In this study, WashU Researchers discovered how protein homeostasis mechanism, unfolded protein response (UPR) signaling regulates blood cell lineage output. Given that UPR signaling is upregulated in many cancers, this study provides important insights into targeting UPR signaling as therapeutic strategies. Their findings were published in Blood Advances.
Choi, H., Jung, S.-E., Earth, Y., Paik, H., Lin, S., Yi, J., Cox, M.J., Sykes, S.M., Oh, S.T. and Kang, Y.-A., 2026. Unfolded protein response signaling promotes myeloid cell production and cooperates with oncogenic mutation. Blood Advances, Advance online publication. DOI: https://doi.org/10.1182/bloodadvances.2026019895.