Oncology Division

Nathan Singh, MD, MS

Assistant Professor
Department of Medicine
Oncology Division
Stem Cell Biology

Clinical Interests

  • Hematopoietic cell transplantation
  • Acute leukemias

Research Interests

  • CAR T cell therapy
  • Cellular therapies
  • T cell signaling


  • 314-273-1103 (office)
  • 314-273-1106 (lab)
  • Room 643 Southwest Tower
  • Division of Oncology
    Section of Stem Cell Biology
    Campus Box 8007
    Washington University Medical School
    660 South Euclid Avenue
    St. Louis, MO 63110
  • Singh Lab Website

Original Manuscripts

  • Impaired Death Receptor Signaling in Leukemia Causes Antigen-Independent Resistance by Inducing CAR T Cell Dysfunction
    Singh N, Lee YG, Shestova O, Ravikumar P, Hayer KE, Hong SJ, Lu XM, Pajarillo R, Agarwal S, Kuramitsu S, Orlando EJ, Mueller KT, Good CR, Berger SL, Shalem O, Weitzman MD, Frey NV, Maude SL, Grupp SA, June CH, Gill S, Ruella M
    Cancer Discov 2020 Jan 30; [Epub ahead of print]
  • Mechanisms of Resistance to CAR T Cell Therapies
    Singh N, Orlando E, Xu J, Xu J, Binder Z, Collins MA, O'Rourke DM, Melenhorst JJ
    Semin Cancer Biol 2019 Dec 19; [Epub ahead of print]
  • Erythropoietic Protoporphyria in an Adult With Sequential Liver and Hematopoietic Stem Cell Transplantation: A Case Report
    Windon AL, Tondon R, Singh N, Abu-Gazala S, Porter DL, Russell JE, Cook C, Lander E, Smith G, Olthoff KM, Shaked A, Hoteit M, Furth EE, Serper M
    Am J Transplant 2018 Mar;18(3):745-749
  • Monocyte Lineage-Derived IL-6 Does Not Affect Chimeric Antigen Receptor T-Cell Function
    Singh N, Hofmann TJ, Gershenson Z, Levine BL, Grupp SA, Teachey DT, Barrett DM
    Cytotherapy 2017 Jul;19(7):867-880
  • Early Memory Phenotypes Drive T Cell Proliferation in Patients With Pediatric Malignancies
    Singh N, Perazzelli J, Grupp SA, Barrett DM
    Sci Transl Med 2016 Jan 6;8(320):320ra3
  • T Cells Targeting NY-ESO-1 Demonstrate Efficacy Against Disseminated Neuroblastoma
    Singh N, Kulikovskaya I, Barrett DM, Binder-Scholl G, Jakobsen B, Martinez D, Pawel B, June CH, Kalos MD, Grupp SA
    Oncoimmunology 2015 Aug 12;5(1):e1040216
  • Combined B12 and Folate Deficiency Presenting as an Aggressive Hematologic Malignancy
    Singh N, Qayyum S, Wasik MA, Luger SM
    Am J Hematol 2015 Oct;90(10):964-5
  • Nature of Tumor Control by Permanently and Transiently Modified GD2 Chimeric Antigen Receptor T Cells in Xenograft Models of Neuroblastoma
    Singh N, Liu X, Hulitt J, Jiang S, June CH, Grupp SA, Barrett DM, Zhao Y
    Cancer Immunol Res 2014 Nov;2(11):1059-70
  • Relation of Clinical Culture Method to T-Cell Memory Status and Efficacy in Xenograft Models of Adoptive Immunotherapy
    Barrett DM, Singh N, Liu X, Jiang S, June CH, Grupp SA, Zhao Y
    Cytotherapy 2014 May;16(5):619-30