Faculty
Oncology Division
Alphabetical list (active faculty):   
Grazia Abou-Ezzi

Grazia Abou-Ezzi, PhD

Instructor

Department of Medicine

Oncology Division

Stem Cell Biology

Research Interests

  • Bone marrow niche and its interaction with the hematopoietic compartment
  • The possible presence of a specialized niche in other vital organs (e.g., intestine and spleen)

Contact

  • 314-362-8872 (office)
  • 314-362-1953 (fax)
  • Division of Oncology
    Campus Box 8007
    Washington University
    660 South Euclid Avenue
    St. Louis, MO 63110
  • Room 724, Southwest Tower (office)
  • Room 724, Southwest Tower (lab)

Original Articles

  • Canonical Signaling by TGF Family Members in Mesenchymal Stromal Cells Is Dispensable for Hematopoietic Niche Maintenance Under Basal and Stress Conditions
    Krambs JR, Abou-Ezzi G, Yao JC, Link DC
    PLoS One 2020 May 29;15(5):e0233751
  • TGF-Beta Signaling Plays an Essential Role in the Lineage Specification of Mesenchymal Stem/Progenitor Cells in Fetal Bone Marrow
    Abou-Ezzi G, Supakorndej T, Zhang J, Anthony B, Krambs J, Celik H, Karpova D, Craft CS, Link DC
    Stem Cell Reports 2019 Jul 9;13(1):48-60
  • Targeting VLA4 Integrin and CXCR2 Mobilizes Serially Repopulating Hematopoietic Stem Cells
    Karpova D, Rettig MP, Ritchey J, Cancilla D, Christ S, Gehrs L, Chendamarai E, Evbuomwan MO, Holt M, Zhang J, Abou-Ezzi G, Celik H, Wiercinska E, Yang W, Gao F, Eissenberg LG, Heier RF, Arnett SD, Meyers MJ, Prinsen MJ, Griggs DW, Trumpp A, Ruminski PG, Morrow DM, Bonig HB, Link DC, DiPersio JF
    J Clin Invest 2019 May 14;130
  • Bone Marrow Dendritic Cells Regulate Hematopoietic Stem/Progenitor Cell Trafficking
    Zhang J, Supakorndej T, Krambs JR, Rao M, Abou-Ezzi G, Ye RY, Li S, Trinkaus K, Link DC
    J Clin Invest 2019 Apr 30;130
  • Site-1 Protease Regulates Skeletal Stem Cell Population and Osteogenic Differentiation in Mice
    Patra D, DeLassus E, Mueller J, Abou-Ezzi G, Sandell LJ
    Biol Open 2018 Feb 22;7(2)
  • Continuous Blockade of CXCR4 Results in Dramatic Mobilization and Expansion of Hematopoietic Stem and Progenitor Cells
    Karpova D, Ritchey JK, Holt MS, Abou-Ezzi G, Monlish D, Batoon L, Millard S, Spohn G, Wiercinska E, Chendamarai E, Yang W, Christ S, Gehrs L, Schuettpelz LG, Dembowsky K, Pettit AR, Rettig MP, Bonig H, DiPersio JF
    Blood 2017 May 25;129(21):2939-2949
  • N-Cadherin Regulation of Bone Growth and Homeostasis Is Osteolineage Stage-Specific
    Fontana F, Hickman-Brecks CL, Salazar VS, Revollo L, Abou-Ezzi G, Grimston SK, Jeong SY, Watkins M, Fortunato M, Alippe Y, Link DC, Mbalaviele G, Civitelli R
    J Bone Miner Res 2017 Jun;32(6):1332-1342
  • Marrow Adipose Tissue Expansion Coincides With Insulin Resistance in MAGP1-Deficient Mice
    Walji TA, Turecamo SE, Sanchez AC, Anthony BA, Abou-Ezzi G, Scheller EL, Link DC, Mecham RP, Craft CS
    Front Endocrinol (Lausanne) 2016 Jun 30;7:87
  • Inflammatory Osteoclasts Prime TNFalpha-Producing CD4(+) T Cells and Express CX3 CR1
    Ibanez L*, Abou-Ezzi G*, Ciucci T, Amiot V, Belaid N, Obino D, Mansour A, Rouleau M, Wakkach A, Blin-Wakkach C (*co-first authors)
    J Bone Miner Res 2016 Oct;31(10):1899-1908
  • Peroxisomal Lipid Synthesis Regulates Inflammation by Sustaining Neutrophil Membrane Phospholipid Composition and Viability
    Lodhi IJ, Wei X, Yin L, Feng C, Adak S, Abou-Ezzi G, Hsu FF, Link DC, Semenkovich CF
    Cell Metab 2015 Jan 6;21(1):51-64
  • Bone Marrow Th17 TNFalpha Cells Induce Osteoclast Differentiation, and Link Bone Destruction to IBD
    Ciucci T, Ibanez L, Boucoiran A, Birgy-Barelli E, Pene J, Abou-Ezzi G, Arab N, Rouleau M, Hebuterne X, Yssel H, Blin-Wakkach C, Wakkach A
    Gut 2015 Jul;64(7):1072-81
  • Osteoclasts Promote the Formation of Hematopoietic Stem Cell Niches in the Bone Marrow
    Mansour A, Abou-Ezzi G, Sitnicka E, Jacobsen SE, Wakkach A, Blin-Wakkach C
    J Exp Med 2012 Mar 12;209(3):537-49