Clinical Protocols

Oncology

Oncology Clinical Trials

 

 

Hematology

Click on a protocol's title to view its description in ClinicalTrials.gov.
Click on download to view the protocol (WUSTL key password required).
 

Disease Protocol (Sponsor) Status PI/Contact Comments
Atypical HUS Atypical Hemolytic-Uremic Syndrome (aHUS) Registry Open to enrollment PI: Elaine Majerus
Contact: Vanetta Worthy
worthyv@wustl.edu
314-362-9998		 Atypical HUS
Autoimmune Hemolytic Anemia A Phase 2 Study of INCB050465 in Participants with Autoimmune Hemolytic Anemia Open PI: Morey Blinder
Contact: Ashley Simpson
ashley.simpson@wustl.edu
314-286-1550
Banking Laboratory Studies Blood Acquistion for Investigation of Thrombotic Disorders Open PI: Elaine Majerus
Contact: Lisa Garrett
garrett_l@wustl.edu
314-362-9998		 Thrombosis Banking
Bleeding and clotting disorders CDC Community Counts: Surveillance Project for Patients with Bleeding and Blood Clotting Disorders Open PI: Elaine Majerus
Contact: Bill Berger
bberger@wustl.edu
314-362-9998
CNL/aCML Ruxolitinib Phosphate in Treating Patients With Chronic Neutrophilic Leukemia or Atypical Chronic Myeloid Leukemia Open to enrollment PI: Stephen Oh
Contact: Karyn Gordon
kdgordon@wustl.edu
314-362-0156		  
Essential Thrombocythemia A Phase 2 Study of Ruxolitinib Versus Anagrelide in Subjects with Essential Thrombocythemia Who Are Resistant to or Intolerant of Hydroxyurea Open PI: Stephen Oh
Contact: Nicole Gaudin
nrgaudin@wustl.edu
314-747-7960		 No prior treatment with JAK inhibitors or anagrelide
Hemophilia A A Phase 3 Study of Valoctocogene Roxaparvovec in Hemophilia A Patients at a Dose of 4E13 vg/kg Open PI: Elaine Majerus
Contact: Ashley Simpson
ashley.simpson@wustl.edu
314-286-1550		 Male patients only
Hemophilia A A Phase 3 Study of Valoctocogene Roxaparvovec in Hemophilia A Patients Open PI: Elaine Majerus
Contact: Ashley Simpson
ashley.simpson@wustl.edu
314-286-1550		 Male patients only
Hemophilia A and B My Life Our Future: Genotyping of Patients with Hemophilia A or B and Tissue Repository Open PI: Elaine Majerus
Contact: Bill Berger
bberger@wustl.edu
314-362-9998
Hemophilia/Bleeding American Thrombosis and Hemostasis Network Data Collection Open PI: Elaine Majerus
Contact: Bill Berger
bberger@wustl.edu
314-362-9998
Myelodysplastic Syndrome A Phase 3 Study of Roxadustat for Anemia in MDS patients Open to enrollment PI: Amy Zhou
Contact: Nicole Gaudin
nrgaudin@wustl.edu
314-747-7960
Myelofibrosis A Phase 2 Study of INCB050465 in Combination With Ruxolitinib in Subjects With Myelofibrosis Open and enrolling
download		 PI: Stephen Oh
Contact: Nicole Gaudin
nrgaudin@wustl.edu
314-747-7960		 MF patients with suboptimal response to ruxolitinib
Myelofibrosis A Phase 2 Study of Pacritinib in Myelofibrosis Patients Previously Treated with Ruxolitinib Suspended to enrollment
download		 PI: Stephen Oh
Contact: Karyn Gordon
kdgordon@wustl.edu
314-362-0156		 Prior ruxolitinib treatment failure/intolerance and palpable splenomegaly
Myelofibrosis Extended Access of Momelotinib in Adults with Myelofibrosis (352-4365) Enrolling by invitation only
download		 PI: Stephen Oh
Contact: Karyn Gordon
kdgordon@wustl.edu
314-362-0156
Myelofibrosis Pevondistat in Combination with Ruxolitinib in Myelofibrosis Patients Open to enrollment
download		 PI: Stephen Oh
Contact: Nicole Gaudin
nrgaudin@wustl.edu
314-747-7960
Myelofibrosis Phase 2 Study of KRT-232 in Myelofibrosis Patients Who Failed Prior JAK Inhibitor Open to enrollment PI: Stephen Oh
Contact: Karyn Gordon
kdgordon@wustl.edu
314-362-0156
Myelofibrosis Phase 3 Study of Fedratinib in Myelofibrosis Patients Previously Treated with Ruxolitinib Pending PI: Stephen Oh
Contact: Karyn Gordon
kdgordon@wustl.edu
314-747-7960
Myelofibrosis and Essential Thrombocythemia Myelofibrosis and Essential Thrombocythemia Observational Study (MOST) Open to enrollment
download		 PI: Stephen Oh
Contact: Nicole Gaudin
nrgaudin@wustl.edu
314-747-7960
Myeloid/Lymphoid Neoplasms A Phase 2, Open-Label, Monotherapy, Multicenter Study to Evaluate the Efficacy and Safety of INCB054828 in Subjects With Myeloid/Lymphoid Neoplasms With FGFR1 Rearrangement Open PI: Stephen Oh
Contact: Nicole Gaudin
nrgaudin@wustl.edu
314-747-7960		 Patients with 8p11 (FGFR1) rearrangement
PNH Paroxysmal Nocturnal Hemoglobinuria (PNH) Registry Open to enrollment PI: Elaine Majerus
Contact: Vanetta Worthy
worthyv@wustl.edu
314-362-9998		 PNH Registry
Polycythemia Vera Prospective Observational Study Of Patients With Polycythemia Vera In US Clinical Practices (REVEAL) Ongoing; closed to enrollment PI: Stephen Oh
Contact: Karyn Gordon
kdgordon@wustl.edu
314-362-0156		  
Polycythemia Vera Phase 2 Study of KRT-232 Vs. Ruxolitinib in Phlebotomy-Dependent Polycythemia Vera Patients Pending PI: Stephen Oh
Contact: Nicole Gaudin
nrgaudin@wustl.edu
314-747-7960
Sickle Cell Disease A Phase 3 Study of GBTT440 Administered Orally to Patients with Sickle Cell Disease, GBT_HOPE Enrollment on Hold PI: Morey Blinder
Contact: Ashley Simpson
ashley.simpson@wustl.edu
314-286-1550
Sickle Cell Disease A Phase II Trial of Regadenoson in Sickle Cell Anemia Open to enrollment PI: Elaine Majerus
Contact: Lisa Garrett
garrett_l@wustl.edu
314-362-0156		 HbSS and S Beta Null
Sickle Cell Disease Safety, Pharmacokinetic, and Pharmacodynamic Study of NKTT120 in Adult Patients With Stable Sickle Cell Disease (SCD) Ongoing; closed to enrollment PI: Elaine Majerus
Contact: Lisa Garrett
garrett_l@wustl.edu
314-362-0156		 Hb SS and S Beta Null
Thrombocytopenia Avatrombopag for the Treatment of Thrombocytopenia in Adults Scheduled for a Surgical Procedure Open PI: Morey Blinder
Contact: Ashley Simpson
ashley.simpson@wustl.edu
314-286-1550
Thrombosis ATTRACT Ongoing; closed to enrollment PI: Suresh Vedantham
Contact: Morey Blinder
mblinder@wustl.edu
314-362-9998		 New DVT
TTP/microangiopathy Low Dose Rituximab in Thrombotic Thrombocytopenic Purpura Open to enrollment PI: Evan Sadler
Contact: Vanetta Worthy
worthyv@wustl.edu
314-362-9998		 Low dose Rituximab for TTP