Jieya Shao.jpg

Jieya Shao, PhD

Assistant Professor
Department of Medicine
Oncology Division
Molecular Oncology

Research Interests

  • Breast cancer
  • Molecular mechanisms
  • Translational research


  • 314-362-8695 (office)
  • 314-747-9310 (lab)
  • 314-747-9320 (fax)
  • Room 3308, 4515 McKinley Research Building (office)
  • Division of Oncology
    Campus Box 8076
    Washington University School of Medicine
    660 South Euclid Avenue
    St. Louis, MO 63110
  • Lab website (www.shaolab.org)

Peer-reviewed Manuscripts

  • Breast Tumors Educate the Proteome of Stromal Tissue in an Individualized but Coordinated Manner
    Wang X, Mooradian AD, Erdmann-Gilmore P, Zhang Q, Viner R, Davies SR, Huang KL, Bomgarden R, Van Tine BA, Shao J, Ding L, Li S, Ellis MJ, Rogers JC, Townsend RR, Fenyo D, Held JM
    Sci Signal 2017 Aug 8;10(491)
  • Dynamic Changes in the Clonal Structure of MDS and AML in Response to Epigenetic Therapy
    Uy GL, Duncavage EJ, Chang GS, Jacoby MA, Miller CA, Shao J, Heath S, Elliott K, Reineck T, Fulton RS, Fronick CC, O'Laughlin M, Ganel L, Abboud CN, Cashen AF, DiPersio JF, Wilson RK, Link DC, Welch JS, Ley TJ, Graubert TA, Westervelt P, Walter MJ
    Leukemia 2017 Apr;31(4):872-881
  • Targeted Sequencing Informs the Evaluation of Normal Karyotype Cytopenic Patients for Low-Grade Myelodysplastic Syndrome
    Duncavage EJ, O'Brien J, Vij K, Miller CA, Chang GS, Shao J, Jacoby MA, Heath S, Janke MR, Elliott K, Fulton RS, Fronick C, O'Laughlin M, Westervelt P, Ley TJ, Wilson RK, Walter MJ
    Leukemia 2016 Dec;30(12):2422-2426
  • Efficacy of SERD/SERM Hybrid-CDK4/6 Inhibitor Combinations in Models of Endocrine Therapy-Resistant Breast Cancer
    Wardell SE, Ellis MJ, Alley HM, Eisele K, VanArsdale T, Dann SG, Arndt KT, Primeau T, Griffin E, Shao J, Crowder R, Lai JP, Norris JD, McDonnell DP, Li S
    Clin Cancer Res 2015 Nov 15;21(22):5121-30
  • Subcellular Localization and Ser-137 Phosphorylation Regulate Tumor-Suppressive Activity of Profilin-1
    Diamond MI, Cai S, Boudreau A, Carey CJ Jr, Lyle N, Pappu RV, Swamidass SJ, Bissell M, Piwnica-Worms H, Shao J
    J Biol Chem 2015 Apr 3;290(14):9075-86
  • Endocrine-Therapy-Resistant ESR1 Variants Revealed by Genomic Characterization of Breast-Cancer-Derived Xenografts
    Li S, Shen D, Shao J, Crowder R, Liu W, Prat A, He X, Liu S, Hoog J, Lu C, Ding L, Griffith OL, Miller C, Larson D, Fulton RS, Harrison M, Mooney T, McMichael JF, Luo J, Tao Y, Goncalves R, Schlosberg C, Hiken JF, Saied L, Sanchez C, Giuntoli T, Bumb C, Cooper C, Kitchens RT, Lin A, Phommaly C, Davies SR, Zhang J, Kavuri MS, McEachern D, Dong YY, Ma C, Pluard T, Naughton M, Bose R, Suresh R, McDowell R, Michel L, Aft R, Gillanders W, DeSchryver K, Wilson RK, Wang S, Mills GB, Gonzalez-Angulo A, Edwards JR, Maher C, Perou CM, Mardis ER, Ellis MJ
    Cell Rep 2013 Sep 26;4(6):1116-30
  • Prion-Like Nuclear Aggregation of TDP-43 During Heat Shock Is Regulated by HSP40/70 Chaperones
    Udan-Johns M, Bengoechea R, Bell S, Shao J, Diamond MI, True HL, Weihl CC, Baloh RH
    Hum Mol Genet 2014 Jan 1;23(1):157-70
  • Protein Phosphatase 1 Dephosphorylates Profilin-1 at Ser-137
    Shao J, Diamond MI
    PLoS One 2012;7(3):e32802
  • Interaction With Polyglutamine Aggregates Reveals a Q/N-Rich Domain in TDP-43
    Fuentealba RA, Udan M, Bell S, Wegorzewska I, Shao J, Diamond MI, Weihl CC, Baloh RH
    J Biol Chem 2010 Aug 20;285(34):26304-14
  • F-Actin Binding Regions on the Androgen Receptor and Huntingtin Increase Aggregation and Alter Aggregate Characteristics
    Angeli S, Shao J, Diamond MI
    PLoS One 2010 Feb 4;5(2):e9053
  • Phosphorylation of Profilin by ROCK1 Regulates Polyglutamine Aggregation
    Shao J, Welch WJ, Diprospero NA, Diamond MI
    Mol Cell Biol 2008 Sep;28(17):5196-208
  • A Common Motif Targets Huntingtin and the Androgen Receptor to the Proteasome
    Chandra S, Shao J, Li JX, Li M, Longo FM, Diamond MI
    J Biol Chem 2008 Aug 29;283(35):23950-5
  • ROCK and PRK-2 Mediate the Inhibitory Effect of Y-27632 on Polyglutamine Aggregation
    Shao J, Welch WJ, Diamond MI
    FEBS Lett 2008 May 28;582(12):1637-42
  • Evidence for Chaperone Heterocomplexes Containing Both Hsp90 and VCP
    Prince T, Shao J, Matts RL, Hartson SD
    Biochem Biophys Res Commun 2005 Jun 17;331(4):1331-7
  • A Rapid Cellular FRET Assay of Polyglutamine Aggregation Identifies a Novel Inhibitor
    Pollitt SK, Pallos J, Shao J, Desai UA, Ma AA, Thompson LM, Marsh JL, Diamond MI
    Neuron 2003 Nov 13;40(4):685-94
  • Functional Dissection of Cdc37: Characterization of Domain Structure and Amino Acid Residues Critical for Protein Kinase Binding
    Shao J, Irwin A, Hartson SD, Matts RL
    Biochemistry 2003 Nov 4;42(43):12577-88
  • High Affinity Binding of Hsp90 Is Triggered by Multiple Discrete Segments of Its Kinase Clients
    Scroggins BT, Prince T, Shao J, Uma S, Huang W, Guo Y, Yun BG, Hedman K, Matts RL, Hartson SD
    Biochemistry 2003 Nov 4;42(43):12550-61
  • Phosphorylation of Serine 13 Is Required for the Proper Function of the Hsp90 Co-Chaperone, Cdc37
    Shao J, Prince T, Hartson SD, Matts RL
    J Biol Chem 2003 Oct 3;278(40):38117-20
  • Evidence That Protein Phosphatase 5 Functions to Negatively Modulate the Maturation of the Hsp90-Dependent Heme-Regulated EIF2alpha Kinase
    Shao J, Hartson SD, Matts RL
    Biochemistry 2002 May 28;41(21):6770-9
  • Hsp90 Regulates P50(Cdc37) Function During the Biogenesis of the Activeconformation of the Heme-Regulated EIF2 Alpha Kinase
    Shao J, Grammatikakis N, Scroggins BT, Uma S, Huang W, Chen JJ, Hartson SD, Matts RL
    J Biol Chem 2001 Jan 5;276(1):206-14
  • P50(Cdc37) Is a Nonexclusive Hsp90 Cohort Which Participates Intimately in Hsp90-Mediated Folding of Immature Kinase Molecules
    Hartson SD, Irwin AD, Shao J, Scroggins BT, Volk L, Huang W, Matts RL
    Biochemistry 2000 Jun 27;39(25):7631-44
  • P50(Cdc37) Can Buffer the Temperature-Sensitive Properties of a Mutant of Hck
    Scholz G, Hartson SD, Cartledge K, Hall N, Shao J, Dunn AR, Matts RL
    Mol Cell Biol 2000 Sep;20(18):6984-95