Faculty
Oncology Division
Malachi Griffith, PhD
Associate Professor
Department of Medicine
Oncology Division
Stem Cell Biology
Research Interests
- Cancer informatics
- Bioinformatics
- Genomics
- Precision medicine
- Immunogenomics
Contact
- 314-286-1274 (office)
- 314-286-1810 (fax)
- mgriffit@wustl.edu
- Division of Oncology
Mail Stop 8501-0029-10
Washington University
660 South Euclid Avenue
St. Louis, MO 63110 - Room 10115, Mid Campus Center (lab)
- Griffith Lab Website
Biosketch
| Education | |
|---|---|
| 1996-2002 | BSc in Biology (Honors) and Biochemistry, University of Winnipeg, Winnipeg, MB, Canada |
| 2004-2005 | Molecular Biology Graduate Exchange, Simon Fraser University, Burnaby, BC, Canada |
| 2004-2010 | PhD in Medical Genetics, University of British Columbia, Vancouver, BC, Canada |
| Academic Positions & Employment | |
| 2010-2011 | Post-Doctoral Fellow, Michael Smith Genome Sciences Center, Vancouver, BC, Canada |
| 2011-2014 | Research Instructor, Genetics, Washington University School of Medicine, St. Louis, MO |
| 2011-2014 | Genome Fellow, McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO |
| 2014-2016 | Assistant Professor (Research Track), Genetics, Washington University School of Medicine, St. Louis, MO |
| 2017-2020 | Assistant Professor (Investigator Track), Medicine, Washington University School of Medicine, St. Louis, MO |
| 2011-present | Instructor, Cold Spring Harbor Laboratory, NY |
| 2011-present | Instructor, Canadian Bioinformatics Workshops, Toronto, ON, Canada |
| 2014-present | Assistant Director, McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO |
| 2017-present | Instructor, Physalia-courses, Freie University, Berlin, Brandenburg, Germany |
| 2018-present | Instructor, PR Informatics, Glasgow, United Kingdom |
| 2018-present | Instructor, Evomics (Fourth Culture LLC), United States |
| 2020-present | Associate Professor, Genetics, Washington University School of Medicine, St. Louis, MO |
| 2020-present | Associate Professor, Medicine, Washington University School of Medicine, St. Louis, MO |
| University & Hospital Appointments & Committees | |
| 2015-present | Member, Siteman Cancer Center |
| 2017-present | Member, Division of Biology and Biomedical Sciences |
| 2018-present | Member, Cordell Institute for Policy in Medicine & Law |
| 2018-present | Member, Institute for Informatics (I2) |
| 2018-present | Member, Center for Human Immunology and Immunotherapy Programs |
| 2021-present | Member, Biomedical Informatics and Data Science Admissions Committee |
| External Committees | |
| 2007 | Conference Chair, Discovery2Diagnostics Conference, 'Emerging Microarrays and Technologies', Philadelphia, PA |
| 2012-2014 | Member, Illumina Sequencing Experts Panel |
| 2015 | Conference Chair, The Clinical Genome Conference, 'Understanding Wellness' Session, San Francisco, CA |
| 2016 | Program Co-Chair, Clinical Interpretation Knowledgebase Hackathon and Curation Jamboree, Amsterdam, Netherlands |
| 2016 | Methods Workshop Chair, American Association of Cancer Research Annual Meeting, Interpretation of Variants in Cancer |
| 2017 | Member, Planning the 5-year Vision of Global Alliance for Genomics Health (GA4GH) |
| 2018 | Methods Workshop Chair, American Association of Cancer Research Annual Meeting, Computational Methods and Resources for Immunogenomics and Immune Therapy |
| 2018 | Discussion Leader of the Data-Driven Approaches for Precision Medicine Session, Human Genetic Variation and Disease, Gordon Research Conference |
| 2012-present | Editor, Biostar Consulting LLC |
| 2013-present | Canadian Bioinformatics Workshops Organizing Committee |
| 2015, 2019 | Annual Meeting Education Committee of the American Association for Cancer Research (AACR) |
| 2016-present | Co-Chair, Variant Interpretation for Cancer Consortium (VICC), GA4GH |
| 2018-present | Steering Committee, GA4GH |
| 2019-2020 | AACR-Cancer Research UK Transatlantic Postdoctoral Fellowships Scientific Review Committee |
| 2019-2020 | Cancer Genomics Consortium (CGC) Annual Meeting Program Committee |
| 2019-2020 | AACR-CRUK Transatlantic Postdoctoral Fellowships Scientific Review Committee |
| 2019-2020 | AACR Basic Cancer Research Fellowships Scientific Review Committee |
| 2021 | Conference Chair, AACR Computational Methods for Immunogenomics and Precision Oncology |
| 2021 | NCI Informatics for Cancer Research Annual Meeting Program Committee |
| 2021-present | Co-Chair, Clinical Genome Resource (ClinGen) – Somatic Cancer Clinical Domain Working Group |
| Awards | |
| 1996 | University of Winnipeg, Special Entrance Scholarship |
| 1999 | University of Winnipeg, Academic Proficiency Scholarship |
| 1999-2002 | University of Winnipeg, Student of Highest Distinction |
| 2001 | Dr. Edgar Van Nuys Allen Scholarship |
| 2004 | University of British Columbia, PhD Tuition Award |
| 2004 | Michael Smith Foundation for Health Research, Junior Trainee Award |
| 2004 | Natural Sciences and Engineering Research Council, Masters Award |
| 2004 | University of British Columbia, Graduate Entrance Scholarship |
| 2005 | Natural Sciences and Engineering Research Council, Doctoral Award |
| 2006 | Michael Smith Foundation for Health Research, Senior Trainee Award |
| 2008 | NCIC and Terry Fox Foundation, Research Studentship |
| 2009 | John Bosdet Memorial Fund, Graduate Student Travel Scholarship |
| 2009 | Lloyd Skarsgard Research Excellence Prize |
| 2018 | V Scholar Award |
| 2022 | V Scholar Summit Travel Scholarship |
| Other Honors | |
| 2012 | Profiled in Genome Technology Magazine’s Seventh Annual Young Investigators issue as an ‘up and coming investigator’ |
| 2013 | Profiled in Wired Magazine’s Second Annual ‘Smart List’ as an emerging talent |
| 2021 | V Foundation VIP Session Presenter |
| 2022 | AACR Most Highly Cited Article Award in Cancer Immunology Research |
| Professional Societies & Organizations | |
| 2014-present | Active Member, American Society of Clinical Oncology (ASCO) |
| 2014-present | Professional Member, International Society for Computational Biology (ISCB) |
| 2015-present | Active Member, American Association for Cancer Research (AACR) |
| 2016-present | Active Member, American Society of Human Genetics (ASHG) |
| 2016-present | Global Alliance for Genomics Health (GA4GH) |
| 2018-present | Affiliate Scientist Member, American College of Medical Genetics and Genomics |
| 2019-present | Active Member, Cancer Genomics Consortium (CGC) |
| 2019-present | Active Member, Association of Molecular Pathologists |
| 2020-present | ClinGen Somatic Cancer Clinical Domain Working Group |
| Bioinformatics Resources Created | |
| 2006-present | ORegAnno - Open Regulatory Annotation (www.oreganno.org) |
| 2011-present | Alternative Expression Analysis of RNA-seq (alexaplatform.org/) |
| 2012-present | RNA-seq analysis workshops (www.bioinformatics.ca/workshops/) |
| 2012-present | Bioinformatics tutorials (www.biostars.org/u/3737/) |
| 2013-present | GMS - Genome Modeling System (www.github.com/genome/gms/wiki) |
| 2013-present | DGIdb - Drug Gene Interaction database (www.dgidb.org) |
| 2013-present | RNA-Bio - RNA-seq analysis on the cloud (www.rnabio.org) |
| 2014-present | DoCM - Database of Curated Mutations (www.docm.info) |
| 2015-present | CIViC - Clinical interpretation of variants in cancer (civicdb.org) |
| 2016-present | GenVisR - Genome visualizations in R (github.com/griffithlab/GenVisR) |
| 2016-present | pVAC-Seq - A cancer immunotherapy pipeline for the identification of personalized Variant Antigens by Cancer Sequencing (github.com/griffithlab/pVAC-Seq) |
| 2016-present | RegTools - Integrated analysis of DNA-seq and RNA-seq data to help identify mutations that have a regulatory effect (regtools.org/) |
| 2017-present | Genome data visualization and interpretation workshop (genviz.org/) |
| 2017-present | pVAC-tools - Bioinformatics tools for immunogenomics (www.pvactools.org) |
| 2017-present | Variant Interpretation for Cancer Consortium (cancervariants.org/) |
| 2018-present | The VICC Meta-Knowledgebase (http://search.cancervariants.org) |
| 2018-present | Precision Medicine Bioinformatics workshop (pmbio.org/) |
| 2018-present | VCF Annotation Tools (http://vatools.org/) |
| 2019-present | OpenCAP - Blueprints for Precision Medicine (http://opencap.org/) |
| 2021-present | pVACview – A visualization and neoantigen prioritization interface (http://pvacview.org/) |
