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George J. Broze, Jr., MD

August 2, 1946 - June 19, 2019

Professor (1979-2019)
Department of Medicine
Hematology Division
Department of Cell Biology & Physiology

Remembrances

Washington University Record (6/27/19)
Journal of Thrombosis & Haemostasis (David Gailani, Thomas J. Girard and Alan E. Mast, 10/17/19)

Obituary

George J. Broze Jr., MD, died suddenly the evening of June 19, 2019, from a heart attack, aged 72. George was a distinguished member of the Washington University faculty, serving as a professor of medicine in the Division of Hematology, and a professor of cell biology and physiology.

George came to Washington University in 1976 as a clinical fellow in hematology. Beginning in 1980, he served as an attending physician at what was then Jewish Hospital (1980-87), at Barnes Hospital (1987-96), and since 1997 had been caring for patients at Barnes-Jewish Hospital through the hematology consult service. He also served as director of the transfusion unit from 1980 to 1990. George was a superb clinician, perennially recognized among the “Best Doctors in America,” whose advice often was sought in the most difficult bleeding and thrombosis cases. In addition to research and clinical responsibilities, George was a talented teacher, and unwaveringly supported young investigators in his laboratory.

Discoveries from George’s laboratory work established him as a world leader in the field of blood coagulation. His research focused predominantly on the endogenous regulators of coagulation - how these regulators must allow coagulation to be triggered in order to mitigate bleeding, yet limit coagulation to avoid thrombosis. His early biochemical work included the purification and characterization of the initiators of coagulation, factor VII and tissue factor. He identified a product from the amyloid precursor protein as an inhibitor of factor XI and discovered the protein Z-dependent inhibitor of factor X. He is best known for the discovery of a protein in plasma that he called LACI, now called TFPI; he and his collaborators established that TFPI plays a central role in regulating coagulation and preventing thrombosis. This work consolidated the mechanism of coagulation from “intrinsic” and “extrinsic” pathways into a unified, shared pathway.

George served on the editorial boards of the journals Blood, Current Opinion in Hematology, and the Journal of Thrombosis and Haemostasis, among others. He was a member of the Association of American Physicians, the American Society for Clinical Investigation, the American Society of Hematology, the American Heart Association, and he served on the Hematology Study Section of the National Heart, Lung, and Blood Institute. He was a recipient of the William Dameshek Prize from the American Society of Hematology, the Sol Sherry Prize from the American Heart Association, and the Pia Glas-Greenwalt Prize and Distinguished Career Award from the International Society on Thrombosis and Haemostasis.

Born in Seattle in 1946, George was a Phi Beta Kappa graduate of the University of Washington, with a bachelor’s degree in physics. He earned his medical degree from the University of Washington School of Medicine and completed his internship and residency at North Carolina Memorial Hospital in Chapel Hill. He is survived by his wife Jilla, his sons George John “Yuri” Broze III and Charles “Chip” Broze Belpedio, his son-in-law Tony Belpedio, and brother Greg. Funeral services will be amongst family.

 

In lieu of flowers, the family requests letters with anecdotes and memories be mailed to his home at 15 West Point Lane, St. Louis, MO, 63131.