Divisions of Hematology & Oncology

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Peer-reviewed Manuscripts

• VLA4-Targeted Nanoparticles Hijack Cell Adhesion-Mediated Drug Resistance to Target Refractory Myeloma Cells and Prolong Survival
  Fontana F, Scott MJ, Allen JS, Yang X, Cui G, Pan D, Yanaba N, Fiala MA, O'Neal J, Schmieder-Atteberry AH, Ritchey J, Rettig M, Simons K, Fletcher S, Vij R, DiPersio JF, Lanza GM
  Clin Cancer Res 2021 Apr 1;27(7):1974-1986
• Nanoparticle T-Cell Engagers as a Modular Platform for Cancer Immunotherapy
  Alhallak K, Sun J, Wasden K, Guenthner N, O'Neal J, Muz B, King J, Kohnen D, Vij R, Achilefu S, DiPersio JF, Azab AK
  Leukemia 2021 Jan 21; [Epub ahead of print]
• Development of [(89)Zr]DFO-Elotuzumab for ImmunoPET Imaging of CS1 in Multiple Myeloma
  Ghai A, Zheleznyak A, Mixdorf M, O'Neal J, Ritchey J, Rettig M, DiPersio J, Shokeen M, Achilefu S
  Eur J Nucl Med Mol Imaging 2020 Nov 11; [Epub ahead of print]
• EZH2 Overexpression in Multiple Myeloma: Prognostic Value, Correlation With Clinical Characteristics, and Possible Mechanisms
  Goldsmith SR, Fiala MA, O'Neal J, Souroullas GP, Toama W, Vij R, Schroeder MA
  Clin Lymphoma Myeloma Leuk 2019 Nov;19(11):744-750
• An "Off-The-Shelf" Fratricide-Resistant CAR-T for the Treatment of T Cell Hematologic Malignancies
  Cooper ML, Choi J, Staser K, Ritchey JK, Devenport JM, Eckardt K, Rettig MP, Wang B, Eissenberg LG, Ghobadi A, Gehrs LN, Prior JL, Achilefu S, Miller CA, Fronick CC, O'Neal J, Gao F, Weinstock DM, Gutierrez A, Fulton RS, DiPersio JF
  Leukemia 2018 Sep;32(9):1970-1983
• A Multiple Myeloma-Specific Capture Sequencing Platform Discovers Novel Translocations and Frequent, Risk-Associated Point Mutations in IGLL5
  White BS, Lanc I, O'Neal J, Gupta H, Fulton RS, Schmidt H, Fronick C, Belter EA Jr, Fiala M, King J, Ahmann GJ, DeRome M, Mardis ER, Vij R, DiPersio JF, Levy J, Auclair D, Tomasson MH
  Blood Cancer J 2018 Mar 21;8(3):35
• Inhibition of 6-Phosphofructo-2-Kinase (PFKFB3) Suppresses Glucose Metabolism and the Growth of HER2+ Breast Cancer
  O'Neal J, Clem A, Reynolds L, Dougherty S, Imbert-Fernandez Y, Telang S, Chesney J, Clem BF
  Breast Cancer Res Treat 2016 Nov;160(1):29-40
• Collaborative Control of Cell Cycle Progression by the RNA Exonuclease Dis3 and Ras Is Conserved Across Species
  Snee MJ, Wilson WC, Zhu Y, Chen SY, Wilson BA, Kseib C, O'Neal J, Mahajan N, Tomasson MH, Arur S, Skeath JB
  Genetics 2016 Jun;203(2):749-62
• Deletion of Rb1 Induces Both Hyperproliferation and Cell Death in Murine Germinal Center B Cells
  He Z*, O'Neal J*, Wilson WC, Mahajan N, Luo J, Wang Y, Su MY, Lu L, Skeath JB, Bhattacharya D, Tomasson MH (*Co-first authors)
  Exp Hematol 2016 Mar;44(3):161-5e4
• Clinical Development of Cancer Therapeutics That Target Metabolism
  Clem BF, O'Neal J, Klarer AC, Telang S, Chesney J
  QJM 2016 Jun;109(6):367-72
• Whole Genome Sequence of Multiple Myeloma-Prone C57BL/KaLwRij Mouse Strain Suggests the Origin of Disease Involves Multiple Cell Types
  Amend SR, Wilson WC, Chu L, Lu L, Liu P, Serie D, Su X, Xu Y, Wang D, Gramolini A, Wen XY, O'Neal J, Hurchla M, Vachon CM, Colditz G, Vij R, Weilbaecher KN, Tomasson MH
  PLoS One 2015 May 28;10(5):e0127828
• Glucose Availability and Glycolytic Metabolism Dictate Glycosphingolipid Levels
  Stathem M, Marimuthu S, O'Neal J, Rathmell JC, Chesney JA, Beverly LJ, Siskind LJ
  J Cell Biochem 2015 Jan;116(1):67-80
• Estradiol Stimulates Glucose Metabolism Via 6-Phosphofructo-2-Kinase (PFKFB3)
  Imbert-Fernandez Y, Clem BF, O'Neal J, Kerr DA, Spaulding R, Lanceta L, Clem AL, Telang S, Chesney J
  J Biol Chem 2014 Mar 28;289(13):9440-8
• Inhibition of 6-Phosphofructo-2-Kinase (PFKFB3) Induces Autophagy as a Survival Mechanism
  Klarer AC, O'Neal J, Imbert-Fernandez Y, Clem A, Ellis SR, Clark J, Clem B, Chesney J, Telang S
  Cancer Metab 2014 Jan 23;2(1):2
• Targeting 6-Phosphofructo-2-Kinase (PFKFB3) as a Therapeutic Strategy Against Cancer
  Clem BF, O'Neal J, Tapolsky G, Clem AL, Imbert-Fernandez Y, Kerr DA 2nd, Klarer AC, Redman R, Miller DM, Trent JO, Telang S, Chesney J
  Mol Cancer Ther 2013 Aug;12(8):1461-70
• Targeting Metabolic Enzymes in Cancer - Clinical Trials Update
  O’Neal J, Chesney J
  Current Enzyme Inhibition 2013;9(2):152-60
• The Function of the Conserved Regulatory Element Within the Second Intron of the Mammalian Csf1r Locus
  Sauter KA, Bouhlel MA, O'Neal J, Sester DP, Tagoh H, Ingram RM, Pridans C, Bonifer C, Hume DA
  PLoS One 2013;8(1):e54935
• Neurobeachin (NBEA) Is a Target of Recurrent Interstitial Deletions at 13q13 in Patients With MGUS and Multiple Myeloma
  O'Neal J, Gao F, Hassan A, Monahan R, Barrios S, Kilimann MW, Lee I, Chng WJ, Vij R, Tomasson MH
  Exp Hematol 2009 Feb;37(2):234-44
• RelB Is the NF-KappaB Subunit Downstream of NIK Responsible for Osteoclast Differentiation
  Vaira S, Johnson T, Hirbe AC, Alhawagri M, Anwisye I, Sammut B, O'Neal J, Zou W, Weilbaecher KN, Faccio R, Novack DV
  Proc Natl Acad Sci U S A 2008 Mar 11;105(10):3897-902
• Myeloproliferative Disease Induced by TEL-PDGFRB Displays Dynamic Range Sensitivity to Stat5 Gene Dosage
  Cain JA, Xiang Z, O'Neal J, Kreisel F, Colson A, Luo H, Hennighausen L, Tomasson MH
  Blood 2007 May 1;109(9):3906-14
• c-MYC Rapidly Induces Acute Myeloid Leukemia in Mice Without Evidence of Lymphoma-Associated Antiapoptotic Mutations
  Luo H, Li Q, O'Neal J, Kreisel F, Le Beau MM, Tomasson MH
  Blood 2005 Oct 1;106(7):2452-61
• An Activated Receptor Tyrosine Kinase, TEL/PDGFbetaR, Cooperates With AML1/ETO to Induce Acute Myeloid Leukemia in Mice
  Grisolano JL, O'Neal J, Cain J, Tomasson MH
  Proc Natl Acad Sci U S A 2003 Aug 5;100(16):9506-11
• OCP1, an F-Box Protein, Co-Localizes With OCP2/SKP1 in the Cochlear Epithelial Gap Junction Region
  Henzl MT, O'Neal J, Killick R, Thalmann I, Thalmann R
  Hear Res 2001 Jul;157(1-2):100-11