Lee Ratner.jpg

Lee Ratner, MD, PhD

Department of Medicine
Oncology Division
Molecular Oncology
Department of Molecular Microbiology
Department of Pathology & Immunology

Clinical Interests

  • AIDS
  • Oncology

Research Interests

  • Human retrovirology (HIV and HTLV)


Review Articles

  • Oncogenic Viruses
    Buck C, Ratner L
    In: DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology, 11th edition, Lippincott, Williams & Wilkins, Chapter 5, in preparation
  • Adult T-Cell Leukemia Lymphoma
    Mehta-Shah N, Ratner L, Horwitz SM
    Journal of Oncology Practice 2017, in press
  • Human T-Lymphotrophic Viruses (1 and 2)
    Spearman P, Ratner L
    In: 21st edition of Nelson Textbook of Pediatrics, 2017, in press
  • Human T-Cell Leukemia Virus-Associated Malignancy
    Panfil AR, Martinez MP, Ratner L, Green PL
    Curr Opin Virol 2016 Oct;20:40-46
  • Contribution of Inducible Nitric Oxide Synthase to the Transformation of HTLV-1 Infected CD4+ T-Cells
    Baydoun HH, Ratner L
    Journal of Leukemia 2015
  • How Does HTLV-1 Cause Adult T-Cell Leukaemia/Lymphoma (ATL)?
    Bangham CR, Ratner L
    Curr Opin Virol 2015 Oct;14:93-100
  • Oncogenic Viruses
    Buck C, Ratner L
    In: DeVita, Hellman, and Rosenberg’s Cancer: Principles & Practice of Oncology, 10th Edition, Lippincott, Williams & Wilkins, Chapter 5, pp 69-82, 2015
  • AIDS Related Malignancies
    Ratner L
    In: Govindin R, Morenszstern D, eds. Washington Manual of Oncology, Lippincott, in press 2015
  • Conference Highlights of the 16th International Conference on Human Retrovirology: HTLV and Related Retroviruses, 26-30 June 2013, Montreal, Canada
    Barbeau B, Hiscott J, Bazarbachi A, Carvalho E, Jones K, Martin F, Matsuoka M, Murphy EL, Ratner L, Switzer WM, Watanabe T
    Retrovirology 2014 Feb 24;11(1):19
  • Immunosuppression-Related Malignancies
    Ratner L
    In: DeVita, Hellman, and Rosenberg's Cancer: Principles & Pracice of Oncology Review (R Govindan, Ed.), Lippincott, Williams & Wilkins, 2011; pp 499-503
  • Molecular Determinants of Human T-Lymphotropic Virus Type 1 Transmission and Spread
    Lairmore MD, Anupam R, Bowden N, Haines R, Haynes RA 2nd, Ratner L, Green PL
    Viruses 2011 Jul;3(7):1131-65
  • Targeting HTLV-1 Activation of NFkappaB in Mouse Models and ATLL Patients
    Rauch DA, Ratner L
    Viruses 2011 Jun;3(6):886-900
  • HIV and Cancer
    Ratner L, Pantoanowitz L
    inPractice (www.inpractice.com)
  • JAK Blockade and HTLV
    Ratner L
    Blood 2011 Feb 10;117(6):1771-2
  • Book Review of "Human Cancer Viruses: Principles of Transformation and Pathogenesis; Edited by J. Nicholas, K.-T. Jeang, and T.C. Wu"
    Ratner L
    N Engl J Med 2009;360:312-3
  • Definition, Prognostic Factors, Treatment, and Response Criteria of Adult T-Cell Leukemia-Lymphoma: A Proposal From an International Consensus Meeting
    Tsukasaki K, Hermine O, Bazarbachi A, Ratner L, Ramos JC, Harrington W Jr, O'Mahony D, Janik JE, Bittencourt AL, Taylor GP, Yamaguchi K, Utsunomiya A, Tobinai K, Watanabe T
    J Clin Oncol 2009 Jan 20;27(3):453-9
  • HIV Preintegration Complexes
    Ratner L
    In: Gallo, R. (ed.), Retroviruses: Biology, Pathogenic Mechanisms and Treatment, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at http://www.hstalks.com/?t=BL0401709-Ratner)
  • AIDS Related Malignancies
    Ratner L, Tan B
    In: The Washington Manual of Oncology, Second Edition (R Govindan, ed) Lippincott Williams and Wilkins, Chapter 30, 2007
  • Cytokines in HTLV-1 Cytokines and Cancer
    Lairmore M, Ratner L
    In: Cytokines in the Genesis and Treatment of Cancer (M Caligiuri and M Lotze, eds), Humana Press Inc. USA, 2007; pp 27-51
  • Immusupression-Related Malignancies
    Tan B, Ratner L
    In: DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology Review, R Govindan (ed), Lippincott, Williams & Wilkins, pp 424-428, 2005
  • Human T Cell Lymphotropic Virus-Associated Leukemia/Lymphoma
    Ratner L
    Curr Opin Oncol 2005 Sep;17(5):469-73
  • Animal Models for Human T-Lymphotropic Virus Type 1 (HTLV-1) Infection and Transformation
    Lairmore MD, Silverman L, Ratner L
    Oncogene 2005 Sep 5;24(39):6005-15
  • Pathogenesis and Treatment of Human T-Cell Leukemia Virus Infection
    Ratner L
    Immunol Res 2005;32(1-3):217-24
  • Adult T Cell Leukemia Lymphoma
    Ratner L
    Front Biosci 2004 Sep 1;9:2852-9
  • AIDS-Related Lymphomas
    Smukler AJ, Tan B, Ratner L
    Contemporary Oncology 2003 Aug 15;2:1-11
  • Tumorigenesis With Transgenic Expression of Human T Cell Leukmia Virus Tax
    Ratner L
    Sugamura K, ed. Two decades of adult T cell leukemia and HTLV-I research: progress in basic research and its implications in clinical advances, Gann Monograph #50 on Cancer Research, Tokyo, Japan, pp 231-240
  • Hepatitis Viruses and Hepatocellular Carcinoma in HIV-Infected Patients
    Smukler AJ, Ratner L
    Curr Opin Oncol 2002 Sep;14(5):538-42
  • AIDS Related Malignancies
    Tan B, Ratner L
    In: Govindin R, Arquette MA, eds. Washington Manual of Oncology, Lippincott, Chapter 6, pp 100-111
  • Multidrug Resistance Transporters and Modulation
    Tan B, Piwnica-Worms D, Ratner L
    Curr Opin Oncol 2000 Sep;12(5):450-8
  • Studies of the Immortalizing Activity of HTLV Type 1 Tax, Using an Infectious Molecular Clone and Transgenic Mice
    Ratner L, Portis T, Robek M, Harding J, Grossman W
    AIDS Res Hum Retroviruses 2000 Nov 1;16(16):1647-51
  • Role of Tax in HTLV-1 Transformation: Studies With an Infectious Proviral Clone and Transgenic Mice
    Ratner L, Robek M, Grossman W
    In:  Hammarskjold M-L and Semmes OJ, Molecular Pathogenesis of HTLV-1,Vandamere Press, p 131-136, 1998
  • The Use of New Antiretroviral Therapy in Combination With Chemotherapy
    Tan B, Ratner L
    Curr Opin Oncol 1997 Sep;9(5):455-64
  • AIDS 1997. Virology: Overview
    Harada S, Ratner L
    AIDS 1997;11 Suppl A:S1-2
  • Virology
    Ratner L, Fenyo EM
    AIDS 1996;10 Suppl A:S1-2
  • Transgenic Mouse Models for HTLV-I Infection
    Grossman WJ, Ratner L
    J Acquir Immune Defic Syndr Hum Retrovirol 1996;13 Suppl 1:S162-9
  • Genetic Organization of HIV
    Ratner L
    In: Gupta A, Immunology of HIV Infection, Plenum Press, New York, pp. 3-22, 1996
  • Animal Models of HTLV-1 Infection
    Ratner L
    In: Hollsberg P, ed. Human T-cell Lymphotropic Viruses, Chap 12, John Wiley & Sons, Ltd, pp 287-307, 1996
  • Nef
    Ratner L, Niederman TM
    Curr Top Microbiol Immunol 1995;193:169-208
  • Systemic Treatment of Kaposi's Sarcoma: Current Status and Future Directions
    Lilenbaum RC, Ratner L
    AIDS 1994 Feb;8(2):141-51
  • Viral Life Cycle and Genetic Approaches
    Ratner L
    Perspectives in Drug Discovery and Design. 1:3-22, 1993
  • Molecular Biology and Pathogenesis of HIV
    Ratner L
    In: Burke D, ed. HIV Infections and AIDS. Current Opinion in Infectious Diseases vol 6, no 2, 6:181-190, 1993
  • CNS Lymphomas Associated With AIDS
    Ratner L
    In: Levine AJ, Schmidek HH, eds. Molecular Genetics of Nervous System Tumors, Wiley-Liss, New York, Chap 30, pp 329-340, 1992
  • Biology and Molecular Biology of Human Immunodeficiency Virus
    Bryant ML, Ratner L
    Pediatr Infect Dis J 1992 May;11(5):390-400
  • Functional Analysis of HIV1 and SIV Nef Proteins
    Niederman TM, Ratner L
    Res Virol 1992 Jan-Feb;143(1):43-6
  • Glucosidase Inhibitors for Treatment of HIV-1 Infection
    Ratner L
    AIDS Res Hum Retroviruses 1992 Feb;8(2):165-73
  • HIV Sequence Heterogeneity, Diverse Levels of Diversity
    McNearney T, Ratner L
    AIDS Targeted Information Newsletter, Sept. 1991
  • Structure and Function of HIV and SIV Nef Protducts
    Ratner L, Niederman TJ, Lozeron H, Bryant M.
    In: Haseltine W, ed. The Genetic Structure and Regualtion of HIV, Raven Press, New York pp 437-450, 1991
  • Structure and Fucntion of the Negative Factor (NEF) of HIV and SIV
    Ratner L, Niederman TJ, Lozeron H, Bryant M.
    In: Kumar A, ed. Advances in Molecular Biology and Targeted Treatment of AIDS. Plenum Press, pp 203-216, 1991
  • The Biology and Molecular Biology of HIV
    Bryant M, Ratner L
    In: Pizzo PA, Wilfert CA, eds. Pediatric AIDS: The Challenge of HIV Infection in Infants, Children, and Adolexcents. Williams & Wilkins, pp 53-74, 1990
  • Molecular Variation Among HTLV Isolates
    Ratner L
    In: Blattner W, ed. Human Retrovirology, HTLV, Raven Press, New York, pp 49-64, 1990
  • Human T-Lymphotropic Retroviruses (HTLV-I, HTLV-II)
    Ratner L, Wong-Staal F
    In: O'Brien S, ed. Genetic Maps, Cold Spring Harbor Press, 5th edition, pp 1.160-1.161, 1990
  • Role of the Negative Factors (NEF) in HIV and SIV Replication
    Ratner L
    AIDS Targeted Information Newsletter 3:1-2, March 1989
  • Measurement of Human Immunodeficiency Virus Load and Its Relation to Disease Progression
    Ratner L
    AIDS Res Hum Retroviruses 1989 Apr;5(2):115-9
  • Human Immunodeficiency Virus-Associated Autoimmune Thrombocytopenic Purpura: A Review
    Ratner L
    Am J Med 1989 Feb;86(2):194-8
  • The Human Immunodeficiency Virus Protease and Its Role in Virus Replciation
    Ratner L
    Minireview. AIDS Targeted Information Newsletter. 2:1-2, February 1988
  • The Family of Immunosuppressive Human Retroviruses
    Ratner L
    Minireview. AIDS Targeted Information Newsletter 1:1-3, June, 1987
  • Is the HIV Envelope Guilty of Murder?
    Ratner L
    Minireview. AIDS Targeted Information Newsletter 1:1-2, January 1987
  • Mechanism of Leukemogenesis by Human T-Cell Leukemia Virus Types I and II: Role of the Lor Gene
    Ratner L, Sodroski JG, Wong-Staal F, Haseltine WA, Shaw GM, Gallo RC
    Cancer Detect Prev 1987;10(5-6):411-24
  • Complete Nucleotide Sequences of Functional Clones of the Virus Associated With the Acquired Immunodeficiency Syndrome, HTLV-III/LAV
    Ratner L, Fisher A, Jagodzinski LL, Liou RS, Mitsuya H, Gallo RC, Wong-Staal F
    Hamatol Bluttransfus 1987;31:404-6
  • Complete Nucleotide Sequence of the AIDS Virus, HTLV-III
    Ratner L, Haseltine W, Patarca R, Livak KJ, Starcich B, Josephs SF, Doran ER, Rafalski A, Whitehorn EA, Baumeister K, Ivanoff L, Petteway SR, Pearson ML, Lauenberger JA, Papas TS, Ghrayeb J, Chang NT, Callo RC, Wong-Staal F
    In: Rivera DS, ed. 1986 Year Book of Cancer, Houston, U of Texas, MD Anderson Hospital Scientific Publications.
  • Human T Cell Lymphotropic Viruses and Their Family of Diseases
    Ratner L, Gallo RC
    In: Notkins AB, Oldstone MB, eds. Concepts in Clinical Pathogenesis II. New York, Springer-Verlag, pp 257-260, 1985
  • Structure and Function of Human Retroviruses
    Ratner L, Gallo RC
    In: Gustafson JP, ed. Genetics, Molecules, and Evolution. New York, Plenum Publishing, pp 307-342, 1985
  • Molecular Biology of Human T-Lymphotropic Retroviruses
    Wong-Staal F, Ratner L, Shaw G, Hahn B, Harper M, Franchini G, Gallo R
    Cancer Res 1985 Sep;45(9 Suppl):4539s-4544s
  • Oncogenes: Their Role in Neoplastic Transformation
    Ratner L, Josephs SF, Wong-Staal F
    Annu Rev Microbiol 1985;39:419-49
  • The Family of Human T-Lymphotropic Retroviruses Called Human T-Cell Leukemia/Lymphoma Virus (HTLV): Their Role in Lymphoid Malignancies and Lymphosuppressive Disorders (AIDS)
    Gallo RC, Ratner L, Popovic M, Salahuddin SZ, Sarngadharan MG, Wong-Staal F, Shaw G, Hahn B, Markam PD, Groopman J, Safai B, Reitz M, Robert-Guroff M
    In: Marks PA, ed. Genetics, Cell Differentiation, and Cancer, New York, Academic Press, 1985
  • Oncogenes and Cellular Transformation by Human T-Cell Leukemia Virus
    Ratner L, Wong-Staal F, Gallo RC
    In: Andersson LC, Gahmberg CG, Ekbom P, eds. Gene Expression During Normal and Malignant Differentiation. Academic Press, pp. 183-209, 1985
  • Human and Primate T-Lymphotropic Retroviruses (HTLV & PTLV) Subtypes, Biological Activity, and Role in Neoplasms
    Ratner L, Sarin PS, Wong-Staal F, Gallo RC
    In: Rigby WJ, Wilkie NM, eds. Viruses and Cancer. Cambridge University Press, pp 261-289, 1985
  • Cellular Transformation by Human T-Cell Leukemia Virus: Possible Role of T-Cell Growth Factor and Platelet-Derived Growth Factor
    Ratner L, Arya S, Wong-Staal F, Gallo RC
    In: Czech MP, Kahn CR, eds. Membrane Receptors and Cellular Recognition, UCLA Symposia on Molecular and Cellular Biology, New Series, vol 23, New York, Alan R Liss, Inc pp 357-367, 1985
  • Cloning Human Oncogenes
    Ratner L, Gallo RC, Wong-Staal F
    In: Becker E, ed. Recombinant DNA Research, Martinus Nijhoff Publishing, pp. 15-35, 1985
  • Molecular Characterization of Human T-Lymphotropic Leukemia Virus Type III Associated With the Acquired Immunodeficiency Syndrome
    Wong-Staal F, Hahn BH, Shaw GM, Arya SK, Harper M, Gonda M, Gilden R, Ratner L, Starcich B, Okamoto T, et al.
    Princess Takamatsu Symp 1984;15:291-300
  • Biochemistry of the Interferon System
    Lengyel P, Desrosiers R, Broeze R, Slattery E, Taira H, Dougherty J, Samata H, Pichon J, Farrell P, Ratner L, Sen GC
    Microbiology, pp. 219, 1980
  • Messenger RNA Methylation, Translation and Degradation in Extracts of Interferon-Treated Cells
    Sen GC, Desrosiers R, Ratner L, Shaila S, Brown GE, Lebleu B, Slattery E, Kawakita M, Cabrer B, Taira H, Lengyel P
    Tex Rep Biol Med 1977;35:221-9
  • Double Stranded RNA and the Mechanism of Interferon Action, a Progress Report
    Lengyel P, Sen GC, Desrosiers R, Ratner L, Shaila S, Brown GE, Lebleu B, Kawakita M, Cabrer B, Taira H, Slattery E
    In: Chakravorty M, ed. Molecular Basis of Host-Virus Interaction. Princeton, New Jersey, Science Press, 1976