Kian H. Lim.jpg

Kian H. Lim, MD, PhD

Assistant Professor
Department of Medicine
Oncology Division
Molecular Oncology

Clinical Interests

  • Pancreatic cancer
  • Colon cancer
  • Biliary cancer
  • Neuroendocrine tumor

Research Interests

  • Inflammation
  • Innate immunity
  • Immunotherapy
  • Tumor-stroma interaction
  • KRas
  • IRAK4


  • 314-362-5740 (tel)
  • 314-362-7086 (fax)
  • Room 502 McDonnell Medical Sciences Building (lab)
  • Division of Oncology
    Campus Box 8069
    Washington University Medical School
    660 South Euclid Avenue
    St. Louis, MO 63110

Peer-reviewed Manuscripts

  • Tumor-Stroma IL-1beta-IRAK4 Feedforward Circuitry Drives Tumor Fibrosis, Chemoresistance, and Poor Prognosis in Pancreatic Cancer
    Zhang D, Li L, Jiang H, Li Q, Wang-Gillam A, Yu J, Head R, Liu J, Ruzinova MB, Lim KH
    Cancer Res 2018 Jan 23; [Epub ahead of print]
  • Distinct Clinical and Magnetic Resonance Features of Metastatic Hepatocellular Carcinoma Treated With Pembrolizumab: A Case Report of Late Response After Pseudoprogression
    Grierson P, Crites D, Ruzinova MB, Yano M, Lim KH
    Hepatol Commun 2017 Dec 19;2(2):148-151
  • Pacritinib to Inhibit JAK/STAT Signaling in Refractory Metastatic Colon and Rectal Cancer
    Regenbogen T, Chen L, Trinkaus K, Wang-Gillam A, Tan BR, Amin M, Pedersen KS, Park H, Suresh R, Lim KH, Ratchford E, Brown A, Lockhart AC
    J Gastrointest Oncol 2017 Dec;8(6):985-989
  • Lack of a Prognostic Impact of the MyD88 L265P Mutation for Diffuse Large B Cell Lymphoma Patients Undergoing Autologous Stem Cell Transplantation
    Lee YS, Liu J, Fricano KA, Webb EM, Toolsie DR, Jones S, Rhoads JA, Vij R, Cashen AF, Abboud CN, Westervelt P, Bartlett NL, DiPersio JF, Kreisel FH, Lim KH
    Biol Blood Marrow Transplant 2017 Dec;23(12):2199-2204
  • Entering the Molecular Era of Gastrointestinal Oncology: Current Updates and Challenges
    Wang-Gillam A, Lim KH
    J Gastrointest Oncol 2017 Jun;8(3):377-378
  • Molecular Landscape and Sub-Classification of Gastrointestinal Cancers: A Review of Literature
    Fakhri B, Lim KH
    J Gastrointest Oncol 2017 Jun;8(3):379-386
  • Current Biologics for Treatment of Biliary Tract Cancers
    Zhao DY, Lim KH
    J Gastrointest Oncol 2017 Jun;8(3):430-440
  • Immunotherapy in Gastrointestinal Cancers
    Grierson P, Lim KH, Amin M
    J Gastrointest Oncol 2017 Jun;8(3):474-484
  • A Clinically Feasible Multiplex Proteomic Immunoassay as a Novel Functional Diagnostic for Pancreatic Ductal Adenocarcinoma
    Lim KH, Langley E, Gao F, Luo J, Li L, Meyer G, Kim P, Singh S, Kushnir VM, Early DS, Mullady DK, Edmundowicz SA, Wani S, Murad FM, Cao D, Azar RR, Wang-Gillam A
    Oncotarget 2017 Apr 11;8(15):24250-24261
  • Utility of a Multidisciplinary Tumor Board in the Management of Pancreatic and Upper Gastrointestinal Diseases: An Observational Study
    Brauer DG, Strand MS, Sanford DE, Kushnir VM, Lim KH, Mullady DK, Tan BR Jr, Wang-Gillam A, Morton AE, Ruzinova MB, Parikh PJ, Narra VR, Fowler KJ, Doyle MB, Chapman WC, Strasberg SS, Hawkins WG, Fields RC
    HPB (Oxford) 2017 Feb;19(2):133-139
  • Constitutive IRAK4 Activation Underlies Poor Prognosis and Chemoresistance in Pancreatic Ductal Adenocarcinoma
    Zhang D, Li L, Jiang H, Knolhoff BL, Lockhart AC, Wang-Gillam A, DeNardo DG, Ruzinova MB, Lim KH
    Clin Cancer Res 2017 Apr 1;23(7):1748-1759
  • Targeting Tumour-Associated Macrophages With CCR2 Inhibition in Combination With FOLFIRINOX in Patients With Borderline Resectable and Locally Advanced Pancreatic Cancer: A Single-Centre, Open-Label, Dose-Finding, Non-Randomised, Phase 1b Trial
    Nywening TM, Wang-Gillam A, Sanford DE, Belt BA, Panni RZ, Cusworth BM, Toriola AT, Nieman RK, Worley LA, Yano M, Fowler KJ, Lockhart AC, Suresh R, Tan BR, Lim KH, Fields RC, Strasberg SM, Hawkins WG, DeNardo DG, Goedegebuure SP, Linehan DC
    Lancet Oncol 2016 May;17(5):651-662
  • Nanoliposomal Irinotecan Plus Fluorouracil and Folinic Acid: A New Treatment Option in Metastatic Pancreatic Cancer
    Saif Ur Rehman S, Lim K, Wang-Gillam A
    Expert Rev Anticancer Ther 2016 May;16(5):485-492
  • Advanced Pancreatic Adenocarcinoma: A Review of Current Treatment Strategies and Developing Therapies
    Teague A, Lim KH, Wang-Gillam A
    Ther Adv Med Oncol 2015 Mar;7(2):68-84
  • Toll-Like Receptor Signaling
    Lim KH, Staudt LM
    Cold Spring Harb Perspect Biol 2013 Jan 1;5(1):a011247
  • Pathogenetic Importance and Therapeutic Implications of NF-KappaB in Lymphoid Malignancies
    Lim KH, Yang Y, Staudt LM
    Immunol Rev 2012 Mar;246(1):359-78
  • Neoadjuvant Therapy of Pancreatic Cancer: The Emerging Paradigm?
    Lim KH, Chung E, Khan A, Cao D, Linehan D, Ben-Josef E, Wang-Gillam A
    Oncologist 2012;17(2):192-200
  • RALA and RALBP1 Regulate Mitochondrial Fission at Mitosis
    Kashatus DF, Lim KH, Brady DC, Pershing NL, Cox AD, Counter CM
    Nat Cell Biol 2011 Aug 7;13(9):1108-15
  • Oncogenically Active MYD88 Mutations in Human Lymphoma
    Ngo VN*, Young RM*, Schmitz R*, Jhavar S*, Xiao W*, Lim KH*, Kohlhammer H, Xu W, Yang Y, Zhao H, Shaffer AL, Romesser P, Wright G, Powell J, Rosenwald A, Muller-Hermelink HK, Ott G, Gascoyne RD, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Fisher RI, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Staudt LM (*co-first authors)
    Nature 2011 Feb 3;470(7332):115-9
  • Sec5 and Exo84 Foster Oncogenic Ras-Mediated Tumorigenesis
    Issaq SH, Lim KH, Counter CM
    Mol Cancer Res 2010 Feb;8(2):223-31
  • Aurora-A Phosphorylates, Activates, and Relocalizes the Small GTPase RalA
    Lim KH, Brady DC, Kashatus DF, Ancrile BB, Der CJ, Cox AD, Counter CM
    Mol Cell Biol 2010 Jan;30(2):508-23
  • The Cytoplasmic Deacetylase HDAC6 Is Required for Efficient Oncogenic Tumorigenesis
    Lee YS, Lim KH, Guo X, Kawaguchi Y, Gao Y, Barrientos T, Ordentlich P, Wang XF, Counter CM, Yao TP
    Cancer Res 2008 Sep 15;68(18):7561-9
  • Tumour Maintenance Is Mediated by ENOS
    Lim KH*, Ancrile BB*, Kashatus DF*, Counter CM (*co-first authors)
    Nature 2008 Apr 3;452(7187):646-9
  • Oncogenic Ras-Induced Secretion of IL6 Is Required for Tumorigenesis
    Ancrile B, Lim KH, Counter CM
    Genes Dev 2007 Jul 15;21(14):1714-9
  • Divergent Roles for RalA and RalB in Malignant Growth of Human Pancreatic Carcinoma Cells
    Lim KH, O'Hayer K, Adam SJ, Kendall SD, Campbell PM, Der CJ, Counter CM
    Curr Biol 2006 Dec 19;16(24):2385-94
  • Use of Retrovirus Expression of Interfering RNA to Determine the Contribution of Activated K-Ras and Ras Effector Expression to Human Tumor Cell Growth
    Baines AT, Lim KH, Shields JM, Lambert JM, Counter CM, Der CJ, Cox AD
    Methods Enzymol 2006;407:556-74
  • Reduction in the Requirement of Oncogenic Ras Signaling to Activation of PI3K/AKT Pathway During Tumor Maintenance
    Lim KH, Counter CM
    Cancer Cell 2005 Nov;8(5):381-92
  • Activation of RalA Is Critical for Ras-Induced Tumorigenesis of Human Cells
    Lim KH, Baines AT, Fiordalisi JJ, Shipitsin M, Feig LA, Cox AD, Der CJ, Counter CM
    Cancer Cell 2005 Jun;7(6):533-45
  • Leveling the Playing Field
    Lim KH, Counter CM
    Mol Cell 2004 Aug 27;15(4):491-2