Clinical Protocols

Oncology
Oncology Clinical Trials

 

Hematology

Click on a protocol's title to view its description in ClinicalTrials.gov.
Click on download to view the protocol (WUSTL key password required).
 
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Disease Protocol (Sponsor) Status PI/Contact Comments
Atypical HUS Atypical Hemolytic-Uremic Syndrome (aHUS) Registry Open to enrollment PI: Elaine Majerus
Contact: Sabrina Barber
s.barber@wustl.edu
314-273-1440
Bleeding and clotting disorders CDC Community Counts: Surveillance Project for Patients with Bleeding and Blood Clotting Disorders Open PI: Elaine Majerus
Contact: Bill Berger
bergerwb@wustl.edu
314-362-9996
Blood clots in cancer patients A multicenter, randomized, open-label, blinded endpoint evaluation, phase 3 study comparing the effects of abelacimab relative to apixaban on venous thromboembolism (VTE) recurrence and bleeding in patients with cancer associated VTE (ANT-007) Open to enrollment
download
PI: Kristen Sanfilippo
Contact: Kim Kramer
kramerka@wustl.edu
314-273-1790
Blood clots in cancer patients A multicenter, randomized, open-label, blinded endpoint evaluation, phase 3 study comparing the effect of abelacimab relative to dalteparin on venous thromboembolism (VTE) recurrence and bleeding in patients with gastrointestinal (GI) / genitourinary (GU) cancer associated VTE (ANT-008) Open to enrollment
download
PI: Kristen Sanfilippo
Contact: Kim Kramer
kramerka@wustl.edu
314-273-1790
Essential Thrombocythemia A Phase 3 Study of P1101 vs Anagrelide in Essential Thrombocythemia Patients who Failed Hydroxyurea (P1101ET) Open to enrollment
download
PI: Stephen Oh
Contact: Nicole Gaudin
nrgaudin@wustl.edu
314-747-7960
Essential Thrombocythemia A Phase 2b Open Label Study of Ropeginterferon (P1101) in Essential Thrombocythemia Patients Pending Open
download
PI: Stephen Oh
Contact: Nicole Gaudin
nrgaudin@wustl.edu
314-747-7960
Hemophilia A A Phase 3 Study of Valoctocogene Roxaparvovec in Hemophilia A Patients Open PI: Elaine Majerus
Contact: Rachel Cody
rcody@wustl.edu
314-362-7306
Hemophilia A Emicizumab In Patients With Acquired Hemophilia A: Multicenter, Single-Arm, Open-Label Clinical Trial Enrollment pending
download
PI: Elaine Majerus
Contact: Sabrina Barber
s.barber@wustl.edu
314-273-1440
Hemophilia A Efficacy and Safety of Concizumab prophylaxis in patients with haemophilia A or B with inhibitors Open to enrollment
download
PI: Elaine Majerus
Contact: Sabrina Barber
s.barber@wustl.edu
314-273-1440
Hemophilia/Bleeding American Thrombosis and Hemostasis Network Data Collection Open PI: Elaine Majerus
Contact: Bill Berger
bergerwb@wustl.edu
314-362-9996
Myelofibrosis Extended Access of Momelotinib in Adults with Myelofibrosis (352-4365) Enrolling by invitation only
download
PI: Stephen Oh
Contact: Karyn Gordon
kdgordon@wustl.edu
314-362-0156
Myelofibrosis A Phase 2 Dose Expansion Study of CPI-0610 with and without Ruxolitinib in Patients with Myelofibrosis (MANIFEST) Ongoing; closed to enrollment
download
PI: Stephen Oh
Contact: Nicole Gaudin
nrgaudin@wustl.edu
314-747-7960
Myelofibrosis Phase 2 Study of KRT-232 in Myelofibrosis Patients Who Failed Prior JAK Inhibitor Open to enrollment
download
PI: Stephen Oh
Contact: Karyn Gordon
kdgordon@wustl.edu
314-362-0156
Myelofibrosis A Phase 1/2 study of INCB000928 ± Ruxolitinib in Myelofibrosis Patients with Anemia (INCB 00928-104) Open to enrollment
download
PI: Stephen Oh
Contact: Karyn Gordon
kdgordon@wustl.edu
314-362-0156
Myelofibrosis A Phase 3 Study of Pelabresib (CPI-0610) plus Ruxolitinib vs Placebo plus Ruxolitinib in Myelofibrosis Patients Ongoing; closed to enrollment
download
PI: Stephen Oh
Contact: Karyn Gordon
kdgordon@wustl.edu
314-362-0156
Myelofibrosis A Phase 1b/2a Study of DISC-0974 in Myelofibrosis Patients with Anemia (DISC-0974-102) Pending Open
download
PI: Amy Zhou
Contact: Nicole Gaudin
nrgaudin@wustl.edu
314-747-7960
PNH Paroxysmal Nocturnal Hemoglobinuria (PNH) Registry Open to enrollment PI: Elaine Majerus
Contact: Sabrina Barber
s.barber@wustl.edu
314-273-1440
PNH A multicenter, single arm, open-label trial to evaluate efficacy and safety of oral, twice daily iptacopan in adult PNH patients who have Hb≥10 g/dL in response to anti-C5 antibody and switch to iptacopan Pending enrollment
download
PI: Elaine Majerus
Contact: Sabrina Barber
s.barber@wustl.edu
314-273-1440
Polycythemia Vera A Phase 2a Study of ISIS 702843 in Phlebotomy Dependent Polycythemia Vera Patients (ISIS 702843-CS4) Open to enrollment
download
PI: Stephen Oh
Contact: Karyn Gordon
kdgordon@wustl.edu
314-362-0156
Polycythemia Vera A Phase 3b Study of Ropeginterferon (P1101) in Polycythemia Vera Patients Pending Open
download
PI: Stephen Oh
Contact: Karyn Gordon
kdgordon@wustl.edu
314-362-0156
Sickle Cell Disease Patient Characteristics and Treatment Patterns from Early Crizanlizumab Use in Real-world Setting download PI: Sana Saif Ur Rehman
Contact: Isuru Gamlath
isuru.gamlath@wustl.edu
314-362-9998
Sickle Cell Disease Sickle Cell Disease Patient Registry (SCDIC-II) Enrolling
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PI: Allison King
Contact: Lisa Garrett
garrett_l@wustl.edu
314-362-0051
Sickle Cell Disease The Epidemiology of Silent and Overt Strokes in Adults with Sickle Cell Disease Enrolling
download
PI: Allison King
Contact: Lisa Garrett
garrett_l@wustl.edu
314-362-0051
Sickle Cell Disease Globin research Network for DATA and Discovery (GRNDaD) download PI: Sana Saif Ur Rehman
Contact: Isuru Gamlath
isuru.gamlath@wustl.edu
314-362-9998
Sickle Cell Disease Globin research Network for DATA and Discovery (GRNDaD) substudy - HUGS download PI: Sana Saif Ur Rehman
Contact: Isuru Gamlath
isuru.gamlath@wustl.edu
314-362-9998
Sickle Cell Disease Sickle Cell Disease and CardiovAscular Risk-Red cell Exchange Trial (SCD-CARRE) Enrolling
download
PI: Allison King
Contact: Lisa Garrett
garrett_l@wustl.edu
314-362-0051
Systemic Mastocytosis A Phase 2 Study of CGT9486 in Patients with Nonadvanced Systemic Mastocytosis (Summit) Open to enrollment
download
PI: Stephen Oh
Contact: Nicole Gaudin
nrgaudin@wustl.edu
314-747-7960
Systemic Mastocytosis A Phase 2 Study of Avapritinib (BLU-285) in Nonadvanced Systemic Mastocytosis Patients with Inadequately Controlled Symptoms (BLU-285-2203) Ongoing; closed to enrollment
download
PI: Stephen Oh
Contact: Nicole Gaudin
nrgaudin@wustl.edu
314-747-7960
Von Willebrand Disease A Natural History Cohort Study of the Safety, Effectiveness, and Practice of Treatment for People with Severe Von Willebrand Disease (VWD) Open to enrollment
download
PI: Elaine Majerus
Contact: Sabrina Barber
s.barber@wustl.edu
314-273-1440