Address:
- Floor 5 Entry 1, McDonnel Pediatric Research Building (Lab)
Clinical Interest: Bleeding disorders (Hemophilia, von Willebrand Disease), Platelet disorders, Thrombosis, Myeloproliferative neoplasms.
I am interested in the genomics and environmental factors that alter platelet development, function and interaction with the body to cause bleeding and thrombotic disorders. Prior to medical training I studied the structural and functional evolutionary changes of clotting factor VIII and clotting factor IX in the laboratory of Dr. Valder Arruda. We described and detailed unexpected regulatory control of factor VIII that is unique to humans (PMID: 27734034, PMID: 23372167) and a previously undescribed factor IX variant (Padua) with increased activity (PMID: 25568350). We were the first to show the use of these variants could be used for hemophilia gene therapy without altering the safety profile or causing immune responses. During my fellowship at Barnes Jewish Hospital and Washington University School of Medicine I began working in the laboratory under the mentorship of Dr. Jorge Di Paola and have primarily studied how changes in systemic factors, such as autoimmune disease and aging, can affect megakaryopoiesis and platelet function leading to both bleeding and thrombosis. The myeloproliferative neoplasms (MPNs) utilize the same inflammatory signaling and drives both symptoms and disease. Within MPNs I study how signaling through megakaryocytes changes the evolution of different disease clones and affects on bleeding and clotting.
Biosketch
Education
- 2014-2018: MD, Cooper Medical School of Rowan University, Camden, NJ.
- 2006-2010: BS, Biochemistry and Molecular Biology, Gettysburg College, Gettysburg, PA.
Post-Graduate Training
- 2021-2024: Hematology and Medical Oncology Fellowship, Washington University in St. Louis / Barnes Jewish Hospital, St. Louis, MO.
- 2018-2021: Internal Medicine Residency, Brown University / Rhode Island Hospital / The Miriam Hospital, Providence, RI.
Academic Positions & Employment
- 2024-present: Instructor, Department of Medicine, Division of Hematology, Washington University in St. Louis, St. Louis, MO.
Board Certification
- 2023-present: American Board of Internal Medicine, Board certified in Internal Medicine
- 2021-present: American Board of Internal Medicine, Board certified in Medical Oncology
Honors & Awards
- 2024: Hanna J Khoury Outstanding Fellow Award, Washington University Hematology/Oncology Fellowship
- 2024: Dean’s Scholar, Division of Physician-Scientists, Washington University School of Medicine
- 2023: Knowlton Incentive for Excellence Award, Foundation for Barnes Jewish Hospital
- Appointments and Committees
- 2022: Emerging Generation Award, American Society for Clinical Investigation
- 2019-2021: Clinical Educator Track, Warren Alpert School of Medicine, Brown University
- 2017: Gold Humanism Honor Society Inductee
- 2015: Hematology Opportunities for the Next Generation of Research Scientist (HONORS) Awardee, American Society of Hematology
- 2014: Meritorious Abstract Travel Award, American Society for Gene & Cell Therapy
- 2012: Abstract Achievement Award, American Society of Hematology