isozymes
Oct 13, 1995	William A. Frazier Department of Biochemistry & Molecular Biophysics	Thrombospondin as a Regulator of Endothelial Phenotype
Oct 27, 1995	Robert P. Mecham Department of Cell Biology & Physiology	Intracellular Forms of Extracellular Proteins: Novel Pathway for Cell Regulation
Nov 10, 1995	Schickwann Tsai Fred Hutchinson Cancer Research Center, Seattle	Developmental Control of Hematopoietic Stem Cells and Progenitors by Retinoic Acid Receptors
Nov 17, 1995	Donald B. Kohn UCLA School of Medicine, Los Angeles	Gene Therapy with Hematopoietic Stem Cells
Dec 8, 1995	Michael Rosenfeld University of California, San Diego	23RD CARL MOORE LECTURE Transcriptional Mechanisms of Organ Commitment
Dec 15, 1995	Jack Rohrer Hematology Division	Sorting of Proteins in the Endosomal/Lysosomal System
Jan 19, 1996	John A. Cooper Department of Cell Biology & Physiology	Control of Actin Assembly by Capping Protein
Feb 2, 1996	Richard D. Cummings University of Oklahoma, Oklahoma City	The Glycobiology of Schistosomiasis: From Molecular Mimicry to Autoimmunity
Feb 16, 1996	Douglas C. Dean Department of Medicine	Mechanism of Action of the Retinoblastoma Tumor Suppressor
Mar 1, 1996	Maurine E. Linder Department of Cell Biology & Physiology	G-protein Palmitoylation: Reversible and Regulated Acylation
Mar 29, 1996	Thomas F. Deuel Beth Israel Hospital, Boston	Mechanisms of Transcriptional Regulation by the Wilms Tumor Suppressor Gene
Apr 5, 1996	Julie Hambleton University of California, San Francisco	Activation of MAP Kinase Signaling Pathways in Monocyte/Macrophage Cells
Apr 12, 1996	Katherine A. High Children’s Hospital of Philadelphia	Gene Therapy for Hemophilia
Apr 19, 1996	Michael E. Nesheim Queen’s University, Kingston, Ontario	Isolation, Characterization, and Thrombin-thrombomodulin Dependent Activation of TAFI
Apr 26, 1996	Vytas A. Bankaitis University of Alabama at Birmingham	Phosphatidylinositol Transfer Proteins: a New Class of Intracellular Regulatory Molecules
May 9, 1996	Sandra L. Hofmann University of Texas Southwestern Medical School, Dallas	Palmitoyl-protein Thioesterase and the Pathogenesis of INCL
May 10, 1996	Jay L. Degen Children’s Hospital Research Foundation, Cincinnati	Hard Knocks to the Hemostatic Balance: Fibrinogen and Plasminogen Deficiency in Mice

1994-1995

Date	Speaker	Title
Sep 12, 1994	Naoyuki Taniguchi Osaka University	Transfection of N-acetylglucosaminyltransferase III Gene into Melanomas Suppresses Lung Metastasis
Sep 30, 1994	Zaverio Ruggeri Scripps Research Institute	Mechanisms of Initiation of Platelet Thrombus Formation
Oct 7, 1994	Dave Ornitz	Regulation of FGF/FGF Receptor Activity
Oct 14, 1994	Gary Gilliland Harvard Medical School	Early Mutations in Leukemia
Oct 21, 1994	Jim Ihle St. Jude Children’s Research Hospital	JAKs and STATs in Cytokine Signaling
Oct 28, 1994	Linton Traub	Clathrin-coated Vesicle Assembly on the Golgi
Nov 4, 1994	Ken Kaushansky University of Washington	The Molecular and Cellular Biology of Thrombopoietin, the MPL-ligand
Nov 11, 1994	Stuart Orkin Boston Children’s Hospital	22ND CARL MOORE LECTURE Multi-layered Regulation of Hematopoietic Development and Transcription
Nov 18, 1994	Celeste Simon University of Chicago	Analysis of Hematopoiesis from the Study of Mutant Mice
Dec 9, 1994	Ric Brown	Signal Transduction by Leukocyte Integrins
Dec 16, 1994	Ken Mann University of Vermont	Modeling the Tissue Factor Pathway to Thrombosis: the Coagulation Explosion
Jan 27, 1995	Qingyu Wu	Studies of Thrombin: Mutagenesis and Gene Targeting
Feb 17, 1995	Susan Wente	Nucleocytoplasmic Trafficking: Insights from Yeast Nuclear Pore Complex Mutants
Mar 3, 1995	John Hancock	Ras Proteins: Membrane Targeting and Biochemical Function
Mar 17, 1995	John Sheehan	Molecular Mechanism of Thrombin Regulation
Apr 7, 1995	Dave Gailani	The Role of Factor XI in a Revised Model of Blood Coagulation
Apr 21, 1995	Helen Heslop St. Jude Children’s Research Hospital	Use of Virus-specific Cytotoxic T Lymphocytes to Control Epstein-Barr Virus-related Lymphoproliferation
May 5, 1995	Dan Link	G-CSF Receptor Signals
May 19, 1995	Tom Look St. Jude Children’s Research Hospital	Chimeric Transcriptional Control Genes in Human Acute Leukemia

1993-1994

Date	Speaker	Title
Sep 24, 1993	Guy Salvesen Duke University	Inhibition of IL-1beta Activation by a Virally Encoded Proteinase Inhibitor
Oct 22, 1993	Nancy Andrews Harvard University	An Erythroid Transcription Factor Regulating Globin Gene Expression and Iron Metabolism
Oct 28, 1993	Richard Lawn Stanford University	Lipoprotein(a)
Oct 29, 1993	Mark Sands University of Pennsylvania	Molecular Characterization of the Genetic Defect and Modes of Treatment in Murine Mucopolysaccharidosis Type 7
Nov 2, 1993	Jules Shafer Merck	Identification of Amino Acid Residues Important for the Heparin-catalyzed Inactivation of Thrombin by Antithrombin III
Nov 5, 1993	Stanley Prusiner University of California, San Francisco	21ST CARL MOORE LECTURE Transgenetic and Protein Structural Approaches to Unraveling the Enigmas of Prion Diseases
Nov 12, 1993	Angel Lee	CSF-1 Receptor: Mechanisms of Intracellular Signalling
Nov 19, 1993	John Dick University of Toronto	Modeling Normal and Leukemic Hematopoiesis in SCID Mice
Dec 16, 1993	Hans Geuze University of Utrecht	New Observations on the Class II Compartment in B Lymphoblasts
Mar 4, 1994	Andy Chan	Link Protein Tyrosine Kinases in T Cell Activation: Bench to Bedside
Mar 11, 1994	Sam Santoro	Structure, Function and Regulation of the a2b1 Integrin
Mar 18, 1994	Fred Kolhouse University of Colorado	The Mechanism of Cellular Uptake of Folate and Methotrexate in Human Cells
Apr 8, 1994	Kathy Hajjar Cornell University	Annexin II: a New Thromboregulatory Protein?
Apr 22, 1994	Susan Bock Temple University	Antithrombin III and Serpin Structure/Function Studies
May 20, 1994	Randal Kaufman University of Michigan	Regulation of Protein Transport Through the Endoplasmic Reticulum Mediated by BiP
Jun 9, 1994	Mark Goldsmith University of California, San Francisco	Structure/function Relationships Within the IL-2 Receptor Complex