Malachi Griffith.jpg

Malachi Griffith, PhD

Assistant Professor
Department of Medicine
Oncology Division
Stem Cell Biology
McDonnell Genome Institute

Research Interests

  • Cancer informatics
  • Bioinformatics
  • Genomics
  • Precision medicine


  • 314-286-1274 (phone)
  • 314-286-1810 (fax)
  • Room 5139, 4444 Forest Park Avenue (lab)
  • McDonnell Genome Institute
    Washington University
    Campus Box 8501
    4444 Forest Park Avenue
    St. Louis, MO 63108
  • Website


I am an Assistant Professor of Medicine and Assistant Director of the McDonnell Genome Institute at Washington University. I have more than 13 years of experience in the fields of genomics, bioinformatics, data mining, and cancer research. My research is focused on improving our understanding of human disease biology and the development of personalized medicine strategies using genomics and informatics technologies. I develop bioinformatics and statistical methods for the analysis of high throughput sequence data and identification of biomarkers for diagnostic, prognostic and drug response prediction. In collaboration with our Genomics Tumor and Pediatric Genome Boards, I am currently leading analyses of sequence data from the genomes and transcriptomes of patients whose conditions are not well addressed by standard-of-care options. I am also leading the analysis of several large-scale genomics projects to help discover genomic signatures relevant to disease initiation, progression and treatment response. I am an instructor for several Canadian Bioinformatics and Cold Spring Harbor Laboratory workshops. I have received numerous competitive research awards from the Natural Sciences and Engineering Research Council, University of Winnipeg, University of British Columbia, National Cancer Institute of Canada and British Columbia Cancer Agency. I was also a Junior and Senior Trainee of the Michael Smith Foundation for Health Research. I was profiled as an ‘up and coming’ investigator in Genome Technology Magazine and listed in Wired Magazine’s second annual ‘smart list’ as an emerging talent. Most recently, I was awarded an NHGRI K99 Pathway to Independence Award to developed integrated analysis and interpretation methods for whole genome, exome and transcriptome sequence data. In particular, I am focused on applying these methods to better understand the regulatory consequence of sequence variants of unknown functional significance. I have also made substantial contributions to open source and open access resources for the scientific community including creation of platforms for alternative expression analysis (www.alexaplatform.org), regulatory region annotation (www.oreganno.org), mining drug-gene interactions (www.dgidb.org), genome analysis development (https://github.com/genome/gms), curation of functional mutations (www.docm.info), and the clinical interpretation of variants in cancer (www.civicdb.org). I have published 59 papers with major areas of focus in precision medicine, cancer, genomics, biomarker discovery, sequence analysis, and alternative splicing.