In this series, research seminars given by Division faculty or guest speakers alternate with work-in-progress talks given by graduate students and post-doctoral fellows.

Schedule

  • Thursday, Noon-1:00 PM
  • Room 8841 Clinical Sciences Research Building (in person)
  • RCR Training: Responsible Conduct of Research (registered participants only)

Archive by Academic year

2023-2024
DateSpeakerTitle
Sep 14, 2023Andrew Young
Grant Challen lab
WORK-IN-PROGRESS SEMINAR
Spatial Organization of Hematopoietic Clones in the Bone Marrow of a Polycythemia Vera Patient
Sep 21, 2023Suneet Agarwal, MD, PHD
Boston Children’s/Harvard Medical School
HEMATOLOGY SPECIAL SEMINAR
Sep 28, 2023Fan He
Steve Oh lab
WORK-IN-PROGRESS SEMINAR
Galectin-1 Fuels Monocyte-Driven Hyperinflammation and Represents a Novel Therapeutic Target in Myeloproliferative Neoplasms
Oct 5, 2023Monique Chavez
Matt Walter lab
WORK-IN-PROGRESS SEMINAR
Oct 12, 2023Orsola di Martino
Steve Sykes lab
WORK-IN-PROGRESS SEMINAR
DDIT4 modulates multiple aspects of mitochondrial and lysosomal network dynamics that influence
AML progression and chemotherapy-response mechanisms
Oct 19, 2023Rong Lu, PHD
University of Southern California (USC)
HEMATOLOGY SPECIAL SEMINAR
Heterogeneity and coordination
of hematopoietic stem cells
Oct 26, 2023Stefan Tarnawsky
Matt Walter
WORK-IN-PROGRESS SEMINAR
The Fitness of U2AF1-Mutant Hematopoietic Clones
Nov 2, 2023Jingu Lee
Gus Cho lab
WORK-IN-PROGRESS SEMINAR
Role of neutrophil CRACR2A in calcium signaling and neutrophil recruitment during vascular inflammation
Nov 30, 2023Jiye Yi
Yoona Kang lab
WORK-IN-PROGRESS SEMINAR
Unfolded protein response signaling as a regulator of myeloid versus erythroid lineage decision
Jan 18, 2024Hochang Jeong
Luis Batista lab
WORK-IN-PROGRESS SEMINAR
Targeted differentiation of human ESCs to unravel the pathogenesis of bone marrow failure
Jan 25, 2024Lei Ding, PHD
Columbia University
HEMATOLOGY SPECIAL SEMINAR
The regulation of hematopoietic stem cells and their niche
in health and disease
Feb 1, 2024Jae-Sung Kim
Gus Cho lab
WORK-IN-PROGRESS SEMINAR
The role of RIPK1 in platelet activation during arterial thrombosis and ischemic stroke
Feb 8, 2024John Hwa, MD, PHD, FRACP
Yale University
HEMATOLOGY SPECIAL SEMINAR
A new platelet novel; rewriting stories without a clot
Feb 22, 2024Sanjay Patel, MD, MPH
Cornell
HEMATOLOGY SPECIAL SEMINAR
Spatial Mapping of Human Hematopoiesis at Single Cell Resolution in Aging and Myelodysplasia
Feb 29, 2024Paul Boucher
David Curi
el lab

Molly Brakhane
Steve Oh lab
WORK-IN-PROGRESS SEMINAR
Engineered Adenovirus-antibody molecular complexes for precision in vivo targeting of hematopoietic cells

Aberrant Activity of the Calcium Sensor STIM1 Underlies Congenital Platelet Disorders and Myeloproliferative Neoplasms
Mar 7, 2024Michael Bern
Timothy Ley lab


Wilbur Song
Todd Fehniger
lab
WORK-IN-PROGRESS SEMINAR
Mechanisms of Chemotherapy Resistance in Primary-Refractory Acute Myeloid Leukemia

Engineering chemotaxis toward secreted solid tumor antigens
Mar 14, 2024Vishwanath Jha
Gus Cho lab
WORK-IN-PROGRESS SEMINAR
Novel mechanisms regulating platelet function under Hypoxia
Mar 21, 2024Judith Sokei
Steve Sykes lab
WORK-IN-PROGRESS SEMINAR
The role of key regulatory enzymes of 1C Metabolism in Normal and Malignant Hematopoiesis
Mar 28, 2024Raj Doray
Stuart Kornfeld lab

WORK-IN-PROGRESS SEMINAR

Molecular Insights into the Regulation of GlcNAc-1-phosphotransferase by TMEM251
Apr 4, 2024Ami Patel
University of Utah Huntsman Cancer Institute
HEMATOLOGY SPECIAL SEMINAR
CMML as an MPN: therapeutic opportunities and future directions
Apr 11, 2024Mousumi Chakraborty
Laura Schuettpelz lab
WORK-IN-PROGRESS SEMINAR
Role of transmembrane adaptor protein SCIMP in the regulation of hematopoietic stem cells
Apr 18, 2024Mia Warmka
Laura Schuettpelz lab
WORK-IN-PROGRESS SEMINAR
The tetraspanin CD53 promotes the clonal advantage of Dnmt3a-deficient hematopoietic stem cells
Apr 25, 2024Jesse Zaretsky
Sid Puram lab
WORK-IN-PROGRESS SEMINAR
Chasing tumor-specific T-cells in HPV + head and neck cancer
May 2, 2024Seongmoon Jo
Luis Batista lab
WORK-IN-PROGRESS SEMINAR
Identification of novel modulators of hematopoietic failure through targeted hematopoiesis and bone marrow organoids
May 30, 2024Aniruddha Samajdar
Luis Batista lab


Jinzhi Wang
Gus Cho Lab
WORK-IN-PROGRESS SEMINAR
Novel pathways involved in the Human Telomerase RNA Processing and Quality Control

Identification of selective ERO1a inhibitors as novel anti-thrombotic inflammatory agents
2022-2023
DateSpeakerTitle
Sep 8, 2022Luis BatistaRCR TRAINING
Misconduct
Sep 22, 2022Lijun Xia, MD, PhD
Oklahoma Medical Research Foundation
HEMATOLOGY SPECIAL SEMINAR
Platelet CLEC-2 in Vascular Integrity and Thrombosis
Sep 29, 2022Benjamin Jennings
Stuart Kornfeld lab


Ho-Chang Jeong
Luis Batista lab
WORK-IN-PROGRESS SEMINAR
A Weak ER Retrieval Motif in SARS CoV-2 Spike Protein Mediates Both New Virus Infectivity and Cell-Cell Spreading

USB1 Is a miRNA Deadenylase That Regulates Hematopoietic Development
Oct 6, 2022Luis BatistaRCR TRAINING
Data Management
Oct 6, 2022Peter Agre, MD
Johns Hopkins University
STANLEY J. KORSMEYER MEMORIAL LECTURE
Aquaporin Water Channels: From Atomic Structure to Malaria
Oct 13, 2022Gregg L. Semenza, MD, PhD
Johns Hopkins University
48TH ANNUAL CARL MOORE LECTURE
Regulation of Erythropoiesis by Hypoxia-Inducible Factors
Oct 27, 2022Tripti Kumari
Gus Cho lab
WORK-IN-PROGRESS SEMINAR
Role of SGLT1/2 on Intravascular Cell-Cell Aggregation and Vaso-Occlusion Mediated Conditions in Mouse Model of Sickle Cell Disease
Nov 3, 2022Luis BatistaRCR TRAINING
Peer Review and Authorship
Nov 10, 2022Monique Chavez
Matt Walter lab


Ethan Cordes
Luis Batista lab
WORK-IN-PROGRESS SEMINAR
The Contribution of Subclonal Gene Mutations in Myelodysplastic Syndrome Progression

TGS1 Depletion Increases Telomerase RNA Stability in Dyskeratosis Congenita
Nov 17, 2022Shannon Elf, PhD
University of Chicago
HEMATOLOGY SPECIAL SEMINAR
Type 1 and Type 2 Calreticulin Mutations Activate Discrete Unfolded Protein Response Pathways to Drive Myeloproliferative Neoplasms
Dec 1, 2022Luis BatistaRCR TRAINING
Resource Sharing
Jan 5, 2023Yoona KangRCR TRAINING
Human and Animal Research
Jan 13, 2023Joan S. Brugge, PhD
Harvard Medical School
12TH ROSALIND KORNFELD LECTURE
Mechanisms of Cancer Therapy Resistance
Jan 19, 2023Angelo Laranjeira
Steve Oh lab
WORK-IN-PROGRESS SEMINAR
Dysregulated Signaling Pathways in Myeloproliferative Neoplasms
Jan 26, 2023Michael Kramer
Tim Ley lab
WORK-IN-PROGRESS SEMINAR
Proteomics of Pre-Leukemic and Leukemic Hematopoietic Cells With AML-Associated DNMT3A and/or NPM1 Mutations
Feb 2, 2023Grant ChallenRCR TRAINING
Mentor/Mentee
Feb 9, 2023Fernando Camargo, PhD
Boston Children’s Hospital
HEMATOLOGY SPECIAL SEMINAR
Ancestry and Function in the Hematopoietic System
Feb 14, 2023Xin Gao, PhD
University of Wisconsin
HEMATOLOGY SPECIAL SEMINAR
Regulation of Hematopoietic Stem Cell Mobilization by the Bone Marrow Niche
Feb 16, 2023Stefan Tarnawsky
Matt Walter lab
WORK-IN-PROGRESS SEMINAR
Fitness of U2AF1-Mutant Clones
Feb 23, 2023Jesse Zaretsky
Sidharth Puram lab
WORK-IN-PROGRESS SEMINAR
Single-Cell Analysis of Neoadjuvant Immunotherapy in Head and Neck Cancer
Feb 28, 2023Jonas S. Jutzi, MD, PhD
Harvard Medical School
HEMATOLOGY SPECIAL SEMINAR
Biology and Therapeutic Targeting of Myeloproliferative Neoplasms
Mar 2, 2023Fan He
Steve Oh lab
WORK-IN-PROGRESS SEMINAR
Single-Cell Analysis Reveals Galectin-1 as a Novel Monocyte Marker and Therapeutic Target in MPN
Mar 9, 2023Paul Boucher
David Curiel lab
WORK-IN-PROGRESS SEMINAR
Adenovirus Vectors for B Cell Gene Therapy
Mar 16, 2023Andrew Dunbar, MD
Memorial Sloan-Kettering Cancer Center
HEMATOLOGY SPECIAL SEMINAR
Molecular Pathogenesis and Therapy of Myeloproliferative Neoplasms
Mar 23, 2023Kim Johansson
Dan Link lab
WORK-IN-PROGRESS SEMINAR
Is Ribosomal Stress a Therapeutic Vulnerability in T-ALL?
Mar 28, 2023Shannon Elf, PhD
University of Chicago
HEMATOLOGY SPECIAL SEMINAR
The Pathobiology of Type 1 Versus Type 2 Calreticulin-Mutated Myeloproliferative Neoplasms
Mar 30, 2023Andrew Young
Grant Challen lab


Jeremy Baeten
Dan Link lab
WORK-IN-PROGRESS SEMINAR
Pre-Leukemic KMT2A Rearrangements After Topoisomerase Inhibitor Therapy

Synergistic Lethality of Decitabine and ATR Inhibition in TP53-Mutant AML
Apr 6, 2023John Crispino, PhD
St. Jude Children’s Research Hospital
HEMATOLOGY SPECIAL SEMINAR
Mechanisms of Leukemogenesis in Down Syndrome
Apr 10, 2023Lev Silberstein, MD, PhD
Fred Hutchinson Cancer Research Center
HEMATOLOGY SPECIAL SEMINAR
Keeping Stem Cells Dormnant
Apr 13, 2023Jae-Sung Kim
Gus Cho lab
WORK-IN-PROGRESS SEMINAR
The Role of RIPK1 in Platelet Activation and Arterial Thrombosis
Apr 20, 2023Darby Agovino
Luis Batista lab
WORK-IN-PROGRESS SEMINAR
Establishing the Molecular Mechanism of Disease Induced by Mutant ENY2
Apr 27, 2023David Russler-Germain
Todd Fehniger lab


Michel Iglesia
Li Ding lab
WORK-IN-PROGRESS SEMINAR
Clinicogenomics of Follicular Lymphoma

Metastasis in Colorectal Cancer: Tumor Microenvironment and Treatment Effects
May 4, 2023Molly Brakhane
Steve Oh lab


Luana Chiquetto
Laura Schuettpelz lab
WORK-IN-PROGRESS SEMINAR
Calcium Dysregulation in MPN Platelets

The Role of Stathmin-1 in Regulation of HSCs
May 11, 2023Barbara Soares
Luis Batista lab
WORK-IN-PROGRESS SEMINAR
Impact of DNMT3A on Telomere Regulation in Human Cells
May 18, 2023Robert Signer, PhD
University of California San Diego
HEMATOLOGY SPECIAL SEMINAR
Stem Cell Fitness and Longevity: The Role of Proteostasis
May 25, 2023Jeeseung Kim
Yoona Kang lab


Jingu Lee
Gus Cho lab
WORK-IN-PROGRESS SEMINAR
MPP3 Subset Is Novel Source of Plasma Cell

Role of Neutrophil CRACR2A in Neutrophil Recruitment During Inflammation
2021-2022
DateSpeakerTitle
Sep 2, 2021Xiaoping Du, MD, PhD
University of Illinois at Chicago
Novel Mechanisms of Integrin Outside-In Signaling and the Concept of Treating Thrombosis and Inflammation Without Causing Bleeding
Sep 16, 2021Hochang Jeong
Luis Batista Lab
WORK-IN-PROGRESS SEMINAR
USB1 Is a miRNA Deacetylase That Regulates Hematopoietic Development
Sep 23, 2021Daniel Fisher
Steve Oh Lab
WORK-IN-PROGRESS SEMINAR
JAK2 and NF Kappa B Hyperactivation in Mouse Hematopoiesis and Myeloproliferative Neoplasms
Sep 30, 2021Won Kyun Koh
Grant Challen Lab
WORK-IN-PROGRESS SEMINAR
Non Canonical Role of DNMT3A in HSC Function
Oct 7, 2021Juo-Chin Robin Yao
Dan Link Lab
WORK-IN-PROGRESS SEMINAR
TGF-β Signaling in Stromal Cells Contributes to Myelofibrosis, but Not Niche Disruption, in MPNs Throught JNK Activation
Oct 21, 2021Tripti Kumari
Gus Cho Lab
WORK-IN-PROGRESS SEMINAR
Identification of an Inhibitor of PDI-GPIbα Signaling as a Novel Anti-Thromboinflammatory Agent
Oct 28, 2021Monique Chavez
Matt Walter Lab
WORK-IN-PROGRESS SEMINAR
A Mouse Model of Subclonal Gene Mutations in Myelodysplastic Syndrome
Nov 4, 2021Balraj Doray
Stuart Kornfeld Lab
WORK-IN-PROGRESS SEMINAR
Insight Into Regulation of GlcNAc-1-Phosphotransferase Function as Revealed Through Cryo-EM Analysis
Nov 11, 2021Angelo Laranjeira
Steve Oh Lab
WORK-IN-PROGRESS SEMINAR
Pevonedistat Targets Malignant Cells in Myeloproliferative Neoplasms in Vitro and in Vivo Via NFκB Pathway Inhibition
Nov 18, 2021Michael Kramer
Tim Ley Lab
WORK-IN-PROGRESS SEMINAR
Analysis of the Proteome of De Novo Acute Myeloid Leukemia
Jan 6, 2022Michel Iglesia
Li Ding Lab
WORK-IN-PROGRESS SEMINAR
Precursor Populations and Transitional States in Breast Cancer
Jan 13, 2022Yoon-A KangDecoding Lineage Specification Mechanisms in Hematopoietic Stem and Multipotent Progenitor Populations
Jan 20, 2022Tim Kong
Steve Oh Lab
WORK-IN-PROGRESS SEMINAR
Comprehensive Profiling of Clinical JAK Inhibitors in Myeloproliferative Neoplasms
Feb 3, 2022Andrew Young
Grant Challen Lab
WORK-IN-PROGRESS SEMINAR
Spacial Characterization of Clonal Mutations in the Bone Marrow
Feb 10, 2022Fan He
Steve Oh Lab
WORK-IN-PROGRESS SEMINAR
The Metabolic Dysregulation of Platelets in MPN Disease
Feb 17, 2022Luana Chiquetto
Laura Schuettpelz Lab
WORK-IN-PROGRESS SEMINAR
The Role of Stathmin-1 in the Regulation of HSCs
Feb 24, 2022David Russler-Germain
Todd Fehniger Lab
WORK-IN-PROGRESS SEMINAR
Updating Our Clinico-Genomic Understanding of Follicular Lymphoma
Mar 3, 2022Jeremy Baeten
Dan Link Lab
WORK-IN-PROGRESS SEMINAR
Synergistic Lethality of Decitabine and ATR Inhibition in TP53-Mutant AML
Mar 9, 2022Matthew Rondina, MD
University of Utah
DIVISION OF HEMATOLOGY SPECIAL SEMINAR
MHC-I Antigen Presentation by Platelets Suppresses CD8+ T Cells During Sepsis
Mar 10, 2022Paul Rice-Boucher
David Curiel Lab
WORK-IN-PROGRESS SEMINAR
Adenoviral Vector Mediated Gene Editing of the B Cell Receptor as an HIV Vaccine
Mar 17, 2022Brendan Mathias
Jeff Bednarski Lab
WORK-IN-PROGRESS SEMINAR
MYSM1 in DNA Damage Signaling During B Cell Development
Apr 1, 2022Nigel Mackman, PhD
UNC – Chapel Hill
J. EVAN SADLER SPECIAL LECTURE
Mechanisms of Cancer-Associated Thrombosis
.mp4
Apr 7, 2022Stephanie Crowley
Jeff Bednarski Lab
WORK-IN-PROGRESS SEMINAR
Bclaf1 Promotes Hematopoietic Stem Cell Repopulating Capacity
Apr 21, 2022Zev Greenberg
Laura Schuettpelz Lab
WORK-IN-PROGRESS SEMINAR
The Tetraspanin CD53 Protects Hematopoietic Stem Cells Following Cellular Stress Through Induction of DREAM Complex-Mediated Quiescence
Apr 28, 2022David O’Leary
Abby Green lab
WORK-IN-PROGRESS SEMINAR
Loss of SMC5/6 Sensitizes Leukemia Cells to APOBEC3A Cytosine Deaminase Activity
May 5, 2022Molly Brakhane
Steve Oh Lab
WORK-IN-PROGRESS SEMINAR
Role of Calcium Signaling in Hematopoiesis in MPNs
May 12, 2022Kim Johansson
Dan Link Lab
WORK-IN-PROGRESS SEMINAR
Idasanutlin and Navitoclax Induce Synergistic Cell Death in T-ALL Patient-Derived Xenografts
May 19, 2022Vishwanath Jha
Gus Cho Lab
WORK-IN-PROGRESS SEMINAR
Role of Platelet ERO1α in Platelet Activation and Arterial Thrombosis
May 26, 2022Barbara Soares
Luis Batista Lab
WORK-IN-PROGRESS SEMINAR
DNMT3A as a Novel Regulator of Telomerase in Human Stem Cells
2020-2021
DateSpeakerTitle
Sep 10, 2020Michael Munroe
Luis Batista lab
WORK-IN-PROGRESS SEMINAR
Telomere Dysfunction Inpairs Hepatocyte Development and Function Via Repression of HNF4A
Sep 17, 2020Daniel Fisher
Stephen Oh lab
WORK-IN-PROGRESS SEMINAR
NF kappa B Hyperactivation in Myeloproliferative Neoplasms
Sep 24, 2020Won Kyun Koh
Grant Challen lab
WORK-IN-PROGRESS SEMINAR
Non-Canonical Role of DNMT3A in HSC Function
Oct 1, 2020Ben Jennings
Stuart Kornfeld lab
WORK-IN-PROGRESS SEMINAR
Molecular Mechanisms Regulating the Localization of SARS-CoV2 Spike Protein and Golgi Glycosyltransferases
Oct 8, 2020Pamela Wong
Todd Fehniger lab
WORK-IN-PROGRESS SEMINAR
The Role of T-box Transcription Factors Eomes and Tbet in Mature Human Natural Killer Cells
Oct 15, 2020Andrea Bredemeyer
Kory Lavine lab
WORK-IN-PROGRESS SEMINAR
Generation of Yolk-Sac-Like and Definitive Macrophages From Human PSCs
Oct 22, 2020Alex Vessoni
Luis Batista lab
WORK-IN-PROGRESS SEMINAR
Investigating the Consequences of Telomere Dysfunction in Human Stem Cells
Oct 29, 2020Monique Chavez
Lukas Wartman lab
WORK-IN-PROGRESS SEMINAR
Investigating Lenalidomide Treatment-Based Secondary B-Cell Acute Lymphoblastic Leukemia
Nov 5, 2020Jared Fowles
Stephen Oh lab
WORK-IN-PROGRESS SEMINAR
Dysregulated Inflammation in Myeloproliferative Neoplasms and Disease Progression
Nov 6, 2020Jennifer Lippincott-Schwartz, PhD
HHMI Janelia Research Campus
11TH ROSALIND KORNFELD LECTURE
Imaging Interacting Organelles to Understand Metabolic Homeostasis
Nov 12, 2020Sharon A. Savage, MD
National Cancer Institute
MEDICINE GRAND ROUNDS
The Growing Clinical and Genetic Spectrum of Telomere Biology Disorders
Jan 7, 2021David Ginsburg, MD
University of Michigan Medical School, Ann Arbor, MI
JOINT SEMINAR WITH DEPARTMENT OF GENETICS
FV/FVIII and Cargo Receptors in the ER: From Bedside to Bench
Jan 14, 2021Farid Kadyrov
Kory Lavine lab
WORK-IN-PROGRESS SEMINAR
The Effects of Hypoxia on Monocyte/Macrophage Specification and Function During Ischemic Heart Injury
Jan 21, 2021Angelo Brunelli
Stephen Oh lab
WORK-IN-PROGRESS SEMINAR
Pevonedistat Targets Malignant Cells in Myeloproliferative Neoplasms in Vitro and in Vivo Via NFkB Pathway Inhibition
Jan 28, 2021Hochang Jeong
Luis Batista lab
WORK-IN-PROGRESS SEMINAR
Human ESC Modeling of Poikiloderma With Neutropenia Unveils Defective Hematopoietic Development Caused by Mutation in USB1
Feb 4, 2021Ryan Day
Tim Ley lab
WORK-IN-PROGRESS SEMINAR
Distinct Profiles of CBF Leukemias
Feb 11, 2021Fan He
Stephen Oh lab
WORK-IN-PROGRESS SEMINAR
The Characteristics of Platelets in Essential Thrombocythemia
Feb 18, 2021Andrew Koenig
Kory Lavine lab
WORK-IN-PROGRESS SEMINAR
Cellular Atlas of the Failing Human Heart
Feb 23, 2021Satish Nandakumar, PhD
Boston Children’s Hospital
HEMATOLOGY FACULTY CANDIDATE
How Can We Learn About Healthy and Diseased Hematopoiesis From Human Genetic Studies?
Feb 25, 2021David Russler-Germain
Todd Fehniger lab
WORK-IN-PROGRESS SEMINAR
Novel Mutations Contributing to Follicular Lymphoma
Mar 2, 2021Bo Shen, PhD
UT Southwestern Medical Center
HEMATOLOGY FACULTY CANDIDATE
Novel Regulators of Bone Marrow Stem Cells: Growth and Mechanical Force
Mar 4, 2021Jeremy Baeten
Dan Link lab
WORK-IN-PROGRESS SEMINAR
TP53 in Clonal Hematopoiesis
Mar 11, 2021Paul Boucher
David Curiel lab
WORK-IN-PROGRESS SEMINAR
Adenoviral Vector Mediated Gene Editing of the B Cell Receptor as an HIV Vaccine
Mar 16, 2021Lingbo Zhang, PhD
Cold Spring Harbor Laboratory
HEMATOLOGY FACULTY CANDIDATE
Understanding and Targeting Hematopoietic Stem and Progenitor Cells
Mar 18, 2021Rachel DeWeerd
Abby Green lab
WORK-IN-PROGRESS SEMINAR
The Experimentally-Defined APOBEC3A Signature Is Prevalent in Human Cancers
Mar 30, 2021Yoon A. Kang, PhD
Columbia University
HEMATOLOGY FACULTY CANDIDATE
Who Does the Work? Lineage-Biased MPPs Tailor Blood Production
Apr 1, 2021Kim Johansson
Dan Link lab
WORK-IN-PROGRESS SEMINAR
Is Nucleolar Stress a Therapeutic Vulnerability for T-Cell Acute Lymphoblastic Leukemia?
Apr 8, 2021Ramon Jin
Jason Mills lab
WORK-IN-PROGRESS SEMINAR
The Role of SOX2 in Barrett’s Esophagus and Esophageal Adenocarcinoma
Apr 13, 2021José A. López, MD
University of Washington, Seattle, WA
HEMATOLOGY SPECIAL SEMINAR
The Significance of Endothelium-Bound von Willebrand Factor
Apr 15, 2021Brett Herzog
David DeNardo lab
WORK-IN-PROGRESS SEMINAR
Restoring Immune-Mediated Tumor Control in the Fibrotic NSCLC Microenvironment
Apr 20, 2021Stephanie Grainger, PhD
San Diego State University
HEMATOLOGY FACULTY CANDIDATE
From Fish to Dish and Back Again: Deciphering Wnt/Fzd Cues in Hematopoietic Stem Cell Development
Apr 22, 2021Michael Iglesia
Li Ding lab
WORK-IN-PROGRESS SEMINAR
Breast Cancer Subtype Heterogeneity at the Single-Cell Level
Apr 27, 2021Alan E. Mast, MD, PhD
Versiti Blood Center of Wisconsin, Milwaukee, WI
HEMATOLOGY SPECIAL SEMINAR
The TFPI Anticoagulant Activity Modulates Cerebrovascular Development
May 6, 2021Babak Razani, MD, PhD
Cardiovascular Division
RESEARCH SEMINAR
Dietary Protein and Amino Acid-Mediated mTOR Signaling in Atherosclerosis
May 13, 2021Stephanie Crowley
Jeffrey Bednarski lab
WORK-IN-PROGRESS SEMINAR
BCLAF1 Regulation of Hematopoietic Stem Cell Repopulating Capacity
May 20, 2021Vishwanath Jha
Gus Cho lab
WORK-IN-PROGRESS SEMINAR
Role of Platelet ERO1α in Platelet Activation and Arterial Thrombosis
Jun 30, 2021Sydney Lu, MD, PhD
Memorial Sloan-Kettering Cancer Center
HEMATOLOGY FACULTY CANDIDATE
Targeting RNA Binding Proteins in Cancer
2019-2020
DateSpeakerTitle
Sep 19, 2019Alex Vessoni
Luis Batista lab


Taylor Collins
Stephen Oh lab
WORK-IN-PROGRESS SEMINAR
DNA Damage Response in Human Embryonic Stem Cells With Short Telomeres

Interrogating the Role of ASXL1 and JAK2 Mutations in MPNs Utilizing Human Pluripotent Stem Cells
Oct 3, 2019Carissa Dege
Chris Sturgeon lab
WORK-IN-PROGRESS SEMINAR
Potently Cytotoxic Natural Killer Cell Potential Initially Emerges From Erythro-Myeloid Progenitors During Mammalian Development
Oct 17, 2019Patrycja M. Dubielecka, PhD
Warren Alpert Medical School of Brown University, Providence, RI
Signaling at the Crossroads: From Inflammaging to Cancer
Oct 24, 2019Brett Herzog
David DeNardo lab


Stephanie Luff
Chris Sturgeon lab
WORK-IN-PROGRESS SEMINAR
Reactive Fibrosis in Lung Cancer: Impact on Immunity and Progression

Top Notch Blood: The Involvement of NOTCH Signaling in Extra-Embryonic Hematopoiesis
Oct 31, 2019Laurie H. Glimcher, MD
Dana-Farber Cancer Institute, Boston, MA
STANLEY J. KORSMEYER MEMORIAL LECTURE
ER Stress: Reprogramming the Tumor Microenvironment
Nov 12, 2019Helen Hobbs, MD
UT Southwestern Medical Center, Dallas, TX
47TH ANNUAL CARL MOORE LECTURE
Mechanisms of Lipid Accumulation: Implications for Fatty Liver Disease
Nov 21, 2019Jared Fowles
Stephen Oh lab


Casey Katerndahl
Tim Ley lab
WORK-IN-PROGRESS SEMINAR
Mass Cytometry Analysis of Bone Marrow and Peripheral Blood Hematopoietic Cell Populations in Polycythemia Vera

The Mechanisms Underlying PML-RARA-Induced Self-Renewal and Transformation
Dec 12, 2019Ben Jennings
Stuart Kornfeld lab


Ramon Jin
Jason Mills lab
WORK-IN-PROGRESS SEMINAR
Identifying Molecular Mechanisms Regulating the Localization of Golgi Glycosyltransferases

Patient-Derived Organoids to Study Barrett’s Esophagus and Esophageal Carcinogenesis
Jan 9, 2020Hochang Jeong
Luis Batista lab


Patrick Grierson
Kian Lim lab
WORK-IN-PROGRESS SEMINAR
USB1 Mutation Causes Defective Hematopoiesis

The MK2/Hsp27 Axis Determines Sensitivity to Chemotherapy in Pancreatic Ductal Adenocarcinoma
Jan 27, 2020Daniel C. Link, MD
Washington University, St. Louis, MO
Pathogenesis of Congenital Neutropenia and Mechanisms of Leukemic Transformation
Jan 30, 2020Daniel Fisher
Stephen Oh lab


Zev Greenberg
Laura Schuettpelz lab
WORK-IN-PROGRESS SEMINAR
NFκB Hyperactivation in Myeloproliferative Neoplasms: Insights From Human Patients and Mouse Models

Loss of CD53 Impairs B Cell Migration
Jan 31, 2020Matthew Rondina, MD
University of Utah, Salt Lake City, UT
HEMATOLOGY GRAND ROUNDS
Platelet Transcriptomics as Discovery Tools in Human Health and Disease
Feb 3, 2020Steven Lentz, MD, PhD
University of Iowa, Iowa City, IA
Vascular Stress Management: Oxidative Mechanisms in Thrombosis and Stroke
Feb 10, 2020Mary Armanios, MD
Johns Hopkins University, Baltimore, MD
The Telomere Syndromes: A Paradigm for Molecular Medicine
Feb 13, 2020Dirk Hockemeyer, PhD
University of California, Berkeley, CA
Elucidating the Mechanisms of Cancer Cell Immortality
Feb 14, 2020Jaehyung (Gus) Cho, PhD
University of Illinois, Chicago, IL
HEMATOLOGY GRAND ROUNDS
Mechanisms Regulating Intravascular Cell-Cell Interactions in Thrombosis and Inflammation
Feb 17, 2020Karin Hoffmeister, MD
Medical College of Wisconsin, Milwaukee, WI
Glycans in Translational and Clinical Research
Feb 27, 2020Wang-Sik Lee
Stuart Kornfeld lab
WORK-IN-PROGRESS SEMINAR
Analysis of Lysosomal Storage Disease-Causing Missense Mutations Within the Transmembrane Domain of GlcNAc-1-Phosphotransferase
Feb 28, 2020Kenneth Ataga, MD
University of Tennessee, Memphis, TN
HEMATOLOGY GRAND ROUNDS
Meeting Unmet Needs in Sickle Cell Disease
Mar 9, 2020Robert Flaumenhaft, MD, PhD
Harvard Medical School, Boston, MA
Test Tube to Trial: Protein Disulfide Isomerase as an Antithrombotic Target
2018-2019
DateSpeakerTitle
Aug 30, 2018Andrew Elefanty, PhD
Murdoch Children’s Research Institute, Melbourne, Australia
Dissection of Human Haematopoiesis From Pluripotent Stem Cells
Sep 20, 2018Lingheng Li, PhD
Stowers Institute, Kansas City, MO
Expansion of Hematopoietic Stem Cells and Targeting Leukemia Stem Cells
Sep 27, 2018Carissa Dege
Chris Sturgeon lab


Kirsten Brenner
Luis Batista lab
WORK-IN-PROGRESS SEMINAR
Ontogeny Is a Critical Determinant of Human Pluripotent Stem Cell Derived Natural Killer Cell Function

A Telomere-Independent Role for the Telomerase RNA Component in Human Embryonic Stem Cells
Oct 11, 2018Joshua Muia
Evan Sadler lab
WORK-IN-PROGRESS SEMINAR
Insights Into the Structure and Regulation of a Metalloprotease Involved in Cardiovascular Disease
Oct 25, 2018Wilson Fok
Luis Batista lab


Darlene Monlish
Laura Schuettpelz lab
WORK-IN-PROGRESS SEMINAR
Inhibition of Polyadenylation Activity by Silencing of PAPD5 Restores Telomerase and Rescues Hematopoietic Failure in Dyskeratosis Congenita

Differential Effects of TLR1/2 and TLR2/6 Signaling on Normal and Premalignant Hematopoietic Stem and Progenitor Cells
Nov 2, 2018Carolyn R. Bertozzi, PhD
Stanford University, Palo Alto, CA
10TH ROSALIND KORNFELD LECTURE
Targeting the Cancer Glycocalyx
Nov 8, 2018Karen Hirschi, PhD
Yale Cardiovascular Research Center, New Haven, CT
Regulation of Hemogenic Endothelial Cell Specification
Dec 13, 2018Taylor Collins
Stephen Oh lab


Megan Zimmerman
Dan Link lab
WORK-IN-PROGRESS SEMINAR
Interrogation of ASXL1 Mutations in Combination With the JAK2 V617F Mutation in MPNs

MDM2 Inhibition in T-Cell Acute Lymphoblastic Leukemia
Jan 7, 2019Jorge A. DiPaola, MD
University of Colorado, Denver, CO
Studying Megakaryocytes, From Inherited Disorders to Old Age Platelets
Jan 17, 2019Deepti Sood Gupta
Jeff Bednarski lab
WORK-IN-PROGRESS SEMINAR
A Novel SPIC/BCLAF1 Complex Reprograms PU.1 Activity in Pre-B Cells With Rag-Mediated DNA Breaks
Jan 24, 2019Daniel Fisher
Stephen Oh lab
WORK-IN-PROGRESS SEMINAR
Interacting Roles of Hyperactive Signaling and Cytokine Overproduction in Myeloproliferative Neoplasms
Jan 31, 2019Mary Armanios, MD
Johns Hopkins University, Baltimore, MD
MEDICINE GRAND ROUNDS
The Telomere Syndromes: Implications for Patient Care
Jan 31, 2019Benjamin L. Ebert, MD, PhD
Harvard Medical School, Boston, MA
46TH CARL MOORE LECTURE
The Genetics of Hematologic Neoplasia: From Clonal Hematopoiesis to Acute Leukemia
Feb 14, 2019Philip Creamer
Chris Sturgeon lab


Julia Wagner
Todd Fehniger lab
WORK-IN-PROGRESS SEMINAR
Defining the Role of CDX4 During Human Definitive Hematopoietic Specification

A Novel NK Cell-Specific Inducible Cre Model Reveals a Critical Role for Eomes in the Survival, Homeostasis, and Function of Mature NK Cells
Feb 21, 2019Jared Fowles
Stephen Oh lab
WORK-IN-PROGRESS SEMINAR
Investigating the Genomic and Inflammatory Profiles of Young and Old Polycythemia Patients
Feb 28, 2019Stephanie Luff
Chris Sturgeon lab


Zev Greenberg
Laura Schuettpelz lab
WORK-IN-PROGRESS SEMINAR
Recapitulating Intraembryonic Hematopoiesis in the Dish

Regulation of Early B Cell Development by the Tetraspanin CD53
Mar 21, 2019Dhanam Anbukumar
Evan Sadler lab
WORK-IN-PROGRESS SEMINAR
The Function of Copper Ions in vWF Multimer Assembly
Mar 28, 2019Alex Vessoni
Luis Batista lab


Christina Mikulka
Mark Sands lab
WORK-IN-PROGRESS SEMINAR
Telomere Dysfunction and Oncogene Stress Induces Differential Responses in Human Embryonic Stem Cells

Cell-Autonomous Expression of the Lysosomal Hydrolase GALC: A New Model of Krabbe Disease
Apr 4, 2019Brett Herzog
David DeNardo lab


Ramon Jin
Jason Mills lab
WORK-IN-PROGRESS SEMINAR
Desmoplasia in Lung Cancer Immunity and Progression

Barrett’s Esophagus and Esophageal Adenocarcinoma
Apr 18, 2019Kyle Cottrell
Jason Weber lab


Melissa Berrien-Elliott
Todd Fehniger lab
WORK-IN-PROGRESS SEMINAR
Upregulation of 5’TOP mRNAs Following Loss of the Tumor Suppressor ARF

miR-142 Is Required for NK Cell Homeostasis and Function
Apr 25, 2019Minori Tamai
Todd Druley lab


Hochang Jeong
Luis Batista lab
WORK-IN-PROGRESS SEMINAR
Modeling Infant Leukemia With Human Pluripotent Stem Cells

Determining Therapeutic Targets to Restore Hematopoietic Output in Dyskeratosis Congenita
May 2, 2019Tom GirardWORK-IN-PROGRESS SEMINAR
The TFPIαβ (γKO) Mouse Is a Better Model for Studying Human TF-Related Diseases
May 9, 2019Patrick Grierson
Kian Lim lab


Casey Katerndahl
Tim Ley lab
WORK-IN-PROGRESS SEMINAR
Overcoming the MK2/ Hsp27 Axis to Potentiate the Effect of Chemotherapy in Pancreatic Ductal Adenocarcinoma (PDAC)

The Mechanisms Underlying PML-RARA-Induced Self-Renewal and Transformation
Jun 3, 2019John P. Sheehan, Jr., MD
University of Wisconsin, Madison, WI
Plasma Factor IXa in Systemic Hypercoagulability
2017-2018
DateSpeakerTitle
Aug 3, 2017Huichun Zhan, MD, MS
Stony Brook University
The Hematopoietic Niche in Myeloproliferative Neoplasms
Sep 22, 2017Bonnie L. Bassler, PhD
Princeton University
9TH ROSALIND KORNFELD LECTURE
Bacterial Quorum Sensing and Its Control
Sep 28, 2017Angela Fleischman, MD, PhD
University of California, Irvine
Inflammation as a Driver of Clonal Expansion in Myeloproliferative Neoplasm
Oct 5, 2017Wilson Fok
Luis Batista lab


Taylor Collins
Stephen Oh lab
WORK-IN-PROGRESS SEMINAR
Understanding How Telomere Dysfunction and RNA Processing Defects Lead to Human Disease

Interrogation of ASXL1 Mutations in Combination With the JAK2 V617F Mutation in MPNs
Oct 10, 2017Riccardo Dalla-Favera, MD
Institute for Cancer Genetics, Columbia University
STANLEY J. KORSMEYER MEMORIAL LECTURE
Molecular Genetics of B Cell Lymphoma
Oct 12, 2017Carissa Dege
Chris Sturgeon lab


Kirsten Brenner
Luis Batista lab
WORK-IN-PROGRESS SEMINAR
Natural Born Killers? Determining Function and Ontological Origins of Two Distinct Natural Killer Cell Populations Derived From Human Pluripotent Stem Cells

A Telomere-Independent Role for the Telomerase RNA Component in Human Embryonic Stem Cells
Oct 27, 2017Vivian G. Cheung, MD
University of Michigan
45TH CARL MOORE LECTURE
It’s in the RNA: Implications for Human Disease
Nov 2, 2017Dhanam Anbukumar
Evan Sadler lab
WORK-IN-PROGRESS SEMINAR
The Involvement of Copper Transport in Von Willebrand Factor Biosynthesis
Nov 16, 2017Steve Snyder
Stephen Oh lab


Julia Wagner
Todd Fehniger lab
WORK-IN-PROGRESS SEMINAR
Exploring the Role of NFκB in PMN Mouse Models

Impact of Inducible Eomes Deletion on the Murine NK Cell Compartment
Nov 30, 2017Joshua Muia
Evan Sadler lab
WORK-IN-PROGRESS SEMINAR
Two Metalloproteases Involved in Cardiovascular Disease
Dec 14, 2017Tanner Johanns
Gavin Dunn lab
WORK-IN-PROGRESS SEMINAR
Neoantigens as Therapeutic Targets in Glioblastoma
Jan 11, 2018Jian Zhu
Evan Sadler lab
WORK-IN-PROGRESS SEMINAR
Structural and Functional Studies of ADAMTS13: AUC, HDX, and EM
Jan 18, 2018Terrence WongClonal Evolution of Hematopoietic Stem Cells During Chemotherapy and Transplantation
Jan 25, 2018Daniel Fisher
Stephen Oh lab
WORK-IN-PROGRESS SEMINAR
Utilizing Mass Cytometry and Mouse Models to Understand Myeloproliferative Neoplasms
Feb 1, 2018Philip Creamer
Chris Sturgeon lab


Jared Fowles
Stephen Oh lab
WORK-IN-PROGRESS SEMINAR
Investigating Gene Expression During Human Definitive Hematopoietic Specification

Genomic Dissection of Age-Related Differences in Polycythemia Vera
Feb 15, 2018Tom GirardA Balance Between Pro- and Anti-Coagulant Factors to Abate Bleeding and Avoid Thrombosis
Feb 22, 2018Agnel Sfeir, PhD
New York University
Protecting Our Genomes: Whenever, Wherever
Mar 7, 2018Stephen S. Chung, MD
Memorial Sloan Kettering Cancer Center
Less Can Be More: Novel Insights Into Hematologic Malignancies Revealed in Rare Stem Cell Populations
Mar 15, 2018Alex Vessoni
Luis Batista lab


Stephanie Luff
Chris Sturgeon lab
WORK-IN-PROGRESS SEMINAR
Investigating Cell Death and DNA Damage Response in hESCs With Short Telomeres

Twice Spliced: Exploring HOXA9 Variants in Embryonic Hematopoiesis
Mar 22, 2018Garima Gupta Tyagi
Evan Sadler lab
WORK-IN-PROGRESS SEMINAR
Single Molecule Analysis of VWF Extension and Cleavage Using Magnetic Tweezers
Mar 29, 2018Chang Liu
Rob Mitra lab
WORK-IN-PROGRESS SEMINAR
Rapid High-Resolution HLA Typing by Nanopore Sequencing
Apr 4, 2018Chris Richardson, PhD
University of California, Berkeley
The Fanconi Anemia Pathway Plays a Key Role in DNA Repair at CRISPR-Cas9 Cut Sites
Apr 5, 2018Paul J. Gadue, PhD
Children’s Hospital of Philadelphia
Megakaryocyte Development From Stem Cell Sources
Apr 12, 2018Lin Liu
Stuart Kornfeld lab
WORK-IN-PROGRESS SEMINAR
Golgi Retention of Glycosyltransferases Requires Binding of Its N-Terminal Cytoplasmic Tail to Coatomer
Apr 26, 2018Casey Katerndahl
Tim Ley lab


Christina Mikulka
Mark Sands lab
WORK-IN-PROGRESS SEMINAR
The Mechanisms Underlying PML-RARA-Induced Transformation and Self-Renewal

Cell-Autonomous Expression of the Lysosomal Enzyme GALC in the Twitcher Mouse
2016-2017
DateSpeakerTitle
Sep 15, 2016Patrick M. Viatour, PharmD, PhD
University of Pennsylvania
E2f Factors Integrate Cell Cycle and Non Cell Cycle Functions to Dictate Stem Cell Fate
Sep 22, 2016Wilson Fok
Luis Batista lab


Dhanam Anbukumar
Evan Sadler lab
WORK-IN-PROGRESS
p53 Stabilization Following Progressive Telomere Shortening Differentially Regulates Human Hematopoietic Specification

Copper Transport in Von Willebrand Factor Biosynthesis
Sep 29, 2016Jeffrey J. Bednarski, MD, PhD
Department of Pediatrics
Physiologic and Genotoxic DNA Damage Activate Distinct Cellular Responses in Developing B Lymphocytes
Oct 14, 2016John Stamatoyannopoulos, MD
University of Washington
44TH CARL MOORE LECTURE
Decoding the Human Regulatory Genome
Oct 20, 2016Kirsten Brenner
Luis Batista lab


Joshua Muia
Evan Sadler lab
WORK-IN-PROGRESS
Telomere-independent Functions of the Telomerase RNA Component in Human Stem Cells

Evolution and Allosteric Regulation of ADAMTS13
Oct 27, 2016Steve Snyder
Stephen Oh lab


Carissa Dege
Chris Sturgeon lab
WORK-IN-PROGRESS
The Role of NFκB in MPN Mouse Models

Generation and Characterization of Human Pluripotent Stem Cell-derived Natural Killer Cells
Nov 3, 2016Hani S. Zaher, PhD
Department of Biology
Insights Into the Role of the Ribosome During mRNA and Nascent-Protein Quality Control
Nov 17, 2016Fernando D. Camargo, PhD
Boston Children’s Hospital
Clonal Analysis of Native Hematopoiesis
Jan 12, 2017Tom Girard
George Broze lab
WORK-IN-PROGRESS
The Roles of Tissue Factor Pathway Inhibitor in Health and Disease
Jan 19, 2017Garima Gupta Tyagi
Evan Sadler lab


Alexandre Vessoni
Luis Batista lab
WORK-IN-PROGRESS
Single Molecule Analysis of VWF Extension and Cleavage Using Magnetic Tweezers

Impact of Telomere Shortening on Mitochondria of Human Embryonic Stem Cells
Jan 26, 2017Michael R. Bruchas, PhD
Departments of Anesthesiology & Neurobiology
Dissecting Neuromodulatory Circuits in Affective Behavior
Feb 2, 2017Tanner Johanns
Gavin Dunn lab


Jian Zhu
Evan Sadler lab
WORK-IN-PROGRESS
Effect of Prior Radiation on Gliomagenesis and Tumor Immunity

The Hunt for the “Minimal” Structure of a Functional ADAMTS13 by Small-Angle X-Ray Scattering
Feb 6, 2017David B. Sykes, MD, PhD
Massachusetts General Hospital
“Curing by Maturing” – Developing Differentiation Therapy for the Treatment of Patients with Acute Myeloid Leukemia
Feb 9, 2017Milan G. Chheda, MD
Oncology Division
Developing a Synthetic Lethal Genetic Screen to Identify Vulnerabilities in IDH1 Mutant Gliomas
Feb 16, 2017Taylor Brost Collins
Stephen Oh lab


Julia Wagner
Todd Fehniger lab
WORK-IN-PROGRESS
Utilizing iPSCs as a Model System to Interrogate Genetically Distinct Clones in Myeloproliferative Neoplasms

CD56bright NK Cells Exhibit Potent Anti-Tumor Responses Following IL-15 Priming
Feb 23, 2017Blair B. Madison, PhD
Gastroenterology Division
PLAGL2, a Zinc Finger Transcription Factor That Drives Stem Cell Identity and Colorectal Cancer Tumorigenesis
Mar 2, 2017Yedda Li
Mark Sands lab


Evandro Niero
Luis Batista lab
WORK-IN-PROGRESS
Combination Therapy Improves Lifespan and Clinicobehavioral Performance in Murine Globoid Cell Leukodystrophy

Teleomere Shortening Impairs Hepatocyte Differentiation by DNA Damage Signaling Activation
Mar 9, 2017Alessandro Vindigni, PhD
Saint Louis University
Mechanisms of Replication Stress Response to Chemotherapeutics
Mar 23, 2017Charles K. Kaufman, MD, PhD
Oncology Division
Key Events During Cancer Initiation: From Melanocyte to Melanoma
Mar 30, 2017Melanie Fields
K12 Heme Scholars Program
WORK-IN-PROGRESS
Cerebral Oxygen Metabolism and Vasoreactivity in Sickle Cell Disease
Apr 6, 2017Babak Razani, MD, PhD
Cardiology Division
Macrophages Epitomize Firefighter Arsonists in Metabolic Diseases. Can We Promote Better Behavior?
Apr 13, 2017Lin Liu
Stuart Kornfeld lab


Daniel Fisher
Stephen Oh lab
WORK-IN-PROGRESS
Producing Highly Phosphorylated Lysosomal Enzymes for Enzyme Replacement Therapy

Cytokines and Intracellular Signaling Abnormalities in Myeloproliterative Neoplasms
Apr 20, 2017Indira U. Mysorekar, PhD
Department of Obstetrics & Gynecology
Understanding Pathogenesis of Maternal Fetal Transmission of the Emerging Zika Virus
Apr 27, 2017Jared Fowles
Stephen Oh lab


Chang Liu
Rob Mitra lab
WORK-IN-PROGRESS
Genomic Dissection of Age-Related Differences in Polycythemia Vera

Single-Molecule HLA Typing by Oxford Nonopore Technology
2015-2016
DateSpeakerTitle
Sep 10, 2015Daniel Fisher
Stephen Oh lab


Balraj Doray
Stuart Kornfeld lab
WORK-IN-PROGRESS
NFkB Hyperactivation in Myeloproliferative Neoplasms

Understanding How GlcNAc-1-Phosphotransferase Recognizes Lysosomal Enzymes: Part I
Sep 24, 2015Patrick Y. Jay, MD, PhD
Pediatrics – Cardiology
Solving Congenital Heart Disease
Oct 1, 2015Terrence Wong
Dan Link, mentor
WORK-IN-PROGRESS
Non-Malignant Oligoclonal Hematopoiesis Commonly Follows Induction Chemotherapy for Adult De Novo AML
Oct 8, 2015Jason Mills, MD, PhD
Medicine – Gastroenterology
Stem Cells, Reprogramming, and the Origins of Cancer
Oct 15, 2015Wilson Fok
Luis Batista lab


Joshua Muia
Evan Sadler lab
WORK-IN-PROGRESS
Telomere Dysfunction in Stem Cell Proliferation and Differentiation

In Search of the Minimalist ADAMTS13 Using Evolutionary Variations in its Allosteric Properties
Oct 29, 2015Jeffrey R Millman, PhD
Medicine – Endocrinology
Generation of Functional Human Pancreatic β Cells from Pluripotent Stem Cells In Vitro
Nov 5, 2015Minji Byun, PhD
Medicine – Rheumatology
Searching for the Genetic Etiology of Infectious Diseases
Nov 13, 2015Jennifer A. Doudna, PhD
UC Berkeley
8TH ROSALIND KORNFELD LECTURE
The CRISPR-Cas9 Genome Engineering Revolution
Nov 19, 2015Alan E. Mast, MD, PhD
Blood Center of Wisconsin
Tissue Factor Pathway Inhibitor Biochemistry and Relation to Bleeding and Clotting Disorders
Dec 10, 2015Tom Girard
George Broze lab


Dhanam Anbukumar
Evan Sadler lab
WORK-IN-PROGRESS
Evaluating Blockade of the Protein Z-Dependent Protease Inhibitor Pathway as a Potential Treatment for Hemophilia

The ATP7A Copper Transporter Is Required for VWF Multimerization
Dec 17, 2015Vivek K. Arora, MD, PhD
Medicine – Oncology
Defining Novel Oncogenic Drug Targets in Bladder Cancer
Jan 7, 2016Cates Mullaney
Grant Challen lab
WORK-IN-PROGRESS
The Role of Kdm6b in Hematopoiesis
Jan 11, 2016Ammon M. Fager, MD, PhD
Duke University
Human Platelets Express Endothelial Protein C Receptor Which Contributes to the Binding and Activity of rFVIIa
Jan 14, 2016Alfred Kim, MD, PhD
Medicine – Rheumatology
Glomerular Podocyte Cytokine Signaling Drives Proteinuria: Implications in Nephrotic Syndromes
Jan 15, 2016James G. Taylor, MD
Hematology Branch, NHLBI
Epidemiologic and Mechanistic Insights into Risk Factors for Death in Adults with Sickle Cell Anemia
Jan 21, 2016Brian Kim, MD
Dermatology
Immune Regulation of Atopic and Chronic Itch
Jan 28, 2016Ren-Huai Huang
Evan Sadler lab


Wang-Sik Lee
Stuart Kornfeld lab
WORK-IN-PROGRESS
pH-Dependent Association Within N-terminal D Domains of Von Willebrand Factor

Role of the Subunits of GlcNAc-Phosphotransferase in Lysosomal Enzyme Recognition
Feb 4, 2016Nima Mosammaparast, MD, PhD
Pathology & Immunology
Ubiquitin Dependent Regulatory Mechanisms in the Alkylation Damage Response
Feb 11, 2016Garima Gupta Tyagi
Evan Sadler lab


Matt Christopher
Tim Ley lab
WORK-IN-PROGRESS
Single Molecule Analysis of Von Willebrand Factor Extension and Cleavage Using Magnetic Tweezers

WT1 in Normal and Malignant Hematopoiesis
Feb 16, 2016Yvette Y. Yien, PhD
Harvard Medical School
Mitochondrial Transporters in Erythroid Heme Metabolism
Feb 18, 2016Kory Lavine, MD, PhD
Medicine – Cardiology
Making Sense of Cardiac Macrophage Ontogeny and Function
Feb 25, 2016Jeff Ward
Robert Schreiber lab
WORK-IN-PROGRESS
Identification and Therapeutic Targeting of Tumor Specific Mutant Antigens
Mar 2, 2016Hans Clevers, MD, PhD
University of Utrecht, The Netherlands
43RD CARL MOORE LECTURE
Lgr5 Stem Cell-Grown Organoids and Their Applications
Mar 8, 2016Isabel Beerman, PhD
Boston Children’s Hospital
Hematopoietic Stem Cell Aging
Mar 10, 2016Steve Snyder
Stephen Oh lab


Jian Zhu
Evan Sadler lab
WORK-IN-PROGRESS
Mechanisms of Dysregulated Signaling in Mouse Models of Myeloproliferative Neoplasms

Study of Allosteric Regulation of ADAMTS13 by Small-Angle X-Ray Scattering
Mar 17, 2016Gregory Wu, MD, PhD
Neurology
The Role of B Cell Antigen Presentation in a Murine Autoimmune Model of Multiple Sclerosis
Mar 24, 2016Yedda Li
Mark Sands lab


Kirsten Brenner
Luis Batista lab
WORK-IN-PROGRESS
Combination Therapy Increases Lifespan and Improves Clinicobehavioral Performance in the Murine Model of Globoid Cell Leukodystrophy

Telomere-Independent Functions of the Telomerase RNA Component in Human Stem Cells
Mar 31, 2016Katherine C. Fuh, MD, PhD
Obstetrics & Gynecology
Functional Genomics of Ovarian Cancer Metastasis
Mar 31, 2016Paul F. Bray, MD
Jefferson Medical College
Plateletomics: Exploring Platelet Biology Via Multi-omic Data Integration
Apr 7, 2016Lin Liu
Stuart Kornfeld lab
WORK-IN-PROGRESS
Uncovering Novel Regulatory Roles of the “Spacer 1” Region of the GlcNAc-1-Phosphotransferase
Apr 14, 2016Michael Kharas, PhD
Sloan Kettering Institute
RNA Binding Proteins and the Control of the Leukemic Stem Cell Program
Apr 21, 2016Kristen Sanfilippo
Ken Carson, mentor


Melanie Fields
Jin-Moo Lee labas, PhD
Sloan Kettering Institute
WORK-IN-PROGRESS
Statin Therapy Increases Survival in Myeloma

Functional Connectivity in Sickle Cell Disease
May 5, 2016Carissa Dege
Chris Sturgeon lab


Tanner Johanns
Gavin Dunn lab
WORK-IN-PROGRESS
Characterization of Human Pluripotent Stem Cell Derived Natural Killer Cells

An Immunogenomic Approach to Identify Glioblastoma-Specific CD8 T Cells
May 12, 2016Frank McCormick, PhD
UC San Francisco
STANLEY J. KORSMEYER MEMORIAL LECTURE
New Ways of Targeting Ras
May 19, 2016Taylor Brost
Stephen Oh lab
WORK-IN-PROGRESS
Interrogation of Genetically Distinct Clones Using MPN Patient-Specific IPSCs
Jul 20, 2016Rami Khoriaty, MD
University of Michigan
Congenital Dyserythropoietic Anemia Type II and Transport of Proteins from the ER to Golgi
2014-2015
DateSpeakerTitle
Sep 5, 2014Ren-Huai Huang
Evan Sadler lab


Tom Girard
George Broze lab
WORK-IN-PROGRESS
The Role of D Domains in VWF Tubule Assembling

Impact of Coagulation Regulators in Mouse Models of Various Diseases
Sep 19, 2014J. Evan Sadler, MD, PhD
Chair, Division of Hematology


P. Roy Vagelos, MD
Chairman of the Board, University of Pennsylvania
Chairman, Regeneron and Theravance Pharmaceuticals


Sandra Hofmann, MD, PhD
Professor of Internal Medicine and Molecular Genetics
University of Texas Southwestern Medical Center


Stephen Prescott, MD
President
Oklahoma Medical Research Foundation


John York, PhD
Chair, Department of Biochemistry
Vanderbilt University Medical Center
PHILIP W. MAJERUS SYMPOSIUM
Introduction

Phil, Science, and Medicine

Molecular Basis of Infantile Batten Disease

Lipid Messengers: I Met Them in St. Louis

Insights into Inositol Phosphate Cellular Signaling Pathways
Sep 26, 2014Daniel Fisher
Stephen Oh lab
WORK-IN-PROGRESS
Mass Cytometry Study Identifies NFκB Signaling as a Potential Disease Driver in Myeloproliferative Neoplasms
Oct 3, 2014David B. Wilson, MD, PhD
Department of Pediatrics
RESPONSIBLE CONDUCT OF RESEARCH
Human Experimentation
Oct 10, 2014Paul F. Bray, MD
Thomas Jefferson University
Platelet PAR4 Functional Genomics: Racial Disparities in Anti-Platelet Therapy
Oct 17, 2014Dhanam Anbukumar
Evan Sadler lab


Helena van Meel
Stuart Kornfeld lab
WORK-IN-PROGRESS
A Calcium Conundrum: The Role of Calcium in VWF Multimerization

Analysis of Mucolipidosis II/III GNPTAB Missense Mutations Identifies Domains of GlcNAc-1-Phosphotransferase Involved in Catalytic Function and Lysosomal Enzyme Recognition
Oct 24, 2014Sandra Schmid, PhD
University of Texas Southwestern Medical Center
7TH ROSALIND KORNFELD LECTURE
Dynamin: The Master Regulator of Clathrin-Mediated Endocytosis
Oct 31, 2014Eric Duncavage
Matt Walter lab


Terrence Wong
Dan Link lab
WORK-IN-PROGRESS
Sequencing Based Detection of Low Frequency Variants in MDS

The Role of Early TP53 Mutations in the Origin and Evolution of Therapy-Related AML
Nov 7, 2014Monita P. Wilson, PhD
Hematology Division
The Many Roles of ITPK1, an Inositol Kinase
Nov 14, 2014Balraj Doray
Stuart Kornfeld lab


Wilson Fok
Luis Batista lab
WORK-IN-PROGRESS
Assembly of UDP-GlcNAc-1-Phosphotransferase, a Multi-Subunit Protein

Telomere Dysfunction in Stem Cell Proliferation and Differentiation
Nov 21, 2014David Sabatini, MD, PhD
Whitehead Institute
42ND CARL MOORE LECTURE
Regulation of Growth by the mTOR Pathway
Dec 12, 2014Monita P. Wilson, PhD
Hematology Division
RESPONSIBLE CONDUCT OF RESEARCH
Collection, Recording, and Analysis of Data
Dec 19, 2014Douglas M. Tollefsen, MD, PhD
Hematology Division
RESPONSIBLE CONDUCT OF RESEARCH
Accusation of Fraud
Jan 9, 2015J. Evan Sadler, MD, PhD
Hematology Division
Von Willebrand Factor, ADAMTS13 and Thrombotic Microangiopathy
Jan 16, 2015Luis Batista, PhD
Hematology Division
RESPONSIBLE CONDUCT OF RESEARCH
Student-Mentor Relationships
Jan 23, 2015Tomas Ganz, MD, PhD
University of California – Los Angeles
Systemic Iron Homeostasis and Its Disorders
Jan 30, 2015Joshua Muia
Evan Sadler lab


Cates Mallaney
Grant Challen lab
WORK-IN-PROGRESS
Insights Into ADAMTS13 Diversity Across Multiple Animal Species

Interactions Between Dnmt3a and Repressive Chromatin Regulate Hematopoietic Stem Cell Function and Transformation
Feb 6, 2015Stuart Kornfeld, MD
Hematology Division
Role of the γ Subunit of UDP-GlcNAc:Lysosomal Enzyme GlcNAc-1-Phosphotransferase in Lysosomal Enzyme Phosphorylation
Feb 13, 2015Wang-Sik Lee
Stuart Kornfeld lab


Kirsten Brenner
Luis Batista lab
WORK-IN-PROGRESS
The Mannose 6-Phosphate Lysosomal Targeting Pathway and Persistent Stuttering

Regulation of the Telomerase RNA Component TERC in Human Development and Disease
Feb 20, 2015Christopher M. Sturgeon, PhD
Hematology Division
Modeling Developmental Hematopoiesis Using Pluripotent Stem Cells
Feb 27, 2015Elizabeth Engle
Stephen Oh lab
WORK-IN-PROGRESS
Intersection of Dysregulated Cytokines and Signaling in Myeloproliferative Neoplasms
Mar 6, 2015Kenneth Murphy, MD, PhD
Department of Pathology & Immunology
Dendritic Cell Diversification
Mar 9, 2015Sang Min, MD, PhD
University of Pennsylvania
Role of Phosphoinositides in Platelet-Mediated Inflammation and Thrombosis
Mar 13, 2015Angela Hirbe
David Gutmann lab


Mathew Cherian
Lee Ratner lab
WORK-IN-PROGRESS
Whole Exome Sequencing Reveals the Temporal Sequence of Genetic Changes During Malignant Transformation and Metastasis in a Single Patient With NF1-Associated Plexiform Neurofibroma

Role of the PI3K-Akt-mTOR Pathway in HTLV Induced Leukemogenesis
Mar 20, 2015Marielle Boonen, PhD
Université de Namur, Belgium
Cathepsin D and Neuronal Differentiation: Lessons From the Identification of a New Binding Partner
Mar 27, 2015Grant A. Challen, PhD
Oncology Division
RESPONSIBLE CONDUCT OF RESEARCH
Authorship, Peer Review, and Confidentiality
Apr 3, 2015Anthony R. French, MD, PhD
Department of Pediatrics
Regulation of NK Cell Proliferation
Apr 10, 2015Jeff Ward
Robert Schreiber lab


Matt Christopher
Tim Ley lab
WORK-IN-PROGRESS
High-Throughput Identification of Tumor Neoantigen-Specific Cytotoxic T-Cells

Cold Shock Domain Proteins in Normal and Malignant Hematopoiesis
Apr 17, 2015Dana Abendschein, PhD
Department of Medicine, Cardiovascular Division
Can We Inhibit Thrombosis Without Increasing Bleeding?
Apr 24, 2015David Russler-Germain
Tim Ley lab
WORK-IN-PROGRESS
Molecular Consequences of DNMT3A Mutations in AML
May 1, 2015Kian-Huat Lim, MD, PhD
Oncology Division
Toll-like Receptor Signaling in Human Cancer
May 8, 2015Jian Zhu
Evan Sadler lab


Melanie Fields
Jin-Moo Lee lab
WORK-IN-PROGRESS
A Folded ADAMTS13 Conformation Identified by SAXS Can Account for Allosteric Regulation by Distal TSP and CUB Domains

MR Measurements of Cerebral Blood Flow and Oxygen Extraction Fraction in Pediatric Sickle Cell Disease
May 15, 2015Beth Wang
Chris Sturgeon lab
WORK-IN-PROGRESS
Transcriptional Regulation of Human Primitive and Definitive Hematopoietic Progenitor Specification
May 22, 2015Katherine P. Ponder, MD
Hematology Division
Central Nervous System-Directed Gene Therapy for Mucopolysaccharidosis VII
May 29, 2015Luis F. Z. Batista, PhD
Hematology Division
Generation of an Isogenic Model to Study the Consequences of Telomerase Mutations in Human Stem Cells
2013-2014
DateSpeakerTitle
Sep 6, 2013David G. DeNardo, PhD
Oncology Division, Molecular Oncology Section
Reprogramming Macrophages to Improve Responses to Chemo- and Immunotherapy
Sep 13, 2013Stephen T. Oh, MD, PhD
Hematology Division
RESPONSIBLE CONDUCT OF RESEARCH (FOR TRAINEES)
Human Experimentation
Sep 20, 2013Jing Huang
Evan Sadler laboratory


Ryan Sullivan
Todd Fehniger laboratory
WORK-IN-PROGRESS
The Distinct Role of Two pH Sensing Histidines in the Multimer Assembly and Tubular Storage of von Willebrand Factor

MiR-15/16 Antagonizes Myb to Control Natural Killer Cell Differentiation and Maturation
Sep 27, 2013Monita P. Wilson, PhD
Hematology Division
RESPONSIBLE CONDUCT OF RESEARCH (FOR TRAINEES)
Collection, Recording, and Analysis of Data
Oct 4, 2013Matthew J. C. Ellis, MB, BChir, PhD
Oncology Division, Breast Oncology Section
The Genomics and Proteomics of Breast Cancer
Oct 11, 2013Beth Levine, MD
Department of Medicine, UT Southwestern Medical Center
6TH ROSALIND KORNFELD LECTURE
Novel Links Between Autophagy Proteins, Cell Biology, and Metabolism
Oct 18, 2013Jacqueline E. Payton, MD, PhD
Department of Pathology & Immunology
Targeting the Malignant Epigenome in B cell Lymphoma
Oct 25, 2013Eline van Meel
Stuart Kornfeld laboratory


Tom Girard
George Broze laboratory
WORK-IN-PROGRESS
Mislocalization of Phosphotransferase as a Cause of Mucolipidosis III alpha/beta

Tissue Factor Pathway Inhibitor Structures, Functions and Physiology
Nov 1, 2013Todd A. Fehniger, MD, PhD
Oncology Division, Stem Cell Biology Section
Molecular Regulation of NK Cell Development and Function
Nov 8, 2013Ren-Huai Huang
Evan Sadler laboratory


Monica Qian
Stuart Kornfeld laboratory
WORK-IN-PROGRESS
VWF Tubular Assembly in Vitro by D Domains

Analysis of Mutations in MLII and MLIII α/β Patients – a New Way to Study Lysosomal Enzyme Sorting
Nov 15, 2013Dan R. Littman, MD, PhD
Department of Pathology, NYU Langone Medical Center
41ST CARL MOORE LECTURE
Shaping of the Immune Response by the Commensal Microbiota
Dec 13, 2013Grant A. Challen, PhD
Oncology Division, Molecular Oncology Section
The Epigenetics of Hematopoietic Stem Cell Self-Renewal and Transformation
Dec 20, 2013Dhanam Anbukumar
Evan Sadler laboratory


Balraj Doray
Stuart Kornfeld laboratory
WORK-IN-PROGRESS
Cation Dependence of vWF Multimerization

Influence of Genetic Background on Lethality of GGA2 Knockout Mice
Jan 10, 2014Deborah Novack, MD, PhD
Department of Medicine, Division of Bone & Mineral Diseases
NIK’ing the Bone: Mechanisms for Control of the Osteoclast
Jan 17, 2014Maria Trissal
Dan Link laboratory


Angela Verdoni
Tim Ley laboratory
WORK-IN-PROGRESS
Dysregulation and Recurrent Mutation of miRNA-142 in Acute Myeloid Leukemia

Understanding the Role of the DNMT3A R882H Mutation in AML Pathogenesis
Jan 24, 2014Andrew Yoo, PhD
Department of Developmental Biology
Control of Neuronal Subtype Specificity During MicroRNA-Mediated Neuronal Reprogramming
Jan 31, 2014Matthew J. Walter, MD
Oncology Division, Stem Cell Biology Section
RESPONSIBLE CONDUCT OF RESEARCH (FOR TRAINEES)
Student-Mentor Relationships
Feb 7, 2014Deepta Bhattacharya, PhD
Department of Pathology & Immunology
Convergent Differentiation During Hematopoiesis
Feb 14, 2014Daniel Fisher
Stephen Oh laboratory


Kristen Sanfilippo
Ken Carson, mentor
WORK-IN-PROGRESS
Signaling in Myeloproliferative Neoplasms Studied by Single Cell Mass Cytometry

Zoledronic Acid Versus Pamidronate in Patients with Multiple Myeloma: a Comparative Effectiveness Research Project
Feb 28, 2014Terrence Wong
Dan Link laboratory


Eric Duncavage
Matt Walter laboratory
WORK-IN-PROGRESS
The Role of TP53 Mutations in the Origin and Evolution of Therapy-Related AML

Detection of Subclonal Population in MDS
Mar 7, 2014Gregory A. Storch, MD
Department of Pediatrics
Virologic, Genomic, and Transcriptomic Analysis of Fever Without a Source in Young Children
Mar 14, 2014Garima Gupta Tyagi
Evan Sadler laboratory
WORK-IN-PROGRESS
Interactions Between VWF and ADAMTS13 (Catalytic and Non-catalytic)
Mar 21, 2014J. Evan Sadler, MD, PhD
Hematology Division
RESPONSIBLE CONDUCT OF RESEARCH (FOR TRAINEES)
Authorship, Peer Review, and Confidentiality
Mar 28, 2014Joshua Muia
Evan Sadler laboratory


Christopher Cole
Tim Ley laboratory
WORK-IN-PROGRESS
ADAMTS13 is Conformationally Autoinhibited by its Distal Domains and is Allosterically Activated by Von Willebrand Factor

The Role of Dnmt3a in Acute Promyelocytic Leukemia
Apr 4, 2014Joshua Field, MD, MS
Medical College of Wisconsin
The Potential Role of Invariant NKT Cells in Sickle Cell Disease
Apr 11, 2014Wang-Sik Lee
Stuart Kornfeld laboratory


Meagan Jacoby
Matt Walter laboratory
WORK-IN-PROGRESS
Analysis of Missense Mutations in the α,β-Subunit of GlcNAc-Phosphotransferase Associated with Stuttering

Investigating DNA Double-Strand Break Repair in MDS and AML
Apr 18, 2014Jacques U. Baenziger, MD, PhD
Department of Pathology & Immunology
Molecular Multi-tasking: New Insights into Hepatic Glycan Receptor Function
Apr 25, 2014Cates Mallaney
Grant Challen laboratory


Mathew Cherian
Lee Ratner laboratory
WORK-IN-PROGRESS
Interactions Between Dnmt3a and Repressive Chromatin Regulate Hematopoietic Stem Cell Function and Transformation

Role of the PI3K-Akt mTOR Pathway in Human T Cell Leukemia Induced Transformation
May 9, 2014Jian Zhu
Evan Sadler laboratory


Angela Hirbe
David Gutmann laboratory
WORK-IN-PROGRESS
Structural Studies of ADAMTS13 Using Small-angle X-ray Scattering

Defining the Molecular Events Underlying Malignant Transformation in NF1-related MPNSTs Through Whole Genome Sequencing
May 15, 2014Robert D. Schreiber, PhD
Department of Pathology & Immunology
STANLEY J. KORSMEYER MEMORIAL LECTURE
Cancer Immunoediting: Applying Mechanistic Insights to Cancer Immunotherapy
May 23, 2014Elizabeth Engle
Stephen Oh laboratory


David Germain
Tim Ley laboratory
WORK-IN-PROGRESS
Genetic Complexity and Disease Evolution in Myeloproliferative Neoplasms

DNMT3A Mutations in AML
May 30, 2014Ron Bose, MD, PhD
Oncology Division, Breast Oncology Section
RESPONSIBLE CONDUCT OF RESEARCH (FOR TRAINEES)
Allegations of Misconduct
2012-2013
DateSpeakerTitle
Sep 14, 2012Eline van Meel
Stuart Kornfeld laboratory


Cara Lunn
Matt Walter laboratory
WORK-IN-PROGRESS
Mannose 6-Phosphate Independent Lysosomal Targeting of Acid alpha-Glucosidase

U2AF1 Splicing Factor Mutations in Myelodysplastic Syndromes
Sep 21, 2012Monita P. Wilson, PhD
Hematology Division
ITPK1: an Inositol Kinase Linked to Neural Tube Defects
Sep 28, 2012Ryan Sullivan
Todd Fehniger laboratory


Jing Huang
Evan Sadler laboratory
WORK-IN-PROGRESS
The Role of miR-155 in Natural Killer Cell Function

Distinct Functions of pH-Sensing Histidine Residues in the Multimer Assembly and Storage of von Willebrand Factor in Weibel-Palade Bodies
Oct 5, 2012John S. Welch, MD, PhD
Oncology Division, Stem Cell Biology Section
The Origin and Evolution of AML Mutations
Oct 12, 2012Angela Verdoni
Tim Ley laboratory


Ren-Huai Huang
Evan Sadler laboratory
WORK-IN-PROGRESS
Understanding the Role of DNMT3A Mutations in AML Pathogenesis

How Von Willebrand Factor is Condensed into Weibel-Palade Bodies
Oct 18, 2012Roger J. S. Preston, PhD
Department of Haematology, Trinity College Dublin, Ireland
Regulating the Regulator: Modulating Activated Protein C Functions for Therapeutic Gain
Oct 19, 2012Daniel C. Link, MD
Oncology Division, Stem Cell Biology Section
Characterizing the Stem Cell Niche
Oct 26, 2012Monica Qian
Stuart Kornfeld laboratory


Daniel Fisher
Stephen Oh laboratory
WORK-IN-PROGRESS
Missense Mutations in Mucolipidosis II and Mucolipidosis III

Genomic Study of Myeloproliferative Neoplasia
Nov 2, 2012Susan R. Wente, PhD
Vanderbilt University
5TH ROSALIND KORNFELD LECTURE (ERLANGER AUDITORIUM)
Beyond the Pore: From Nuclear mRNA Export to Translation
Nov 9, 2012Gerald R. Crabtree, MD
HHMI/Stanford University
40TH CARL MOORE LECTURE (MOORE AUDITORIUM)
Chromatin Regulation: New Methods and Concepts
Nov 16, 2012Tom Girard
George Broze laboratory


Dhanam Anbukumar
Evan Sadler laboratory
WORK-IN-PROGRESS
Protein Z, Protein Z-Dependent Protease Inhibitor (SerpinA10) and the Acute Phase Response

Characterizing VWF Propeptide Ca2+ Binding Sites
Dec 14, 2012Daniel E. Goldberg, MD, PhD
Infectious Diseases Division
Trial by Fire and Famine: How the Malaria Parasite Survives in its Host Erythrocyte
Jan 3, 2013Rong Lu, PhD
Institute for Stem Cell Biology and Regenerative Medicine, Stanford University
Systems Analysis of Mouse Hematopoietic Stem Cells in Vivo at the Single Cell Level
Jan 11, 2013Balraj Doray
Stuart Kornfeld laboratory


Joshua Muia
Evan Sadler laboratory
WORK-IN-PROGRESS
Gga2 Knockout Mice Revisited

pH Dependent Activity of ADAMTS13 and Self-regulatory Mechanisms
Jan 15, 2013Jongseong Kim, PhD
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Single-molecule Mechanobiology of Von Willebrand Factor (VWF) to Arbitrate Between Bleeding, Hemostasis, and Thrombosis
Jan 18, 2013J. Evan Sadler, MD, PhD
Hematology Division
Assembly and Destruction of von Willebrand Factor
Jan 25, 2013Sarah Amend
Kathy Weilbaecher laboratory


Terrence Wong
Dan Link laboratory
WORK-IN-PROGRESS
Of Mice and Men: Genetic Contributions of Susceptibility to MGUS, the Requisite Precursor of Multiple Myeloma

The Genetics of Therapy-related AML
Feb 1, 2013Stuart Kornfeld, MD
Hematology Division
New Insights into the Man-6-P Lysosomal Targeting Pathway Through Analysis of Mutations in I-cell Disease and Pseudo-Hurler Polydystrophy
Feb 7, 2013Eirini Trompouki, PhD
Division of Hematology Oncology, Children’s Hospital Boston
From Zebrafish to Man: BMP and Wnt Signaling Pathways in Normal and Stress Hematopoiesis
Feb 8, 2013Adam Searleman
Ron Bose laboratory


Kristen Sanfilippo
Ken Carson laboratory
WORK-IN-PROGRESS
Mechanisms of Transformation in HER2-Overexpressing Mammary Epithelium

Thrombosis in Myeloma
Feb 14, 2013Dhvanit I. Shah, PhD
Division of Hematology, Brigham and Women’s Hospital, Boston
Genetic Screen to Identify Genes Regulating Hematopoiesis
Feb 15, 2013George J. Broze Jr., MD
Hematology Division
Translational Studies of Tissue Factor Inhibitors
Feb 22, 2013Leili Dolatshahi
Evan Sadler laboratory


Meagan Jacoby
Matt Walter laboratory
WORK-IN-PROGRESS
Adjuvant Low Dose Rituximab for Patients with TTP

Dysfunctional Double Strand Break Repair in Therapy-related AML
Mar 1, 2013Garima Gupta
Evan Sadler laboratory


Mathew Cherian
Lee Ratner laboratory
WORK-IN-PROGRESS
Non-catalytic Interaction Between VWF and ADAMTS-13

Role of PI3K-Akt-mTOR in HTLV-Tax Induced Transformation
Mar 8, 2013Katherine N. Weilbaecher, MD
Oncology Division, Molecular Oncology Section
Targeting Beta3 Integrin Pathway Genes to Treat Cancer
Mar 15, 2013David B. Wilson, MD, PhD
Division of Hematology/Oncology, Department of Pediatrics
Adrenocortical Development and Tumorigenesis: the Saga of Rosie
Mar 21, 2013Luis F. Z. Batista, PhD
Department of Medicine/Hematology, Stanford University
Human iPS Cells as a Model to Study Telomere Dysfunction-induced Disease
Mar 22, 2013Christopher Cole
Tim Ley laboratory


Jian Zhu
Evan Sadler laboratory
WORK-IN-PROGRESS
Role of DNMT3A in Acute Promyelocytic Leukemia

Regulation of ADAMTS13 Activity
Mar 29, 2013Stephen T. Oh, MD, PhD
Hematology Division
Towards an Understanding of Genetic and Phenotypic Complexity in Myeloproliferative Neoplasms
Apr 5, 2013Maria Trissal
Dan Link laboratory


Wang-Sik Lee
Stuart Kornfeld laboratory
WORK-IN-PROGRESS
Dysregulation of the Imprinted DLK1-DIO3 Locus in Promyelocytic Leukemia

Structure and Function of the DUF2233 Domain in Bacteria and in Human UCE
Apr 11, 2013Christopher M. Sturgeon, PhD
McEwen Centre for Regenerative Medicine, Toronto
Modeling Developmental Hematopoiesis Using Pluripotent Stem Cells
Apr 12, 2013Katherine P. Ponder, MD
Hematology Division
The Effect of Gene Therapy for Mucopolysaccharidosis After a Decade
Apr 19, 2013Rachel Idol
Stuart Kornfeld laboratory
WORK-IN-PROGRESS
CNS Defects in Mice Lacking Mannose-6-Phosphate
Apr 26, 2013Anna M. Randi, PhD
National Heart & Lung Institute, Imperial College London
Von Willebrand Factor Regulates Angiogenesis and Endothelial Progenitors’ Function
May 3, 2013Betsy Engle
Stephen Oh laboratory


Timothy Collier
Ron Bose laboratory
WORK-IN-PROGRESS
Genetic Complexity and Clonal Evolution in Myeloproliferative Neoplasms

Probing the Structure and Dimerization of EGFR Family Tyrosine Kinases
May 10, 2013Michael H. Tomasson, MD
Oncology Division, Molecular Oncology Section
The Role of Orphan snoRNA ACA11 in the Pathogenesis of t(4;14)-positive Multiple Myeloma
Sep 6, 2013David G. DeNardo, PhD
Oncology Division, Molecular Oncology Section
Reprogramming Macrophages to Improve Responses to Chemo- and Immunotherapy
2011-2012
DateSpeakerTitle
Sep 7, 2011Jeff Lichtman, MD
Harvard University
INTERDISCIPLINARY SEMINAR SERIES [SPONSORED BY BIOCHEMISTRY & MOLECULAR BIOPHYSICS, BIOMEDICAL ENGINEERING, CELL BIOLOGY & PHYSIOLOGY, DEVELOPMENTAL BIOLOGY, INTERNAL MEDICINE (HEMATOLOGY), AND PEDIATRICS]
Imaging the Connectome
Sep 14, 2011John D. York, PhD
Howard Hughes Medical Institute, Duke University
INTERDISCIPLINARY SEMINAR SERIES
Inositol Phosphate Communication: Insights into the Cell’s ‘iPhone’
Sep 16, 2011Jing (Christie) Huang
Evan Sadler laboratory


Wang-Sik Lee
Stuart Kornfeld laboratory
WORK-IN-PROGRESS
Cells as a Model System to Study Weibel-Palade Body Targeting and Regulated Secretion of Ultra-large von Willebrand Factor

Update on Studies of Mutations Found in the Gene Encoding Uncovering Enzyme in Individuals with Persistent Stuttering
Sep 21, 2011Matthew Vander Heiden, MD, PhD
Massachusetts Institute of Technology
INTERDISCIPLINARY SEMINAR SERIES
Metabolic Alterations that Support Cell Proliferation
Sep 28, 2011Alejandro Sánchez Alvarado, PhD
Stowers Institute
INTERDISCIPLINARY SEMINAR SERIES
Regeneration: New Parts from Old
Sep 30, 2011Margaret Young
Tim Ley laboratory


Ryan Sullivan
Todd Fehniger laboratory
WORK-IN-PROGRESS
Canonical and Non-canonical HOX Expression Patterns in Acute Myelogenous Leukemia

MicroRNA Deficient Natural Killer Cells Exhibit Decreased Survival but Enhanced Cytokine Production and Degranulation Capacity
Oct 5, 2011Timothy J. Ley, MD
Washington University School of Medicine
INTERDISCIPLINARY SEMINAR SERIES
The AML Genome
Oct 14, 2011Eline van Meel
Stuart Kornfeld laboratory


Matthew Ndonwi
George Broze laboratory
WORK-IN-PROGRESS
Discovery of the First Disease Causing Mutations in Methionyl-tRNA Synthetase (MARS)

Studies on Lipoprotein-free and Lipoprotein-associated Plasma Tissue Factor Pathway Inhibitor
Oct 19, 2011Carl-Philipp Heisenberg, PhD
Institute of Science and Technology Austria
INTERDISCIPLINARY SEMINAR SERIES
Cell and Tissue Mechanics in Zebrafish Gastrulation
Oct 26, 2011Mimi Koehl, PhD
University of California, Berkeley
INTERDISCIPLINARY SEMINAR SERIES
Fluid Mechanics of Larvae
Nov 4, 2011Robert P. Mecham, PhD
Department of Cell Biology & Physiology
Regulation of Growth Factor Activity by Extracellular Matrix
Nov 11, 2011Cara Lunn
Matt Walter laboratory


Jasna Marjanovic
Phil Majerus laboratory
WORK-IN-PROGRESS
U2AF1 Mutations in Myelodysplastic Syndromes
Nov 18, 2011Ajit Varki, MD
University of California, San Diego
39TH CARL MOORE LECTURE
Adventures in Anthropogeny: From Sialic Acids to Human Uniqueness
Dec 2, 2011Angela Verdoni
Tim Ley laboratory


Ren-Huai Huang
Evan Sadler laboratory
WORK-IN-PROGRESS
Understanding the Role of DNA Methyltransferase 3A Mutations in Acute Myeloid Leukemia Pathogenesis

Von Willbrand Factor Assembly by D-domains Before Furin Cleavage
Dec 16, 2011Monica Qian
Stuart Kornfeld laboratory


Radhika Jagannathan
Greg Longmore laboratory
WORK-IN-PROGRESS
Functions of the α, β and γ Subunits of UDP-G1cNAc:Lysosomal Enzyme N-acetylglucosamine-1-phosphotransferase

Negative Regulation of the Hippo Pathway by the Ajuba LIM Family of Proteins
Jan 6, 2012Cynthia Kenyon, PhD
University of California, San Francisco
4TH ROSALIND KORNFELD LECTURE
Genes and Cells that Affect the Rate of C. elegans’ Aging
Jan 13, 2012J. Evan Sadler, MD, PhD
Division of Hematology
Von Willebrand Factor, ADAMTS13, and Thrombotic Microangiopathy
Jan 20, 2012Daniel Fisher
Steve Oh laboratory


Jaebok Choi
John DiPersio laboratory
WORK-IN-PROGRESS
Mass Cytometry Study of Human Myeloproliferative Neoplasia

Interferon Gamma Receptor Signaling and T Cell Trafficking in Graft vs. Host Disease
Jan 25, 2012Katherine A. High, MD
The Children’s Hospital of Philadelphia
BIOLOGIC THERAPEUTICS / HEMATOLOGY JOINT SEMINAR
In Vivo Gene Transfer for Genetic Disease: Progress and Challenges
Feb 3, 2012Tom Girard
George Broze laboratory


Dhanam Anbukumar
Evan Sadler laboratory
WORK-IN-PROGRESS
Tissue Factor Pathway Inhibitor – βefore and αfter

Calcium Binding Studies of von Willebrand Factor Propeptide
Feb 9, 2012Ann Mullally, MD
Harvard Medical School
Characterizing and Therapeutically Targeting MPN Stem Cells in Vivo
Feb 10, 2012Shin-Ichiro Imai, MD, PhD
Department of Developmental Biology
Towards Productive Aging: The Importance of SIRT1 and NAMPT-mediated NAD Biosynthesis in the NAD World
Feb 17, 2012Balraj Doray
Stuart Kornfeld laboratory


Joshua Muia
Evan Sadler laboratory
WORK-IN-PROGRESS
GGA Null Mice: The Final Chapter? Or Not?

An Optimized Fluorogenic Assay for ADAMTS13 and Inhibitors in Thrombotic Thrombocytopenic Purpura Patients
Feb 24, 2012Clay F. Semenkovich, MD
Division of Endocrinology, Metabolism & Lipid Research
Lipogenesis: Much More Than Making Fat
Mar 2, 2012Mark Schroeder
John DiPersio laboratory


Sarah Amend
Kathy Weilbaecher laboratory
WORK-IN-PROGRESS
Mobilization of Allogeniec Sibling Peripheral Blood Stem Cell Donors with GM-CSF and Plerixafor – an Interim Analysis

Identification of the Genetic Basis of MGUS and Multiple Myeloma Susceptibility in KaLwRij Mice
Mar 9, 2012Mary C. Dinauer, MD, PhD
Department of Pediatrics
Getting a License to Kill: Regulation of the Leukocyte NADPH Oxidase
Mar 16, 2012Adam Searleman
Ron Bose laboratory
WORK-IN-PROGRESS
Characterization of a Mouse Model of Ductal Carcinoma In Situ of the Breast
Mar 23, 2012James H. Morrissey, PhD
University of Illinois at Urbana-Champaign
Platelet Polyphosphate at the Nexus of Blood Clotting and Inflammation
Mar 30, 2012Jian Zhu
Evan Sadler laboratory


Megan Jacoby
Matt Walter laboratory
WORK-IN-PROGRESS
Small-angle X-ray Scattering Studies of ADAMTS13 Demonstrate a Conformational Response to Substrate Binding in Solution

Dysfunctional Double Strand Break Repair is Present in a Subset of Therapy-related MDS/AML Myeloblasts
Apr 6, 2012John P. Atkinson, MD
Division of Rheumatology
Atypical Hemolytic Uremic Syndrome
Apr 13, 2012Chunfen Zhang
Phil Majerus laboratory


Maria Trissal
Dan Link laboratory
WORK-IN-PROGRESS
The role of Myotubularin-related Phosphatases MTMR8 and MTMR9 in the Control of Autophagy

Small Non Coding RNAs in Normal and Malignant Hematopoiesis
Apr 20, 2012Kyunghee Choi, PhD
Department of Pathology & Immunology
Regulation of Hematopoietic and Vascular Development
May 4, 2012Weikai Li, PhD
Department of Biochemistry & Molecular Biophysics
Structure and Function of Vitamin K Epoxide Reductase: Connecting Oxidative Protein Folding with Blood Coagulation
May 11, 2012Rachel Idol
Stuart Kornfeld laboratory
WORK-IN-PROGRESS
Uncovering New Phenotypes in Uncovering Enzyme-Deficient Mice
May 18, 2012Stephen Oh
K12 Training Grant Awardee
WORK-IN-PROGRESS
JAK2 and Beyond: Genomics and Signaling in Myeloproliferative Neoplasms
2010-2011
DateSpeakerTitle
Sep 10, 2010Erin O’Shea, PhD
Department of Molecular and Cellular Biology, Harvard University
3RD ROSALIND KORNFELD LECTURE
Translating DNA Sequence into Gene Expression Output
Sep 17, 2010Jing Huang
Evan Sadler laboratory
WORK-IN-PROGRESS
The B Subunits of Shiga-like Toxins Induce Regulated VWF Secretion in a Phospholipase D1 Dependent Manner
Sep 24, 2010Monita P. Wilson, PhD
Division of Hematology
A Mouse Model Linking Aberrant Inositol Metabolism to Defects in Neural Development
Oct 1, 2010Wang-Sik Lee
Stuart Kornfeld laboratory


Lucas Wartman
Tim Ley laboratory
WORK-IN-PROGRESS
Update of the Uncovering Enzyme Research with Stutterers’ mutations

Conserved Progression Mutations in Mouse and Human Leukemia Genomes
Oct 8, 2010Daniel C. Link, MD
Division of Oncology
Regulation of Stem Cell and Neutrophil Trafficking from the Bone Marrow
Oct 15, 2010Marina Kisseleva
Phil Majerus laboratory


Matthew Ndonwi
George Broze laboratory
WORK-IN-PROGRESS
O, Brother, Where Art Thou? MTMR8 and MTMR9 Journey Inside the Cell

Interaction of TFPI with Factor V
Oct 22, 2010Douglas M. Tollefsen, MD, PhD
Division of Hematology
Activation of Heparin Cofactor II by Arterial Dermatan Sulfate
Nov 5, 2010Philip W. Majerus, MD
Division of Hematology
Inositol Signaling in Human Disease
Nov 12, 2010Terry Riehl
Bill Stenson and Doug Tollefsen laboratories


Cara Lunn
Matt Walter laboratory
WORK-IN-PROGRESS
COX-1+/-COX-2-/- Genotype in Mice is Associated with Shortened Time to Carotid Artery Occlusion Through Increased PAI-1

Discovery of Mutations in Myelodysplastic Syndrome Genomes
Nov 19, 2010Hal Dietz, MD
Institute of Genetic Medicine, Johns Hopkins University
38TH CARL MOORE LECTURE
TGFβ in the Pathogenesis and Prevention of Aneurysm: Embracing Paradox
Dec 10, 2010George J. Broze, Jr., MD
Division of Hematology
Tissue Factor Pathway Inhibitor
Dec 17, 2010Monica Qian
Stuart Kornfeld laboratory


Paul Bigg
Kathy Ponder laboratory
WORK-IN-PROGRESS
UDP-GlcNAc:Lysosomal Enzyme N-Acetylglucosamine-1-Phosphotransferase

The Pathogenesis of Mitral Valve Disease in Mucopolysaccharidosis VII Dogs
Jan 7, 2011Brian Van Tine
Matthew Ellis and Jim Hsieh laboratories


Tom Girard
George Broze laboratory
WORK-IN-PROGRESS
Taspase1 and HER2+ Breast Cancer

The Ups and Downs of Protein Z and the Z-dependent Protease Inhibitor
Jan 14, 2011Stuart Kornfeld, MD and Terra D. Barnes, PhD
Division of Hematology and Department of Anatomy & Neurobiology
The Mannose 6-Phosphate Lysosomal Targeting Pathway and Persistent Stuttering
Jan 21, 2011Meagan Jacoby
Matt Walter laboratory
WORK-IN-PROGRESS
DNA Repair Dysfunction in Primary Therapy-related AML/MDS Myeloblasts
Jan 28, 2011Gregory D. Longmore, MD
Division of Hematology
Epithelial Morphogenesis in Development and Disease
Feb 4, 2011Mark Schroeder
John DiPersio laboratory


Jennifer Govero
Stuart Kornfeld laboratory
WORK-IN-PROGRESS
Exploring Cytokines to Treat Graft-vs-Host Disease

Strain Dependent Lethality of GGA2 Null Mice: Embryonic vs Neonatal
Feb 11, 2011Helen M. Piwnica-Worms, PhD
Department of Cell Biology & Physiology
Translation of Fundamental Cell Cycle Principles to Targeted Cancer Therapies
Feb 18, 2011Margaret Young
Tim Ley laboratory


Ren-Huai Huang
Evan Sadler laboratory
WORK-IN-PROGRESS
Whole Genome Sequencing of Murine Induced Pluripotent Stem Cells

Calcium and pH-Dependent Interactions Within VWF Tubule
Mar 4, 2011Balraj Doray
Stuart Kornfeld laboratory


Radhika Jagannathan
Greg Longmore laboratory
WORK-IN-PROGRESS
GGA Autoinhibition Re-revisited: Do Internal Dileucines Bind GGA VHS Domains

Negative Regulation of the Salvador-Warts-Hippo Pathway by the Ajuba LIM Family of Proteins
Mar 11, 2011Ron Bose, MD, PhD
Division of Oncology
Kinase Activation and Signaling: How Does the Her2 Tyrosine Kinase Give Rise to Breast Cancer?
Mar 18, 2011Ghada Kunter
Dan Link laboratory


Jian Zhu
Evan Sadler laboratory
WORK-IN-PROGRESS
Molecular Pathogenesis of Leukemia in Severe Congenital Neutropenia

Structural and Functional Study of ADAMTS13
Apr 1, 2011Adam Searleman
Ron Bose laboratory


David Tran
Greg Longmore laboratory
WORK-IN-PROGRESS
Determination of In Vivo Signaling Networks Governing Ductal Carcinoma In Situ Progression

The Snail1-Twist1 Cooperation in EMT Maintenance and Cancer Dormancy
Apr 8, 2011Elaine M. Majerus, MD, PhD
Division of Hematology
Studies with an Enhancer of VWF Cleavage–A Novel Potential Anti-thrombotic?
Apr 22, 2011Katherine P. Ponder, MD
Division of Hematology
The Pathogenesis of Mucopolysaccharidosis May Involve Complement Activation
Apr 29, 2011Chunfen Zhang
Phil Majerus laboratory
WORK-IN-PROGRESS
Lysine Acetylation of Inositol 1,3,4-Trisphosphate 5/6 Kinase
May 6, 2011Lawrence F. “Skip” Brass, MD, PhD
Division of Hematology/Oncology, University of Pennsylvania
Dynamic Regulation of Platelet Accumulation Following Vascular Injury
May 13, 2011Maria Trissal
Dan Link laboratory


Guilherme Baldo
Kathy Ponder laboratory
WORK-IN-PROGRESS
Role of Small Non-coding RNAs in Normal and Malignant Hematopoiesis

Pathogenesis of the Aortic Valve Disease in MPS VII
May 20, 2011Stephen T. Oh, MD, PhD
Division of Hematology
The Missing LNK: Mechanisms of Dysregulated Signaling in Myeloproliferative Neoplasms
May 27, 2011Rachel Idol
Stuart Kornfeld laboratory
WORK-IN-PROGRESS
Phenotypic Analysis of Phosphotransferase Deficient Mice
Jun 1, 2011Thomas F. Deuel, MD
Harvard Medical School and The Scripps Research Institute
Shaping the Tumor Phenotype and Microenvironment: New Pathways, New Therapeutic Targets
2009-2010
DateSpeakerTitle
Sep 11, 2009Gregory D. Longmore, MD
Division of Hematology
Epithelial Morphogenesis in Development and Cancer
Sep 18, 2009Baiwei Gu
Monica Bessler and Phil Mason laboratory


Ren-Huai Huang
Evan Sadler laboratory
WORK-IN-PROGRESS
DNA Damage Accumulation, Accelerated Hematopoietic Stem Cell Aging, and Partial Reversal by Antioxidant Treatment in a Mouse Model of Dyskeratosis Congenita

A Structural Explanation for the Antithrombotic Activity of ARC1172, a DNA Aptamer that Binds Von Willebrand Factor Domain A1
Sep 25, 2009George J. Broze, Jr., MD
Division of Hematology
Regulation of Coagulation
Oct 2, 2009Marielle Boonen
Stuart Kornfeld laboratory


Jing (Christie) Huang
Evan Sadler laborator
y
WORK-IN-PROGRESS
Mucolipidosis Type II Mice Accumulate Autophagolysosomes in Fibroblasts and Serous/mucous Type Secretory Cells

The B Subunits of Type 1 and Type 2 Shiga-like Toxins Induce Regulated VWF Secretion in a Phospholipase D Dependent Manner
Oct 16, 2009Matthew Ndonwi
George Broze laboratory
WORK-IN-PROGRESS
Effect of Malarial Histidine-rich Protein II (HRPII) on Blood Coagulation
Oct 23, 2009Audrey R. Odom, MD, PhD
Department of Pediatrics
Malaria
Oct 30, 2009Joan A. Steitz, PhD
Department of Molecular Biophysics & Biochemistry, Yale University
2ND ROSALIND KORNFELD LECTURE
Regulating the Activity of MicroRNAs in Vertebrate Cells
Nov 6, 2009Gerald I. Shulman, MD, PhD
Department of Internal Medicine, Yale University
37TH CARL MOORE LECTURE
Cellular Mechanisms of Insulin Resistance: Implications for Obesity, Lipodystrophy, Metabolic Syndrome and Type 2 Diabetes
Nov 20, 2009Daniel S. Ory, MD
Division of Cardiology
The Niemann-Pick C Pathway: a Key Regulator of Cholesterol Homeostasis
Dec 11, 2009Balraj Doray
Stuart Kornfeld laboratory


Trish Anderson
Evan Sadler laboratory
WORK-IN-PROGRESS
Characterization of Mouse GGA2 Antibodies

More on ADAMTS13 Spacer Domain and VWF Substrate Recognition
Jan 8, 2010Marina Kisseleva
Phil Majerus laboratory


Kazuhiko Ikeda
Monica Bessler and Phil Mason laboratory
WORK-IN-PROGRESS
Regulation of Nuclear PI(5)P in Stress Signaling

Myeloproliferative Neoplasm-like Hematopoiesis in Mice with Truncated Hmga2 cDNA
Jan 15, 2010Linda J. Pike, PhD
Department of Biochemistry & Molecular Biophysics
Bi-Directional Signaling in the EGF Receptor
Jan 22, 2010Monica Qian
Stuart Kornfeld laboratory


Anguo Li
Doug Tollefsen laboratory
WORK-IN-PROGRESS
Functions of the α, β and γ Subunits of UDP-GlcNAc:Lysosomal Enzyme N-Acetylglucosamine-1-Phosphotransferase

Activation of Heparin Cofactor II by Fibroblast Proteoglycans
Jan 29, 2010Kerry Kornfeld, MD, PhD
Department of Developmental Biology
The Role of Zinc in Animal Development and Physiology
Feb 5, 2010Jingping Ge
Monica Bessler and Phil Mason laboratory
WORK-IN-PROGRESS
The Consequences of Dyskerin Ablation in Mouse Liver
Feb 26, 2010Katherine N. Weilbaecher, MD
Division of Oncology, Molecular Oncology Section
Hedgehog Signaling in Osteoclasts and Bone Metastasis
Mar 5, 2010Yukio Fujiki
Department of Biology, Kyushu University, Fukuoka, Japan
Peroxisome Biogenesis and Its Dysfunctions in Humans
Mar 12, 2010Mark S. Sands, PhD
Division of Oncology, Stem Cell Biology Section
Lysosomal Dysfunction Results in Altered Energy Balance
Mar 19, 2010Luke Dang
Evan Sadler laboratory


Jennifer Govero
Stuart Kornfeld laboratory
WORK-IN-PROGRESS
Two Histidine Residues Required for the pH Dependent Multimerization of Von Willebrand Factor

All GGAs Are Not Created Equal
Mar 26, 2010David Gailani, MD
Departments of Pathology and Medicine, Vanderbilt University
Factor XI and the Intrinsic Pathway in Normal and Pathologic Coagulation
Apr 2, 2010Rachel Idol
Monica Bessler and Phil Mason laboratory
WORK-IN-PROGRESS
Mouse Models of Diamond Blackfan Anemia
Apr 23, 2010Jun Zou
Phil Majerus laboratory


Chunfen Zhang
Phil Majerus laboratory
WORK-IN-PROGRESS
Characterization of Myotubularin Related Protein 8

Lysine Acetylation of Inositol 1,3,4-Trisphosphate 5/6-kinase
Apr 30, 2010Lucio Cocco, MD, PhD
Department of Anatomical Sciences, Bologna, Italy
Nuclear Phospholipase C β1 Signalling, MDS and AML: From Bench to Clinics
May 7, 2010Sandy Chang, MD, PhD
Departments of Genetics and Hematopathology, M.D. Anderson Cancer Center
How Telomeres Repress the DNA Damage Response
May 14, 2010Julie Karue
Doug Tollefsen laboratory


Ruth Howe
Kathy Ponder laboratory
WORK-IN-PROGRESS
Function of the N-terminal Domain of Heparin Cofactor II

The Role of Cathepsin S and MMP-12 in MPS VII Aortic Disease
May 21, 2010Weiqiang Gao
Evan Sadler laboratory
WORK-IN-PROGRESS
Functional Differences of the Non-Catalytic Domains in Human ADAMTS13 and ADAMTS5 in Substrate Cleavage
May 28, 2010Fang Liu
Evan Sadler laboratory
WORK-IN-PROGRESS
The Mechanism of VWF Basolateral Secretion in HUVECs
2008-2009
DateSpeakerTitle
Sep 5, 2008Intaek Lee
Stuart Kornfeld laboratory


Coy Heldermon
Mark Sands laboratory
WORK-IN-PROGRESS
The Role of the Gamma-subunit of UDP-GlcNAc:lysosomal Enzyme N-acetylglucosamine-1-phosphotransferase

The Effect of Bone Marrow Transplant and Intracranial Gene Therapy in Mucopolysaccharidosis IIIB Mice
Sep 19, 2008
Ren-Huai Huang
Evan Sadler laboratory


Baiwei Gu
Monica Bessler and Phil Mason laboratory
WORK-IN-PROGRESS
Structural Basis of VWF for Aptamer Binding and Tubular Storage

Is Dyskerin Crucial for Telomere Maintenance, DNA Damage Response and Ageing?
Sep 26, 2008Monita P. Wilson, PhD
Division of Hematology
Neural Tube Defects in Mice with Aberrant Inositol Metabolism
Oct 3, 2008Marielle Boonen
Stuart Kornfeld laboratory


John Welch
Tim Ley laboratory
Characterization of UCE (Uncovering Enzyme) Knock-out Mouse

PML-RARα: Clonal Dominance Precedes Leukemia
Oct 10, 2008Anmaar Abdul-Nabi
Nabeel Yaseen laboratory (Pathology)


Priya Gopalan
Dan Link laboratory
WORK-IN-PROGRESS
Molecular and Biological Effects of AML-associated Fusion Proteins on Primary Human CD34+ Cells

Regulation of Hematopoietic Stem Cells by the Bone Marrow Niche
Oct 24, 2008Jing (Christie) Huang
Evan Sadler laboratory


Jeff Hiken
Phil Mason and Monica Bessler laboratory
WORK-IN-PROGRESS
The B-subunits of Shiga-like Toxins 1 and 2 Promote VWF Secretion Via a Cholesterol Sensitive, Clathrin-independent Mechanism in Human Endothelial Cells

Quantitative Differences Between Expression Profiles of RBC Proteomes
Oct 31, 2008Elizabeth Neufeld, PhD
Department of Biological Chemistry, David Geffen School of Medicine at UCLA
1ST ROSALIND KORNFELD LECTURE
Four Decades of Research on MPS
Nov 7, 2008Philip J. Mason, PhD
Division of Hematology
Telomeres, Ribosomes and Bone Marrow Failure
Nov 14, 2008Tony Vomund
Elaine Majerus laboratory


Jennifer Govero
Stuart Kornfeld laboratory
WORK-IN-PROGRESS
Characterizing the Interaction Between ADAMTS13 and Endothelial Cells

Characterization of the GGA Null Mice
Nov 21, 2008Donald E. Ganem, MD
Howard Hughes Medical Institute, University of California, San Francisco
36TH CARL MOORE LECTURE
Small Noncoding RNAs and the Biology of Kaposi’s Sarcoma-associated Herpesvirus
Dec 12, 2008Trish Anderson
Evan Sadler laboratory


Kazu Ikeda
Monica Bessler and Phil Mason laboratory
WORK-IN-PROGRESS
Substrate Recognition by the ADAMTS13 Spacer Domain

Overexpression of HMGA2 in Normal and PNH Hematopoiesis
Jan 9, 2009Philip W. Majerus, MD
Division of Hematology
Inositols Do It All
Jan 16, 2009Matthew Ndonwi
George Broze laboratory


Jun Zou
Phil Majerus laboratory
WORK-IN-PROGRESS
Malarial Histidine Rich Protein II (HRPII) and Blood Coagulation

MTMR9 Increases MTMR6 Enzyme Activity, Stability, and Has a Role in Apoptosis
Jan 23, 2009Katherine P. Ponder, MD
Division of Hematology
The Pathogenesis of Disease in Mucopolysaccharidosis
Jan 30, 2009Jingping Ge
Monica Bessler and Phil Mason laboratory
WORK-IN-PROGRESS
Microarray Analysis of snoRNA Expression in Dyskerin Knockout Mice
Feb 6, 2009J. Evan Sadler, MD, PhD
Division of Hematology
Assembly and Destruction of Von Willebrand Factor
Feb 13, 2009Angie Purvis
Evan Sadler laboratory


Balraj Doray
Stuart Kornfeld laboratory
WORK-IN-PROGRESS
pH Dependence of VWF Multimerization and Storage

Understanding the GGA Null Phenotype
Feb 20, 2009Stuart Kornfeld, MD
Division of Hematology
New Insights into the Man-6-P Lysosomal Enzyme Targeting System from Mouse Models
Feb 27, 2009Nayan Sarma
Nabeel Yaseen laboratory (Pathology)


Rachel Idol
Monica Bessler and Phil Mason laboratory
WORK-IN-PROGRESS
Molecular Interactions of the Oncogene Nup98-HoxA9

A Mouse Model of Diamond Blackfan Anemia
Mar 13, 2009Meagan Jacoby
Matt Walter laboratory


Fang Liu
Evan Sadler laboratory
WORK-IN-PROGRESS
DNA Repair Genes in Treatment-related AML and MDS

Cell Signaling in Stx B Subunit-induced VWF Secretion
Mar 20, 2009Douglas M. Tollefsen, MD, PhD
Division of Hematology
TAP-Annexin V: a Novel Antithrombotic Agent
Mar 27, 2009Chunfen Zhang
Phil Majerus laboratory


Rachel Orlowski
Elaine Majerus laboratory
WORK-IN-PROGRESS
Identification of Lysine Acetylation Sites on Inositol 1,3,4-Trisphosphate 5/6-Kinase

Studies with Protein O-fucosyltransferase 2
Apr 3, 2009Monica Bessler, MD, PhD
Division of Hematology
Towards a New Understanding of Bone Marrow Failure
Apr 10, 2009Mark Schroeder
John DiPersio laboratory


Weiqiang Gao
Evan Sadler laboratory
WORK-IN-PROGRESS
Graft Versus Host Disease: a Novel Mouse Model and Therapy

Fluorescent VWF Substrates for ADAMTS13
Apr 17, 2009Elaine M. Majerus, MD, PhD
Division of Hematology
Studies on ADAMTS13 and Protein O-fucosyltransferase 2
May 8, 2009Wang-Sik Lee
Stuart Kornfeld laboratory


Sharon McDonald
Monica Bessler and Phil Mason laboratory
WORK-IN-PROGRESS
The Role of the γ-Subunit of GlcNAc-Phosphotransferase

Investigating the Interaction of Dyskerin and Pot1b
May 15, 2009Giri Ramsingh
Dan Link laboratory


Jason Metcalf
Kathy Ponder laboratory
WORK-IN-PROGRESS
Characterizing MicroRNAs in Acute Myeloid Leukemia

A New and Safer Gene Therapy Vector for Mucopolysaccharidosis I
2007-2008
DateSpeakerTitle
Sep 14, 2007Ren-Huai Huang
Evan Sadler laboratory


Shannon Alford
Greg Longmore laboratory
WORK-IN-PROGRESS
Assembly and Structure of Von Willebrand Factor Tubules in Weibel-Palade Bodies

Sphingosine 1-phosphate-mediated Endothelial Cell Migration in Human Platelet Poor Plasma
Sep 21, 2007Michael H. Tomasson, MD
Bone Marrow Transplantation & Leukemia Section, Department of Medicine
Mechanisms of Apoptosis and Transformation in Myc-induced Acute Myeloid Leukemia
Sep 28, 2007Intaek Lee
Stuart Kornfeld laboratory


Rachel Idol
Monica Bessler and Phil Mason laboratory
WORK-IN-PROGRESS
Binding of Cargo Sorting Signals to AP-1 Enhances its Association with ARF1-GTP

Human Ribosomal Biogenesis
Oct 5, 2007Jacques U. Baenziger, MD, PhD
Department of Pathology and Immunology
Oct 12, 2007BaiWei Gu
Monica Bessler and Phil Mason laboratory


Kyuhwan Shim
Evan Sadler laboratory
WORK-IN-PROGRESS
Dyskerin, Telomerase and DNA Damage

Platelet-von Willebrand Factor Complexes Are Preferred Substrates of ADAMTS13 Under Fluid Shear Stress
Oct 19, 2007Katherine N. Weilbaecher, MD
Molecular Oncology Section, Department of Medicine
CXCR4 Regulation of Osteoclast Development and Tumor Osteolysis
Oct 26, 2007Balraj Doray
Stuart Kornfeld laboratory


Weiqiang Gao
Evan Sadler laboratory
WORK-IN-PROGRESS
Identification of Acidic-dileucine Signals That Bind to GGAs and AP-1/AP-2

Contacts Between Several ADAMTS13 Structural Domains and Von Willebrand Factor Domain A2 Contribute to Substrate Cleavage
Nov 9, 2007Jun Zou
Phil Majerus laboratory


Jing (Christie) Huang
Evan Sadler laboratory
WORK-IN-PROGRESS
Type I Phosphatidylinositol-4,5-bisphosphate 4-phosphatase Regulates Stress-induced Apoptosis

The B Subunits of Shiga Toxins Induce Von Willebrand Factor Secretion and Cytoskeletal Remodeling in Human Endothelial Cells
Nov 16, 2007Arthur Horwich, MD
Department of Genetics, Yale University School of Medicine
35TH CARL MOORE LECTURE
Protein Folding and Misfolding in the Cell
Nov 30, 2007Daniel C. Link, MD
Stem Cell Biology Section, Department of Medicine
Regulation of the Hematopoietic Stem Cell Niche by G-CSF
Dec 5, 2007Vytas A. Bankaitis, PhD
Department of Cell & Developmental Biology, University of North Carolina, Chapel Hill
A High Resolution Look at a Superfamily of Nanoreactors that Control Phosphoinositide Signaling in Eukaryotic Cells
Dec 14, 2007Emily H.-Y. Cheng, MD, PhD
Molecular Oncology Section, Department of Medicine
Regulation of Cell Death by BCL-2 Family and Beyond
Jan 4, 2008Fang Liu
Evan Sadler laboratory
WORK-IN-PROGRESS
The Characteristic of Signaling Pathways Involved in Stx B-induced von Willebrand Factor Secretion
Jan 11, 2008Lee Ratner, MD, PhD
Molecular Oncology Section, Department of Medicine
T-Cell Activation and Lymphoma
Jan 18, 2008Tony Vomund
Elaine Majerus laboratory


HongYan Du
Monica Bessler and Phil Mason laboratory
WORK-IN-PROGRESS
The Interaction of ADAMTS13 and Endothelial Cells

The Significance of Telomere Length Measurement in the Diagnosis of Dyskeratosis Congenita
Jan 25, 2008James J.-D. Hsieh, MD, PhD
Molecular Oncology Section, Department of Medicine
Taspase1 Links MLL Proteolysis to Cell Cycle Progression and Beyond
Feb 1, 2008Zheyong (Jeff) Yu
Evan Sadler laboratory


Steve Warner
Greg Longmore laboratory
WORK-IN-PROGRESS
Modulation of ADAMTS13 Activity by Free Amino Acids

A Glance at the In Vivo Function of Rho GTPases Through the Fly Eye
Feb 8, 2008Tom Ellenberger, DVM, PhD
Department of Biochemistry and Molecular Biophysics
Chemical Biology of DNA Repair
Feb 15, 2008Jasna Marjanovic
Phil Majerus laboratory


Jeff Hiken
Monica Bessler and Phil Mason laboratory
WORK-IN-PROGRESS
Characterization of Myotubularin Related Protein 8

Label-free Quantitative Proteomic Analysis of Normal and PNH RBC Membranes
Feb 22, 2008Jason D. Weber, PhD
Molecular Oncology Section, Department of Medicine
Regulating mRNA Translation Programs in Cancer
Feb 29, 2008Trish Anderson
Evan Sadler laboratory


Yunfeng Feng
Greg Longmore laboratory
WORK-IN-PROGRESS
ADAMTS13 Spacer Domain and Substrate Recognition

Regulation of Cell Migration by α-actinin
Mar 7, 2008Loren S. Michel, MD
Medical Oncology Section, Department of Medicine
Oncogenic Role and Therapeutic Targeting of the Transmembrane Protein Trop-2 in Epithelial Tumors
Mar 14, 2008Anguo Li
Doug Tollefsen laboratory


Sara Robledo
Monica Bessler and Phil Mason laboratory
WORK-IN-PROGRESS
Differential Gene Expression of Injured Arteries in HCII Knockout Mice

The Role of Human Ribosomal Proteins in the Maturation of rRNA and Ribosome Production
Mar 28, 2008Bo Jin
Evan Sadler laboratory


Matthew Ndonwi
George Broze laboratory
WORK-IN-PROGRESS
Structural Basis of VWF Cleavage by ADAMTS13

Effect of Protein S on Tissue Factor Pathway Inhibitor (TFPI) Activity
Apr 4, 2008Daniel E. Goldberg, MD, PhD
Division of Infectious Diseases, Department of Medicine
Targeting Intraerythrocytic Malaria Parasites for Chemical Destruction
Apr 11, 2008Angie Purvis
Evan Sadler laboratory


Jingping Ge
Monica Bessler and Phil Mason laboratory
WORK-IN-PROGRESS
Von Willebrand Factor: the Free Thiol Saga Continues

Is Dyskerin Essential for Cell Survival and Proliferation?
Apr 18, 2008Jennifer Govero
Stuart Kornfeld laboratory


Kazuhiko Ikeda
Monica Bessler and Phil Mason laboratory
WORK-IN-PROGRESS
Characterization of the GGA Null Mice

Overexpression of HMGA2 in Normal and PNH Hematopoietic Cells
Apr 25, 2008Wang-Sik Lee
Stuart Kornfeld laboratory
WORK-IN-PROGRESS
IFG, a Potential Therapeutic Agent for Gaucher Disease, Reduces Cholesterol Accumulation in Neimann-Pick C1 Fibroblasts
May 2, 2008Jonathan D. Gitlin, MD
Department of Pediatrics
Copper Homeostasis in Early Development
May 9, 2008Xiucua Ma
Kathy Ponder laboratory


Jason Metcalf
Kathy Ponder laboratory
WORK-IN-PROGRESS
A Self-inactivating Retroviral Vector with Improved Safety for Gene Therapy in Mucopolysaccharidosis I Mice

Pathogenesis of Short Bones in Mucopolysaccharidosis VII
May 16, 2008Meghna Das Thakur
Greg Longmore laboratory


Hendrik Feys
Evan Sadler laboratory
WORK-IN-PROGRESS
Role of the Ajuba LIM Protein in Size Control in Drosophila Epithelia

Understanding ADAMTS13 When Under (Shear) Stress
May 23, 2008Timothy A. Graubert, MD
Stem Cell Biology Section, Department of Medicine
Genetic Basis of Susceptibility to Therapy-related Leukemia
2006-2007
DateSpeakerTitle
Sep 8, 2006Monita P. Wilson, PhD
Division of Hematology
What the Structure of an Inositol Kinase Tells Us About Its Function
Sep 15, 2006Jason Metcalf
Kathy Ponder laboratory


Weiqiang Gao
Evan Sadler laboratory
WORK-IN-PROGRESS
The Role of Fibroblast Growth Factor Signaling in Mucopolysaccharidosis Bone Defects

A C-terminal Exosite of von Willebrand Factor Domain A2 Interacts with ADAMTS13 Spacer Domain to Accelerate Substrate Cleavage
Sep 22, 2006Paul E. Bock, PhD
Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN
Blood Coagulation Out of Control: Molecular Sexuality Mechanism of Prothrombin Activation by Staphylocoagulase
Sep 29, 2006Phillip I. Tarr, MD
Division of Gastroenterology and Nutrition, Department of Pediatrics
Escherichia Coli O157:H7 and the Hemolytic Uremic Syndrome: Host and Microbial Aspects
Oct 6, 2006John D. York, PhD
Department of Pharmacology and Cancer Biology, Duke University, Durham, NC
Signaling Specificity: Inositol Polyphosphate Messengers Regulate Drosophila Development
Oct 13, 2006Yungfeng Feng
Greg Longmore laboratory


Intaek Lee
Stuart Kornfeld laboratory
WORK-IN-PROGRESS
RNAi Oriented Loss of Function Research on α-Actinin

Crosstalk Between Two Cargo Binding Sites of Adaptor Protein Complex AP-1
Oct 17, 2006Barry L. Stoddard, PhD
Fred Hutchinson Cancer Research Center, Seattle, WA
The Structure of Human Factor VIII and Its Inhibition Via Mutations, Antibodies, and Small Molecules
Oct 20, 2006Craig B. Thompson, MD
Division of Hematology-Oncology, University of Pennsylvania, Philadelphia, PA
34TH CARL MOORE LECTURE
Programmed Cell Death: Apoptosis, Autophagy, and Necrosis
Oct 27, 2006Baiwei Gu
Phil Mason and Monica Bessler laboratory


Marina Kisseleva
Greg Longmore laboratory
WORK-IN-PROGRESS
Molecular Mechanism of Mouse Dyskerin Mutation in Telomere Maintenance and Ribosomal RNA Processing

Macrophages Plagued by LIM Protein Deficiency
Nov 3, 2006Stuart Kornfeld, MD
Division of Hematology
Toward a Chaperone-based Therapy for Gaucher Disease
Nov 10, 2006Kyuhwan Shim
Evan Sadler laboratory


Hilary Luderer
Greg Longmore laboratory
WORK-IN-PROGRESS
Platelet-VWF Complexes are Preferred Substrates of ADAMTS13 Under Fluid Shear Stress

LIMD1: a New Key to Understanding Skeletal Dynamics
Nov 17, 2006Katherine P. Ponder, MD
Division of Hematology
Gene Therapy for Mucopolysaccharidosis
Jan 5, 2007Douglas M. Tollefsen, MD, PhD
Division of Hematology
Heparin Cofactor II Modulates the Response to Arterial Injury
Jan 12, 2007Rachel Idol
Monica Bessler and Phil Mason laboratory


Lindsay Ricketts
Elaine Majerus laboratory
WORK-IN-PROGRESS
Investigations of Ribosomal Biogenesis in Diamond Blackfan Anemia

O-fucosylation of ADAMTS13
Jan 19, 2007Jun Zho
Phil Majerus laboratory


Holly Epple
Greg Longmore laboratory
WORK-IN-PROGRESS
The Role of Type I PIP2 4-phosphatase in Stress Signaling

From the Skeleton to the Cytoskeleton: Mechanisms of Osteoclast Function
Jan 26, 2007Gregory D. Longmore, MD
Division of Hematology
LIM Proteins and Epithelial Development and Cancer
Feb 2, 2007Balraj Doray
Stuart Kornfeld laboratory


Ren-Huai Huang
Evan Sadler laboratory
WORK-IN-PROGRESS
The α/σ2 Hemicomplex of Clathrin Adaptor AP-2 Harbors the Dileucine Recognition Site

How VWF Propeptide and D’D3 Domain Assemble the Storage Rings in Weibel-Palade Bodies
Feb 9, 2007Hong-Yan Du
Phil Mason and Monica Bessler laboratory
WORK-IN-PROGRESS
TERT Haploinsufficiency and Telomere Length in Individuals with 5p- Syndrome
Feb 16, 2007J. Evan Sadler, MD, PhD
Division of Hematology
Von Willebrand Factor, ADAMTS13, and the Regulation of Platelet Adhesion
Feb 23, 2007Matthew J. Walter, MD
Stem Cell Biology Section, Division of Oncology
Myelodysplastic Syndrome and Deletions of Chromosome 5q31.2
Mar 2, 2007Xiucui Ma
Kathy Ponder laboratory


Jing Huang
Evan Sadler laboratory
WORK-IN-PROGRESS
Mechanism of Up-regulation of MMP-12 and Cathepsin S in the Aorta of Mucopolysaccharidosis I Mice

αvβ3 Integrin is Involved in the Stabilization of Shear-induced Ultra-long VWF Strings on Endothelial Surface
Mar 9, 2007George J. Broze Jr., MD
Division of Hematology
Protein Z-dependent Protease Inhibitor
Mar 16, 2007Meghna Das Thakur
Greg Longmore laboratory


Jeff Hiken
Monica Bessler and Phil Mason laboratory
WORK-IN-PROGRESS
The Role of LIM Proteins in Cell-Cell Adhesion and Epithelial Polarity

Proteomic Analysis of PNH RBCs
Mar 23, 2007Philip W. Majerus, MD
Division of Hematology
Phosphatidylinositol Signaling and Human Disease
Mar 30, 2007Trish Anderson
Evan Sadler laboratory


Wang-Sik Lee
Stuart Kornfeld laboratory
WORK-IN-PROGRESS
ADAMTS13 Structure and Function

Studies of a Mouse Model with I-cell Disease and Pseudo-Hurler Polydystrophy
Apr 6, 2007Monica Bessler, MD, PhD
Division of Hematology
Housekeeping Ain’t No Joke! The Importance of Ribosome Biogenesis in Human Blood Disorders
Apr 13, 2007Sara Robledo
Monica Bessler and Phil Mason laboratory


Jasna Marjanovic
Phil Majerus laboratory
WORK-IN-PROGRESS
The Role of Ribosomal Proteins in the Pathogenesis of Diamond Blackfan Anemia

Phosphatidylinositol-5-phosphate is a Novel Phospholipase C (PLC) Substrate
Apr 20, 2007Philip J. Mason, PhD
Division of Hematology
Telomeres, Ribosomes and Bone Marrow Failure
Apr 27, 2007Bo Jin
Evan Sadler laboratory


Ellen Langer
Greg Longmore laboratory
WORK-IN-PROGRESS
Studies on the von Willebrand Factor Cysteine Knot Domain

Ajuba LIM Proteins are Snail Corepressors that Contribute to Xenopus Neural Crest Development
May 4, 2007Angie Purvis
Evan Sadler laboratory


Jingpin Ge
Monica Bessler and Phil Mason laboratory
WORK-IN-PROGRESS
Identification of Cysteine Residues Essential for von Willebrand Factor (VWF) Multimerization: an Elephant is Born

Study of the Function of Dyskerin in a Liver Specific Knock-out Mouse Model
May 11, 2007Jeff Yu
Evan Sadler laboratory


Mindy Tittiger
Kathy Ponder laboratory
WORK-IN-PROGRESS
Investigation of the Biological Function of the C-terminal Domains in ADAMTS13

Parallels in Mucopolysaccharidosis (MPS) I and MPS 7 Aortic Disease
May 18, 2007Elaine M. Majerus, MD, PhD
Division of Hematology
Studies on ADAMTS13
2005-2006
DateSpeakerTitle
Sep 2, 2005William F. Stenson, MD
Division of Gastroenterology, Department of Medicine
Prostaglandins and the Epithelial Response to Radiation Injury
Sep 23, 2005Lijuan Zhang, PhD
Division of Laboratory Medicine, Department of Pathology & Immunology
Heparan and Chondroitin Sulfate Glycosaminoglycans: a Journey from Structure to Function
Sep 30, 2005Anna Margret Halldorsdottir
Doug Tollefsen laboratory
WORK-IN-PROGRESS
Oct 7, 2005Scott Saunders, MD, PhD
Developmental Biology & Genetics, Department of Pediatrics
Heparan Sulfate Proteoglycans: Essential Modulators of Cellular Functions at the Plasma Membrane
Oct 14, 2005John P. Atkinson, MD
Division of Rheumatology, Department of Medicine
HUS: Not Enough Regulation of Innate Immunity
Oct 21, 2005Weiqiang Gao
Evan Sadler laboratory
WORK-IN-PROGRESS
Oct 28, 2005Hongyan Du
Monica Bessler and Phil Mason laboratory
WORK-IN-PROGRESS
Nov 4, 2005Jason D. Weber, PhD
Molecular Oncology Section, Department of Medicine
Interpretation of Oncogenic Signals by the Nucleolus
Nov 11, 2005Eric Green, MD, PhD
National Human Genome Research Institute, NIH, Bethesda, MD
33RD CARL MOORE LECTURE
Comparative Genomics: Using Evolution to Decode the Human Genome
Nov 18, 2005Alex Ungewickell
Phil Majerus laboratory
WORK-IN-PROGRESS
Dec 2, 2005Louis J. Muglia, MD, PhD
Division of Endocrinology & Diabetes, Department of Pediatrics
Glucocorticoid Receptor Action During Inflammation
Dec 16, 2005Christine Pham, MD
Division of Rheumatology, Department of Medicine
Neutrophil Serine Proteases: Specific Regulatory Effectors of Immunity
Jan 6, 2006Rich Steet
Stuart Kornfeld laboratory
WORK-IN-PROGRESS
Jan 13, 2006Alison Goate, PhD
Department of Psychiatry
A Novel Risk Factor for Alzheimer’s Disease on Chromosome 10
Jan 20, 2006Matthew Ndonwi
George Broze laboratory
WORK-IN-PROGRESS
Jan 27, 2006William S. Sly, MD
Department of Biochemistry & Molecular Biology, St. Louis University
Functional Genomics of Carbonic Anhydrases: From Osteopetrosis to Protein Folding Diseases
Feb 3, 2006Hilary Luderer
Greg Longmore laboratory
WORK-IN-PROGRESS
Feb 10, 2006Andrey S. Shaw, MD
Department of Pathology & Immunology
Macropinocytosis and Nephrotic Syndrome
Feb 17, 2006Elaine Majerus
Hematology Division
WORK-IN-PROGRESS
Feb 24, 2006Ren-Huai Huang
Evan Sadler laboratory
WORK-IN-PROGRESS
Mar 3, 2006Raj Doray
Stuart Kornfeld laboratory
WORK-IN-PROGRESS
Mar 10, 2006Tusar Giri
Doug Tollefsen laboratory
WORK-IN-PROGRESS
Mar 24, 2006Sheila A. Stewart, Ph D.
Department of Cell Biology & Physiology
The Yin and Yang of Cellular Senescence
Apr 7, 2006Anton McCaffrey, PhD
Division of Infectious Diseases, Department of Medicine, University of Iowa, Iowa City, IA
Keep It Down: There’s More Than One Way to Silence a Gene
Apr 14, 2006Angie Purvis
Evan Sadler laboratory
WORK-IN-PROGRESS
Apr 21, 2006Richard A. Anderson, PhD
Department of Pharmacology, University of Wisconsin, Madison, WI
Phosphoinositide Signaling: From Biochemistry to Human Disease
May 5, 2006Holly Epple
Greg Longmore laboratory
WORK-IN-PROGRESS
May 12, 2006Rachel Idol
Monica Bessler and Phil Mason laboratory
WORK-IN-PROGRESS
May 19, 2006Jun He
Monica Bessler and Phil Mason laboratory
WORK-IN-PROGRESS
2004-2005
DateSpeakerTitle
Sep 10, 2004Shao-Chun Chang, MD, PhD
Division of Hematology
The Pathway to Inositol Hexakisphosphate Synthesis
Sep 24, 2004Emily H.-Y. Cheng, MD, PhD
Division of Oncology, Molecular Oncology Section
Apoptotic Checkpoints at the Mitochondrion
Oct 8, 2004Enrico Di Cera, MD
Department of Biochemistry & Molecular Biophysics
Rational Design of a Thrombin Mutant with Potent and Safe Anticoagulant/antithrombotic Activity in Vivo
Oct 22, 2004Elaine M. Majerus, MD, PhD
Division of Hematology
Regulation of VWF Cleaving Protease (ADAMTS13) Activity
Nov 5, 2004James J.-D. Hsieh, MD, PhD
Division of Oncology, Molecular Oncology Section
Taspase1 Cleaves Mixed-lineage Leukemia Proto-oncogene
Nov 12, 2004Charles J. Sherr, MD, PhD
St. Jude Children’s Research Hospital, Memphis, TN
32ND CARL MOORE LECTURE
INK4a-ARF: a Marriage of Tumor Suppressors
Nov 19, 2004Richard A. Steet, PhD
Division of Hematology
COG7 Deficiency: a Novel Congenital Disorder of Glycosylation
Dec 10, 2004Philip W. Majerus, MD
Division of Hematology
Inositol Phosphate Signaling
Dec 17, 2004Gregory D. Longmore, MD
Division of Hematology
Role of LIM Proteins in Cell Adhesion and Migration
Jan 7, 2005Raj Doray
Stuart Kornfeld laboratory


Angie Purvis
Evan Sadler laboratory
WORK-IN-PROGRESS
Jan 14, 2005Monica Bessler, MD, PhD
Division of Hematology
Paroxysmal Nocturnal Hemoglobinuria – From Bench to Bedside
Jan 21, 2005Trish Anderson
Evan Sadler laboratory


Steve Pratt
Greg Longmore laboratory
WORK-IN-PROGRESS
Jan 28, 2005Katherine P. Ponder, MD
Division of Hematology
Reducing Immune Responses after Gene Therapy for Genetic Diseases
Feb 4, 2005Marina Kisseleva
Greg Longmore laboratory


Wang-Sik Lee
Stuart Kornfeld laboratory
WORK-IN-PROGRESS
Feb 11, 2005J. Evan Sadler, MD, PhD
Division of Hematology
Von Willebrand Factor, Bleeding, and Thrombosis
Feb 18, 2005Alex Ungewickell
Phil Majerus laboratory


Jun He
Phil Mason laboratory
WORK-IN-PROGRESS
Feb 25, 2005Douglas M. Tollefsen, MD, PhD
Division of Hematology
Activation of Heparin Cofactor II by Vascular Glycosaminoglycans
Mar 4, 2005Cristina Vicente
Doug Tollefsen laboratory


Michael Ward
Greg Longmore laboratory
WORK-IN-PROGRESS
Mar 11, 2005Stuart Kornfeld, MD
Division of Hematology
The GGA Family of Coat Proteins – Key Players in Protein Sorting at the Trans-Golgi Network
Mar 18, 2005Marek Jasinski
Monica Bessler laboratory


Lingfei Xu
Kathy Ponder laboratory
WORK-IN-PROGRESS
Mar 25, 2005Philip J. Mason, PhD
Division of Hematology
Bone Marrow Failure Caused by Inherited Defects in Telomerase
Apr 1, 2005Ellen Langer
Greg Longmore laboratory


Kyuhwan Shim
Evan Sadler laboratory
WORK-IN-PROGRESS
Apr 15, 2005Matthew Ndonwi
George Broze laboratory


Chris Hugge
Phil Majerus laboratory
WORK-IN-PROGRESS
Apr 22, 2005George J. Broze, Jr., MD
Division of Hematology
TFPI Alpha and Beta
Apr 29, 2005Lukas Wartman
Stuart Kornfeld laboratory


Li He
Doug Tollefsen laboratory
WORK-IN-PROGRESS
May 6, 2005Ajit Varki, MD
University of California – San Diego
Selectins and Cancer: Mechanistic Connections with Therapeutic Implications
May 13, 2005Rich Steet
Stuart Kornfeld laboratory


Yunfeng Feng
Greg Longmore laboratory
WORK-IN-PROGRESS
2003-2004
DateSpeakerTitle
Sep 12, 2003Robert P. Mecham, PhD
Department of Cell Biology & Physiology
Developmental Adaptation of the Mouse Cardiovascular System to Elastin Haploinsufficiency
Sep 26, 2003Helen M. Piwnica-Worms, PhD
Department of Cell Biology & Physiology
Cell Cycle- and Checkpoint-Control: the CHK1/CDC25A Regulatory Pathway
Oct 10, 2003Janet D. Rowley, MD
Department of Medicine, University of Chicago
31ST CARL MOORE LECTURE
New Paradigms from Leukemias
Oct 24, 2003Anthony J. Muslin, MD
Department of Medicine, Division of Cardiovascular Diseases
Signaling Protein Function in Cardiovascular Disease
Nov 7, 2003Thomas J. Baranski, MD, PhD
Department of Medicine, Division of Endocrinology, Diabetes & Metabolism
Understanding the Receptor Switch: How Do Hormones Activate G Proteins?
Nov 21, 2003Jeffrey D. Milbrandt, MD, PhD
Department of Pathology & Immunology
Ret Signaling in Development and Disease
Jan 16, 2004William C. Parks, PhD
Department of Pediatrics, Division of Allergy & Pulmonary Medicine
Extracellular Proteolysis in Epithelial Repair and Defense
Jan 30, 2004Jan A. Nolta, PhD
Department of Medicine, Division of Oncology
Immune Deficient Mouse Models for Studying Human Hematopoietic Stem Cell Biology
Feb 13, 2004Raphael Kopan, PhD
Department of Molecular Biology & Pharmacology
Multiple Roles of Notch in Mouse Development and Tissue Renewal
Feb 27, 2004Jeffrey E. Saffitz, MD, PhD
Department of Pathology & Immunology
Mechanisms of Sudden Death in Cardiomyopathies Caused by Mutations in Cell-Cell Junction Proteins
Mar 12, 2004Scott J. Hultgren, PhD
Department of Molecular Microbiology
Intracellular Bacterial Communities in Bacterial Infections
Mar 26, 2004Daniel P. Kelly, MD
Department of Medicine, Division of Cardiovascular Diseases
PPAR Gamma Coactivator-1 (PGC-1): an Inducible Regulator of Cardiac Mitochondrial Biogenesis and Function
Apr 9, 2004Guojun Bu, PhD
Department of Pediatrics
The LDL Receptor Family: What These Receptors Don’t Do
Apr 23, 2004Herbert W. “Skip” Virgin, MD, PhD
Department of Pathology & Immunology
Learning from Growth of an Ungrowable Virus
May 7, 2004Kendall J. Blumer, PhD
Department of Cell Biology & Physiology
RGS Proteins: New Regulators of Blood Pressure Homeostasis and G Protein-mediated Vasoconstrictor Signaling
2002-2003
DateSpeakerTitle
Sep 13, 2002Philip W. Majerus, MD
Hematology Division
Inositol Signaling
Sep 27, 2002J. Evan Sadler, MD, PhD
Hematology Division
VWF, ADAMTS13, and TTP
Oct 11, 2002Stuart Kornfeld, MD
Hematology Division
GGAs – Key Players in Packaging Man-6-P Receptors into Transport Vesicles
Oct 25, 2002Ajit P. Varki, MD
Department of Medicine, University of California, San Diego
Multiple Differences in Sialic Acid Biology Between Humans and Great Apes
Nov 1, 2002Monica Bessler, MD, PhD
Hematology Division
Bone Marrow Failure and Telomerase
Nov 8, 2002Richard P. Lifton, MD, PhD
Department of Genetics, Yale University
30TH CARL MOORE LECTURE
New Insights into Cardiovascular, Renal, and Bone Disease from Human Genetic Studies
Nov 22, 2002Francois Moreau-Gaudry, MD, PhD
Laboratory of Molecular Pathology and Gene Therapy, University of Bordeaux
Gene Therapy of a Mouse Model of Protoporphyria with an Erythroid-specific Lentiviral Vector
Dec 13, 2002George J. Broze, Jr., MD
Hematology Division
Regulation of Coagulation by Protein Z
Jan 10, 2003Daniel E. Goldberg, MD, PhD
Departments of Medicine and Molecular Microbiology
Falciparum Malaria: A Hematological Infectious Disease
Jan 24, 2003Gregory D. Longmore, MD
Hematology Division
The Role of Lim Proteins in Cell Adhesion and Motility
Feb 14, 2003Mary M. Zutter, MD
Department of Pathology and Immunology
The α2β1-integrin Deficient Mouse: Defective Platelet and Mast Cell Function
Feb 21, 2003David Ginsburg, MD
Howard Hughes Medical Institute, University of Michigan, Ann Arbor
Disorders of Hemostasis Due to Genes Outside of the Coagulation System
Mar 6, 2003Philip J. Mason, PhD
Department of Haematology, Imperial College, London
Bone Marrow Failure Caused by Inherited Telomerase Deficiency
Mar 7, 2003Daniel C. Link, MD
Division of Stem Cell Biology
Regulation of Hematopoiesis by G-CSF
Mar 14, 2003Timothy A. Graubert, MD
Division of Stem Cell Biology
Modeling t(8;21) Associated Acute Myelogenous Leukemia in Mice
Apr 4, 2003Mark S. Sands, PhD
Division of Stem Cell Biology
Hematopoietic-directed Therapies for Lysosomal Storage Diseases
Apr 18, 2003Douglas M. Tollefsen, MD, PhD
Hematology Division
Heparin Cofactor II and Thrombosis
May 2, 2003Linda J. Pike, PhD
Department of Biochemistry & Molecular Biophysics
EGF Receptors and Lipid Rafts: Bringing Order to Chaos
May 9, 2003Katherine P. Ponder, MD
Hematology Division
Liver-directed Gene Therapy Corrects Hemophilia B and Mucopolysaccharidosis VII in Dogs
May 30, 2003Nicholas O. Davidson, MBBS
Division of Gastroenterology
RNA Editing: Molecular Mechanisms and Biological Consequences
2001-2002
DateSpeakerTitle
Sep 14, 2001Steven L. Teitelbaum, MD
Department of Pathology
RANK Ligand and Bone Cells
Sep 28, 2001Rainer K. Brachmann, MD
Division of Oncology
Stories Of and Around p53
Oct 12, 2001Michael H. Tomasson, MD
Division of Oncology
The Role of Fusion Oncogenes in the Multi-step Pathogenesis of Acute Leukemia
Oct 24, 2001Steven R. Lentz, MD, PhD
Department of Medicine, University of Iowa
Hyperhomocysteinemia
Oct 26, 2001Douglas C. Dean, PhD
Division of Oncology
The Role for Rb in Tumor Suppression
Nov 16, 2001Robert J. Lefkowitz, MD
Department of Medicine, Duke University
29TH CARL MOORE LECTURE
G Protein-coupled Receptors and Their Regulation
Nov 30, 2001Katherine N. Weilbaecher, MD
Division of Oncology
The Role of Beta 3 Integrin in Metastasis
Dec 13, 2001Timothy J. Ley, MD
Division of Oncology
Modeling Acute Promyelocytic Leukemia in the Mouse
Jan 11, 2002Jay W. Heinecke, MD
Division of Lipid Research
Regulation of Matrix Metalloproteinase Activation and Plaque Rupture by Myeloperoxidase
Jan 22, 2002Beni B. Wolf, MD, PhD
University of California, San Diego
Evasion of Mitochondria-dependent Apoptosis by Cancer Cells
Jan 25, 2002Gerald P. Linette, MD, PhD
Division of Oncology
Melanoma Cell Death
Feb 22, 2002David A. Harris, MD, PhD
Department of Cell Biology & Physiology
Molecular Mechanisms Underlying Familial Prion Diseases
Mar 8, 2002Howard L. McLeod, PharmD
Division of Oncology
Cancer Pharmacogenomics
Mar 22, 2002William A. Frazier, PhD
Department of Biochemistry & Molecular Biophysics
Integrin Associated Protein (CD47): a Receptor with Multiple Roles in Vascular Disease
Apr 3, 2002Philip J. Hogg, PhD
Department of Pathology, University of New South Wales, Sydney, Australia
Control of von Willebrand Factor Multimer Size by Thrombospondin-1
Apr 19, 2002David M. Ornitz, MD, PhD
Department of Molecular Biology & Pharmacology
FGF and FGF Receptor Signaling in Skeletal Development and Genetic Disease
May 3, 2002Jean E. Schaffer, MD
Division of Cardiology
Models and Mechanisms of Lipotoxicity
May 17, 2002Clay F. Semenkovich, MD
Division of Endocrinology, Diabetes & Metabolism
Fatty Acid Metabolism as a Mediator of Vascular Disease and Beta Cell Failure in Diabetes
2000-2001
DateSpeakerTitle
Sep 8, 2000David B. Wilson, MD, PhD
Department of Pediatrics
Blood and Guts: Erythroid Transcription Factors and Endoderm Development
Sep 22, 2000Rosalind H. Kornfeld, PhD
Division of Hematology
The Mannose 6-Phosphate ‘Uncovering Enzyme’ Resides in the Trans-Golgi Network
Oct 6, 2000Jonathan D. Gitlin, MD
Department of Pediatrics
The Copper Chaperones
Oct 20, 2000George J. Broze, Jr., MD
Division of Hematology
Protein Z and Thrombosis
Nov 3, 2000Monica Bessler, MD, PhD
Division of Hematology
PNH: the Human Disease and Animal Models
Nov 10, 2000Philip J. Mason, PhD
Hammersmith Hospital, Imperial College, London
The Molecular Genetics of Dyskeratosis Congenita
Nov 17, 2000Stuart Kornfeld, MD
Division of Hematology
The Assembly of Clathrin-Coated Vesicles on Golgi Membranes
Dec 8, 2000Ronald A. DePinho, MD
Harvard Medical School
28TH CARL MOORE LECTURE
Telomerase, Tumor Suppressors and Tumorigenesis
Jan 12, 2001J. Evan Sadler, MD, PhD
Division of Hematology
Structure and Function of von Willebrand Factor
Jan 26, 2001John D. York, PhD
Duke University Medical Center
Insights into the Biology of Inositol Signaling
Feb 2, 2001Katherine P. Ponder, MD
Division of Hematology
Degradation of Hepatocyte Nuclear Factor 4 Contributes to Liver Failure
Feb 9, 2001Susan E. Lyons, MD, PhD
National Human Genome Research Institute, NIH
Hematopoietic Studies in the Zebra Fish Model
Feb 9, 2001Douglas M. Tollefsen, MD, PhD
Division of Hematology
Function of Heparin Cofactor II in Vitro and in Vivo
Feb 23, 2001Susan R. Wente, PhD
Department of Cell Biology & Physiology
Nuclear Entry and Exit: the Rules and the Players
Mar 9, 2001Morgan L. McLemore, MD
Division of Oncology
The Effect of Granulocyte Colony-Stimulating Factor Receptor (G-CSFR) Mutations on Granulopoiesis
Mar 23, 2001Gerard Ailhaud, PhD
University of Nice
Early Events and Redundancy in Adipogenesis
Apr 6, 2001Philip W. Majerus, MD
Division of Hematology
Intracellular Signaling by Inositol Phosphates
Apr 20, 2001Gregory D. Longmore, MD
Division of Hematology
Red Blood Cell Development and Leukemogenesis
Apr 24, 2001Colin S. Duckett, PhD
Metabolism Branch, National Cancer Institute, NIH
Role of IAP Proteins in the Control of Cell Survival
May 4, 2001Monita P. Wilson, PhD
Division of Hematology
A Promiscuous Inositol Kinase
May 18, 2001John P. Atkinson, MD
Division of Rheumatology
Immune Adherence Revisited
1999-2000
DateSpeakerTitle
Sep 17, 1999John F. Hancock, MD, PhD
University of Queensland Medical School, Brisbane, Australia
Caveolae, Cholesterol and Trafficking: New Insights into Biological Differences Between the Ras Proteins
Oct 1, 1999Lyuba Varticovski, MD
Department of Medicine, Tufts University
Angiopoietins: Signal Transduction and Regulation of Endothelial Cell Biology
Oct 15, 1999Samuel L. Stanley, Jr., MD
Division of Infectious Diseases
Pathways for Amebic Induction of Inflammation and Programmed Cell Death
Nov 5, 1999Mark S. Sands, PhD
Division of Bone Marrow Transplantation & Stem Cell Biology
Gene Therapy for Lysosomal Storage Diseases
Nov 19, 1999Mark T. Keating, MD
University of Utah
27TH CARL MOORE LECTURE
Molecular and Cellular Mechanisms of Cardiac Arrhythmias
Dec 10, 1999Thomas G. Diacovo, MD
Department of Pediatrics
Platelets and the Molecular and Cellular Interactions Governing Their Adhesion: From Arterial Injury to Venular Inflammation
Jan 14, 2000Timothy J. Ley, MD
Division of Bone Marrow Transplantation & Stem Cell Biology
How Do Cytotoxic Lymphocytes Kill Their Target?
Jan 28, 2000Lee Ratner, MD, PhD
Division of Medical & Molecular Oncology
Human T-cell Leukemia Virus Tax, Transactivation, and Transformation
Feb 11, 2000Samuel A. Santoro, MD, PhD
Division of Laboratory Medicine, Departments of Medicine and Pathology
Collagen Receptors: From Ligand Binding to Control of Cell Phenotype
Feb 18, 2000Othon Iliopoulos, MD
Dana-Farber Cancer Institute, Harvard Medical School
Functional Analysis of the von Hippel-Lindau Tumor Suppressor Protein
Feb 25, 2000Thomas J. Baranski, MD, PhD
Division of Endocrinology, Diabetes & Metabolism, Departments of Medicine and Molecular Biology & Pharmacology
Genetic Analysis of G Protein Signalling
Mar 3, 2000Brian J. Druker, MD
Department of Medicine, Oregon Health Sciences University
HEMATOLOGY-ONCOLOGY GRAND ROUNDS
CML and STI 571: Validating the Promise of Molecularly Targeted Therapy
Mar 7, 2000Diana M. Gilligan, MD, PhD
Yale University School of Medicine, New Haven, CT
Knockout of β-Adducin Causes Spherocytosis in Mice
Mar 10, 2000Raphael Kopan, PhD
Department of Molecular Biology & Pharmacology
Signaling Through Notch: a Proteolytic Cascade Regulating Cell Fate
Mar 24, 2000Leif W. Ellisen, MD, PhD
Harvard Medical School
Acute Leukemia, Telomeres and DNA Damage Responses
Apr 7, 2000Joanne E. Levy, MD
Harvard Medical School
Iron Metabolism: Insights from Mutant Mice
Apr 21, 2000William C. Hahn, MD, PhD
Whitehead Institute, MIT
Telomerase Immortality in Cancer
May 5, 2000David R. Piwnica-Worms, MD, PhD
Departments of Radiology and Molecular Biology & Pharmacology
Molecular Imaging: Functional Identification of MDR1 Pgp Transport Activity in Tumors and Tissues in Vivo
1998-1999
DateSpeakerTitle
Oct 9, 1998Rainer Brachmann
Division of Molecular Oncology
Yeast as a Genetic Tool to Study the Tumor Suppressor Protein p53
Oct 23, 1998Nancy Andrews
Department of Pediatrics, Harvard University
Iron Deficiency and Iron Overload: Insights from Anemic Animals
Nov 20, 1998Kerry Kornfeld
Department of Molecular Biology & Pharmacology
A Modular System of Docking Sites Mediates MAP Kinase Recognition of Substrate Proteins
Dec 11, 1998Owen Witte
UCLA School of Medicine
26TH CARL MOORE LECTURE
Hematolymphoid Signal Transduction by Cytoplasmic Tyrosine Kinases
Dec 18, 1998George Broze
Division of Hematology
What About Protein Z?
Jan 8, 1999Linton Traub
Division of Hematology
Lysosomes, Liposomes and Synaptosomes: What Do They Teach Us About Clathrin-coat Assembly?
Jan 22, 1999Evan Sadler
Division of Hematology
Enteropeptidase, Initiator of a Digestive Protease Cascade
Jan 29, 1999Rosalind Kornfeld
Division of Hematology
Cloning and Expression of N-Acetylglucosamine-1-Phosphodiester α-N-Acetylglucosaminidase, a Key Enzyme in Formation of the Mannose-6-Phosphate Targeting Signal
Feb 12, 1999Doug Tollefsen
Division of Hematology
Allosteric Regulation of Thrombin by a Monoclonal Antibody that Binds to Exosite II
Feb 26, 1999Greg Longmore
Division of Hematology
Role of LIM Proteins in Cell Growth
Mar 12, 1999Kathy Ponder
Division of Hematology
Hepatic Gene Therapy for Plasma Protein Deficiencies and Lysosomal Storage Diseases
Mar 26, 1999Monica Bessler
Division of Hematology
Clonal Evolution in Paroxysmal Nocturnal Hemoglobinuria
Apr 7, 1999Gerardo Lederkremer
Department of Cell Research & Immunology, Tel Aviv University, Israel
Location and Regulation of ER/Proteasomal Protein Quality Control
Apr 9, 1999Stuart Kornfeld
Division of Hematology
Clathrin-Coated Vesicle Formation on Liposomes and Golgi Membranes
Apr 23, 1999Dan Kelly
Division of Cardiology
The Role of PPARa as a ‘Lipostat’ Transcription Factor
May 7, 1999Jacques Baenziger
Department of Pathology
The Sulfated Oligosaccharides on LH Reveal the Roles Played by Glycosylation During the Reproductive Cycle
May 21, 1999Phil Majerus
Division of Hematology
Phosphatidyl Inositols in Cell Signaling
Jun 4, 1999Mike Dustin
Department of Pathology
Visualizing Molecular Events in the Immune Response: Building an Immunological Synapse
1997-1998
DateSpeakerTitle
Oct 17, 1997Monica Bessler
Hematology Division
A Mouse Model for Paroxysmal Nocturnal Hemoglobinuria: Use of the Cre/loxP System to Circumvent Embryonic Lethality
Oct 24, 1997Jeffrey M. Friedman
Rockefeller University
25TH CARL MOORE LECTURE
Leptin, Leptin Receptors and the Control of Body Weight
Oct 31, 1997Anthony J. Muslin
Cardiovascular Division
The Role of 14-3-3 Protein in Ras-mediated Signal Transduction
Nov 14, 1997Daniel C. Link
Division of BMT & Stem Cell Biology
Role of G-CSF in Hematopoiesis: Lessons from the G-CSF Receptor Knockout Mice
Dec 12, 1997Herbert W. “Skip” Virgin
Departments of Pathology and Molecular Microbiology
Interplay Between Herpesviruses and the Immune System
Dec 19, 1997John F. DiPersio
Division of BMT & Stem Cell Biology
Cytokine Signaling Pathways
Jan 23, 1998Matthew L. Thomas
Department of Pathology
The Regulation of Adhesion and Signal Transduction by Protein Tyrosine Phosphatases
Jan 30, 1998Craig A. MacArthur
Department of Pediatrics
FGF-8 in Development and Tumorigenesis
Feb 13, 1998Enrico Di Cera
Department of Biochemistry and Molecular Biophysics
Thrombin Allostery
Feb 27, 1998Nancy M. Dahms
Department of Biochemistry, Medical College of Wisconsin
Insight into Lysosomal Enzyme Recognition by the Mannose 6-Phosphate Receptors
Mar 13, 1998Dwight A. Towler
Division of Endocrinology, Diabetes, and Metabolism
Structure-Function Analysis of Msx2-Mediated Transcriptional Suppression: Promoter Repression via RAP74 and the FGF Response Element DNA Binding Protein
Apr 10, 1998Frank A. “Andy” Norris
Hematology Division
The Regulation of PI 3-Kinase Signaling by Inositol Polyphosphate 4-Phosphatases
Apr 24, 1998Daniel E. Goldberg
Division of Infectious Diseases
The Pathway of Hemoglobin Degradation in the Malaria Parasite P. falciparum
May 8, 1998Gregory D. Longmore
Hematology Division
Cytokine Regulation of Lineage Commitment During Hematopoiesis
Jun 5, 1998William S. Sly
Department of Biochemistry, St. Louis University Medical School
Mutations in HFE Protein Cause Hemochromatosis
Jun 12, 1998Minxiang Gu
Hematology Division
Characterization of a Novel Protein Tyrosine Phosphatase – PTPMEG
1996-1997
DateSpeakerTitle
Sep 20, 1996Phil Majerus
Hematology Division
Role of Inositol Phosphates in Intracellular Signalling
Oct 4, 1996George Broze
Hematology Division
Effects of Tissue Factor and Tissue Factor Pathway Inhibitor Gene Deletion
Oct 18, 1996Stuart Kornfeld
Hematology Division
Regulation of Mannose Phosphorylation on Lysosomal and Secretory Glycoproteins
Nov 1, 1996Greg Longmore
Hematology Division
Erythropoietin Receptor Signalling and Red Cell Development
Nov 8, 1996
Monica Bessler
Department of Human Genetics, Memorial Sloan-Kettering Cancer Institute
Molecular Basis of Paroxysmal Nocturnal Hemoglobinuria
Nov 15, 1996Richard Klausner
National Cancer Institute, NIH
24TH CARL MOORE LECTURE
Cancer Genetics: Dissecting a Tumor Suppressor Gene Pathway
Dec 13, 1996Kathy Ponder
Hematology Division
Gene Therapy for Plasma Protein Deficiencies
Jan 24, 1997Doug Tollefsen
Hematology Division
The Two Faces of Thrombin: Interactions of Exosites I and II with Inhibitors
Feb 7, 1997Rosalind Kornfeld
Hematology Division
Enzymes of Glycoprotein Oligosaccharide Processing
Feb 21, 1997Evan Sadler
Hematology Division
Thrombin Structure and Biological Function
Feb 28, 1997Alan Permutt
Endocrinology, Diabetes & Metabolism Division
Genetic Analysis of Monogenic and Polygenic Disorders of Glucose Metabolism
Mar 28, 1997Dave Wilson
Department of Pediatrics
GATA-binding Proteins and Cardiovascular Development
Apr 11, 1997Rogier M. Bertina
University Hospital, Leiden, The Netherlands
Factor V Leiden and Resistance to Activated Protein C
May 2, 1997Helen Piwnica-Worms
Department of Cell Biology & Physiology
Reversible Phosphorylation and Cell Cycle Control
May 9, 1997Jonathan Gitlin
Department of Pediatrics
Aceruloplasminemia
May 16, 1997Wayne Yokoyama
Rheumatology Division
The Emerging Spectrum of NK Cell Receptors
May 23, 1997David Harris
Department of Cell Biology & Physiology
Prion Diseases: a Cell Biological Perspective
1995-1996
DateSpeakerTitle
Sep 15, 1995Ramesh A. Shivdasani
Dana-Farber Cancer Institute, Boston
Transcriptional Control of Cell Fate Determination and Differentiation in Hematopoiesis: Lessons from Knockout Mice
Sep 29, 1995Anne Bennett Jefferson
Hematology Division
Cell Signalling and the Inositol Polyphosphate 5-Phosphatase Isozymes
Oct 13, 1995William A. Frazier
Department of Biochemistry & Molecular Biophysics
Thrombospondin as a Regulator of Endothelial Phenotype
Oct 27, 1995Robert P. Mecham
Department of Cell Biology & Physiology
Intracellular Forms of Extracellular Proteins: Novel Pathway for Cell Regulation
Nov 10, 1995Schickwann Tsai
Fred Hutchinson Cancer Research Center, Seattle
Developmental Control of Hematopoietic Stem Cells and Progenitors by Retinoic Acid Receptors
Nov 17, 1995Donald B. Kohn
UCLA School of Medicine, Los Angeles
Gene Therapy with Hematopoietic Stem Cells
Dec 8, 1995Michael Rosenfeld
University of California, San Diego
23RD CARL MOORE LECTURE
Transcriptional Mechanisms of Organ Commitment
Dec 15, 1995Jack Rohrer
Hematology Division
Sorting of Proteins in the Endosomal/Lysosomal System
Jan 19, 1996John A. Cooper
Department of Cell Biology & Physiology
Control of Actin Assembly by Capping Protein
Feb 2, 1996Richard D. Cummings
University of Oklahoma, Oklahoma City
The Glycobiology of Schistosomiasis: From Molecular Mimicry to Autoimmunity
Feb 16, 1996Douglas C. Dean
Department of Medicine
Mechanism of Action of the Retinoblastoma Tumor Suppressor
Mar 1, 1996Maurine E. Linder
Department of Cell Biology & Physiology
G-protein Palmitoylation: Reversible and Regulated Acylation
Mar 29, 1996Thomas F. Deuel
Beth Israel Hospital, Boston
Mechanisms of Transcriptional Regulation by the Wilms Tumor Suppressor Gene
Apr 5, 1996Julie Hambleton
University of California, San Francisco
Activation of MAP Kinase Signaling Pathways in Monocyte/Macrophage Cells
Apr 12, 1996Katherine A. High
Children’s Hospital of Philadelphia
Gene Therapy for Hemophilia
Apr 19, 1996Michael E. Nesheim
Queen’s University, Kingston, Ontario
Isolation, Characterization, and Thrombin-thrombomodulin Dependent Activation of TAFI
Apr 26, 1996Vytas A. Bankaitis
University of Alabama at Birmingham
Phosphatidylinositol Transfer Proteins: a New Class of Intracellular Regulatory Molecules
May 9, 1996Sandra L. Hofmann
University of Texas Southwestern Medical School, Dallas
Palmitoyl-protein Thioesterase and the Pathogenesis of INCL
May 10, 1996Jay L. Degen
Children’s Hospital Research Foundation, Cincinnati
Hard Knocks to the Hemostatic Balance: Fibrinogen and Plasminogen Deficiency in Mice
1994-1995
DateSpeakerTitle
Sep 12, 1994Naoyuki Taniguchi
Osaka University
Transfection of N-acetylglucosaminyltransferase III Gene into Melanomas Suppresses Lung Metastasis
Sep 30, 1994Zaverio Ruggeri
Scripps Research Institute
Mechanisms of Initiation of Platelet Thrombus Formation
Oct 7, 1994Dave OrnitzRegulation of FGF/FGF Receptor Activity
Oct 14, 1994Gary Gilliland
Harvard Medical Schoo
l
Early Mutations in Leukemia
Oct 21, 1994Jim Ihle
St. Jude Children’s Research Hospital
JAKs and STATs in Cytokine Signaling
Oct 28, 1994Linton TraubClathrin-coated Vesicle Assembly on the Golgi
Nov 4, 1994Ken Kaushansky
University of Washington
The Molecular and Cellular Biology of Thrombopoietin, the MPL-ligand
Nov 11, 1994Stuart Orkin
Boston Children’s Hospital
22ND CARL MOORE LECTURE
Multi-layered Regulation of Hematopoietic Development and Transcription
Nov 18, 1994Celeste Simon
University of Chicago
Analysis of Hematopoiesis from the Study of Mutant Mice
Dec 9, 1994Ric BrownSignal Transduction by Leukocyte Integrins
Dec 16, 1994Ken Mann
University of Vermont
Modeling the Tissue Factor Pathway to Thrombosis: the Coagulation Explosion
Jan 27, 1995Qingyu WuStudies of Thrombin: Mutagenesis and Gene Targeting
Feb 17, 1995Susan WenteNucleocytoplasmic Trafficking: Insights from Yeast Nuclear Pore Complex Mutants
Mar 3, 1995John HancockRas Proteins: Membrane Targeting and Biochemical Function
Mar 17, 1995John SheehanMolecular Mechanism of Thrombin Regulation
Apr 7, 1995Dave GailaniThe Role of Factor XI in a Revised Model of Blood Coagulation
Apr 21, 1995Helen Heslop
St. Jude Children’s Research Hospital
Use of Virus-specific Cytotoxic T Lymphocytes to Control Epstein-Barr Virus-related Lymphoproliferation
May 5, 1995Dan LinkG-CSF Receptor Signals
May 19, 1995Tom Look
St. Jude Children’s Research Hospital
Chimeric Transcriptional Control Genes in Human Acute Leukemia
1993-1994
DateSpeakerTitle
Sep 24, 1993Guy Salvesen
Duke University
Inhibition of IL-1beta Activation by a Virally Encoded Proteinase Inhibitor
Oct 22, 1993Nancy Andrews
Harvard University
An Erythroid Transcription Factor Regulating Globin Gene Expression and Iron Metabolism
Oct 28, 1993Richard Lawn
Stanford University
Lipoprotein(a)
Oct 29, 1993Mark Sands
University of Pennsylvania
Molecular Characterization of the Genetic Defect and Modes of Treatment in Murine Mucopolysaccharidosis Type 7
Nov 2, 1993Jules Shafer
Merck
Identification of Amino Acid Residues Important for the Heparin-catalyzed Inactivation of Thrombin by Antithrombin III
Nov 5, 1993Stanley Prusiner
University of California, San Francisco
21ST CARL MOORE LECTURE
Transgenetic and Protein Structural Approaches to Unraveling the Enigmas of Prion Diseases
Nov 12, 1993Angel LeeCSF-1 Receptor: Mechanisms of Intracellular Signalling
Nov 19, 1993John Dick
University of Toronto
Modeling Normal and Leukemic Hematopoiesis in SCID Mice
Dec 16, 1993Hans Geuze
University of Utrecht
New Observations on the Class II Compartment in B Lymphoblasts
Mar 4, 1994Andy ChanLink Protein Tyrosine Kinases in T Cell Activation: Bench to Bedside
Mar 11, 1994Sam SantoroStructure, Function and Regulation of the a2b1 Integrin
Mar 18, 1994Fred Kolhouse
University of Colorado
The Mechanism of Cellular Uptake of Folate and Methotrexate in Human Cells
Apr 8, 1994Kathy Hajjar
Cornell University
Annexin II: a New Thromboregulatory Protein?
Apr 22, 1994Susan Bock
Temple University
Antithrombin III and Serpin Structure/Function Studies
May 20, 1994Randal Kaufman
University of Michigan
Regulation of Protein Transport Through the Endoplasmic Reticulum Mediated by BiP
Jun 9, 1994Mark Goldsmith
University of California, San Francisco
Structure/function Relationships Within the IL-2 Receptor Complex