Faculty
Tim Ley.jpg

Timothy J. Ley, MD

Professor
Department of Medicine
Oncology Division
Stem Cell Biology
Department of Genetics

Research Interests

  • Mouse models of acute myeloid leukemias
  • Cancer genomics

Contact

  • 314-362-8831 (office)
  • 314-362-8832 (lab)
  • 314-362-9333 (fax)
  • 629 Southwest Tower (office)
  • 629 Southwest Tower (lab)
  • Division of Oncology
    Section of Stem Cell Biology
    Campus Box 8007
    Washington University Medical School
    660 South Euclid Avenue
    St. Louis, MO 63110

Peer-reviewed Manuscripts

  • Comprehensive Discovery of Noncoding RNAs in Acute Myeloid Leukemia Cell Transcriptomes
    Zhang J, Griffith M, Miller CA, Griffith OL, Spencer DH, Walker JR, Magrini V, McGrath SD, Ly A, Helton NM, Trissal M, Link DC, Dang HX, Larson DE, Kulkarni S, Cordes MG, Fronick CC, Fulton RS, Klco JM, Mardis ER, Ley TJ, Wilson RK, Maher CA
    Exp Hematol 2017 Nov;55:19-33
  • Haploinsufficiency for DNA Methyltransferase 3A Predisposes Hematopoietic Cells to Myeloid Malignancies
    Cole CB, Russler-Germain DA, Ketkar S, Verdoni AM, Smith AM, Bangert CV, Helton NM, Guo M, Klco JM, O'Laughlin S, Fronick C, Fulton R, Chang GS, Petti AA, Miller CA, Ley TJ
    J Clin Invest 2017 Oct 2;127(10):3657-3674
  • Dynamic Changes in the Clonal Structure of MDS and AML in Response to Epigenetic Therapy
    Uy GL, Duncavage EJ, Chang GS, Jacoby MA, Miller CA, Shao J, Heath S, Elliott K, Reineck T, Fulton RS, Fronick CC, O'Laughlin M, Ganel L, Abboud CN, Cashen AF, DiPersio JF, Wilson RK, Link DC, Welch JS, Ley TJ, Graubert TA, Westervelt P, Walter MJ
    Leukemia 2017 Apr;31(4):872-881
  • CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression
    Spencer DH, Russler-Germain DA, Ketkar S, Helton NM, Lamprecht TL, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Shinawi M, Westervelt P, Payton JE, Wartman LD, Welch JS, Wilson RK, Walter MJ, Link DC, DiPersio JF, Ley TJ
    Cell 2017 Feb 23;168(5):801-816
  • Mutational Landscape and Response Are Conserved in Peripheral Blood of AML and MDS Patients During Decitabine Therapy
    Duncavage EJ, Uy GL, Petti AA, Miller CA, Lee YS, Tandon B, Gao F, Fronick CC, O'Laughlin M, Fulton RS, Wilson RK, Jacoby MA, Cashen AF, Wartman LD, Walter MJ, Westervelt P, Link DC, DiPersio JF, Ley TJ, Welch JS
    Blood 2017 Mar 9;129(10):1397-1401
  • TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes
    Welch JS, Petti AA, Miller CA, Fronick CC, O'Laughlin M, Fulton RS, Wilson RK, Baty JD, Duncavage EJ, Tandon B, Lee YS, Wartman LD, Uy GL, Ghobadi A, Tomasson MH, Pusic I, Romee R, Fehniger TA, Stockerl-Goldstein KE, Vij R, Oh ST, Abboud CN, Cashen AF, Schroeder MA, Jacoby MA, Heath SE, Luber K, Janke MR, Hantel A, Khan N, Sukhanova MJ, Knoebel RW, Stock W, Graubert TA, Walter MJ, Westervelt P, Link DC, DiPersio JF, Ley TJ
    N Engl J Med 2016 Nov 24;375(21):2023-2036
  • Targeted Sequencing Informs the Evaluation of Normal Karyotype Cytopenic Patients for Low-Grade Myelodysplastic Syndrome
    Duncavage EJ, O'Brien J, Vij K, Miller CA, Chang GS, Shao J, Jacoby MA, Heath S, Janke MR, Elliott K, Fulton RS, Fronick C, O'Laughlin M, Westervelt P, Ley TJ, Wilson RK, Walter MJ
    Leukemia 2016 Dec;30(12):2422-2426
  • Visualizing Tumor Evolution With the Fishplot Package for R
    Miller CA, McMichael J, Dang HX, Maher CA, Ding L, Ley TJ, Mardis ER, Wilson RK
    BMC Genomics 2016 Nov 7;17(1):880
  • Comprehensive Genomic Analysis Reveals FLT3 Activation and a Therapeutic Strategy for a Patient With Relapsed Adult B-Lymphoblastic Leukemia
    Griffith M, Griffith OL, Krysiak K, Skidmore ZL, Christopher MJ, Klco JM, Ramu A, Lamprecht TL, Wagner AH, Campbell KM, Lesurf R, Hundal J, Zhang J, Spies NC, Ainscough BJ, Larson DE, Heath SE, Fronick C, O'Laughlin S, Fulton RS, Magrini V, McGrath S, Smith SM, Miller CA, Maher CA, Payton JE, Walker JR, Eldred JM, Walter MJ, Link DC, Graubert TA, Westervelt P, Kulkarni S, DiPersio JF, Mardis ER, Wilson RK, Ley TJ
    Exp Hematol 2016 Jul;44(7):603-13
  • Rapid Expansion of Preexisting Nonleukemic Hematopoietic Clones Frequently Follows Induction Therapy for De Novo AML
    Wong TN, Miller CA, Klco JM, Petti A, Demeter R, Helton NM, Li T, Fulton RS, Heath SE, Mardis ER, Westervelt P, DiPersio JF, Walter MJ, Welch JS, Graubert TA, Wilson RK, Ley TJ, Link DC
    Blood 2016 Feb 18;127(7):893-7
  • PML-RARA Requires DNA Methyltransferase 3A to Initiate Acute Promyelocytic Leukemia
    Cole CB, Verdoni AM, Ketkar S, Leight ER, Russler-Germain DA, Lamprecht TL, Demeter RT, Magrini V, Ley TJ
    J Clin Invest 2016 Jan 4;126(1):85-98
  • Patterns and Functional Implications of Rare Germline Variants Across 12 Cancer Types
    Lu C, Xie M, Wendl MC, Wang J, McLellan MD, Leiserson MD, Huang KL, Wyczalkowski MA, Jayasinghe R, Banerjee T, Ning J, Tripathi P, Zhang Q, Niu B, Ye K, Schmidt HK, Fulton RS, McMichael JF, Batra P, Kandoth C, Bharadwaj M, Koboldt DC, Miller CA, Kanchi KL, Eldred JM, Larson DE, Welch JS, You M, Ozenberger BA, Govindan R, Walter MJ, Ellis MJ, Mardis ER, Graubert TA, DiPersio JF, Ley TJ, Wilson RK, Goodfellow PJ, Raphael BJ, Chen F, Johnson KJ, Parvin JD, Ding L
    Nat Commun 2015 Dec 22;6:10086
  • Genomic Analysis of Germ Line and Somatic Variants in Familial Myelodysplasia/Acute Myeloid Leukemia
    Churpek JE, Pyrtel K, Kanchi KL, Shao J, Koboldt D, Miller CA, Shen D, Fulton R, O'Laughlin M, Fronick C, Pusic I, Uy GL, Braunstein EM, Levis M, Ross J, Elliott K, Heath S, Jiang A, Westervelt P, DiPersio JF, Link DC, Walter MJ, Welch J, Wilson R, Ley TJ, Godley LA, Graubert TA
    Blood 2015 Nov 26;126(22):2484-90
  • Optimizing Cancer Genome Sequencing and Analysis
    Griffith M, Miller CA, Griffith OL, Krysiak K, Skidmore ZL, Ramu A, Walker JR, Dang HX, Trani L, Larson DE, Demeter RT, Wendl MC, McMichael JF, Austin RE, Magrini V, McGrath SD, Ly A, Kulkarni S, Cordes MG, Fronick CC, Fulton RS, Maher CA, Ding L, Klco JM, Mardis ER, Ley TJ, Wilson RK
    Cell Syst 2015 Sep 23;1(3):210-223
  • Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia
    Klco JM, Miller CA, Griffith M, Petti A, Spencer DH, Ketkar-Kulkarni S, Wartman LD, Christopher M, Lamprecht TL, Helton NM, Duncavage EJ, Payton JE, Baty J, Heath SE, Griffith OL, Shen D, Hundal J, Chang GS, Fulton R, O'Laughlin M, Fronick C, Magrini V, Demeter RT, Larson DE, Kulkarni S, Ozenberger BA, Welch JS, Walter MJ, Graubert TA, Westervelt P, Radich JP, Link DC, Mardis ER, DiPersio JF, Wilson RK, Ley TJ
    JAMA 2015 Aug 25;314(8):811-822
  • Whole Exome Sequencing Reveals the Order of Genetic Changes During Malignant Transformation and Metastasis in a Single Patient With NF1-Plexiform Neurofibroma
    Hirbe AC, Dahiya S, Miller CA, Li T, Fulton RS, Zhang X, McDonald S, DeSchryver K, Duncavage EJ, Walrath J, Reilly KM, Abel HJ, Pekmezci M, Perry A, Ley TJ, Gutmann DH
    Clin Cancer Res 2015 Sep 15;21(18):4201-11
  • Genetic Heterogeneity of Induced Pluripotent Stem Cells: Results From 24 Clones Derived From a Single C57BL/6 Mouse
    Li C, Klco JM, Helton NM, George DR, Mudd JL, Miller CA, Lu C, Fulton R, O'Laughlin M, Fronick C, Wilson RK, Ley TJ
    PLoS One 2015 Mar 23;10(3):e0120585
  • Quantifying Ultra-Rare Pre-Leukemic Clones Via Targeted Error-Corrected Sequencing
    Young AL, Wong TN, Hughes AE, Heath SE, Ley TJ, Link DC, Druley TE
    Leukemia 2015 Jul;29(7):1608-1611
  • Epigenomic Analysis of the HOX Gene Loci Reveals Mechanisms That May Control Canonical Expression Patterns in AML and Normal Hematopoietic Cells
    Spencer DH, Young MA, Lamprecht TL, Helton NM, Fulton R, O'Laughlin M, Fronick C, Magrini V, Demeter RT, Miller CA, Klco JM, Wilson RK, Ley TJ
    Leukemia 2015 Jun;29(6):1279-1289
  • U2AF1 Mutations Alter Sequence Specificity of Pre-mRNA Binding and Splicing
    Okeyo-Owuor T, White BS, Chatrikhi R, Mohan DR, Kim S, Griffith M, Ding L, Ketkar-Kulkarni S, Hundal J, Laird KM, Kielkopf CL, Ley TJ, Walter MJ, Graubert TA
    Leukemia 2015 Apr;29(4):909-917
  • Clonal Evolution Revealed by Whole Genome Sequencing in a Case of Primary Myelofibrosis Transformed to Secondary Acute Myeloid Leukemia
    Engle EK, Fisher DA, Miller CA, McLellan MD, Fulton RS, Moore DM, Wilson RK, Ley TJ, Oh ST
    Leukemia 2015 Apr;29(4):869-876
  • Role of TP53 Mutations in the Origin and Evolution of Therapy-Related Acute Myeloid Leukaemia
    Wong TN, Ramsingh G, Young AL, Miller CA, Touma W, Welch JS, Lamprecht TL, Shen D, Hundal J, Fulton RS, Heath S, Baty JD, Klco JM, Ding L, Mardis ER, Westervelt P, DiPersio JF, Walter MJ, Graubert TA, Ley TJ, Druley TE, Link DC, Wilson RK
    Nature 2015 Feb 26;518(7540):552-555
  • Clonal Architectures and Driver Mutations in Metastatic Melanomas
    Ding L, Kim M, Kanchi KL, Dees ND, Lu C, Griffith M, Fenstermacher D, Sung H, Miller CA, Goetz B, Wendl MC, Griffith O, Cornelius LA, Linette GP, McMichael JF, Sondak VK, Fields RC, Ley TJ, Mule JJ, Wilson RK, Weber JS
    PLoS One 2014 Nov 13;9(11):e111153
  • Caspase-9 Is Required for Normal Hematopoietic Development and Protection From Alkylator-Induced DNA Damage in Mice
    Lu EP, McLellan M, Ding L, Fulton R, Mardis ER, Wilson RK, Miller CA, Westervelt P, DiPersio JF, Link DC, Walter MJ, Ley TJ, Graubert TA
    Blood 2014 Dec 18;124(26):3887-95
  • Age-Related Mutations Associated With Clonal Hematopoietic Expansion and Malignancies
    Xie M, Lu C, Wang J, McLellan MD, Johnson KJ, Wendl MC, McMichael JF, Schmidt HK, Yellapantula V, Miller CA, Ozenberger BA, Welch JS, Link DC, Walter MJ, Mardis ER, DiPersio JF, Chen F, Wilson RK, Ley TJ, Ding L
    Nat Med 2014 Dec;20(12):1472-1478
  • SciClone: Inferring Clonal Architecture and Tracking the Spatial and Temporal Patterns of Tumor Evolution
    Miller CA, White BS, Dees ND, Griffith M, Welch JS, Griffith OL, Vij R, Tomasson MH, Graubert TA, Walter MJ, Ellis MJ, Schierding W, DiPersio JF, Ley TJ, Mardis ER, Wilson RK, Ding L
    PLoS Comput Biol 2014 Aug 7;10(8):e1003665
  • Primary Acute Myeloid Leukemia Cells With IDH1 or IDH2 Mutations Respond to a DOT1L Inhibitor in Vitro
    Sarkaria SM, Christopher MJ, Klco JM, Ley TJ
    Leukemia 2014 Dec;28(12):2403-6
  • Clonal Architecture of Secondary Acute Myeloid Leukemia Defined by Single-Cell Sequencing
    Hughes AE, Magrini V, Demeter R, Miller CA, Fulton R, Fulton LL, Eades WC, Elliott K, Heath S, Westervelt P, Ding L, Conrad DF, White BS, Shao J, Link DC, DiPersio JF, Mardis ER, Wilson RK, Ley TJ, Walter MJ, Graubert TA
    PLoS Genet 2014 Jul 10;10(7):e1004462
  • The R882H DNMT3A Mutation Associated With AML Dominantly Inhibits Wild-Type DNMT3A by Blocking Its Ability to Form Active Tetramers
    Russler-Germain DA, Spencer DH, Young MA, Lamprecht TL, Miller CA, Fulton R, Meyer MR, Erdmann-Gilmore P, Townsend RR, Wilson RK, Ley TJ
    Cancer Cell 2014 Apr 14;25(4):442-54
  • Functional Heterogeneity of Genetically Defined Subclones in Acute Myeloid Leukemia
    Klco JM, Spencer DH, Miller CA, Griffith M, Lamprecht TL, O'Laughlin M, Fronick C, Magrini V, Demeter RT, Fulton RS, Eades WC, Link DC, Graubert TA, Walter MJ, Mardis ER, DiPersio JF, Wilson RK, Ley TJ
    Cancer Cell 2014 Mar 17;25(3):379-92
  • Mutational Landscape and Significance Across 12 Major Cancer Types
    Kandoth C, McLellan MD, Vandin F, Ye K, Niu B, Lu C, Xie M, Zhang Q, McMichael JF, Wyczalkowski MA, Leiserson MD, Miller CA, Welch JS, Walter MJ, Wendl MC, Ley TJ, Wilson RK, Raphael BJ, Ding L
    Nature 2013 Oct 17;502(7471):333-9
  • DGIdb: Mining the Druggable Genome
    Griffith M, Griffith OL, Coffman AC, Weible JV, McMichael JF, Spies NC, Koval J, Das I, Callaway MB, Eldred JM, Miller CA, Subramanian J, Govindan R, Kumar RD, Bose R, Ding L, Walker JR, Larson DE, Dooling DJ, Smith SM, Ley TJ, Mardis ER, Wilson RK
    Nat Methods 2013 Dec;10(12):1209-10
  • Genomic Landscapes and Clonality of De Novo AML
    Miller CA, Wilson RK, Ley TJ
    N Engl J Med 2013 Oct 10;369(15):1473
  • The Cancer Genome Atlas Pan-Cancer Analysis Project
    Chang K, Creighton CJ, Davis C, Donehower L, Drummond J, Wheeler D, Ally A, Balasundaram M, Birol I, Butterfield YS, Chu A, Chuah E, Chun HJ, Dhalla N, Guin R, Hirst M, Hirst C, Holt RA, Jones SJ, Lee D, Li HI, Marra MA, Mayo M, Moore RA, Mungall AJ, Robertson AG, Schein JE, Sipahimalani P, Tam A, Thiessen N, Varhol RJ, Beroukhim R, Bhatt AS, Brooks AN, Cherniack AD, Freeman SS, Gabriel SB, Helman E, Jung J, Meyerson M, Ojesina AI, Pedamallu CS, Saksena G, Schumacher SE, Tabak B, Zack T, Lander ES, Bristow CA, Hadjipanayis A, Haseley P, Kucherlapati R, Lee S, Lee E, Luquette LJ, Mahadeshwar HS, Pantazi A, Parfenov M, Park PJ, Protopopov A, Ren X, Santoso N, Seidman J, Seth S, Song X, Tang J, Xi R, Xu AW, Yang L, Zeng D, Auman JT, Balu S, Buda E, Fan C, Hoadley KA, Jones CD, Meng S, Mieczkowski PA, Parker JS, Perou CM, Roach J, Shi Y, Silva GO, Tan D, Veluvolu U, Waring S, Wilkerson MD, Wu J, Zhao W, Bodenheimer T, Hayes DN, Hoyle AP, Jeffreys SR, Mose LE, Simons JV, Soloway MG, Baylin SB, Berman BP, Bootwalla MS, Danilova L, Herman JG, Hinoue T, Laird PW, Rhie SK, Shen H, Triche T, Weisenberger DJ, Carter SL, Cibulskis K, Chin L, Zhang J, Getz G, Sougnez C, Wang M, Saksena G, Carter SL, Cibulskis K, Chin L, Zhang J, Getz G, Dinh H, Doddapaneni HV, Gibbs R, Gunaratne P, Han Y, Kalra D, Kovar C, Lewis L, Morgan M, Morton D, Muzny D, Reid J, Xi L, Cho J, Dicara D, Frazer S, Gehlenborg N, Heiman DI, Kim J, Lawrence MS, Lin P, Liu Y, Noble MS, Stojanov P, Voet D, Zhang H, Zou L, Stewart C, Bernard B, Bressler R, Eakin A, Iype L, Knijnenburg T, Kramer R, Kreisberg R, Leinonen K, Lin J, Liu Y, Miller M, Reynolds SM, Rovira H, Shmulevich I, Thorsson V, Yang D, Zhang W, Amin S, Wu CJ, Wu CC, Akbani R, Aldape K, Baggerly KA, Broom B, Casasent TD, Cleland J, Creighton C, Dodda D, Edgerton M, Han L, Herbrich SM, Ju Z, Kim H, Lerner S, Li J, Liang H, Liu W, Lorenzi PL, Lu Y, Melott J, Mills GB, Nguyen L, Su X, Verhaak R, Wang W, Weinstein JN, Wong A, Yang Y, Yao J, Yao R, Yoshihara K, Yuan Y, Yung AK, Zhang N, Zheng S, Ryan M, Kane DW, Aksoy BA, Ciriello G, Dresdner G, Gao J, Gross B, Jacobsen A, Kahles A, Ladanyi M, Lee W, Lehmann KV, Miller ML, Ramirez R, Ratsch G, Reva B, Sander C, Schultz N, Senbabaoglu Y, Shen R, Sinha R, Sumer SO, Sun Y, Taylor BS, Weinhold N, Fei S, Spellman P, Benz C, Carlin D, Cline M, Craft B, Ellrott K, Goldman M, Haussler D, Ma S, Ng S, Paull E, Radenbaugh A, Salama S, Sokolov A, Stuart JM, Swatloski T, Uzunangelov V, Waltman P, Yau C, Zhu J, Hamilton SR, Getz G, Sougnez C, Abbott S, Abbott R, Dees ND, Delehaunty K, Ding L, Dooling DJ, Eldred JM, Fronick CC, Fulton R, Fulton LL, Kalicki-Veizer J, Kanchi KL, Kandoth C, Koboldt DC, Larson DE, Ley TJ, Lin L, Lu C, Magrini VJ, Mardis ER, McLellan MD, McMichael JF, Miller CA, O'Laughlin M, Pohl C, Schmidt H, Smith SM, Walker J, Wallis JW, Wendl MC, Wilson RK, Wylie T, Zhang Q, Burton R, Jensen MA, Kahn A, Pihl T, Pot D, Wan Y, Levine DA, Black AD, Bowen J, Frick J, Gastier-Foster JM, Harper HA, Helsel C, Leraas KM, Lichtenberg TM, McAllister C, Ramirez NC, Sharpe S, Wise L, Zmuda E, Chanock SJ, Davidsen T, Demchok JA, Eley G, Felau I, Ozenberger BA, Sheth M, Sofia H, Staudt L, Tarnuzzer R, Wang Z, Yang L, Zhang J, Omberg L, Margolin A, Raphael BJ, Vandin F, Wu HT, Leiserson MD, Benz SC, Vaske CJ, Noushmehr H, Knijnenburg T, Wolf D, Veer LV, Collisson EA, Anastassiou D, Ou Yang TH, Lopez-Bigas N, Gonzalez-Perez A, Tamborero D, Xia Z, Li W, Cho DY, Przytycka T, Hamilton M, McGuire S, Nelander S, Johansson P, Jornsten R, Kling T, Sanchez J, Weinstein JN, Collisson EA, Mills GB, Shaw KR, Ozenberger BA, Ellrott K, Shmulevich I, Sander C, Stuart JM
    Nat Genet 2013 Sep 26;45(10):1113-20
  • Acquired Copy Number Alterations of miRNA Genes in Acute Myeloid Leukemia Are Uncommon
    Ramsingh G, Jacoby MA, Shao J, De Jesus Pizzaro RE, Shen D, Trissal M, Getz AH, Ley TJ, Walter MJ, Link DC
    Blood 2013 Oct 10;122(15):e44-e51
  • BreakTrans: Uncovering the Genomic Architecture of Gene Fusions
    Chen K, Navin NE, Wang Y, Schmidt HK, Wallis JW, Niu B, Fan X, Zhao H, McLellan MD, Hoadley KA, Mardis ER, Ley TJ, Perou CM, Wilson RK, Ding L
    Genome Biol 2013 Aug 23;14(8):R87
  • Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia
    Ley TJ, Miller C, Ding L, Raphael BJ, Mungall AJ, Robertson A, Hoadley K, Triche TJ Jr, Laird PW, Baty JD, Fulton LL, Fulton R, Heath SE, Kalicki-Veizer J, Kandoth C, Klco JM, Koboldt DC, Kanchi KL, Kulkarni S, Lamprecht TL, Larson DE, Lin L, Lu C, McLellan MD, McMichael JF, Payton J, Schmidt H, Spencer DH, Tomasson MH, Wallis JW, Wartman LD, Watson MA, Welch J, Wendl MC, Ally A, Balasundaram M, Birol I, Butterfield Y, Chiu R, Chu A, Chuah E, Chun HJ, Corbett R, Dhalla N, Guin R, He A, Hirst C, Hirst M, Holt RA, Jones S, Karsan A, Lee D, Li HI, Marra MA, Mayo M, Moore RA, Mungall K, Parker J, Pleasance E, Plettner P, Schein J, Stoll D, Swanson L, Tam A, Thiessen N, Varhol R, Wye N, Zhao Y, Gabriel S, Getz G, Sougnez C, Zou L, Leiserson MD, Vandin F, Wu HT, Applebaum F, Baylin SB, Akbani R, Broom BM, Chen K, Motter TC, Nguyen K, Weinstein JN, Zhang N, Ferguson ML, Adams C, Black A, Bowen J, Gastier-Foster J, Grossman T, Lichtenberg T, Wise L, Davidsen T, Demchok JA, Shaw KR, Sheth M, Sofia HJ, Yang L, Downing JR, Eley G, Alonso S, Ayala B, Baboud J, Backus M, Barletta SP, Berton DL, Chu AL, Girshik S, Jensen MA, Kahn A, Kothiyal P, Nicholls MC, Pihl TD, Pot DA, Raman R, Sanbhadti RN, Snyder EE, Srinivasan D, Walton J, Wan Y, Wang Z, Issa JP, Le Beau M, Carroll M, Kantarjian H, Kornblau S, Bootwalla MS, Lai PH, Shen H, Van Den Berg DJ, Weisenberger DJ, Link DC, Walter MJ, Ozenberger BA, Mardis ER, Westervelt P, Graubert TA, DiPersio JF, Wilson RK
    N Engl J Med 2013 May 30;368(22):2059-74
  • Clonal Diversity of Recurrently Mutated Genes in Myelodysplastic Syndromes
    Walter MJ, Shen D, Shao J, Ding L, White BS, Kandoth C, Miller CA, Niu B, McLellan MD, Dees ND, Fulton R, Elliot K, Heath S, Grillot M, Westervelt P, Link DC, DiPersio JF, Mardis E, Ley TJ, Wilson RK, Graubert TA
    Leukemia 2013 Jun;27(6):1275-82
  • Notch Signaling in Acute Promyelocytic Leukemia
    Grieselhuber NR, Klco JM, Verdoni AM, Lamprecht T, Sarkaria SM, Wartman LD, Ley TJ
    Leukemia 2013 Jul;27(7):1548-57
  • Genomic Impact of Transient Low-Dose Decitabine Treatment on Primary AML Cells
    Klco JM, Spencer DH, Lamprecht TL, Sarkaria SM, Wylie T, Magrini V, Hundal J, Walker J, Varghese N, Erdmann-Gilmore P, Lichti CF, Meyer MR, Townsend RR, Wilson RK, Mardis ER, Ley TJ
    Blood 2013 Feb 28;121(9):1633-43
  • An Inv(16)(p13.3q24.3)-Encoded CBFA2T3-GLIS2 Fusion Protein Defines an Aggressive Subtype of Pediatric Acute Megakaryoblastic Leukemia
    Gruber TA, Larson Gedman A, Zhang J, Koss CS, Marada S, Ta HQ, Chen SC, Su X, Ogden SK, Dang J, Wu G, Gupta V, Andersson AK, Pounds S, Shi L, Easton J, Barbato MI, Mulder HL, Manne J, Wang J, Rusch M, Ranade S, Ganti R, Parker M, Ma J, Radtke I, Ding L, Cazzaniga G, Biondi A, Kornblau SM, Ravandi F, Kantarjian H, Nimer SD, Dohner K, Dohner H, Ley TJ, Ballerini P, Shurtleff S, Tomizawa D, Adachi S, Hayashi Y, Tawa A, Shih LY, Liang DC, Rubnitz JE, Pui CH, Mardis ER, Wilson RK, Downing JR
    Cancer Cell 2012 Nov 13;22(5):683-97
  • Expression and Function of PML-RARA in the Hematopoietic Progenitor Cells of Ctsg-PML-RARA Mice
    Wartman LD, Welch JS, Uy GL, Klco JM, Lamprecht T, Varghese N, Nagarajan R, Ley TJ
    PLoS One 2012;7(10):e46529
  • The Origin and Evolution of Mutations in Acute Myeloid Leukemia
    Welch JS*, Ley TJ*, Link DC*, Miller CA, Larson DE, Koboldt DC, Wartman LD, Lamprecht TL, Liu F, Xia J, Kandoth C, Fulton RS, McLellan MD, Dooling DJ, Wallis JW, Chen K, Harris CC, Schmidt HK, Kalicki-Veizer JM, Lu C, Zhang Q, Lin L, O'Laughlin MD, McMichael JF, Delehaunty KD, Fulton LA, Magrini VJ, McGrath SD, Demeter RT, Vickery TL, Hundal J, Cook LL, Swift GW, Reed JP, Alldredge PA, Wylie TN, Walker JR, Watson MA, Heath SE, Shannon WD, Varghese N, Nagarajan R, Payton JE, Baty JD, Kulkarni S, Klco JM, Tomasson MH, Westervelt P, Walter MJ, Graubert TA, Dipersio JF, Ding L, Mardis ER, Wilson RK (*authors contributed equally to this work)
    Cell 2012 Jul 20;150(2):264-78
  • Whole-Genome Analysis Informs Breast Cancer Response to Aromatase Inhibition
    Ellis MJ, Ding L, Shen D, Luo J, Suman VJ, Wallis JW, Van Tine BA, Hoog J, Goiffon RJ, Goldstein TC, Ng S, Lin L, Crowder R, Snider J, Ballman K, Weber J, Chen K, Koboldt DC, Kandoth C, Schierding WS, McMichael JF, Miller CA, Lu C, Harris CC, McLellan MD, Wendl MC, DeSchryver K, Allred DC, Esserman L, Unzeitig G, Margenthaler J, Babiera GV, Marcom PK, Guenther JM, Leitch M, Hunt K, Olson J, Tao Y, Maher CA, Fulton LL, Fulton RS, Harrison M, Oberkfell B, Du F, Demeter R, Vickery TL, Elhammali A, Piwnica-Worms H, McDonald S, Watson M, Dooling DJ, Ota D, Chang LW, Bose R, Ley TJ, Piwnica-Worms D, Stuart JM, Wilson RK, Mardis ER
    Nature 2012 Jun 10;486(7403):353-60
  • The Pediatric Cancer Genome Project
    Downing JR, Wilson RK, Zhang J, Mardis ER, Pui CH, Ding L, Ley TJ, Evans WE
    Nat Genet 2012 May 29;44(6):619-22
  • BreakFusion: Targeted Assembly-Based Identification of Gene Fusions in Whole Transcriptome Paired-End Sequencing Data
    Chen K, Wallis JW, Kandoth C, Kalicki-Veizer JM, Mungall KL, Mungall AJ, Jones SJ, Marra MA, Ley TJ, Mardis ER, Wilson RK, Weinstein JN, Ding L
    Bioinformatics 2012 Jul 15;28(14):1923-4
  • Background Mutations in Parental Cells Account for Most of the Genetic Heterogeneity of Induced Pluripotent Stem Cells
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    Nature 2012 Jan 11;481(7382):506-10
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    Blood 2011 Feb 24;117(8):2460-8
  • Next-Generation Sequencing Identifies the Natural Killer Cell MicroRNA Transcriptome
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    Blood 2010 Dec 9;116(24):5316-5326
  • A Protease-Resistant PML-RAR{alpha} Has Increased Leukemogenic Potential in a Murine Model of Acute Promyelocytic Leukemia
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    Blood 2010 Nov 4;116(18):3604-10
  • Mcl1 Haploinsufficiency Protects Mice From Myc-Induced Acute Myeloid Leukemia
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  • Latent Herpesvirus Infection Arms NK Cells
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    Blood 2010 Jun 3;115(22):4377-83
  • POU4F1 Is Associated With t(8;21) Acute Myeloid Leukemia and Contributes Directly to Its Unique Transcriptional Signature
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  • Genome Remodelling in a Basal-Like Breast Cancer Metastasis and Xenograft
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    Nature 2010 Apr 15;464(7291):999-1005
  • Granzyme B Is Not Required for Regulatory T Cell-Mediated Suppression of Graft-Versus-Host Disease
    Cai SF, Cao X, Hassan A, Fehniger TA, Ley TJ
    Blood 2010 Mar 4;115(9):1669-77
  • Interleukin 12 Stimulates IFN-Gamma-Mediated Inhibition of Tumor-Induced Regulatory T-Cell Proliferation and Enhances Tumor Clearance
    Cao X, Leonard K, Collins LI, Cai SF, Mayer JC, Payton JE, Walter MJ, Piwnica-Worms D, Schreiber RD, Ley TJ
    Cancer Res 2009 Nov 15;69(22):8700-9
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    Nat Methods 2009 Sep;6(9):677-81
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  • High Throughput Digital Quantification of mRNA Abundance in Primary Human Acute Myeloid Leukemia Samples
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  • Chemosensitization of Acute Myeloid Leukemia (AML) Following Mobilization by the CXCR4 Antagonist AMD3100
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  • Sociology. The Gender Gap in NIH Grant Applications
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    Nature 2008 Nov 6;456(7218):66-72
  • Quantitative Trait Loci Associated With Susceptibility to Therapy-Related Acute Murine Promyelocytic Leukemia in HCG-PML/RARA Transgenic Mice
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    Blood 2008 Aug 15;112(4):1434-42
  • WuHMM: A Robust Algorithm to Detect DNA Copy Number Variation Using Long Oligonucleotide Microarray Data
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    Genome Biol 2008;9(2):R38
  • Somatic Mutations and Germline Sequence Variants in the Expressed Tyrosine Kinase Genes of Patients With De Novo Acute Myeloid Leukemia
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    Blood 2008 May 1;111(9):4797-808
  • Identification of Somatic JAK1 Mutations in Patients With Acute Myeloid Leukemia
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  • Granzyme B and Perforin Are Important for Regulatory T Cell-Mediated Suppression of Tumor Clearance
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    Immunity 2007 Oct 26;27(4):635-646
  • Distinct Patterns of Mutations Occurring in De Novo AML Versus AML Arising in the Setting of Severe Congenital Neutropenia
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  • Acquisition of Murine NK Cell Cytotoxicity Requires the Translation of a Pre-Existing Pool of Granzyme B and Perforin mRNAs
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  • A High-Resolution Map of Segmental DNA Copy Number Variation in the Mouse Genome
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  • Commonly Dysregulated Genes in Murine APL Cells
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  • Neutrophil Elastase Is Important for PML-Retinoic Acid Receptor Alpha Activities in Early Myeloid Cells
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  • Neutrophil Elastase Cleaves PML-RARalpha and Is Important for the Development of Acute Promyelocytic Leukemia in Mice
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    Cell 2003 Oct 31;115(3):305-18
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    Blood 2003 Sep 1;102(5):1857-65
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    Blood 2003 Aug 15;102(4):1531-3
  • Cell Death Induced by Granzyme C
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    Blood 2003 Apr 15;101(8):3093-101
  • PML/RARalpha and FLT3-ITD Induce an APL-Like Disease in a Mouse Model
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  • Adaptive Immunity Cooperates With Liposomal All-Trans-Retinoic Acid (ATRA) to Facilitate Long-Term Molecular Remissions in Mice With Acute Promyelocytic Leukemia
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  • Removing Career Obstacles for Young Physician-Scientists -- Loan-Repayment Programs
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  • Granzyme B Can Cause Mitochondrial Depolarization and Cell Death in the Absence of BID, BAX, and BAK
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    Proc Natl Acad Sci U S A 2001 Dec 18;98(26):14985-90
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  • Lack of Neighborhood Effects From a Transcriptionally Active Phosphoglycerate Kinase-Neo Cassette Located Between the Murine Beta-Major and Beta-Minor Globin Genes
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    Blood 2001 Jul 1;98(1):65-73
  • Sudden Death Among Patients With Acute Promyelocytic Leukemia Treated With Arsenic Trioxide
    Westervelt P, Brown RA, Adkins DR, Khoury H, Curtin P, Hurd D, Luger SM, Ma MK, Ley TJ, DiPersio JF
    Blood 2001 Jul 15;98(2):266-71
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    Proc Natl Acad Sci U S A 2000 Nov 21;97(24):13306-11
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    Immunity 2000 Jun;12(6):621-32
  • Deletions Within the Mouse Beta-Globin Locus Control Region Preferentially Reduce Beta(Min) Globin Gene Expression
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    Genomics 2000 Feb 1;63(3):417-24
  • Independent Formation of DnaseI Hypersensitive Sites in the Murine Beta-Globin Locus Control Region
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    Blood 2000 Jun 1;95(11):3600-4
  • The Physician-Scientist: Career Issues and Challenges at the Year 2000
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    FASEB J 2000 Feb;14(2):221-30
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    Proc Natl Acad Sci U S A 1999 Dec 21;96(26):15103-8
  • Normal Neutrophil Function in Cathepsin G-Deficient Mice
    MacIvor DM, Shapiro SD, Pham CT, Belaaouaj A, Abraham SN, Ley TJ
    Blood 1999 Dec 15;94(12):4282-93
  • Transgenic Analysis of a 100-Kb Human Beta-Globin Cluster-Containing DNA Fragment Propagated as a Bacterial Artificial Chromosome [Published Erratum Appears in Blood 2000 Feb 1;95(3):744]
    Kaufman RM, Pham CT, Ley TJ
    Blood 1999 Nov 1;94(9):3178-84
  • Dipeptidyl Peptidase I Is Required for the Processing and Activation of Granzymes A and B in Vivo
    Pham CT, Ley TJ
    Proc Natl Acad Sci U S A 1999 Jul 20;96(15):8627-32
  • Granzyme a Initiates an Alternative Pathway for Granule-Mediated Apoptosis
    Shresta S, Graubert TA, Thomas DA, Raptis SZ, Ley TJ
    Immunity 1999 May;10(5):595-605
  • The 5' Flanking Region of the Human Granzyme H Gene Directs Expression to T/Natural Killer Cell Progenitors and Lymphokine-Activated Killer Cells in Transgenic Mice
    MacIvor DM, Pham CT, Ley TJ
    Blood 1999 Feb 1;93(3):963-73
  • Augmented Inflammatory Responses and Altered Wound Healing in Cathepsin G-Deficient Mice
    Abbott RE, Corral CJ, MacIvor DM, Lin X, Ley TJ, Mustoe TA
    Arch Surg 1998 Sep;133(9):1002-6
  • Stochastic, Stage-Specific Mechanisms Account for the Variegation of a Human Globin Transgene
    Graubert TA, Hug BA, Wesselschmidt R, Hsieh CL, Ryan TM, Townes TM, Ley TJ
    Nucleic Acids Res 1998 Jun 15;26(12):2849-58
  • Mice Lacking Neutrophil Elastase Reveal Impaired Host Defense Against Gram Negative Bacterial Sepsis
    Belaaouaj A, McCarthy R, Baumann M, Gao Z, Ley TJ, Abraham SN, Shapiro SD
    Nat Med 1998 May;4(5):615-8
  • Production of Fully Active Recombinant Murine Granzyme B in Yeast
    Pham CT, Thomas DA, Mercer JD, Ley TJ
    J Biol Chem 1998 Jan 16;273(3):1629-33
  • Perforin/Granzyme-Dependent and Independent Mechanisms Are Both Important for the Development of Graft-Versus-Host Disease After Murine Bone Marrow Transplantation
    Graubert TA, DiPersio JF, Russell JH, Ley TJ
    J Clin Invest 1997 Aug 15;100(4):904-11
  • Residual Cytotoxicity and Granzyme K Expression in Granzyme A-Deficient Cytotoxic Lymphocytes
    Shresta S, Goda P, Wesselschmidt R, Ley TJ
    J Biol Chem 1997 Aug 8;272(32):20236-44
  • Mechanisms Responsible for Granzyme B-Independent Cytotoxicity
    Shresta S, Russell JH, Ley TJ
    Blood 1997 Jun 1;89(11):4085-91
  • Molecular Cloning, Chromosomal Localization, and Expression of Murine Dipeptidyl Peptidase I
    Pham CTN, Armstrong RJ, Zimonjic DB, Popescu NC, Payan DG, Ley TJ
    J Biol Chem 1997 Apr 18;272(16):10695-703
  • Altered Myeloid Development and Acute Leukemia in Transgenic Mice Expressing PML-RAR Alpha Under Control of Cathepsin G Regulatory Sequences
    Grisolano JL, Wesselschmidt RL, Pelicci PG, Ley TJ
    Blood 1997 Jan 15;89(2):376-87
  • Long-Range Disruption of Gene Expression by a Selectable Marker Cassette
    Pham CT, MacIvor DM, Hug BA, Heusel JW, Ley TJ
    Proc Natl Acad Sci U S A 1996 Nov 12;93(23):13090-5
  • Cleavage of CPP32 by Granzyme B Represents a Critical Role for Granzyme B in the Induction of Target Cell DNA Fragmentation
    Darmon AJ, Ley TJ, Nicholson DW, Bleackley RC
    J Biol Chem 1996 Sep 6;271(36):21709-12
  • Metalloelastase Is Required for Macrophage-Mediated Proteolysis and Matrix Invasion in Mice
    Shipley JM, Wesselschmidt RL, Kobayashi DK, Ley TJ, Shapiro SD
    Proc Natl Acad Sci U S A 1996 Apr 30;93(9):3942-6
  • Analysis of Mice Containing a Targeted Deletion of Beta-Globin Locus Control Region 5' Hypersensitive Site 3
    Hug BA, Wesselschmidt RL, Fiering S, Bender MA, Epner E, Groudine M, Ley TJ
    Mol Cell Biol 1996 Jun;16(6):2906-12
  • The Role of Granzyme B in Murine Models of Acute Graft-Versus-Host Disease and Graft Rejection
    Graubert TA, Russell JH, Ley TJ
    Blood 1996 Feb 15;87(4):1232-7
  • An Intramolecular Triplex in the Human Gamma-Globin 5'-Flanking Region Is Altered by Point Mutations Associated With Hereditary Persistence of Fetal Hemoglobin
    Bacolla A, Ulrich MJ, Larson JE, Ley TJ, Wells RD
    J Biol Chem 1995 Oct 13;270(41):24556-63
  • Targeted Deletion of 5'HS2 of the Murine Beta-Globin LCR Reveals That It Is Not Essential for Proper Regulation of the Beta-Globin Locus
    Fiering S, Epner E, Robinson K, Zhuang Y, Telling A, Hu M, Martin DI, Enver T, Ley TJ, Groudine M
    Genes Dev 1995 Sep 15;9(18):2203-13
  • Natural Killer and Lymphokine-Activated Killer Cells Require Granzyme B for the Rapid Induction of Apoptosis in Susceptible Target Cells
    Shresta S, MacIvor DM, Heusel JW, Russell JH, Ley TJ
    Proc Natl Acad Sci U S A 1995 Jun 6;92(12):5679-83
  • Development of Leukemia in Mice Transgenic for the Tax Gene of Human T- Cell Leukemia Virus Type I
    Grossman WJ, Kimata JT, Wong FH, Zutter M, Ley TJ, Ratner L
    Proc Natl Acad Sci U S A 1995 Feb 14;92(4):1057-61
  • Early Myeloid Cell-Specific Expression of the Human Cathepsin G Gene in Transgenic Mice
    Grisolano JL, Sclar GM, Ley TJ
    Proc Natl Acad Sci U S A 1994 Sep 13;91(19):8989-93
  • A Human Protein Containing a "Cold Shock" Domain Binds Specifically to H-DNA Upstream From the Human Gamma-Globin Genes
    Horwitz EM, Maloney KA, Ley TJ
    J Biol Chem 1994 May 13;269(19):14130-9
  • Cytotoxic Lymphocytes Require Granzyme B for the Rapid Induction of DNA Fragmentation and Apoptosis in Allogeneic Target Cells
    Heusel JW, Wesselschmidt RL, Shresta S, Russell JH, Ley TJ
    Cell 1994 Mar 25;76(6):977-87
  • Cloning and Characterization of a Unique Elastolytic Metalloproteinase Produced by Human Alveolar Macrophages
    Shapiro SD, Kobayashi DK, Ley TJ
    J Biol Chem 1993 Nov 15;268(32):23824-9
  • Consensus AP-1 and CRE Motifs Upstream From the Human Cytotoxic Serine Protease B (CSP-B/CGL-1) Gene Synergize to Activate Transcription
    Hanson RD, Grisolano JL, Ley TJ
    Blood 1993 Nov 1;82(9):2749-57
  • Molecular Mechanisms Regulating the Production of Collagenase and TIMP in U937 Cells: Evidence for Involvement of Delayed Transcriptional Activation and Enhanced mRNA Stability
    Shapiro SD, Doyle GA, Ley TJ, Parks WC, Welgus HG
    Biochemistry 1993 Apr 27;32(16):4286-92
  • The Human Mast Cell Chymase Gene (CMA1): Mapping to the Cathepsin G/Granzyme Gene Cluster and Lineage-Restricted Expression
    Caughey GH, Schaumberg TH, Zerweck EH, Butterfield JH, Hanson RD, Silverman GA, Ley TJ
    Genomics 1993 Mar;15(3):614-20
  • Molecular Cloning, Chromosomal Location, and Tissue-Specific Expression of the Murine Cathepsin G Gene
    Heusel JW, Scarpati EM, Jenkins NA, Gilbert DJ, Copeland NG, Shapiro SD, Ley TJ
    Blood 1993 Mar 15;81(6):1614-23
  • Structure and Function of the Murine Beta-Globin Locus Control Region 5' HS-3
    Hug BA, Moon AM, Ley TJ
    Nucleic Acids Res 1992 Nov 11;20(21):5771-8
  • An Intramolecular DNA Triplex Is Disrupted by Point Mutations Associated With Hereditary Persistence of Fetal Hemoglobin
    Ulrich MJ, Gray WJ, Ley TJ
    J Biol Chem 1992 Sep 15;267(26):18649-58
  • Characterization of the 5' Untranslated Region of the Human c-Fgr Gene and Identification of the Major Myelomonocytic c-Fgr Promoter
    Link DC, Gutkind SJ, Robbins KC, Ley TJ
    Oncogene 1992 May;7(5):877-84
  • Molecular Cloning, Chromosomal Localization, and Bacterial Expression of a Murine Macrophage Metalloelastase
    Shapiro SD, Griffin GL, Gilbert DJ, Jenkins NA, Copeland NG, Welgus HG, Senior RM, Ley TJ
    J Biol Chem 1992 Mar 5;267(7):4664-71
  • A-T-Rich Scaffold Attachment Regions Flank the Hematopoietic Serine Protease Genes Clustered on Chromosome 14q11.2
    Hanson RD, Ley TJ
    Blood 1992 Feb 1;79(3):610-8
  • The 5'-Flanking Region of the Human CGL-1/Granzyme B Gene Targets Expression of a Reporter Gene to Activated T-Lymphocytes in Transgenic Mice
    Hanson RD, Sclar GM, Kanagawa O, Ley TJ
    J Biol Chem 1991 Dec 25;266(36):24433-8
  • 1,25-Dihydroxyvitamin D3 Induces Monocytic Differentiation of the PLB-985 Leukemic Line and Promotes c-Fgr mRNA Expression
    Perkins SL, Link DC, Kling S, Ley TJ, Teitelbaum SL
    J Leukoc Biol 1991 Nov;50(5):427-33
  • Functional Properties of the Beta-Globin Locus Control Region in K562 Erythroleukemia Cells
    Moon AM, Ley TJ
    Blood 1991 May 15;77(10):2272-84
  • Structure and Expression of a Cluster of Human Hematopoietic Serine Protease Genes Found on Chromosome 14q11.2
    Heusel JW, Hanson RD, Silverman GA, Ley TJ
    J Biol Chem 1991 Apr 5;266(10):6152-8
  • A Novel c-Fgr Exon Utilized in Epstein-Barr Virus-Infected B Lymphocytes but Not in Normal Monocytes
    Gutkind JS, Link DC, Katamine S, Lacal P, Miki T, Ley TJ, Robbins KC
    Mol Cell Biol 1991 Mar;11(3):1500-7
  • Transcriptional Activation of the Human Cytotoxic Serine Protease Gene CSP-B in T Lymphocytes
    Hanson RD, Ley TJ
    Mol Cell Biol 1990 Nov;10(11):5655-62
  • Conservation of the Primary Structure, Organization, and Function of the Human and Mouse Beta-Globin Locus-Activating Regions
    Moon AM, Ley TJ
    Proc Natl Acad Sci U S A 1990 Oct;87(19):7693-7
  • Function of Normal and Mutated Gamma-Globin Gene Promoters in Electroporated K562 Erythroleukemia Cells
    Ulrich MJ, Ley TJ
    Blood 1990 Feb 15;75(4):990-9
  • A Cluster of Hematopoietic Serine Protease Genes Is Found on the Same Chromosomal Band as the Human Alpha/Delta T-Cell Receptor Locus
    Hanson RD, Hohn PA, Popescu NC, Ley TJ
    Proc Natl Acad Sci U S A 1990 Feb;87(3):960-3
  • Developmental Regulation of the Human Cathepsin G Gene in Myelomonocytic Cells
    Hanson RD, Connolly NL, Burnett D, Campbell EJ, Senior RM, Ley TJ
    J Biol Chem 1990 Jan 25;265(3):1524-30
  • Nucleotide Sequence and Regulation of a Human 90-KDa Heat Shock Protein Gene
    Rebbe NF, Hickman WS, Ley TJ, Stafford DW, Hickman S
    J Biol Chem 1989 Sep 5;264(25):15006-11
  • Analysis of Epitope Expression and the Functional Repertoire of Recombinant Complement Receptor 2 (CR2/CD21) in Mouse and Human Cells
    Carel JC, Frazier B, Ley TJ, Holers VM
    J Immunol 1989 Aug 1;143(3):923-30
  • Genomic Organization and Chromosomal Localization of the Human Cathepsin G Gene
    Hohn PA, Popescu NC, Hanson RD, Salvesen G, Ley TJ
    J Biol Chem 1989 Aug 15;264(23):13412-9
  • Globin Gene Expression in Erythroid Human Fetal Liver Cells
    Ley TJ, Maloney KA, Gordon JI, Schwartz AL
    J Clin Invest 1989 Mar;83(3):1032-8
  • Tissue-Specific Expression and Developmental Regulation of the Human Fgr Proto-Oncogene
    Ley TJ, Connolly NL, Katamine S, Cheah MS, Senior RM, Robbins KC
    Mol Cell Biol 1989 Jan;9(1):92-9
  • High-Resolution Analysis of the Human Gamma-Globin Gene Promoter in K562 Erythroleukemia Cell Chromatin
    Gimble JM, Max EE, Ley TJ
    Blood 1988 Aug;72(2):606-12
  • An Enhancer Element Lies 3' to the Human a Gamma Globin Gene
    Bodine DM, Ley TJ
    EMBO J 1987 Oct;6(10):2997-3004
  • Hydroxyurea Induction of Hemoglobin F Production in Sickle Cell Disease: Relationship Between Cytotoxicity and F Cell Production
    Dover GJ, Humphries RK, Moore JG, Ley TJ, Young NS, Charache S, Nienhuis AW
    Blood 1986 Mar;67(3):735-8
  • Fgr Proto-Oncogene mRNA Induced in B Lymphocytes by Epstein-Barr Virus Infection
    Cheah MS, Ley TJ, Tronick SR, Robbins KC
    Nature 1986 Jan 16-22;319(6050):238-40
  • 5-Azacytidine Acts Directly on Both Erythroid Precursors and Progenitors to Increase Production of Fetal Hemoglobin
    Humphries RK, Dover G, Young NS, Moore JG, Charache S, Ley T, Nienhuis AW
    J Clin Invest 1985 Feb;75(2):547-57
  • Disseminated Infection Caused by Cunninghamella Bertholletiae in a Patient With Beta-Thalassemia. Case Report and Review of the Literature
    Sands JM, Macher AM, Ley TJ, Nienhuis AW
    Ann Intern Med 1985 Jan;102(1):59-63
  • DNA Methylation and Regulation of the Human Beta-Globin-Like Genes in Mouse Erythroleukemia Cells Containing Human Chromosome 11
    Ley TJ, Chiang YL, Haidaris D, Anagnou NP, Wilson VL, Anderson WF
    Proc Natl Acad Sci U S A 1984 Nov;81(21):6618-22
  • Beta O-39 Thalassemia Gene: A Premature Termination Codon Causes Beta- mRNA Deficiency Without Affecting Cytoplasmic Beta-mRNA Stability
    Humphries RK, Ley TJ, Anagnou NP, Baur AW, Nienhuis AW
    Blood 1984 Jul;64(1):23-32
  • Human Globin Gene Expression in Hybrid 2S MEL X Human Fibroblast Cells
    Chiang YL, Ley TJ, Sanders-Haigh L, Anderson WF
    Somat Cell Mol Genet 1984 Jul;10(4):399-407
  • Inducible Transcription of Five Globin Genes in K562 Human Leukemia Cells
    Dean A, Ley TJ, Humphries RK, Fordis M, Schechter AN
    Proc Natl Acad Sci U S A 1983 Sep;80(18):5515-9
  • Acquired Alpha-Thalassemia in Preleukemia Is Due to Decreased Expression of All Four Alpha-Globin Genes
    Anagnou NP, Ley TJ, Chesbro B, Wright G, Kitchens C, Liebhaber S, Nienhuis AW, Deisseroth AB
    Proc Natl Acad Sci U S A 1983 Oct;80(19):6051-5
  • "Silent" Nucleotide Substitution in a Beta+-Thalassemia Globin Gene Activates Splice Site in Coding Sequence RNA
    Goldsmith ME, Humphries RK, Ley T, Cline A, Kantor JA, Nienhuis AW
    Proc Natl Acad Sci U S A 1983 Apr;80(8):2318-22
  • 5-Azacytidine Increases Gamma-Globin Synthesis and Reduces the Proportion of Dense Cells in Patients With Sickle Cell Anemia
    Ley TJ, DeSimone J, Noguchi CT, Turner PH, Schechter AN, Heller P, Nienhuis AW
    Blood 1983 Aug;62(2):370-80
  • A Weak Upstream Promoter Gives Rise to Long Human Beta-Globin RNA Molecules
    Ley TJ, Nienhuis AW
    Biochem Biophys Res Commun 1983 May 16;112(3):1041-8
  • 5-Azacytidine Selectively Increases Gamma-Globin Synthesis in a Patient With Beta+ Thalassemia
    Ley TJ, DeSimone J, Anagnou NP, Keller GH, Humphries RK, Turner PH, Young NS, Keller P, Nienhuis AW
    N Engl J Med 1982 Dec 9;307(24):1469-75
  • Spontaneous Subarachnoid Hemorrhage Simulating Acute Transmural Myocardial Infarction
    Gascon P, Ley TJ, Toltzis RJ, Bonow RO
    Am Heart J 1983 Mar;105(3):511-3
  • RNA Processing Errors in Patients With Beta-Thalassemia
    Ley TJ, Anagnou NP, Pepe G, Nienhuis AW
    Proc Natl Acad Sci U S A 1982 Aug;79(15):4775-9
  • Differences in Human Alpha-, Beta- and Delta-Globin Gene Expression in Monkey Kidney Cells
    Humphries RK, Ley T, Turner P, Moulton AD, Nienhuis AW
    Cell 1982 Aug;30(1):173-83